Fibrosis

Respiratory·MeSH: Fibrosis

Prevalence

4.0 / 100K

Incidence

3.5 / 100K/yr

159 drugs in development·83 companies·2 clinical trials

Drug Pipeline by Phase

Approved(18)

Drug	Company
ARIKAYCE	INSMED Inc (INSM)
BRINSUPRI	INSMED Inc (INSM)
cayston	GILEAD SCIENCES, INC. (GILD)
Creon™	ABBOTT LABORATORIES (ABT)
Cystic fibrosis franchise	Royalty Pharma plc (RPRX)
etorel	GYRE THERAPEUTICS, INC. (GYRE)
kalydeco	VERTEX PHARMACEUTICALS INC / MA (VRTX)
nintedanib	EXELIXIS, INC. (EXEL)
nintedanib	X4 Pharmaceuticals, Inc (XFOR)
nintedanib	Aptinyx Inc. (APTX)
nintedanib	DR REDDYS LABORATORIES LTD (RDY)
nintedanib	NYMOX PHARMACEUTICAL CORP (NYMXF)
orbera	Apollo Endosurgery, Inc. (APEN)
pirfenidone	Amneal Pharmaceuticals, Inc. (AMRX)
Rezdiffra	MADRIGAL PHARMACEUTICALS, INC. (MDGL)
tobi podhaler	Viatris Inc (VTRS)
trikafta	VERTEX PHARMACEUTICALS INC / MA (VRTX)
vonjo	CTI BIOPHARMA CORP (CTIC)

Phase 3(31)

Drug	Company
ARIKACE™	INSMED Inc (INSM)
Arikayce™	INSMED Inc (INSM)
best available therapy	GERON CORP (GERN)
efruxifermin	Akero Therapeutics, Inc. (AKRO)
Efruxifermin	Keros Therapeutics, Inc. (KROS)
efruxifermin (EFX)	Akero Therapeutics, Inc. (AKRO)
elritercept	TAKEDA PHARMACEUTICAL CO LTD (TKPHF)
elritercept	Takeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) (TAK)
elritercept	Takeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) (TAK)
elritercept (KER-050)	Keros Therapeutics, Inc. (KROS)
elx/tez/iva	VERTEX PHARMACEUTICALS INC / MA (VRTX)
fedratinib	BRISTOL MYERS SQUIBB CO (BMY)
hec585	SUNSHINE BIOPHARMA INC. (SBFM)
hec585 dose a	SUNSHINE BIOPHARMA INC. (SBFM)
hec585 dose b	SUNSHINE BIOPHARMA INC. (SBFM)
hydronidone	GYRE THERAPEUTICS, INC. (GYRE)
imetelstat	GERON CORP (GERN)
iva	VERTEX PHARMACEUTICALS INC / MA (VRTX)
JAK Inhibitor	Assertio Holdings, Inc. (ASRT)
Liposomal amikacin for inhalation	INSMED Inc (INSM)
luspatercept	CELGENE CORP /DE/ (CELG)
mnkd-101	MANNKIND CORP (MNKD)
momelotinib	Sierra Oncology, Inc. (SRRA)
navitoclax	AbbVie Inc. (ABBV)
Pegozafermin	89bio, Inc. (ETNB)
pelabresib	Novartis AG (NVS)
pirfenidone	PureTech Health plc (PRTC)
SLIT™ Amikacin	INSMED Inc (INSM)
vnz/tez/d-iva	VERTEX PHARMACEUTICALS INC / MA (VRTX)
vx-121/tez/d-iva	VERTEX PHARMACEUTICALS INC / MA (VRTX)
vx-828	VERTEX PHARMACEUTICALS INC / MA (VRTX)

Phase 2(56)

