Most Shorted Biotech Stocks

Short interest as a percentage of float measures how heavily a stock is being bet against. Biotech is one of the most heavily shorted sectors because of its binary, event-driven nature. This ranking sorts biotech and pharma companies by short percent of float — the standard measure of short positioning — and shows days-to-cover (short ratio) as context.

Top 100 · data as of May 22, 2026.

  1. 1Monopar TherapeuticsMNPR · $636.6M67.1%9.0 days to cover
  2. 2LENZ Therapeutics, Inc.LENZ · $181.5M49.5%7.8 days to cover
  3. 3ARS Pharmaceuticals, Inc.SPRY · $788.5M41.5%15.7 days to cover
  4. 4Intellia Therapeutics, Inc.NTLA · $2.41B36.8%12.4 days to cover
  5. 5ImmunityBio, Inc.IBRX · $9.64B35.8%4.9 days to cover
  6. 6Rallybio CorpRLYB · $92.5M35.8%23.9 days to cover
  7. 7Replimune Group, Inc.REPL · $929.3M35.5%10.2 days to cover
  8. 8The Beauty Health CompanySKIN · $93.0M35.4%26.0 days to cover
  9. 9RECURSION PHARMACEUTICALS, INC.RXRX · $1.95B34.9%14.0 days to cover
  10. 10KalVista Pharmaceuticals, Inc.KALV · $1.44B31.9%3.2 days to cover
  11. 11Beam Therapeutics Inc.BEAM · $3.44B31.5%9.7 days to cover
  12. 12ABEONA THERAPEUTICS INC.ABEO · $344.8M31.1%16.9 days to cover
  13. 13Neuronetics Inc.STIM · $93.6M30.5%5.0 days to cover
  14. 14NOVAVAX INCNVAX · $1.56B30.3%15.6 days to cover
  15. 15SELLAS Life Sciences Group, Inc.SLS · $2.61B30.0%6.5 days to cover
  16. 16Pacira BioSciences, Inc.PCRX · $984.9M30.0%9.8 days to cover
  17. 17Neurogene Inc.NGNE · $535.4M29.8%22.6 days to cover
  18. 18Twist Bioscience CorpTWST · $6.37B28.7%11.0 days to cover
  19. 19Absci CorporationABSI · $1.88B28.6%8.7 days to cover
  20. 20IOVANCE BIOTHERAPEUTICS, INC.IOVA · $1.77B28.4%7.8 days to cover
  21. 21QuidelOrtho CorpQDEL · $1.24B28.4%5.7 days to cover
  22. 22Arcturus Therapeutics Holdings Inc.ARCT · $195.8M28.2%15.5 days to cover
  23. 23Sarepta Therapeutics, Inc.SRPT · $1.92B28.0%7.7 days to cover
  24. 24Sana Biotechnology, Inc.SANA · $990.7M27.8%11.5 days to cover
  25. 25Cardiff Oncology, Inc.CRDF · $88.2M27.5%25.5 days to cover
  26. 26Schrodinger, Inc.SDGR · $1.22B27.4%10.1 days to cover
  27. 27Tango Therapeutics, Inc.TNGX · $4.68B26.9%12.9 days to cover
  28. 28CRISPR Therapeutics AGCRSP · $5.48B26.7%12.9 days to cover
  29. 29Kodiak Sciences Inc.KOD · $2.33B26.5%5.4 days to cover
  30. 30Syndax Pharmaceuticals IncSNDX · $1.85B26.4%13.5 days to cover
  31. 31Candel Therapeutics, Inc.CADL · $723.9M26.1%8.9 days to cover
  32. 32Stoke Therapeutics, Inc.STOK · $2.04B25.8%13.3 days to cover
  33. 33HERON THERAPEUTICS, INC. /DE/HRTX · $80.3M25.7%19.9 days to cover
  34. 34Karyopharm Therapeutics Inc.KPTI · $219.4M25.5%3.4 days to cover
  35. 35Corvus Pharmaceuticals, Inc.CRVS · $1.24B24.9%14.9 days to cover
  36. 36Journey Medical CorpDERM · $193.8M24.5%17.6 days to cover
  37. 37Rocket Pharmaceuticals Inc.RCKT · $384.4M24.2%7.9 days to cover
  38. 38Biomea Fusion, Inc.BMEA · $98.3M24.2%7.2 days to cover
  39. 39Nuvation Bio Inc.NUVB · $1.89B24.1%15.1 days to cover
  40. 40TG THERAPEUTICS, INC.TGTX · $8.19B23.7%13.6 days to cover
  41. 414D Molecular Therapeutics, Inc.FDMT · $663.4M23.4%14.1 days to cover
  42. 42Legend Biotech CorpLEGN · $5.78B23.4%7.7 days to cover
  43. 43aTYR PHARMA INCATYR · $57.8M23.3%22.0 days to cover
  44. 44OMEROS CORPOMER · $681.1M22.7%11.7 days to cover
  45. 45XOMA Royalty CorporationXOMA · $753.5M22.6%12.8 days to cover
  46. 46Tectonic Therapeutic, Inc.TECX · $617.8M22.6%7.5 days to cover
  47. 47Zenas BioPharma, Inc.ZBIO · $1.77B22.5%11.6 days to cover
  48. 48Greenwich LifeSciences, Inc.GLSI · $347.9M22.5%11.6 days to cover
  49. 49Tyra Biosciences, Inc.TYRA · $1.75B22.4%6.2 days to cover
  50. 50Tenaya Therapeutics, Inc.TNYA · $161.9M22.2%4.5 days to cover
  51. 51Altimmune, Inc.ALT · $612.6M22.1%9.4 days to cover
  52. 52ANAPTYSBIO, INCANAB · $1.94B22.1%6.3 days to cover
  53. 53Immunovant, Inc.IMVT · $7.83B21.9%13.2 days to cover
