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| ABTABBOTT LABORATORIES | 15,142,201 | $1.55B |
| AMGNAMGEN INC | 4,417,289 | $1.55B |
| PMPhilip Morris International Inc | 9,366,547 | $1.55B |
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| REGNREGENERON PHARMACEUTICALS, INC. | 1,504,658 | $1.16B |
| MCKMcKesson Corporation | 1,305,081 | $1.13B |
| VRTXVERTEX PHARMACEUTICALS INC / MA | 2,466,575 | $1.10B |
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| IONSIONIS PHARMACEUTICALS INC | 1,699,847 | $127.6M |
| SNYSanofi | 2,582,456 | $124.4M |
| RPRXRoyalty Pharma plc | 2,547,546 | $122.2M |
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| ELANElanco Animal Health Inc | 1,434,135 | $34.3M |
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| BCRXBIOCRYST PHARMACEUTICALS INC | 2,347,443 | $22.3M |
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| BMRNBIOMARIN PHARMACEUTICAL INC | 379,596 | $21.4M |
| BHVNBiohaven Ltd. | 2,513,181 | $21.3M |
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| TYRATyra Biosciences, Inc. | 550,334 | $21.1M |
| MLTXMoonLake Immunotherapeutics | 1,130,233 | $21.1M |
| DAWNDay One Biopharmaceuticals, Inc. | 979,238 | $21.0M |
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| NEOGNEOGEN CORP | 2,226,830 | $20.7M |
| QUREuniQure N.V. | 1,263,236 | $20.7M |
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| ARRYARRAY BIOPHARMA INC | 2,776,145 | $20.1M |
| EWTXEdgewise Therapeutics, Inc. | 629,820 | $19.8M |
| CRSPCRISPR Therapeutics AG | 414,220 | $19.7M |
| AVBPArriVent BioPharma, Inc. | 853,427 | $19.7M |
| ARDXARDELYX, INC. | 3,216,210 | $19.3M |
| COLLCOLLEGIUM PHARMACEUTICAL, INC | 575,141 | $19.0M |
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| OLMAOlema Pharmaceuticals, Inc. | 1,252,689 | $18.7M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 6,065,661 | $18.6M |
| ELVNEnliven Therapeutics, Inc. | 473,115 | $18.5M |
| FMSFresenius Medical Care AG American Depositary Shares (Each representing 1/2 of an Ordinary Share) | 818,002 | $18.5M |
| ANABANAPTYSBIO, INC | 332,743 | $18.5M |
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| REPLReplimune Group, Inc. | 2,277,276 | $17.4M |
| ANIPANI PHARMACEUTICALS INC | 219,755 | $16.9M |
| OSCROscar Health Inc. | 1,471,754 | $16.9M |
| BLTEBELITE BIO, INC | 105,509 | $16.8M |
| GERNGERON CORP | 11,176,591 | $16.7M |
| KALVKalVista Pharmaceuticals, Inc. | 824,293 | $16.6M |
| GLUEMonte Rosa Therapeutics, Inc. | 1,001,527 | $16.5M |
| ALMSALUMIS INC. | 718,040 | $15.8M |
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| ZYMEZymeworks Inc. | 599,486 | $15.0M |
| TRVITrevi Therapeutics, Inc. | 1,227,772 | $14.6M |
| NVAXNOVAVAX INC | 1,784,246 | $14.5M |
| MBXMBX Biosciences, Inc. | 457,945 | $13.7M |
| SYRESpyre Therapeutics, Inc. | 269,938 | $13.6M |
| SHCSotera Health Company | 936,482 | $13.4M |
| VMDViemed Healthcare Inc. | 1,421,634 | $13.1M |
| ABCLAbCellera Biologics Inc. | 3,751,212 | $13.1M |
| PGENPRECIGEN, INC. | 3,350,477 | $13.0M |
| SLNOSOLENO THERAPEUTICS INC | 385,798 | $12.9M |
| ORKAOruka Therapeutics, Inc. | 246,711 | $12.1M |
| ANNXAnnexon, Inc. | 2,152,880 | $11.9M |
| RIGLRIGEL PHARMACEUTICALS INC | 439,101 | $11.9M |
| KURAKura Oncology, Inc. | 1,433,471 | $11.7M |
| BCAXBicara Therapeutics Inc. | 558,964 | $11.1M |
| INBXInhibrx Biosciences, Inc. | 161,574 | $10.9M |
| URGNUroGen Pharma Ltd. | 598,528 | $10.8M |
| MANEVeradermics Incorporated | 168,975 | $10.7M |
| MYGNMYRIAD GENETICS INC | 2,366,092 | $10.6M |
| GRFSGrifols S.A. | 1,325,965 | $10.6M |
| CMPXCompass Therapeutics, Inc. | 1,995,394 | $10.6M |
| SIONSionna Therapeutics, Inc. | 263,174 | $10.6M |
| WVEWave Life Sciences Ltd. | 1,383,590 | $10.0M |
| PAHCPHIBRO ANIMAL HEALTH CORP | 176,200 | $9.7M |
| OGNOrganon & Co. | 1,605,325 | $9.6M |
