| ALNYALNYLAM PHARMACEUTICALS, INC. | 838,187 | $277.3M |
| FOLDAMICUS THERAPEUTICS, INC. | 8,809,340 | $127.4M |
| ROIVRoivant Sciences Ltd. | 3,450,904 | $95.6M |
| REGNREGENERON PHARMACEUTICALS, INC. | 83,358 | $64.4M |
| AXSMAxsome Therapeutics, Inc. | 335,334 | $56.7M |
| RVMDREVOLUTION MEDICINES, INC. | 553,290 | $53.8M |
| CYTKCYTOKINETICS INC | 779,446 | $51.4M |
| JAZZJazz Pharmaceuticals plc | 262,553 | $49.6M |
| DAWNDay One Biopharmaceuticals, Inc. | 1,954,552 | $41.9M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 689,721 | $39.0M |
| MRNAModerna, Inc. | 700,692 | $35.6M |
| PTCTPTC THERAPEUTICS, INC. | 513,823 | $35.0M |
| KNSAKiniksa Pharmaceuticals International, plc | 686,853 | $33.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 548,222 | $30.3M |
| TERNTerns Pharmaceuticals, Inc. | 537,884 | $28.4M |
| NKTRNEKTAR THERAPEUTICS | 390,675 | $28.1M |
| BEAMBeam Therapeutics Inc. | 1,084,768 | $25.9M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 498,198 | $25.8M |
| CNTACentessa Pharmaceuticals plc | 628,049 | $24.9M |
| INSMINSMED Inc | 148,515 | $24.3M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 277,943 | $24.2M |
| XERSXeris Biopharma Holdings, Inc. | 4,114,425 | $23.9M |
| ACADACADIA PHARMACEUTICALS INC | 950,299 | $21.2M |
| TVTXTravere Therapeutics, Inc. | 669,159 | $19.9M |
| ARGXARGENX SE | 25,536 | $18.6M |
| INVAInnoviva, Inc. | 786,107 | $18.3M |
| GMABGenmab A/S | 677,346 | $18.2M |
| ANNXAnnexon, Inc. | 3,114,314 | $17.3M |
| ARQTArcutis Biotherapeutics, Inc. | 724,067 | $17.1M |
| GILDGILEAD SCIENCES, INC. | 121,052 | $16.9M |
| ADMAADMA BIOLOGICS, INC. | 1,829,670 | $16.5M |
| SLNOSOLENO THERAPEUTICS INC | 483,884 | $16.2M |
| ANIPANI PHARMACEUTICALS INC | 210,130 | $16.2M |
| COGTCogent Biosciences, Inc. | 394,000 | $15.2M |
| ARDXARDELYX, INC. | 2,435,548 | $14.6M |
| ANABANAPTYSBIO, INC | 254,736 | $14.1M |
| CMPXCompass Therapeutics, Inc. | 2,550,356 | $13.5M |
| KURAKura Oncology, Inc. | 1,636,733 | $13.3M |
| BHVNBiohaven Ltd. | 1,540,445 | $13.0M |
| ZYMEZymeworks Inc. | 511,937 | $12.8M |
| ARVNARVINAS, INC. | 1,201,635 | $12.7M |
| RGNXREGENXBIO Inc. | 1,310,493 | $11.0M |
| ORICOric Pharmaceuticals, Inc. | 859,491 | $10.9M |
| CTMXCytomX Therapeutics, Inc. | 2,249,583 | $10.6M |
| ATAIAtai Beckley N.V. | 2,891,942 | $10.2M |
| HRMYHarmony Biosciences Holdings, Inc. | 352,637 | $9.9M |
| LGNDLigand Pharmaceuticals Incorporated | 47,659 | $9.5M |
| ADPTAdaptive Biotechnologies Corp | 639,377 | $8.9M |
| NUVBNuvation Bio Inc. | 2,042,312 | $8.8M |
| PCVXVaxcyte, Inc. | 145,371 | $8.4M |
| DFTXDefinium Therapeutics Inc. | 426,055 | $8.1M |
| KROSKeros Therapeutics, Inc. | 724,926 | $8.0M |
| ZVRAZEVRA THERAPEUTICS, INC. | 842,319 | $7.9M |
| NRIXNurix Therapeutics, Inc. | 485,212 | $7.5M |
| DMRADamora Therapeutics, Inc. | 282,436 | $7.3M |
| OCGNOcugen, Inc. | 3,773,066 | $6.8M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 187,667 | $6.3M |
| RLAYRelay Therapeutics, Inc. | 619,652 | $6.2M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 614,603 | $6.0M |
| UPBUpstream Bio, Inc. | 619,321 | $5.6M |
| CMPSCOMPASS Pathways plc | 948,554 | $5.2M |
| OLMAOlema Pharmaceuticals, Inc. | 312,812 | $4.7M |
| RLMDRELMADA THERAPEUTICS, INC. | 653,333 | $4.5M |
| VRDNViridian Therapeutics, Inc.\DE | 231,270 | $4.5M |
| OCULOCULAR THERAPEUTIX, INC | 531,816 | $4.5M |
| INCYIncyte Corp. | 45,431 | $4.3M |
| MAZEMaze Therapeutics, Inc. | 134,950 | $4.0M |
