Locally Advanced

Oncology·MeSH: Carcinoma

177 drugs in development·71 companies·5 clinical trials

Drug Pipeline by Phase

Approved(18)

Drug	Company
afinitor	Novartis AG (NVS)
docetaxel	Amneal Pharmaceuticals, Inc. (AMRX)
emrelis	AbbVie Inc. (ABBV)
Erivedge	CURIS INC (CRIS)
hydroxyurea	AVEDRO INC (AVDR)
ibrance	PFIZER INC (PFE)
ibtrozi	Nuvation Bio Inc. (NUVB)
krazati	Mirati Therapeutics, Inc. (MRTX)
krazati	BRISTOL MYERS SQUIBB CO (BMY)
loqtorzi	Coherus Oncology, Inc. (CHRS)
paclitaxel	Mylan II B.V. (MYL)
pemetrexed	DR REDDYS LABORATORIES LTD (RDY)
pemfexy	EAGLE PHARMACEUTICALS, INC. (EGRX)
trodelvy	Immunome Inc. (IMNM)
unloxcyt	Checkpoint Therapeutics, Inc. (CKPT)
unloxcyt	Fortress Biotech Inc. (FBIO)
unloxcyt	Fortress Biotech Inc. (FBIO)
ZYNYZ	MACROGENICS INC (MGNX)

Phase 3(52)

Drug	Company
acasunlimab	Genmab A/S (GMAB)
an2025	Adlai Nortye Ltd. (ANL)
avelumab	GH Research PLC (GHRS)
Avelumab	Merck & Co., Inc. (MRK)
AXAL (axalimogene filolisbac / ADXS-HPV)	Ayala Pharmaceuticals, Inc. (ADXS)
azd0171	ASTRAZENECA PLC (AZN)
AZD5305	ASTRAZENECA PLC (AZN)
Cabozantinib	Royalty Pharma plc (RPRX)
CAN-2409	Candel Therapeutics, Inc. (CADL)
Capivasertib	ASTRAZENECA PLC (AZN)
Cemiplimab	ENANTA PHARMACEUTICALS INC (ENTA)
cetuximab	Novartis AG (NVS)
Concurrent chemotherapy	Crinetics Pharmaceuticals, Inc. (CRNX)
erlotinib 150/100 mg	ASTRAZENECA PLC (AZN)
FOLFIRINOX chemotherapy	Merus N.V. (MRUS)
folfox	GH Research PLC (GHRS)
FOLFOX	KYNTRA BIO INC. (KYNB)
folinic acid	Merus N.V. (MRUS)
GDC-9545	ENANTA PHARMACEUTICALS INC (ENTA)
Giredestrant	ENANTA PHARMACEUTICALS INC (ENTA)
GnRH Agonist	ENANTA PHARMACEUTICALS INC (ENTA)
iag	RenovoRx, Inc. (RNXT)
Immune induction therapy	Crinetics Pharmaceuticals, Inc. (CRNX)
Immunomaintenance therapy	Crinetics Pharmaceuticals, Inc. (CRNX)
Inavolisib	ENANTA PHARMACEUTICALS INC (ENTA)
Ipatasertib	ENANTA PHARMACEUTICALS INC (ENTA)
JDQ443	Novartis AG (NVS)
l-leucovorin	Merus N.V. (MRUS)
Lartesertib	Merck & Co., Inc. (MRK)
Leucovorin/levofolinate calcium	Merus N.V. (MRUS)
LHRH Agonist	ENANTA PHARMACEUTICALS INC (ENTA)
Mitomycin	KYNTRA BIO INC. (KYNB)
Multikine	CEL SCI CORP (CVM)
nbtxr3	LianBio (LIANY)
Neoadjuvant olaparib	ENANTA PHARMACEUTICALS INC (ENTA)
panitumumab	GH Research PLC (GHRS)
pemetrexed	Crinetics Pharmaceuticals, Inc. (CRNX)
Procarbazine Hydrochloride	ENANTA PHARMACEUTICALS INC (ENTA)
sacituzumab govitecan	Phoenix Life Sciences International Limited. (PLSI)
sunvozertinib	Merus N.V. (MRUS)
surzebiclimab	BeOne Medicines Ltd. (ONC)
SYS6010	Merus N.V. (MRUS)
t-dxd	ASTRAZENECA PLC (AZN)
tak-280	Takeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) (TAK)
tak-280	TAKEDA PHARMACEUTICAL CO LTD (TKPHF)
Trametinib	Novartis AG (NVS)
vepdegestrant	ARVINAS, INC. (ARVN)
vinflunine	Phoenix Life Sciences International Limited. (PLSI)
Volrustomig	ASTRAZENECA PLC (AZN)
zipalertinib	Cullinan Therapeutics, Inc. (CGEM)
zolbetuximab	Merus N.V. (MRUS)
zongertinib	Merus N.V. (MRUS)