Drug	Company
[F-18]-FAPI-74	ENANTA PHARMACEUTICALS INC (ENTA)
4D-710	4D Molecular Therapeutics, Inc. (FDMT)
adrulipase	GridAI Technologies Corp. (GRDX)
AP-PA02	Armata Pharmaceuticals, Inc. (ARMP)
AR-501	Aridis Pharmaceuticals, Inc. (ARDS)
ARCT-032	Arcturus Therapeutics Holdings Inc. (ARCT)
AZD2389	ASTRAZENECA PLC (AZN)
Bexotegrast (PLN-74809)	PLIANT THERAPEUTICS, INC. (PLRX)
bomedemstat	UNITED THERAPEUTICS Corp (UTHR)
Busulfan	Assertio Holdings, Inc. (ASRT)
Chlorhexidine	Bausch Health Companies Inc. (BHC)
Chlorhexidine Gluconate	Bausch Health Companies Inc. (BHC)
cpi-0610	CONSTELLATION PHARMACEUTICALS INC (CNST)
disc-0974	Disc Medicine, Inc. (IRON)
env-101	Generate Biomedicines Inc. (GENB)
Fludarabine	Assertio Holdings, Inc. (ASRT)
galicaftor	Sionna Therapeutics, Inc. (SION)
gb2064	Damora Therapeutics, Inc. (DMRA)
gri-0621	GRI Bio, Inc. (GRI)
hydroxycarbamide	SPRING PHARMACEUTICAL GROUP, INC. (CYIG)
ifetroban	CUMBERLAND PHARMACEUTICALS INC (CPIX)
Itepekimab	REGENERON PHARMACEUTICALS, INC. (REGN)
local antibiotic application of topical minocycline	Bausch Health Companies Inc. (BHC)
losartan 25 milligram	WELLNESS CENTER USA, INC. (WCUI)
lti-03	Rein Therapeutics, Inc. (RNTX)
lti-05	Rein Therapeutics, Inc. (RNTX)
Melphalan	Assertio Holdings, Inc. (ASRT)
Minocycline	Bausch Health Companies Inc. (BHC)
mn-001	MEDICINOVA INC (MNOV)
momelotinib	Karyopharm Therapeutics Inc. (KPTI)
mrt5005	Translate Bio, Inc. (TBIO)
Mupirocin	Bausch Health Companies Inc. (BHC)
nal er	Trevi Therapeutics, Inc. (TRVI)
navocaftor	Sionna Therapeutics, Inc. (SION)
pacritinib	Karyopharm Therapeutics Inc. (KPTI)
pipe-791 dose a	Contineum Therapeutics, Inc. (CTNM)
pipe-791 dose b	Contineum Therapeutics, Inc. (CTNM)
PLN-1474	PLIANT THERAPEUTICS, INC. (PLRX)
PLN-74809	PLIANT THERAPEUTICS, INC. (PLRX)
pur1900	Pulmatrix, Inc. (PULM)
Rencofilstat (formerly CRV431; CPI-431-32)	Hepion Pharmaceuticals, Inc. (CTRVP)
rencofilstat (formerly CRV431)	Hepion Pharmaceuticals, Inc. (CTRVP)
sar445399	Sanofi (SNY)
SAR445399	Sanofi (SNY)
sion-2851	Sionna Therapeutics, Inc. (SION)
sion-3067	Sionna Therapeutics, Inc. (SION)
sion-719	Sionna Therapeutics, Inc. (SION)
Tacrolimus	ENANTA PHARMACEUTICALS INC (ENTA)
Tacrolimus	Assertio Holdings, Inc. (ASRT)
Trimethoprim Sulfamethoxazole	Bausch Health Companies Inc. (BHC)
tti-101	Tvardi Therapeutics, Inc. (TVRD)
Vasculan	CUMBERLAND PHARMACEUTICALS INC (CPIX)
vx-581	VERTEX PHARMACEUTICALS INC / MA (VRTX)
vx-661	VERTEX PHARMACEUTICALS INC / MA (VRTX)
xiaflex	Endo LP (NDOI)
Zinc gluconate	Bausch Health Companies Inc. (BHC)

Phase 1(22)

