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| ALNYALNYLAM PHARMACEUTICALS, INC. | 6,491,280 | $2.15B |
| INSMINSMED Inc | 10,371,802 | $1.70B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,720,774 | $1.33B |
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| INCYIncyte Corp. | 7,759,183 | $730.3M |
| RVMDREVOLUTION MEDICINES, INC. | 7,502,623 | $729.6M |
| BBIOBridgeBio Pharma, Inc. | 8,080,573 | $600.1M |
| IONSIONIS PHARMACEUTICALS INC | 7,808,902 | $586.4M |
| JAZZJazz Pharmaceuticals plc | 2,983,242 | $564.0M |
| ROIVRoivant Sciences Ltd. | 19,838,698 | $549.5M |
| EXELEXELIXIS, INC. | 12,085,273 | $518.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 8,298,475 | $468.8M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 7,146,136 | $448.1M |
| CYTKCYTOKINETICS INC | 5,843,782 | $385.2M |
| PTGXProtagonist Therapeutics, Inc | 3,481,211 | $366.9M |
| PCVXVaxcyte, Inc. | 6,279,545 | $364.9M |
| AXSMAxsome Therapeutics, Inc. | 2,058,170 | $347.9M |
| PTCTPTC THERAPEUTICS, INC. | 4,804,594 | $327.3M |
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| TGTXTG THERAPEUTICS, INC. | 8,273,979 | $274.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 3,040,718 | $264.5M |
| NUVLNuvalent, Inc. | 2,500,907 | $256.2M |
| LGNDLigand Pharmaceuticals Incorporated | 1,100,267 | $219.7M |
| APLSApellis Pharmaceuticals, Inc. | 5,404,559 | $217.4M |
| FOLDAMICUS THERAPEUTICS, INC. | 13,974,932 | $202.1M |
| ACADACADIA PHARMACEUTICALS INC | 8,671,645 | $193.0M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 3,238,693 | $167.4M |
| VKTXViking Therapeutics, Inc. | 4,464,298 | $145.3M |
| OGNOrganon & Co. | 21,846,036 | $130.9M |
| IBRXImmunityBio, Inc. | 16,322,844 | $125.2M |
| DNLIDenali Therapeutics Inc. | 6,120,160 | $117.5M |
| BEAMBeam Therapeutics Inc. | 4,570,797 | $108.9M |
| SMMTSummit Therapeutics Inc. | 5,233,252 | $99.2M |
| INVAInnoviva, Inc. | 4,224,951 | $98.4M |
| RCUSArcus Biosciences, Inc. | 4,272,056 | $92.3M |
| IMVTImmunovant, Inc. | 3,704,905 | $92.0M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 2,611,035 | $88.3M |
| KNSAKiniksa Pharmaceuticals International, plc | 1,766,268 | $85.0M |
| ADMAADMA BIOLOGICS, INC. | 8,868,657 | $79.9M |
| NTLAIntellia Therapeutics, Inc. | 6,223,325 | $79.8M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 22,759,100 | $69.9M |
| ADPTAdaptive Biotechnologies Corp | 4,491,474 | $62.3M |
| TVTXTravere Therapeutics, Inc. | 1,709,139 | $50.8M |
| ARQTArcutis Biotherapeutics, Inc. | 1,954,685 | $46.1M |
| DAWNDay One Biopharmaceuticals, Inc. | 2,095,813 | $44.9M |
| ARVNARVINAS, INC. | 3,889,628 | $41.2M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 11,700,844 | $41.1M |
| ARDXARDELYX, INC. | 6,661,693 | $39.9M |
| TERNTerns Pharmaceuticals, Inc. | 722,389 | $38.1M |
| SRRKScholar Rock Holding Corp | 721,744 | $35.5M |
| APGEApogee Therapeutics, Inc. | 396,330 | $33.4M |
| VRDNViridian Therapeutics, Inc.\DE | 1,641,477 | $32.1M |
| VCELVericel Corp | 991,626 | $31.9M |
