| GILDGILEAD SCIENCES, INC. | 11,065,214 | $1.54B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,300,558 | $1.00B |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 9,589,114 | $529.2M |
| MRNAModerna, Inc. | 6,603,697 | $335.5M |
| ROIVRoivant Sciences Ltd. | 11,111,591 | $307.8M |
| INCYIncyte Corp. | 2,351,221 | $221.3M |
| RVMDREVOLUTION MEDICINES, INC. | 2,185,500 | $212.5M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 1,965,432 | $170.9M |
| COGTCogent Biosciences, Inc. | 4,434,054 | $170.7M |
| ARGXARGENX SE | 231,985 | $169.4M |
| FOLDAMICUS THERAPEUTICS, INC. | 11,556,008 | $167.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 469,388 | $155.3M |
| INSMINSMED Inc | 942,646 | $154.1M |
| CYTKCYTOKINETICS INC | 2,205,758 | $145.4M |
| TEVATeva Pharmaceutical Industries Limited | 4,826,245 | $145.4M |
| BBIOBridgeBio Pharma, Inc. | 1,897,716 | $140.9M |
| IONSIONIS PHARMACEUTICALS INC | 1,699,847 | $127.6M |
| SNYSanofi | 2,582,456 | $124.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,739,923 | $109.1M |
| TNGXTango Therapeutics, Inc. | 5,076,392 | $106.2M |
| EXELEXELIXIS, INC. | 2,118,574 | $90.9M |
| DNLIDenali Therapeutics Inc. | 4,407,255 | $84.6M |
| PTGXProtagonist Therapeutics, Inc | 778,945 | $82.1M |
| APLSApellis Pharmaceuticals, Inc. | 1,980,144 | $79.7M |
| LGNDLigand Pharmaceuticals Incorporated | 381,111 | $76.1M |
| TGTXTG THERAPEUTICS, INC. | 2,287,688 | $76.0M |
| PCVXVaxcyte, Inc. | 1,275,036 | $74.1M |
| AXSMAxsome Therapeutics, Inc. | 421,447 | $71.2M |
| SRRKScholar Rock Holding Corp | 1,398,983 | $68.8M |
| KODKodiak Sciences Inc. | 1,689,003 | $64.4M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 1,946,374 | $62.3M |
| TERNTerns Pharmaceuticals, Inc. | 1,106,961 | $58.4M |
| PTCTPTC THERAPEUTICS, INC. | 827,631 | $56.4M |
| NUVLNuvalent, Inc. | 537,158 | $55.0M |
| APGEApogee Therapeutics, Inc. | 652,590 | $54.9M |
| TVTXTravere Therapeutics, Inc. | 1,719,721 | $51.1M |
| JAZZJazz Pharmaceuticals plc | 250,321 | $47.3M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 548,010 | $46.0M |
| CNTACentessa Pharmaceuticals plc | 1,144,560 | $45.5M |
| ADPTAdaptive Biotechnologies Corp | 3,242,077 | $45.0M |
| IMVTImmunovant, Inc. | 1,785,107 | $44.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 856,487 | $44.3M |
| IRONDisc Medicine, Inc. | 639,842 | $40.9M |
| MPLTMapLight Therapeutics, Inc. | 1,994,873 | $40.6M |
| FDMT4D Molecular Therapeutics, Inc. | 4,205,438 | $39.2M |
| ABVXAbivax SA | 348,797 | $38.8M |
| ARQTArcutis Biotherapeutics, Inc. | 1,603,013 | $37.8M |
| INVAInnoviva, Inc. | 1,593,383 | $37.1M |
| HRMYHarmony Biosciences Holdings, Inc. | 1,239,207 | $34.7M |
| ACADACADIA PHARMACEUTICALS INC | 1,557,804 | $34.7M |
| DFTXDefinium Therapeutics Inc. | 1,675,411 | $31.7M |
| CLDXCelldex Therapeutics, Inc. | 988,416 | $31.4M |
| VKTXViking Therapeutics, Inc. | 960,570 | $31.3M |
| VRDNViridian Therapeutics, Inc.\DE | 1,591,945 | $31.1M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 8,760,060 | $30.7M |
| LQDALiquidia Corp | 811,990 | $30.6M |
| ONCBeOne Medicines Ltd. | 96,677 | $28.7M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 911,976 | $27.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 805,776 | $27.3M |