Drug	Company
ABBV-142	AbbVie Inc. (ABBV)
ANPA-0073	Structure Therapeutics Inc. (GPCR)
ARO-ENaC	ARROWHEAD PHARMACEUTICALS, INC. (ARWR)
ARO-MMP7	ARROWHEAD PHARMACEUTICALS, INC. (ARWR)
ARO-MMP7 Inhalation Solution	ARROWHEAD PHARMACEUTICALS, INC. (ARWR)
Axatilimab	Syndax Pharmaceuticals Inc (SNDX)
bkm120	Novartis AG (NVS)
CB-280	Calithera Biosciences, Inc. (CALA)
deupirfenidone	PureTech Health plc (PRTC)
inc424	Novartis AG (NVS)
incb057643	Incyte Corp. (INCY)
itacitinib	Incyte Corp. (INCY)
mnkd-201	MANNKIND CORP (MNKD)
nintedanib	SUNSHINE BIOPHARMA INC. (SBFM)
parsaclisib	Incyte Corp. (INCY)
pelabresib	Novartis AG (NVS)
rosuvastatin	VERTEX PHARMACEUTICALS INC / MA (VRTX)
sion-109	Sionna Therapeutics, Inc. (SION)
sion-2222	Sionna Therapeutics, Inc. (SION)
sion-451	Sionna Therapeutics, Inc. (SION)
vx-118	VERTEX PHARMACEUTICALS INC / MA (VRTX)
vx-272	VERTEX PHARMACEUTICALS INC / MA (VRTX)

Preclinical(17)

Drug	Company
aeol 20415	AEOLUS PHARMACEUTICALS, INC. (AOLS)
ATYR0101	aTYR PHARMA INC (ATYR)
ATYR0750	aTYR PHARMA INC (ATYR)
cb5138-3	COHBAR, INC. (COBU)
chit1 small molecule	Ocean Biomedical, Inc. (OCEA)
CPI-935	Corvus Pharmaceuticals, Inc. (CRVS)
CT-2401	Carisma Therapeutics Inc. (CARM)
cystic fibrosis program	Prime Medicine, Inc. (PRME)
dmr-001	Damora Therapeutics, Inc. (DMRA)
eg-i08	ENGENE HOLDINGS INC. (ENGN)
f351	GYRE THERAPEUTICS, INC. (GYRE)
JAK2 program	Cogent Biosciences, Inc. (COGT)
LTSE-2578	Structure Therapeutics Inc. (GPCR)
morf-088	Morphic Holding, Inc. (MORF)
ProLectin-F	BIOXYTRAN, INC (BIXT)
ProLectin-I	BIOXYTRAN, INC (BIXT)
REC-4209	RECURSION PHARMACEUTICALS, INC. (RXRX)

Unknown(1)

Drug	Company
acg-701	Aceragen, Inc. (ACGN)

BLA Filed(1)

Drug	Company
fedratinib	CELGENE CORP /DE/ (CELG)

Phase 1/Phase 2(6)

Drug	Company
kb407	Krystal Biotech, Inc. (KRYS)
KB407	Krystal Biotech, Inc. (KRYS)
KB407	Krystal Biotech, Inc. (KRYS)
MRT5005	Sanofi (SNY)
pelabresib	CONSTELLATION PHARMACEUTICALS INC (CNST)
vx-522 mrna therapy	VERTEX PHARMACEUTICALS INC / MA (VRTX)

Phase 4(7)

Drug	Company
bms-986158	BRISTOL MYERS SQUIBB CO (BMY)
BMS-986278	BRISTOL MYERS SQUIBB CO (BMY)
elexacaftor / ivacaftor / tezacaftor	GH Research PLC (GHRS)
inhaled treprostinil	UNITED THERAPEUTICS Corp (UTHR)
Inhaled treprostinil	UNITED THERAPEUTICS Corp (UTHR)
panobinostat	NOVARTIS AG (NVSEF)
panobinostat	Novartis AG (NVS)

Compare drugs

ARIKAYCE vs BRINSUPRI ARIKAYCE vs cayston ARIKAYCE vs Creon™

Frequently asked questions

How many drugs are in development for Fibrosis?

BioSniper tracks 159 drugs in development for Fibrosis across 83 companies.

How many clinical trials target Fibrosis?

There are 2 clinical trials targeting Fibrosis tracked by BioSniper.

What is the prevalence of Fibrosis?

The estimated prevalence of Fibrosis is approximately 4.0 per 100,000 population.

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