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xiaflex

Generic: collagenase clostridium histolyticum·Brand: Qwo, Xiaflex

xiaflex: sourced relationships with 3 companies · 6 clinical trials tracked.

xiaflex evidence translation

What we can confirm

6 tracked trials

What it means

More than one company relationship is source-backed. Until you choose one, AI stays drug-only and does not guess ownership.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

What is verified about xiaflex, and what remains unknown?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence3 indications · 0 study sponsors

Related indications

Uterine fibroidsplantar fasciitisarthrofibrosis of the knee post arthroplasty

Study sponsors

No additional listed-company sponsor is linked.

Dated Pipeline Records (3)
CompanyDated record stage
BIOSPECIFICS TECHNOLOGIES CORP (BSTC)
licensee · Reported 2019-08-09 · Current development: unknownSource
Uterine fibroids
Phase 1
Endo International plc (ENDP)
developer · Reported 2023-03-06 · Current development: unknownSource
Preclinical
Endo LP (NDOI)
developer · Reported 2025-03-13 · Current development: unknownSource
arthrofibrosis of the knee post arthroplasty
Phase 2
Clinical Trial Registry Records (6)

Efficacy of a Step-wise Protocol in Optimizing CCH Outcomes in Men With Peyronie's Disease

NCT06649539Registry updated 2026-08-26·Phase 4
Active, not recruiting

Primary endpoint: Penile Curvature

Interventionalopen40 targetStarted 2024-10Completion 2029-101 site · United StatesCharitable Union for the Research and Education of Peyronie's Disease

A Phase 2, Double-blind, Randomized, Placebo-controlled, Dose-ranging Study to Assess the Efficacy, Safety, and Tolerability of EN3835 vs Placebo in the Treatment of Plantar Fasciitis (PFA)

NCT06169319Registry updated 2025-09-30·Phase 2
Completed

Primary endpoint: Change from Baseline at Week 12 in the Weekly Mean of the Average Daily (24-hour) Pain (ADP) Score as Measured on the Pain Intensity Numeric Rating Scale (NRS)

InterventionalRandomizeddouble231 enrolledStarted 2024-01Completion 2024-0939 sites · United StatesEndo Pharmaceuticals

A Phase 3, Double-blind, Randomized, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis (PFI) (Also Known as Ledderhose Disease)

NCT06151197Registry updated 2026-06-09·Phase 3
Active, not recruiting

Primary endpoint: Change from Baseline to Week 12 in the Weekly Mean of the Average Daily (24-hour) Pain (ADP) Score as Measured on the Pain Intensity Numeric Rating Scale (NRS)

InterventionalRandomizeddouble418 targetStarted 2023-11Completion 2026-0650 sites · United StatesEndo USA Inc., a Keenova Therapeutics Company

Safety and Efficacy of Collagenase Clostridium Histolyticum After Prior Intralesional Platelet Rich Plasma for Peyronie's Disease

NCT05777031Registry updated 2026-06-04·Phase 4
Active, not recruiting

Primary endpoint: Number of Treatment Related Adverse Events

Interventionalopen12 targetStarted 2023-10Completion 2027-012 sites · United StatesUniversity of Miami

Phase 2, Double-blind, Randomized, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis

NCT05152173Registry updated 2026-03-27·Phase 2
Completed

Primary endpoint: Change From Baseline to Day 57 in the Foot Function Index (FFI) Pain Subscale Score

InterventionalRandomizeddouble176 enrolledStarted 2021-11Completion 2023-0143 sites · United StatesEndo Pharmaceuticals

To Assess the Effectiveness of Multiple Dose, Multiple Concentrations of Clostridium Histolyticum-aases, Qwo, for the Treatment of Mild to Moderate Cellulite in Adult Females to the Buttocks and Thighs

NCT05026216Registry updated 2026-05-28·Phase 4
Completed

Primary endpoint: Proportion of Subjects With ≥1-point Improvement on Investigator Global Aesthetic Improvement Scale (I-GAIS) at Day 90 (Buttocks)

Interventionalopen5 enrolledStarted 2021-03Completion 2021-081 site · United StatesDMR Research, PLLC

Frequently asked questions

Which companies have sourced relationships with xiaflex?

xiaflex has dated SEC/FDA relationship records for BIOSPECIFICS TECHNOLOGIES CORP, Endo International plc, Endo LP.

How many clinical trials involve xiaflex?

BioSniper tracks 6 clinical trials involving xiaflex.