AMICUS THERAPEUTICS, INC.
FOLD evidence brief
What we can confirm
What it means
What to watch
Prepared research question
What matters most for FOLD—catalysts, financial risk and supporting evidence?
Traceable citations · Unknowns marked
BioSniper AI · FOLD
Amicus Therapeutics, Inc. is a biotechnology company focused on the discovery, development, and commercialization of therapies for rare and orphan diseases.
Key risk: Ongoing Funding Requirements
BioSniper Score
Based on 5 of 6 signals
Financial data as of Dec 31, 2025.
Tracking 7 pipeline candidates · 19 clinical trials · 2 catalysts · 3 FDA decisions for AMICUS THERAPEUTICS, INC..
Amicus Therapeutics, Inc. is a biotechnology company focused on the discovery, development, and commercialization of therapies for rare and orphan diseases.
- As of December 31, 2025, the company reported $217.3 million in cash and equivalents, $185.2 million in total revenue, and a net income of $1.7 million [sec].
- Total debt was reported at $392.7 million as of December 31, 2025 [sec].
- The company's commercial portfolio includes Pombiliti™ + Opfolda™ for the treatment of Pompe disease, which has received regulatory approvals in markets including Spain [sec].
- Amicus continues to advance its pipeline, including research into Fabry disease gene therapy and other novel technologies [sec].
Risks & what to watch (2)›
Key risks
- Ongoing Funding Requirements — The company expects to continue incurring significant costs for R&D and clinical trials [sec_mda].
- Clinical and Manufacturing Dependencies — Future capital needs depend on clinical trial results and the costs of manufacturing drug supplies [sec_mda].
What to watch
- Progress and results of clinical trials for current drug candidates [sec_mda].
- Manufacturing costs and supply chain management for Pombiliti® [sec_mda].
- Potential future acquisitions or in-licensing of assets to support the rare disease pipeline [sec_mda].
Sources: SEC filings · SEC MD&A · Generated June 27, 2026 · How we verify sources →
Run AMICUS THERAPEUTICS, INC. through your own thesis
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Evidence & data
Score breakdownBased on 5 of 6 signals · derived from public data
Profitable (positive operating cash flow)
D/E 2.46
Lead: Approved
7 candidates
2 upcoming, next in ~123d
No insider transactions in the last 180 days
Catalysts
Pipeline
Regulatory
Financials
Institutional Holdings
Source: SEC Form 13F · as of Mar 2026Institutional holders
297
Total value held
$4.81B
| Holder | Shares | Value |
|---|---|---|
| blackrock, inc. | 33,879,048 | $489.9M |
| vanguard capital management llc | 28,047,114 | $405.6M |
| ubs group ag | 15,957,913 | $230.8M |
| pentwater capital management lp | 14,000,000 | $202.4M |
| vanguard portfolio management llc | 13,974,932 | $202.1M |
| state street corp | 12,893,897 | $186.4M |
| fil ltd | 12,560,028 | $181.6M |
| goldman sachs group inc | 11,556,008 | $167.1M |
| qube research & technologies ltd | 8,809,340 | $127.4M |
| hbk investments l p | 8,783,448 | $127.0M |
Showing top 10 of 297 institutional holders of AMICUS THERAPEUTICS, INC.. Open the full 13F history after sign-in.
Short Interest
as of Apr 19, 2026- % of float
- 6.8%
- Days to cover
- 5.6
- Shares short
- 21,099,073
- Daily short volume
- -
Short percent of float and days-to-cover reflect reported short positioning. Daily short volume is the exchange-reported short share of a single day's trading volume and is noisier. See the most-shorted biotech ranking →
FOLD short interestGovernance
Frequently asked questions
What is the AI investment thesis for AMICUS THERAPEUTICS, INC.?
Amicus Therapeutics, Inc. is a biotechnology company focused on the discovery, development, and commercialization of therapies for rare and orphan diseases.
What is AMICUS THERAPEUTICS, INC.'s lead drug candidate?
AMICUS THERAPEUTICS, INC.'s most advanced tracked candidate is AT2221 (Phase 3) for Pompe Disease (Late-onset); Pompe Disease.
What is AMICUS THERAPEUTICS, INC.'s next catalyst?
AMICUS THERAPEUTICS, INC.'s next tracked catalyst is a Phase3_Topline event — "Phase 3 Topline: An Open-label Study to Evaluate the Safety and Pharmacokinetics of Migalastat HCl in Subjects With F" — expected December 31, 2026.
Who is the CEO of AMICUS THERAPEUTICS, INC.?
Mr. Bradley L. Campbell M.B.A. is the chief executive officer of AMICUS THERAPEUTICS, INC. (FOLD).
Where is AMICUS THERAPEUTICS, INC. headquartered?
AMICUS THERAPEUTICS, INC. (FOLD) is headquartered in Princeton, NJ, United States.
The AI overview and BioSniper Score are neutral, data-derived signals built from public SEC filings, ClinicalTrials.gov and FDA records — not investment advice.