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lenvatinib

Generic: LENVATINIB MESYLATE·Brand: LENVIMA, Lenvima

lenvatinib: 43 clinical trials tracked.

lenvatinib evidence translation

What we can confirm

43 tracked trials

No verified listed developer

What it means

AI will separate confirmed drug evidence from unknown company context.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

What is verified about lenvatinib, and what remains unknown?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence8 indications · 10 study sponsors
Clinical Trials (43)showing 10 most recent

A Clinical Study of Iparomlimab and Tuvonralimab Combined With Lenvatinib, Radiotherapy, and Hepatic Arterial Infusion Chemotherapy as First-Line Treatment for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus

NCT07776080·Phase 2
Not yet recruiting

Primary endpoint: Progression-Free Survival (PFS)

Interventionalopen35 targetStarted 2026-10Completion 2028-101 site · ChinaUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

A Multicenter Single-arm Phase 2 Study of Pembrolizumab and Lenvatinib in Previously Treated Inoperable or Advanced Anal Squamous Cell Cancer

NCT07680088·Phase 2
Not yet recruiting

Primary endpoint: Objective response rate of pembrolizumab and lenvatinib combination

Interventionalopen17 targetStarted 2026-09Completion 2030-09University of Texas Southwestern Medical Center

Phase III Double Blinded Trial of Immune-Based Therapy With a Live Biotherapeutic MO-03 or Placebo for Frontline Therapy of Advanced Clear Cell Renal Cell Carcinoma [BioFront Trial]

NCT07383441·Phase 3
Recruiting

Primary endpoint: Progression-free survival (PFS)

InterventionalRandomizeddouble718 targetStarted 2026-06Completion 2034-0141 sites · United StatesSWOG Cancer Research Network

A Multicenter, Open-label, Phase 3 Extension Study to Evaluate the Long-term Efficacy and Safety in Participants Who Are Currently on Treatment in a Belzutifan Study (LITESPARK-043)

NCT07405164·Phase 3
Recruiting

Primary endpoint: Cohort A and Cohort B: Overall Survival (OS)

Interventionalopen450 targetStarted 2026-03Completion 2034-0150 sites · Australia, Belgium, Brazil, Canada…Merck Sharp & Dohme LLC

A Multicenter, Open-Label, Randomized, Phase II Study of Lenvatinib Plus Pembrolizumab With or Without Branched-Chain Amino Acids in Unresectable Hepatocellular Carcinoma

NCT07412054·Phase 2·ENTA
Not yet recruiting

Primary endpoint: Progression-Free Survival (PFS)

InterventionalRandomizedopen234 targetStarted 2026-03Completion 2028-06Fudan University

A Phase II Study of STRIDE (Durvalumab + Tremelimumab) With Lenvatinib Versus STRIDE Alone in Patients With Unresectable Hepatocellular Carcinoma (SLIDE-HCC)

NCT06880523·Phase 2
Recruiting

Primary endpoint: Progression-free Survival using RECIST 1.1

InterventionalRandomizedopen140 targetStarted 2025-10Completion 2028-1213 sites · CanadaCanadian Cancer Trials Group

A Pilot Study of Lenvatinib in Combination With Pembrolizumab in HPV-associated Recurrent Respiratory Papillomatosis Patients

NCT04645602·Phase 2
Recruiting

Primary endpoint: Objective Response Rate (ORR)

Interventionalopen20 targetStarted 2025-07Completion 2027-121 site · United StatesYale University

A Phase 1 First-in-Human Study Evaluating Safety, Pharmacokinetics and Efficacy of ABBV 324 in Adults With Hepatocellular Cancer or Squamous Cell Non-Small Cell Lung Cancer

NCT06858813·Phase 1·ABBV
Recruiting

Primary endpoint: Number of Participants with Adverse Events (AE)s

InterventionalRandomizedopen232 targetStarted 2025-04Completion 2030-0922 sites · China, Israel, Japan, Puerto Rico…AbbVie

A Phase Ib/II Trial of Lenvatinib Plus Pembrolizumab Plus Fulvestrant in ER-positive/ HER2- Negative Metastatic Breast Cancer

NCT06110793·Phase 1/Phase 2
Recruiting

Primary endpoint: The number of adverse events and dose-limiting toxicities to find the Recommended Phase 2 Dose (RP2D)

Interventionalopen56 targetStarted 2023-12Completion 2027-117 sites · United StatesMemorial Sloan Kettering Cancer Center

A Multicenter, Randomized, Double-Blind, Phase 2, Basket Study of MK-4280A, a Coformulation of Favezelimab (MK-4280) With Pembrolizumab (MK-3475) in Selected Solid Tumors (KeyForm-010)

NCT06036836·Phase 2·MRK
Active, not recruiting

Primary endpoint: Clinical Benefit Rate - Cohort A

InterventionalRandomizedtriple160 targetStarted 2023-09Completion 2026-0344 sites · Australia, Canada, France, Germany…Merck Sharp & Dohme LLC