| STOKStoke Therapeutics, Inc. | 830,702 | $27.0M |
| ADMAADMA BIOLOGICS, INC. | 2,803,530 | $25.3M |
| GMABGenmab A/S | 931,259 | $25.0M |
| IBRXImmunityBio, Inc. | 3,237,078 | $24.8M |
| VCELVericel Corp | 754,151 | $24.3M |
| PVLAPALVELLA THERAPEUTICS, INC. | 194,179 | $24.2M |
| BEAMBeam Therapeutics Inc. | 1,005,743 | $24.0M |
| RCUSArcus Biosciences, Inc. | 999,786 | $21.6M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 379,596 | $21.4M |
| BHVNBiohaven Ltd. | 2,513,181 | $21.3M |
| MLTXMoonLake Immunotherapeutics | 1,130,233 | $21.1M |
| DAWNDay One Biopharmaceuticals, Inc. | 979,238 | $21.0M |
| NTLAIntellia Therapeutics, Inc. | 1,628,241 | $20.9M |
| QUREuniQure N.V. | 1,263,236 | $20.7M |
| NRIXNurix Therapeutics, Inc. | 1,318,659 | $20.4M |
| ARDXARDELYX, INC. | 3,216,210 | $19.3M |
| ORICOric Pharmaceuticals, Inc. | 1,475,712 | $18.7M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 6,065,661 | $18.6M |
| ELVNEnliven Therapeutics, Inc. | 473,115 | $18.5M |
| ANABANAPTYSBIO, INC | 332,743 | $18.5M |
| ANIPANI PHARMACEUTICALS INC | 219,755 | $16.9M |
| GERNGERON CORP | 11,176,591 | $16.7M |
| KALVKalVista Pharmaceuticals, Inc. | 824,293 | $16.6M |
| ALMSALUMIS INC. | 718,040 | $15.8M |
| OLMAOlema Pharmaceuticals, Inc. | 1,045,589 | $15.6M |
| RGNXREGENXBIO Inc. | 1,839,463 | $15.4M |
| ZYMEZymeworks Inc. | 599,486 | $15.0M |
| SYRESpyre Therapeutics, Inc. | 269,938 | $13.6M |
| ABCLAbCellera Biologics Inc. | 3,751,212 | $13.1M |
| PGENPRECIGEN, INC. | 3,350,477 | $13.0M |
| SLNOSOLENO THERAPEUTICS INC | 385,798 | $12.9M |
| GPCRStructure Therapeutics Inc. | 260,543 | $12.6M |
| ORKAOruka Therapeutics, Inc. | 246,711 | $12.1M |
| HROWHARROW, INC. | 341,707 | $12.0M |
| ANNXAnnexon, Inc. | 2,152,880 | $11.9M |
| KURAKura Oncology, Inc. | 1,433,471 | $11.7M |
| BCAXBicara Therapeutics Inc. | 558,964 | $11.1M |
| MANEVeradermics Incorporated | 168,975 | $10.7M |
| GRFSGrifols S.A. | 1,325,965 | $10.6M |
| CMPXCompass Therapeutics, Inc. | 1,995,394 | $10.6M |
| SIONSionna Therapeutics, Inc. | 263,174 | $10.6M |
| OGNOrganon & Co. | 1,605,325 | $9.6M |
| OCULOCULAR THERAPEUTIX, INC | 1,110,366 | $9.4M |
| XERSXeris Biopharma Holdings, Inc. | 1,613,650 | $9.4M |
| SANASana Biotechnology, Inc. | 3,181,115 | $9.2M |
| NKTRNEKTAR THERAPEUTICS | 126,942 | $9.1M |
| LBRXLB PHARMACEUTICALS INC | 363,799 | $9.0M |
| OPKOPKO HEALTH, INC. | 7,675,026 | $8.7M |
| KNSAKiniksa Pharmaceuticals International, plc | 174,901 | $8.4M |
| MAZEMaze Therapeutics, Inc. | 279,713 | $8.3M |
| RDYDR REDDYS LABORATORIES LTD | 602,836 | $8.3M |
| NUVBNuvation Bio Inc. | 1,929,953 | $8.3M |
| ARVNARVINAS, INC. | 756,875 | $8.0M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 818,885 | $8.0M |
| ZBIOZenas BioPharma, Inc. | 381,461 | $7.5M |
| LRMRLarimar Therapeutics, Inc. | 1,561,585 | $7.0M |
| ZVRAZEVRA THERAPEUTICS, INC. | 743,124 | $6.9M |
| CTMXCytomX Therapeutics, Inc. | 1,459,839 | $6.9M |
| SLDBSolid Biosciences Inc. | 935,535 | $6.7M |
| ESPREsperion Therapeutics, Inc. | 2,410,454 | $6.6M |
| CGEMCullinan Therapeutics, Inc. | 455,449 | $6.5M |
