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BioSniper ranking

Most Shorted Biotech Stocks

Short interest as a percentage of float measures how heavily a stock is being bet against. Biotech is one of the most heavily shorted sectors because of its binary, event-driven nature. This ranking sorts biotech and pharma companies by short percent of float — the standard measure of short positioning — and shows days-to-cover (short ratio) as context.

Ranked entities
100
Freshness
data as of May 22, 2026
Method
Published source data
BioSniper AIPage evidence connected

Prepared research question

Why is Faeth Therapeutics, Inc. — Most Shorted Biotech Stocks → FTH in this position, and what could change the ranking?

Run cited research

Traceable citations · Unknowns marked

  1. 1Faeth Therapeutics, Inc.FTH · $1.01B88.5%19.6 days to cover
  2. 2Monopar TherapeuticsMNPR · $738.1M67.1%9.0 days to cover
  3. 3LENZ Therapeutics, Inc.LENZ · $148.3M49.5%7.8 days to cover
  4. 4ARS Pharmaceuticals, Inc.SPRY · $536.0M41.5%15.7 days to cover
  5. 5Lifevantage CorpLFVN · $79.5M38.6%21.6 days to cover
  6. 6Intellia Therapeutics, Inc.NTLA · $1.65B36.8%12.4 days to cover
  7. 7ImmunityBio, Inc.IBRX · $8.79B35.8%4.9 days to cover
  8. 8Rallybio CorpRLYB · $89.6M35.8%23.9 days to cover
  9. 9Replimune Group, Inc.REPL · $1.39B35.5%10.2 days to cover
  10. 10The Beauty Health CompanySKIN · $87.8M35.4%26.0 days to cover
  11. 11RECURSION PHARMACEUTICALS, INC.RXRX · $1.83B34.9%14.0 days to cover
  12. 12Beam Therapeutics Inc.BEAM · $2.49B31.5%9.7 days to cover
  13. 13ABEONA THERAPEUTICS INC.ABEO · $309.7M31.1%16.9 days to cover
  14. 14NOVAVAX INCNVAX · $1.62B30.3%15.6 days to cover
  15. 15Pacira BioSciences, Inc.PCRX · $1.02B30.0%9.8 days to cover
  16. 16SELLAS Life Sciences Group, Inc.SLS · $2.72B30.0%6.5 days to cover
  17. 17Neurogene Inc.NGNE · $710.0M29.8%22.6 days to cover
  18. 18Twist Bioscience CorpTWST · $8.43B28.7%11.0 days to cover
  19. 19Absci CorporationABSI · $1.41B28.6%8.7 days to cover
  20. 20IOVANCE BIOTHERAPEUTICS, INC.IOVA · $4.01B28.4%7.8 days to cover
  21. 21Arcturus Therapeutics Holdings Inc.ARCT · $444.3M28.2%15.5 days to cover
  22. 22Sarepta Therapeutics, Inc.SRPT · $2.19B28.0%7.7 days to cover
  23. 23Sana Biotechnology, Inc.SANA · $949.0M27.8%11.5 days to cover
  24. 24Cardiff Oncology, Inc.CRDF · $94.1M27.5%25.5 days to cover
  25. 25Schrodinger, Inc.SDGR · $1.42B27.4%10.1 days to cover
  26. 26Tango Therapeutics, Inc.TNGX · $3.83B26.9%12.9 days to cover
  27. 27CRISPR Therapeutics AGCRSP · $5.30B26.7%12.9 days to cover
  28. 28Kodiak Sciences Inc.KOD · $2.12B26.5%5.4 days to cover
  29. 29Syndax Pharmaceuticals IncSNDX · $1.77B26.4%13.5 days to cover
  30. 30Candel Therapeutics, Inc.CADL · $806.9M26.1%8.9 days to cover