| IRWDIRONWOOD PHARMACEUTICALS INC | 2,690,634 | $9.4M |
| OCULOCULAR THERAPEUTIX, INC | 1,110,366 | $9.4M |
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| XNCRXencor Inc | 763,793 | $9.2M |
| SANASana Biotechnology, Inc. | 3,181,115 | $9.2M |
| NKTRNEKTAR THERAPEUTICS | 126,942 | $9.1M |
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| LBRXLB PHARMACEUTICALS INC | 363,799 | $9.0M |
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| AQSTAquestive Therapeutics, Inc. | 466,767 | $1.9M |
| TECXTectonic Therapeutic, Inc. | 62,426 | $1.9M |
| MNPRMonopar Therapeutics | 34,710 | $1.9M |
| LCTXLineage Cell Therapeutics, Inc. | 1,169,427 | $1.8M |
| KYTXKyverna Therapeutics, Inc. | 212,910 | $1.8M |
| RZLTRezolute, Inc. | 602,296 | $1.8M |
| OCSOculis Holding AG | 67,753 | $1.8M |
| ABSIAbsci Corporation | 591,712 | $1.8M |
| IMRXImmuneering Corp | 327,655 | $1.7M |
| LENZLENZ Therapeutics, Inc. | 183,756 | $1.7M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,070,517 | $1.7M |
| VYGRVoyager Therapeutics, Inc. | 427,597 | $1.7M |
| CYRXCryoport, Inc. | 198,834 | $1.6M |
| NATRNATURES SUNSHINE PRODUCTS INC | 67,120 | $1.6M |
| FATEFATE THERAPEUTICS INC | 1,327,757 | $1.6M |
| USNAUSANA HEALTH SCIENCES INC | 91,149 | $1.6M |
| SNDLSNDL Inc. | 1,182,075 | $1.6M |
| ARCTArcturus Therapeutics Holdings Inc. | 198,681 | $1.5M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 167,573 | $1.5M |
| IRDOpus Genetics, Inc. | 326,809 | $1.5M |
| BDTXBlack Diamond Therapeutics, Inc. | 684,418 | $1.5M |
| INNVINNOVUS PHARMACEUTICALS, INC. | 179,241 | $1.4M |
| NRCNational Research Corporation Common Stock (Delaware) | 82,692 | $1.4M |
| FBRXForte Biosciences, Inc. | 53,473 | $1.4M |
| EDITEditas Medicine, Inc. | 558,577 | $1.4M |
| EIKNEikon Therapeutics Inc. | 129,306 | $1.4M |
| GLPGGalapagos NV | 45,371 | $1.4M |
| CRONCronos Group Inc. | 520,962 | $1.3M |
| ALECAlector, Inc. | 604,562 | $1.3M |
| IPEXInflection Point Acquisition Corp. V | 122,106 | $1.3M |
| ORGOOrganogenesis Holdings Inc. | 520,350 | $1.2M |
| BBNXBeta Bionics Inc. | 121,334 | $1.2M |
| CGCCanopy Growth Corp | 1,263,602 | $1.2M |
| AURAAura Biosciences, Inc. | 178,726 | $1.2M |
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| ELDNEledon Pharmaceuticals, Inc. | 370,090 | $1.1M |
| CADLCandel Therapeutics, Inc. | 227,521 | $1.1M |
| ZNTLZentalis Pharmaceuticals, Inc. | 462,678 | $1.1M |
| TLRYTilray Brands, Inc. | 158,932 | $1.0M |
| CLYMClimb Bio, Inc. | 149,970 | $1.0M |
| IVAInventiva S.A. | 184,907 | $1.0M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 36,205 | $1.0M |
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| GLSIGreenwich LifeSciences, Inc. | 39,521 | $949K |
| ALDXAldeyra Therapeutics, Inc. | 543,146 | $918K |
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| AVTXAvalo Therapeutics, Inc. | 60,106 | $897K |
| SGMTSagimet Biosciences Inc. | 169,259 | $884K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 93,111 | $874K |
| IMMXImmix Biopharma, Inc. | 95,404 | $869K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 1,056,944 | $846K |
| MXCTMaxCyte Inc. | 1,159,019 | $814K |
| NKTXNkarta, Inc. | 385,000 | $812K |
| PRLDPrelude Therapeutics Inc | 236,469 | $809K |
| LFVNLifevantage Corp | 185,114 | $800K |
| MGNXMACROGENICS INC | 273,478 | $790K |
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| XOMAXOMA Royalty Corporation | 23,998 | $753K |
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| MBOTMicrobot Medical Inc. | 309,103 | $745K |
| TNXPTonix Pharmaceuticals Holding Corp. | 53,055 | $730K |
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| SKINThe Beauty Health Company | 626,879 | $558K |
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| VTVTvTv Therapeutics Inc. | 13,350 | $529K |
| TMCITreace Medical Concepts Inc. | 387,685 | $519K |