| CCCCC4 Therapeutics, Inc. | 2,387,378 | $6.3M |
| RCKTRocket Pharmaceuticals Inc. | 1,721,116 | $6.2M |
| MESOMesoblast Limited | 397,215 | $6.1M |
| SMMTSummit Therapeutics Inc. | 310,728 | $5.9M |
| SPRYARS Pharmaceuticals, Inc. | 724,219 | $5.8M |
| DNAGinkgo Bioworks Holdings Inc. | 929,862 | $5.7M |
| DSGNDesign Therapeutics, Inc. | 504,718 | $5.4M |
| CATXPerspective Therapeutics, Inc. | 1,241,816 | $5.2M |
| ABEOABEONA THERAPEUTICS INC. | 1,130,619 | $5.1M |
| ABUSArbutus Biopharma Corp | 1,100,434 | $5.0M |
| FLGTFulgent Genetics Inc. | 311,423 | $5.0M |
| RLMDRELMADA THERAPEUTICS, INC. | 699,039 | $4.9M |
| RNAAtrium Therapeutics Inc. | 349,950 | $4.7M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 669,719 | $4.3M |
| CBIOCRESCENT BIOPHARMA, INC. | 228,475 | $4.2M |
| ALTAltimmune, Inc. | 1,350,649 | $4.2M |
| PHVSPharvaris N.V. | 142,929 | $4.0M |
| XFORX4 Pharmaceuticals, Inc | 882,134 | $3.6M |
| IMCRImmunocore Holdings plc | 119,497 | $3.6M |
| IVVDInvivyd, Inc. | 2,611,445 | $3.4M |
| SIGASIGA TECHNOLOGIES INC | 624,903 | $3.3M |
| SVRASavara Inc | 580,059 | $3.2M |
| UPBUpstream Bio, Inc. | 316,587 | $2.8M |
| BIOABioAge Labs, Inc. | 156,438 | $2.7M |
| TRDAEntrada Therapeutics, Inc. | 212,780 | $2.7M |
| KROSKeros Therapeutics, Inc. | 224,479 | $2.5M |
| AVXLANAVEX LIFE SCIENCES CORP. | 804,435 | $2.5M |
| MISTMilestone Pharmaceuticals Inc. | 2,000,025 | $2.4M |
| SLSSELLAS Life Sciences Group, Inc. | 555,913 | $2.4M |
| LYELLyell Immunopharma, Inc. | 114,491 | $2.3M |
| DMRADamora Therapeutics, Inc. | 88,336 | $2.3M |
| NGNENeurogene Inc. | 107,714 | $2.2M |
| JBIOJade Biosciences, Inc. | 153,037 | $2.2M |
| IMTXImmatics N.V. | 215,978 | $2.1M |
| CMPSCOMPASS Pathways plc | 371,697 | $2.1M |
| OCGNOcugen, Inc. | 1,127,406 | $2.0M |
| AQSTAquestive Therapeutics, Inc. | 466,767 | $1.9M |
| TECXTectonic Therapeutic, Inc. | 62,426 | $1.9M |
| LCTXLineage Cell Therapeutics, Inc. | 1,169,427 | $1.8M |
| ATAIAtai Beckley N.V. | 520,905 | $1.8M |
| RZLTRezolute, Inc. | 602,296 | $1.8M |
| ABSIAbsci Corporation | 591,712 | $1.8M |
| LENZLENZ Therapeutics, Inc. | 183,756 | $1.7M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,070,517 | $1.7M |
| VYGRVoyager Therapeutics, Inc. | 427,597 | $1.7M |
| FATEFATE THERAPEUTICS INC | 1,327,757 | $1.6M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 167,573 | $1.5M |
| IRDOpus Genetics, Inc. | 326,809 | $1.5M |
| BDTXBlack Diamond Therapeutics, Inc. | 684,418 | $1.5M |
| FBRXForte Biosciences, Inc. | 53,473 | $1.4M |
| ALECAlector, Inc. | 604,562 | $1.3M |
| ORGOOrganogenesis Holdings Inc. | 520,350 | $1.2M |
| CHRSCoherus Oncology, Inc. | 696,158 | $1.2M |
| CADLCandel Therapeutics, Inc. | 227,521 | $1.1M |
| ZNTLZentalis Pharmaceuticals, Inc. | 462,678 | $1.1M |
| CLYMClimb Bio, Inc. | 149,970 | $1.0M |
| IVAInventiva S.A. | 184,907 | $1.0M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 36,205 | $1.0M |
| GLSIGreenwich LifeSciences, Inc. | 39,521 | $949K |
| ALDXAldeyra Therapeutics, Inc. | 543,146 | $918K |
| ZURAZura Bio Ltd | 152,915 | $910K |
| AVTXAvalo Therapeutics, Inc. | 60,106 | $897K |