  31. 31Stoke Therapeutics, Inc.STOK · $1.94B25.8%13.3 days to cover
  32. 32HERON THERAPEUTICS, INC. /DE/HRTX · $59.9M25.7%19.9 days to cover
  33. 33Corvus Pharmaceuticals, Inc.CRVS · $1.12B24.9%14.9 days to cover
  34. 34Journey Medical CorpDERM · $204.1M24.5%17.6 days to cover
  35. 35Biomea Fusion, Inc.BMEA · $94.6M24.2%7.2 days to cover
  36. 36Rocket Pharmaceuticals Inc.RCKT · $373.8M24.2%7.9 days to cover
  37. 37Nuvation Bio Inc.NUVB · $2.32B24.1%15.1 days to cover
  38. 38TG THERAPEUTICS, INC.TGTX · $8.25B23.7%13.6 days to cover
  39. 394D Molecular Therapeutics, Inc.FDMT · $745.2M23.4%14.1 days to cover
  40. 40Legend Biotech CorpLEGN · $3.60B23.4%7.7 days to cover
  41. 41OMEROS CORPOMER · $1.34B22.7%11.7 days to cover
  42. 42Tectonic Therapeutic, Inc.TECX · $559.3M22.6%7.5 days to cover
  43. 43Zenas BioPharma, Inc.ZBIO · $2.10B22.5%11.6 days to cover
  44. 44Greenwich LifeSciences, Inc.GLSI · $226.0M22.5%11.6 days to cover
  45. 45Tyra Biosciences, Inc.TYRA · $1.59B22.4%6.2 days to cover
  46. 46Tenaya Therapeutics, Inc.TNYA · $143.5M22.2%4.5 days to cover
  47. 47Altimmune, Inc.ALT · $640.0M22.1%9.4 days to cover
  48. 48ANAPTYSBIO, INCANAB · $1.68B22.1%6.3 days to cover
  49. 49Immunovant, Inc.IMVT · $7.72B21.9%13.2 days to cover
  50. 50Inhibikase Therapeutics, Inc.IKT · $325.1M21.9%18.3 days to cover
  51. 51Viking Therapeutics, Inc.VKTX · $3.93B21.9%9.7 days to cover
  52. 52COLLEGIUM PHARMACEUTICAL, INCCOLL · $724.1M21.9%11.8 days to cover
  53. 53RIGEL PHARMACEUTICALS INCRIGL · $874.8M21.8%11.6 days to cover
  54. 54Xencor IncXNCR · $1.88B21.7%11.4 days to cover
  55. 55Rezolute, Inc.RZLT · $395.3M21.7%9.1 days to cover
  56. 56Summit Therapeutics Inc.SMMT · $14.69B21.6%7.6 days to cover
  57. 57Cabaletta Bio, Inc.CABA · $554.4M21.6%10.4 days to cover
  58. 58Avalo Therapeutics, Inc.AVTX · $876.6M21.5%7.3 days to cover
  59. 59Prime Medicine, Inc.PRME · $604.9M21.5%16.4 days to cover
  60. 60Oric Pharmaceuticals, Inc.ORIC · $1.30B21.5%9.2 days to cover
  61. 61ANAVEX LIFE SCIENCES CORP.AVXL · $246.6M21.4%18.4 days to cover
  62. 62MoonLake ImmunotherapeuticsMLTX · $1.27B21.2%8.4 days to cover
  63. 63Biohaven Ltd.BHVN · $2.22B21.1%12.4 days to cover
  64. 64Ocugen, Inc.OCGN · $349.3M21.0%7.4 days to cover
  65. 65CorMedix Inc.CRMD · $620.4M21.0%16.0 days to cover
  66. 66Humacyte Inc.HUMA · $157.7M20.9%4.5 days to cover
  67. 67CYTOKINETICS INCCYTK · $10.48B20.8%9.3 days to cover
  68. 68Monte Rosa Therapeutics, Inc.GLUE · $1.22B20.6%10.8 days to cover
  69. 69Cullinan Therapeutics, Inc.CGEM · $1.33B20.3%12.5 days to cover
  70. 70Compass Therapeutics, Inc.CMPX · $392.6M20.2%2.4 days to cover
  71. 71CAPRICOR THERAPEUTICS, INC.CAPR · $502.3M20.1%10.7 days to cover
  72. 72Verastem, Inc.VSTM · $690.1M20.1%8.4 days to cover