Phase 2(61)

Drug	Company
Arginine hydrochloride	ENANTA PHARMACEUTICALS INC (ENTA)
Avelumab	NEKTAR THERAPEUTICS (NKTR)
azd5305 microtracer	ASTRAZENECA PLC (AZN)
BNT327 Dose Level 1	BioNTech SE (BNTX)
BNT327 Equivalent Q3W Dose	BioNTech SE (BNTX)
BNT327 Optimized Dose	BioNTech SE (BNTX)
Brigatinib	Merus N.V. (MRUS)
BT8009	BICYCLE THERAPEUTICS PLC (BCYC)
Budigalimab	AbbVie Inc. (ABBV)
Cabozantinib	UNITED THERAPEUTICS Corp (UTHR)
Cemiplimab	Royalty Pharma plc (RPRX)
Cemiplimab	ADMA BIOLOGICS, INC. (ADMA)
Cetrelimab	ENANTA PHARMACEUTICALS INC (ENTA)
Cetrelimab	Janux Therapeutics, Inc. (JANX)
Chlorhexidine	Structure Therapeutics Inc. (GPCR)
Clindamycin	Structure Therapeutics Inc. (GPCR)
Clobetasol	Structure Therapeutics Inc. (GPCR)
Copanlisib Hydrochloride	ENANTA PHARMACEUTICALS INC (ENTA)
Defactinib Hydrochloride	ENANTA PHARMACEUTICALS INC (ENTA)
Doxycycline	Structure Therapeutics Inc. (GPCR)
Eflornithine Hydrochloride	ENANTA PHARMACEUTICALS INC (ENTA)
Eribulin	BioNTech SE (BNTX)
Fianlimab	ADMA BIOLOGICS, INC. (ADMA)
FOLFOX regimen	KYNTRA BIO INC. (KYNB)
Immune checkpoint inhibitor	KYNTRA BIO INC. (KYNB)
Ipatasertib	Merus N.V. (MRUS)
L-NMMA	ENANTA PHARMACEUTICALS INC (ENTA)
L-NMMA	Relay Therapeutics, Inc. (RLAY)
L-NMMA	Cidara Therapeutics, Inc. (CDTX)
L-NMMA	ARROWHEAD PHARMACEUTICALS, INC. (ARWR)
L-NMMA	ADMA BIOLOGICS, INC. (ADMA)
L-NMMA	Novartis AG (NVS)
Lenvatinib	UNITED THERAPEUTICS Corp (UTHR)
Lenvatinib Mesylate	UNITED THERAPEUTICS Corp (UTHR)
Leucovorin	AbbVie Inc. (ABBV)
m6223	GH Research PLC (GHRS)
M6223	NEKTAR THERAPEUTICS (NKTR)
Minocycline	Structure Therapeutics Inc. (GPCR)
Nab-placlitaxel	BioNTech SE (BNTX)
Nilotinib Hydrochloride Monohydrate	ENANTA PHARMACEUTICALS INC (ENTA)
nktr-255	GH Research PLC (GHRS)
Olaparib	ENANTA PHARMACEUTICALS INC (ENTA)
pc14586	PMV Pharmaceuticals, Inc. (PMVP)
Propranolol Hydrochloride	ENANTA PHARMACEUTICALS INC (ENTA)
rtx-224	Rubius Therapeutics, Inc. (RUBY)
rtx-240	Rubius Therapeutics, Inc. (RUBY)
rucosopasem manganese	Galera Therapeutics, Inc. (GRTX)
sacituzumab govitecan	GH Research PLC (GHRS)
Sacituzumab Govitecan	NEKTAR THERAPEUTICS (NKTR)
sig12d-loder	Silexion Therapeutics Corp (SLXN)
Timolol	Structure Therapeutics Inc. (GPCR)
tislelizumab	Novartis AG (NVS)
tislelizumab	Novartis AG (NVS)
trametinib	Novartis AG (NVS)
Tuvusertib	Merck & Co., Inc. (MRK)
TYRA-200	Tyra Biosciences, Inc. (TYRA)
TYRA-300 0.125 mg/kg	Tyra Biosciences, Inc. (TYRA)
TYRA-300 0.25 mg/kg	Tyra Biosciences, Inc. (TYRA)
TYRA-300 0.375 mg/kg	Tyra Biosciences, Inc. (TYRA)
TYRA-300 0.50 mg/kg	Tyra Biosciences, Inc. (TYRA)
Zinc gluconate	Structure Therapeutics Inc. (GPCR)