| SYRESpyre Therapeutics, Inc. | 585,130 | $29.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 349,381 | $29.3M |
| ANIPANI PHARMACEUTICALS INC | 375,965 | $28.9M |
| ANABANAPTYSBIO, INC | 519,870 | $28.8M |
| RDYDR REDDYS LABORATORIES LTD | 1,773,738 | $24.6M |
| LQDALiquidia Corp | 632,625 | $23.9M |
| CLDXCelldex Therapeutics, Inc. | 629,252 | $20.0M |
| BHVNBiohaven Ltd. | 2,279,275 | $19.3M |
| TNGXTango Therapeutics, Inc. | 901,466 | $18.9M |
| RLAYRelay Therapeutics, Inc. | 1,863,565 | $18.5M |
| ORKAOruka Therapeutics, Inc. | 350,892 | $17.2M |
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| OPKOPKO HEALTH, INC. | 14,769,719 | $16.8M |
| RCKTRocket Pharmaceuticals Inc. | 4,690,215 | $16.8M |
| ALTAltimmune, Inc. | 5,382,002 | $16.6M |
| DFTXDefinium Therapeutics Inc. | 872,665 | $16.5M |
| SLNOSOLENO THERAPEUTICS INC | 477,321 | $16.0M |
| IRONDisc Medicine, Inc. | 247,338 | $15.8M |
| ALMSALUMIS INC. | 712,608 | $15.7M |
| XERSXeris Biopharma Holdings, Inc. | 2,665,608 | $15.5M |
| STOKStoke Therapeutics, Inc. | 462,682 | $15.1M |
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| KODKodiak Sciences Inc. | 365,051 | $13.9M |
| OCULOCULAR THERAPEUTIX, INC | 1,594,666 | $13.5M |
| ELVNEnliven Therapeutics, Inc. | 330,964 | $13.0M |
| ZYMEZymeworks Inc. | 499,875 | $12.5M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 379,214 | $11.5M |
| PVLAPALVELLA THERAPEUTICS, INC. | 90,858 | $11.3M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,734,649 | $11.1M |
| HROWHARROW, INC. | 288,875 | $10.2M |
| KURAKura Oncology, Inc. | 1,230,802 | $10.0M |
| NUVBNuvation Bio Inc. | 2,275,446 | $9.8M |
| ESPREsperion Therapeutics, Inc. | 3,532,563 | $9.7M |
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| OLMAOlema Pharmaceuticals, Inc. | 593,031 | $8.8M |
| RGNXREGENXBIO Inc. | 1,018,901 | $8.5M |
| ANNXAnnexon, Inc. | 1,483,090 | $8.2M |
| PGENPRECIGEN, INC. | 2,116,011 | $8.2M |
| CGEMCullinan Therapeutics, Inc. | 552,553 | $7.9M |
| KROSKeros Therapeutics, Inc. | 682,043 | $7.5M |
| SVRASavara Inc | 1,375,477 | $7.5M |
| KALVKalVista Pharmaceuticals, Inc. | 362,900 | $7.3M |
| ORICOric Pharmaceuticals, Inc. | 570,691 | $7.2M |
| GERNGERON CORP | 4,668,783 | $7.0M |
| UPBUpstream Bio, Inc. | 727,711 | $6.5M |
| ABUSArbutus Biopharma Corp | 1,392,024 | $6.3M |
| SLSSELLAS Life Sciences Group, Inc. | 1,462,806 | $6.2M |
| MAZEMaze Therapeutics, Inc. | 195,542 | $5.8M |
| BCAXBicara Therapeutics Inc. | 290,939 | $5.8M |
| CMPXCompass Therapeutics, Inc. | 1,082,651 | $5.7M |
| SIONSionna Therapeutics, Inc. | 142,081 | $5.7M |
| ALECAlector, Inc. | 2,583,542 | $5.6M |
| NKTRNEKTAR THERAPEUTICS | 72,491 | $5.2M |
| FDMT4D Molecular Therapeutics, Inc. | 555,829 | $5.2M |
| BIOABioAge Labs, Inc. | 286,946 | $5.0M |
| FATEFATE THERAPEUTICS INC | 4,134,585 | $5.0M |
| SANASana Biotechnology, Inc. | 1,707,521 | $4.9M |
| ZBIOZenas BioPharma, Inc. | 251,410 | $4.9M |
| RNAAtrium Therapeutics Inc. | 344,369 | $4.6M |
