BioSniper ranking
Most Shorted Biotech Stocks
Short interest as a percentage of float measures how heavily a stock is being bet against. Biotech is one of the most heavily shorted sectors because of its binary, event-driven nature. This ranking sorts biotech and pharma companies by short percent of float — the standard measure of short positioning — and shows days-to-cover (short ratio) as context.
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Frequently asked questions
What does "short percent of float" mean?
It is the number of shares sold short divided by the freely tradable share float, expressed as a percentage. A higher value means a larger share of the float is held short.
What is days-to-cover (short ratio)?
Days-to-cover estimates how many days of average trading volume it would take short sellers to buy back (cover) all shorted shares. A higher ratio can amplify a short squeeze.
Why is biotech so heavily shorted?
Biotech valuations hinge on binary events — trial readouts, PDUFA decisions, cash runway — so both bulls and bears take large, opposing positions around those catalysts.
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