| LRMRLarimar Therapeutics, Inc. | 847,644 | $3.8M |
| KALVKalVista Pharmaceuticals, Inc. | 180,314 | $3.6M |
| IMTXImmatics N.V. | 366,772 | $3.6M |
| GPCRStructure Therapeutics Inc. | 73,599 | $3.5M |
| IVVDInvivyd, Inc. | 2,687,195 | $3.5M |
| IONSIONIS PHARMACEUTICALS INC | 42,856 | $3.2M |
| ZURAZura Bio Ltd | 450,311 | $2.7M |
| AVTXAvalo Therapeutics, Inc. | 174,506 | $2.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 30,354 | $2.5M |
| FBRXForte Biosciences, Inc. | 85,969 | $2.2M |
| SIGASIGA TECHNOLOGIES INC | 415,104 | $2.2M |
| GERNGERON CORP | 1,445,859 | $2.2M |
| PHVSPharvaris N.V. | 71,210 | $2.0M |
| CCCCC4 Therapeutics, Inc. | 752,114 | $2.0M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 69,256 | $1.9M |
| TEVATeva Pharmaceutical Industries Limited | 59,306 | $1.8M |
| GRFSGrifols S.A. | 220,377 | $1.8M |
| IMMXImmix Biopharma, Inc. | 187,675 | $1.7M |
| SIONSionna Therapeutics, Inc. | 42,242 | $1.7M |
| ZNTLZentalis Pharmaceuticals, Inc. | 637,116 | $1.5M |
| BCYCBICYCLE THERAPEUTICS PLC | 308,617 | $1.4M |
| CGEMCullinan Therapeutics, Inc. | 90,316 | $1.3M |
| LYELLyell Immunopharma, Inc. | 55,110 | $1.1M |
| TRDAEntrada Therapeutics, Inc. | 87,453 | $1.1M |
| SGMTSagimet Biosciences Inc. | 182,738 | $955K |
| XFORX4 Pharmaceuticals, Inc | 218,954 | $904K |
| RCUSArcus Biosciences, Inc. | 38,556 | $833K |
| MLTXMoonLake Immunotherapeutics | 42,917 | $800K |
| CLYMClimb Bio, Inc. | 104,217 | $714K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 71,925 | $644K |
| ESPREsperion Therapeutics, Inc. | 208,161 | $570K |
| SLNSilence Therapeutics Plc | 104,555 | $551K |
| SVRASavara Inc | 87,575 | $478K |
| OPKOPKO HEALTH, INC. | 404,358 | $461K |
| TENXTENAX THERAPEUTICS, INC. | 28,285 | $452K |
| SRZNSurrozen Inc. | 14,516 | $423K |
| LCTXLineage Cell Therapeutics, Inc. | 259,561 | $410K |
| DSGNDesign Therapeutics, Inc. | 34,183 | $364K |
| GALTGALECTIN THERAPEUTICS INC | 126,439 | $353K |
| JBIOJade Biosciences, Inc. | 24,792 | $348K |
| SANASana Biotechnology, Inc. | 100,082 | $288K |
| EXELEXELIXIS, INC. | 6,623 | $284K |
| ARMPArmata Pharmaceuticals, Inc. | 26,628 | $273K |
| ALXOALX ONCOLOGY HOLDINGS INC | 107,647 | $216K |
| OVIDOvid Therapeutics Inc. | 94,301 | $209K |
| FENCFENNEC PHARMACEUTICALS INC. | 29,378 | $181K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 18,476 | $173K |
| WHWKWhitehawk Therapeutics, Inc. | 48,307 | $167K |
| ALDXAldeyra Therapeutics, Inc. | 87,078 | $147K |
| ELTXElicio Therapeutics, Inc. | 12,482 | $133K |
| IMUXIMMUNIC, INC. | 111,460 | $124K |
| CAMPCamp4 Therapeutics Corp | 24,803 | $109K |
| SABSSAB BIOTHERAPEUTICS, INC. | 24,098 | $92K |
| ANTXAN2 Therapeutics, Inc. | 24,168 | $83K |
| ORMPORAMED PHARMACEUTICALS INC. | 23,504 | $80K |
| KZIAKAZIA THERAPEUTICS LTD | 10,608 | $79K |
| DMACDiaMedica Therapeutics Inc. | 10,881 | $74K |
| VYGRVoyager Therapeutics, Inc. | 17,505 | $68K |
| CATXPerspective Therapeutics, Inc. | 15,608 | $65K |
| KLRSKalaris Therapeutics, Inc. | 11,103 | $64K |
| PRLDPrelude Therapeutics Inc | 16,417 | $56K |
| AGENAGENUS INC | 10,474 | $35K |
| CNTXContext Therapeutics Inc. | 11,398 | $30K |
| BDTXBlack Diamond Therapeutics, Inc. | 13,407 | $29K |
| INOINOVIO PHARMACEUTICALS, INC. | 14,651 | $25K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 30,355 | $24K |
| ATNMActinium Pharmaceuticals, Inc. | 18,048 | $18K |
| ELUTELUTIA INC. | 17,076 | $18K |
| PLRXPLIANT THERAPEUTICS, INC. | 10,966 | $14K |