| ZVRAZEVRA THERAPEUTICS, INC. | 466,303 | $4.3M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 135,031 | $4.3M |
| SPRYARS Pharmaceuticals, Inc. | 510,551 | $4.1M |
| AGENAGENUS INC | 1,195,109 | $4.0M |
| CTMXCytomX Therapeutics, Inc. | 794,755 | $3.7M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 165,201 | $3.6M |
| DNAGinkgo Bioworks Holdings Inc. | 565,652 | $3.5M |
| ORGOOrganogenesis Holdings Inc. | 1,449,092 | $3.4M |
| FLGTFulgent Genetics Inc. | 215,854 | $3.4M |
| SIGASIGA TECHNOLOGIES INC | 586,974 | $3.1M |
| CATXPerspective Therapeutics, Inc. | 752,033 | $3.1M |
| JBIOJade Biosciences, Inc. | 211,319 | $3.0M |
| AQSTAquestive Therapeutics, Inc. | 691,750 | $2.9M |
| VYGRVoyager Therapeutics, Inc. | 725,769 | $2.8M |
| TRDAEntrada Therapeutics, Inc. | 220,494 | $2.8M |
| LBRXLB PHARMACEUTICALS INC | 112,497 | $2.8M |
| XOMAXOMA Royalty Corporation | 85,797 | $2.7M |
| SLDBSolid Biosciences Inc. | 338,630 | $2.4M |
| AVXLANAVEX LIFE SCIENCES CORP. | 783,148 | $2.4M |
| ABSIAbsci Corporation | 801,063 | $2.4M |
| MPLTMapLight Therapeutics, Inc. | 112,604 | $2.3M |
| TECXTectonic Therapeutic, Inc. | 63,607 | $2.0M |
| LRMRLarimar Therapeutics, Inc. | 406,558 | $1.8M |
| MLTXMoonLake Immunotherapeutics | 95,339 | $1.8M |
| OCGNOcugen, Inc. | 935,799 | $1.7M |
| KRROKorro Bio, Inc. | 148,559 | $1.7M |
| DSGNDesign Therapeutics, Inc. | 138,565 | $1.5M |
| GLSIGreenwich LifeSciences, Inc. | 58,911 | $1.4M |
| LENZLENZ Therapeutics, Inc. | 153,004 | $1.4M |
| DMACDiaMedica Therapeutics Inc. | 203,459 | $1.4M |
| ALDXAldeyra Therapeutics, Inc. | 807,778 | $1.4M |
| CADLCandel Therapeutics, Inc. | 268,249 | $1.3M |
| NGNENeurogene Inc. | 65,080 | $1.3M |
| ABEOABEONA THERAPEUTICS INC. | 270,976 | $1.2M |
| TNXPTonix Pharmaceuticals Holding Corp. | 78,627 | $1.1M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 1,309,312 | $1.0M |
| FENCFENNEC PHARMACEUTICALS INC. | 168,473 | $1.0M |
| CHRSCoherus Oncology, Inc. | 604,525 | $1.0M |
| PLXProtalix BioTherapeutics, Inc. | 432,485 | $938K |
| MDWDMediWound Ltd. | 57,547 | $927K |
| HUMAHumacyte Inc. | 1,417,825 | $861K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 546,600 | $853K |
| ZNTLZentalis Pharmaceuticals, Inc. | 360,600 | $844K |
| NVCTNuvectis Pharma, Inc. | 92,154 | $712K |
| CRDFCardiff Oncology, Inc. | 437,214 | $708K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 17,723 | $492K |
| GYREGYRE THERAPEUTICS, INC. | 69,814 | $487K |
| LYELLyell Immunopharma, Inc. | 23,015 | $462K |
| HURATuHURA Biosciences, Inc./NV | 253,641 | $454K |
| RNACCartesian Therapeutics, Inc. | 60,583 | $373K |
| MANEVeradermics Incorporated | 4,537 | $287K |
| AARDAardvark Therapeutics, Inc. | 75,149 | $283K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 24,365 | $229K |
| FLNAFilana Therapeutics Inc. | 132,693 | $224K |
| BDTXBlack Diamond Therapeutics, Inc. | 93,180 | $198K |
| ALXOALX ONCOLOGY HOLDINGS INC | 97,881 | $196K |
| PLRXPLIANT THERAPEUTICS, INC. | 153,810 | $194K |
| TVRDTvardi Therapeutics, Inc. | 33,833 | $108K |