Phase 1(22)

Drug	Company
amg 436	AMGEN INC (AMGN)
Aminolevulinic Acid	ENANTA PHARMACEUTICALS INC (ENTA)
an0025	Adlai Nortye Ltd. (ANL)
anti-pd-1	TriSalus Life Sciences Inc. (TLSI)
AU-007	ENANTA PHARMACEUTICALS INC (ENTA)
Avelumab	Accustem Sciences Inc. (ACUT)
CB-708 (ATG-037)	Calithera Biosciences, Inc. (CALA)
cosibelimab	Checkpoint Therapeutics, Inc. (CKPT)
CTX-471	Compass Therapeutics, Inc. (CMPX)
CTX-8371	Compass Therapeutics, Inc. (CMPX)
Epacadostat	Merus N.V. (MRUS)
MRG007	ArriVent BioPharma, Inc. (AVBP)
mvt-1075	MABVAX THERAPEUTICS HOLDINGS, INC. (MBVX)
mvt-2163	MABVAX THERAPEUTICS HOLDINGS, INC. (MBVX)
NVL-330	Nuvalent, Inc. (NUVL)
PD-L1 t-haNK	ImmunityBio, Inc. (IBRX)
PH FDC SC	ENANTA PHARMACEUTICALS INC (ENTA)
Photodynamic Therapy	ENANTA PHARMACEUTICALS INC (ENTA)
tpx-0131	Turning Point Therapeutics, Inc. (TPTX)
TYRA-300	Tyra Biosciences, Inc. (TYRA)
XB010	EXELIXIS, INC. (EXEL)
Zidesamtinib	Nuvalent, Inc. (NUVL)

Preclinical(2)

Drug	Company
cypcaps	PharmaCyte Biotech, Inc. (PMCB)
iv rhdnase i	Xenetic Biosciences, Inc. (XBIO)

Phase 1/Phase 2(14)

Drug	Company
bnt323	BioNTech SE (BNTX)
cetuximab	Novartis AG (NVS)
cr-001	CRESCENT BIOPHARMA, INC. (CBIO)
jdq443	Novartis AG (NVS)
Neladalkib	Nuvalent, Inc. (NUVL)
opnurasib	NOVARTIS AG (NVSEF)
opnurasib	Novartis AG (NVS)
oral repotrectinib	TG THERAPEUTICS, INC. (TGTX)
oral repotrectinib	Turning Point Therapeutics, Inc. (TPTX)
sd-101	TriSalus Life Sciences Inc. (TLSI)
TNG462	Tango Therapeutics, Inc. (TNGX)
TNG908	Tango Therapeutics, Inc. (TNGX)
tno155	Novartis AG (NVS)
tno155	Novartis AG (NVS)

Phase 2/Phase 3(2)

Drug	Company
sil204	Silexion Therapeutics Corp (SLXN)
Telisotuzumab Adizutecan	AbbVie Inc. (ABBV)

Phase 4(6)

Drug	Company
5-Flurouracil	Merus N.V. (MRUS)
Avelumab	ENANTA PHARMACEUTICALS INC (ENTA)
Enfortumab Vedotin	Fulgent Genetics Inc. (FLGT)
Fianlimab	ENANTA PHARMACEUTICALS INC (ENTA)
NG-350A IV administration	Merus N.V. (MRUS)
saruparib	ASTRAZENECA PLC (AZN)

Compare drugs

afinitor vs docetaxel afinitor vs emrelis afinitor vs Erivedge

Frequently asked questions

How many drugs are in development for Locally Advanced?

BioSniper tracks 177 drugs in development for Locally Advanced across 71 companies.

How many clinical trials target Locally Advanced?

There are 5 clinical trials targeting Locally Advanced tracked by BioSniper.

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