| GALTGALECTIN THERAPEUTICS INC | 184,737 | $515K |
| BCYCBICYCLE THERAPEUTICS PLC | 110,147 | $511K |
| GYREGYRE THERAPEUTICS, INC. | 73,122 | $510K |
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| SABSSAB BIOTHERAPEUTICS, INC. | 113,940 | $436K |
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| DMACDiaMedica Therapeutics Inc. | 59,288 | $401K |
| GOSSGossamer Bio, Inc. | 1,180,544 | $388K |
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| OVIDOvid Therapeutics Inc. | 152,847 | $339K |
| STIMNeuronetics Inc. | 233,590 | $339K |
| DERMJourney Medical Corp | 69,389 | $325K |
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| NVCTNuvectis Pharma, Inc. | 41,124 | $318K |
| TLSITriSalus Life Sciences Inc. | 75,049 | $300K |
| SOPHSOPHiA GENETICS SA | 57,628 | $285K |
| LUCDLucid Diagnostics Inc. | 242,658 | $279K |
| ALXOALX ONCOLOGY HOLDINGS INC | 138,593 | $278K |
| SLNSilence Therapeutics Plc | 52,511 | $277K |
| NBPNovaBridge Biosciences | 112,463 | $277K |
| INMBInmune Bio, Inc. | 231,586 | $262K |
| IKTInhibikase Therapeutics, Inc. | 149,857 | $252K |
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| PEPGPepGen Inc. | 138,653 | $245K |
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| ATYRaTYR PHARMA INC | 283,236 | $221K |
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| DTILPRECISION BIOSCIENCES INC | 39,752 | $219K |
| WHWKWhitehawk Therapeutics, Inc. | 56,912 | $196K |
| NERVMinerva Neurosciences, Inc. | 32,012 | $193K |
| RNACCartesian Therapeutics, Inc. | 30,927 | $190K |
| DRTSAlpha Tau Medical Ltd. | 26,189 | $185K |
| UNCYUnicycive Therapeutics, Inc. | 27,093 | $178K |
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| AUTLAutolus Therapeutics plc | 116,413 | $161K |
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| BTMDbiote Corp. | 100,609 | $136K |
| HURATuHURA Biosciences, Inc./NV | 70,246 | $126K |
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| PROFProfound Medical Corp. | 18,707 | $121K |
| BMEABiomea Fusion, Inc. | 75,739 | $116K |
| TNYATenaya Therapeutics, Inc. | 154,801 | $107K |
| AGENAGENUS INC | 31,454 | $105K |
| PLYXPolaryx Therapeutics Inc. | 13,483 | $102K |
| ENLVEnlivex Ltd. | 102,093 | $95K |
| SGMOSANGAMO THERAPEUTICS, INC | 377,287 | $93K |
| TLSATiziana Life Sciences Ltd | 75,660 | $89K |
| GNLXGENELUX Corp | 32,610 | $79K |
| CNTBConnect Biopharma Holdings Ltd | 29,833 | $78K |
| INOINOVIO PHARMACEUTICALS, INC. | 44,724 | $78K |
| TVRDTvardi Therapeutics, Inc. | 23,898 | $76K |
| ARTVArtiva Biotherapeutics, Inc. | 11,465 | $74K |
| AARDAardvark Therapeutics, Inc. | 19,404 | $73K |
| ATNMActinium Pharmaceuticals, Inc. | 70,241 | $70K |
| FLNAFilana Therapeutics Inc. | 41,324 | $70K |
| PYXSPyxis Oncology, Inc. | 46,920 | $69K |
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| EVOEvotec SE | 21,390 | $53K |
| SSIISS Innovations International Inc. | 10,601 | $53K |
| MNOVMEDICINOVA INC | 27,824 | $38K |
| TCRXTScan Therapeutics, Inc. | 37,267 | $38K |
| ACTUACTUATE THERAPEUTICS, INC. | 12,408 | $34K |
| HOWLWerewolf Therapeutics, Inc. | 38,266 | $32K |
| GUTSFractyl Health Inc. | 68,433 | $31K |
| COCHEnvoy Medical Inc. | 36,462 | $24K |
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| UPXIUPEXI, INC. | 22,191 | $22K |
| ACRVAcrivon Therapeutics, Inc. | 14,742 | $20K |
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| TELOTelomir Pharmaceuticals, Inc. | 10,411 | $14K |
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| RANIRani Therapeutics Holdings, Inc. | 11,826 | $9K |
| LNAILunai Bioworks Inc. | 12,082 | $5K |
| MGRXMangoceuticals Inc. | 11,757 | $4K |
| NOTVInotiv, Inc. | 13,018 | $4K |
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| KALAKALA BIO, Inc. | 14,048 | $2K |
| OTLKOutlook Therapeutics, Inc. | 10,275 | $2K |