  54. 54Viking Therapeutics, Inc.VKTX · $4.35B21.9%9.7 days to cover
  55. 55Inhibikase Therapeutics, Inc.IKT · $256.1M21.9%18.3 days to cover
  56. 56COLLEGIUM PHARMACEUTICAL, INCCOLL · $1.16B21.9%11.8 days to cover
  57. 57RIGEL PHARMACEUTICALS INCRIGL · $708.4M21.8%11.6 days to cover
  58. 58Xencor IncXNCR · $1.14B21.7%11.4 days to cover
  59. 59Rezolute, Inc.RZLT · $476.6M21.7%9.1 days to cover
  60. 60Summit Therapeutics Inc.SMMT · $11.16B21.6%7.6 days to cover
  61. 61Cabaletta Bio, Inc.CABA · $487.5M21.6%10.4 days to cover
  62. 62Avalo Therapeutics, Inc.AVTX · $908.9M21.5%7.3 days to cover
  63. 63Prime Medicine, Inc.PRME · $702.6M21.5%16.4 days to cover
  64. 64Oric Pharmaceuticals, Inc.ORIC · $1.13B21.5%9.2 days to cover
  65. 65ANAVEX LIFE SCIENCES CORP.AVXL · $239.1M21.4%18.4 days to cover
  66. 66MoonLake ImmunotherapeuticsMLTX · $1.60B21.2%8.4 days to cover
  67. 67Biohaven Ltd.BHVN · $2.37B21.1%12.4 days to cover
  68. 68Ocugen, Inc.OCGN · $501.0M21.0%7.4 days to cover
  69. 69CorMedix Inc.CRMD · $664.5M21.0%16.0 days to cover
  70. 70Humacyte Inc.HUMA · $181.4M20.9%4.5 days to cover
  71. 71CYTOKINETICS INCCYTK · $11.57B20.8%9.3 days to cover
  72. 72Monte Rosa Therapeutics, Inc.GLUE · $2.03B20.6%10.8 days to cover
  73. 73Cullinan Therapeutics, Inc.CGEM · $1.06B20.3%12.5 days to cover
  74. 74Compass Therapeutics, Inc.CMPX · $392.6M20.2%2.4 days to cover
  75. 75CAPRICOR THERAPEUTICS, INC.CAPR · $1.34B20.1%10.7 days to cover
  76. 76Verastem, Inc.VSTM · $360.3M20.1%8.4 days to cover
  77. 77Travere Therapeutics, Inc.TVTX · $5.24B20.0%5.4 days to cover
  78. 78Inhibrx Biosciences, Inc.INBX · $1.39B19.9%10.2 days to cover
  79. 79Apogee Therapeutics, Inc.APGE · $9.98B19.9%13.6 days to cover
  80. 80CRESCENT BIOPHARMA, INC.CBIO · $471.0M19.8%9.0 days to cover
  81. 81MADRIGAL PHARMACEUTICALS, INC.MDGL · $11.86B19.7%13.3 days to cover
  82. 82Immunocore Holdings plcIMCR · $1.61B19.6%19.7 days to cover
  83. 83Organogenesis Holdings Inc.ORGO · $314.0M19.4%7.5 days to cover
  84. 84Immuneering CorpIMRX · $326.7M19.4%12.4 days to cover
  85. 85C4 Therapeutics, Inc.CCCC · $479.9M19.2%7.1 days to cover
  86. 86Coherus Oncology, Inc.CHRS · $222.1M19.1%29.3 days to cover
  87. 87ANI PHARMACEUTICALS INCANIP · $1.89B19.0%10.8 days to cover
  88. 88Emergent BioSolutions Inc.EBS · $427.2M19.0%12.2 days to cover
  89. 89Bicara Therapeutics Inc.BCAX · $1.90B19.0%15.7 days to cover
  90. 90AbCellera Biologics Inc.ABCL · $2.32B18.9%8.8 days to cover
  91. 91Nurix Therapeutics, Inc.NRIX · $2.47B18.8%12.9 days to cover
  92. 92Gossamer Bio, Inc.GOSS · $82.0M18.2%3.6 days to cover
  93. 93Fortress Biotech Inc.FBIO · $102.6M18.1%10.4 days to cover
  94. 94Mirum Pharmaceuticals, Inc.MIRM · $7.35B18.1%11.5 days to cover
  95. 95Lexeo Therapeutics, Inc.LXEO · $349.4M18.0%13.1 days to cover
  96. 96Moderna, Inc.MRNA · $28.77B18.0%10.3 days to cover
  97. 97uniQure N.V.QURE · $3.11B18.0%6.2 days to cover
  98. 98SOLENO THERAPEUTICS INCSLNO · $2.76B17.9%1.0 days to cover
  99. 99INOVIO PHARMACEUTICALS, INC.INO · $97.9M17.9%4.9 days to cover
  100. 100Oruka Therapeutics, Inc.ORKA · $5.63B17.9%3.5 days to cover

Ranked by short interest as a percentage of float. Includes active companies with a market cap of at least $50.0M and reported short-interest data; companies without reported short interest are not shown.

Frequently asked questions

What does "short percent of float" mean?

It is the number of shares sold short divided by the freely tradable share float, expressed as a percentage. A higher value means a larger share of the float is held short.

What is days-to-cover (short ratio)?

Days-to-cover estimates how many days of average trading volume it would take short sellers to buy back (cover) all shorted shares. A higher ratio can amplify a short squeeze.

Why is biotech so heavily shorted?

Biotech valuations hinge on binary events — trial readouts, PDUFA decisions, cash runway — so both bulls and bears take large, opposing positions around those catalysts.