| SGMTSagimet Biosciences Inc. | 169,259 | $884K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 93,111 | $874K |
| IMMXImmix Biopharma, Inc. | 95,404 | $869K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 1,056,944 | $846K |
| PRLDPrelude Therapeutics Inc | 236,469 | $809K |
| PROKPROKIDNEY CORP. | 421,902 | $755K |
| SRZNSurrozen Inc. | 25,851 | $753K |
| XOMAXOMA Royalty Corporation | 23,998 | $753K |
| CNTXContext Therapeutics Inc. | 287,299 | $753K |
| PLRXPLIANT THERAPEUTICS, INC. | 596,837 | $752K |
| TNXPTonix Pharmaceuticals Holding Corp. | 53,055 | $730K |
| STROSUTRO BIOPHARMA, INC. | 27,187 | $677K |
| KLRSKalaris Therapeutics, Inc. | 110,503 | $638K |
| GHRSGH Research PLC | 44,795 | $630K |
| ARMPArmata Pharmaceuticals, Inc. | 60,953 | $624K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 28,711 | $620K |
| ELTXElicio Therapeutics, Inc. | 57,818 | $618K |
| KRROKorro Bio, Inc. | 50,541 | $572K |
| PLXProtalix BioTherapeutics, Inc. | 251,345 | $545K |
| GALTGALECTIN THERAPEUTICS INC | 184,737 | $515K |
| BCYCBICYCLE THERAPEUTICS PLC | 110,147 | $511K |
| GYREGYRE THERAPEUTICS, INC. | 73,122 | $510K |
| TENXTENAX THERAPEUTICS, INC. | 31,854 | $509K |
| ALVOAlvotech | 148,153 | $508K |
| SABSSAB BIOTHERAPEUTICS, INC. | 113,940 | $436K |
| HUMAHumacyte Inc. | 677,015 | $411K |
| DMACDiaMedica Therapeutics Inc. | 59,288 | $401K |
| AGMBAgomAb Therapeutics NV | 35,739 | $375K |
| CAMPCamp4 Therapeutics Corp | 78,345 | $346K |
| FENCFENNEC PHARMACEUTICALS INC. | 55,664 | $342K |
| OVIDOvid Therapeutics Inc. | 152,847 | $339K |
| MDWDMediWound Ltd. | 19,741 | $318K |
| NVCTNuvectis Pharma, Inc. | 41,124 | $318K |
| ALXOALX ONCOLOGY HOLDINGS INC | 138,593 | $278K |
| SLNSilence Therapeutics Plc | 52,511 | $277K |
| NBPNovaBridge Biosciences | 112,463 | $277K |
| CNTNCanton Strategic Holdings, Inc. | 70,297 | $230K |
| CRDFCardiff Oncology, Inc. | 135,598 | $220K |
| WHWKWhitehawk Therapeutics, Inc. | 56,912 | $196K |
| RNACCartesian Therapeutics, Inc. | 30,927 | $190K |
| DRTSAlpha Tau Medical Ltd. | 26,189 | $185K |
| IMUXIMMUNIC, INC. | 149,770 | $166K |
| AUTLAutolus Therapeutics plc | 116,413 | $161K |
| HURATuHURA Biosciences, Inc./NV | 70,246 | $126K |
| BMEABiomea Fusion, Inc. | 75,739 | $116K |
| AGENAGENUS INC | 31,454 | $105K |
| PLYXPolaryx Therapeutics Inc. | 13,483 | $102K |
| SGMOQSANGAMO THERAPEUTICS, INC | 377,287 | $93K |
| TLSATiziana Life Sciences Ltd | 75,660 | $89K |
| INOINOVIO PHARMACEUTICALS, INC. | 44,724 | $78K |
| TVRDTvardi Therapeutics, Inc. | 23,898 | $76K |
| ARTVArtiva Biotherapeutics, Inc. | 11,465 | $74K |
| AARDAardvark Therapeutics, Inc. | 19,404 | $73K |
| ATNMActinium Pharmaceuticals, Inc. | 70,241 | $70K |
| FLNAFilana Therapeutics Inc. | 41,324 | $70K |
| ACIUAC Immune SA | 21,632 | $59K |
| IMAImageneBio, Inc. | 11,458 | $57K |
| EVOEvotec SE | 21,390 | $53K |
| MNOVMEDICINOVA INC | 27,824 | $38K |
| HOWLWerewolf Therapeutics, Inc. | 38,266 | $32K |
| DWTXDogwood Therapeutics, Inc. | 14,598 | $31K |
| VIVSVivoSim Labs, INC. | 16,072 | $23K |
| IGCIGC Pharma, Inc. | 65,541 | $17K |
| CUECue Biopharma, Inc. | 34,151 | $8K |
| OTLKOutlook Therapeutics, Inc. | 10,275 | $2K |
| QNCXQuince Therapeutics, Inc. | 16,064 | $2K |