  73. 73Travere Therapeutics, Inc.TVTX · $6.14B20.0%5.4 days to cover
  74. 74Inhibrx Biosciences, Inc.INBX · $1.66B19.9%10.2 days to cover
  75. 75Apogee Therapeutics, Inc.APGE · $10.22B19.9%13.6 days to cover
  76. 76CRESCENT BIOPHARMA, INC.CBIO · $726.2M19.8%9.0 days to cover
  77. 77MADRIGAL PHARMACEUTICALS, INC.MDGL · $12.34B19.7%13.3 days to cover
  78. 78Immunocore Holdings plcIMCR · $1.82B19.6%19.7 days to cover
  79. 79Organogenesis Holdings Inc.ORGO · $196.9M19.4%7.5 days to cover
  80. 80Immuneering CorpIMRX · $282.7M19.4%12.4 days to cover
  81. 81C4 Therapeutics, Inc.CCCC · $420.7M19.2%7.1 days to cover
  82. 82Coherus Oncology, Inc.CHRS · $186.9M19.1%29.3 days to cover
  83. 83ANI PHARMACEUTICALS INCANIP · $1.61B19.0%10.8 days to cover
  84. 84Emergent BioSolutions Inc.EBS · $301.0M19.0%12.2 days to cover
  85. 85Bicara Therapeutics Inc.BCAX · $1.54B19.0%15.7 days to cover
  86. 86AbCellera Biologics Inc.ABCL · $3.71B18.9%8.8 days to cover
  87. 87Nurix Therapeutics, Inc.NRIX · $2.71B18.8%12.9 days to cover
  88. 88Gossamer Bio, Inc.GOSS · $87.9M18.2%3.6 days to cover
  89. 89Fortress Biotech Inc.FBIO · $84.0M18.1%10.4 days to cover
  90. 90Mirum Pharmaceuticals, Inc.MIRM · $6.07B18.1%11.5 days to cover
  91. 91Lexeo Therapeutics, Inc.LXEO · $357.7M18.0%13.1 days to cover
  92. 92Moderna, Inc.MRNA · $58.56B18.0%10.3 days to cover
  93. 93uniQure N.V.QURE · $3.19B18.0%6.2 days to cover
  94. 94INOVIO PHARMACEUTICALS, INC.INO · $129.2M17.9%4.9 days to cover
  95. 95Oruka Therapeutics, Inc.ORKA · $6.06B17.9%3.5 days to cover
  96. 96Kura Oncology, Inc.KURA · $1.02B17.8%11.3 days to cover
  97. 97GALECTIN THERAPEUTICS INCGALT · $394.3M17.6%21.9 days to cover
  98. 98Janux Therapeutics, Inc.JANX · $1.23B17.5%6.3 days to cover
  99. 99PRECIGEN, INC.PGEN · $2.45B17.3%7.0 days to cover
  100. 100Amylyx Pharmaceuticals, Inc.AMLX · $3.61B17.2%13.1 days to cover

Ranked by short interest as a percentage of float. Includes active companies with a market cap of at least $50.0M and reported short-interest data; companies without reported short interest are not shown.

Frequently asked questions

What does "short percent of float" mean?

It is the number of shares sold short divided by the freely tradable share float, expressed as a percentage. A higher value means a larger share of the float is held short.

What is days-to-cover (short ratio)?

Days-to-cover estimates how many days of average trading volume it would take short sellers to buy back (cover) all shorted shares. A higher ratio can amplify a short squeeze.

Why is biotech so heavily shorted?

Biotech valuations hinge on binary events — trial readouts, PDUFA decisions, cash runway — so both bulls and bears take large, opposing positions around those catalysts.

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