| GILDGILEAD SCIENCES, INC. | 59,858,585 | $8.34B |
| REGNREGENERON PHARMACEUTICALS, INC. | 4,664,478 | $3.60B |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 3,322,698 | $1.10B |
| INSMINSMED Inc | 5,551,699 | $907.8M |
| INCYIncyte Corp. | 9,641,384 | $907.4M |
| MRNAModerna, Inc. | 14,861,409 | $755.0M |
| TEVATeva Pharmaceutical Industries Limited | 17,790,020 | $535.8M |
| ROIVRoivant Sciences Ltd. | 16,186,613 | $448.4M |
| EXELEXELIXIS, INC. | 10,298,439 | $441.7M |
| RVMDREVOLUTION MEDICINES, INC. | 4,402,662 | $428.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 7,295,079 | $412.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 6,496,130 | $407.3M |
| CYTKCYTOKINETICS INC | 5,745,193 | $378.7M |
| BBIOBridgeBio Pharma, Inc. | 4,934,320 | $366.4M |
| JAZZJazz Pharmaceuticals plc | 1,891,646 | $357.6M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 5,998,486 | $334.0M |
| PTGXProtagonist Therapeutics, Inc | 3,116,749 | $328.5M |
| IONSIONIS PHARMACEUTICALS INC | 3,995,564 | $300.0M |
| PTCTPTC THERAPEUTICS, INC. | 4,346,519 | $296.1M |
| TGTXTG THERAPEUTICS, INC. | 8,649,766 | $287.3M |
| APLSApellis Pharmaceuticals, Inc. | 6,844,990 | $275.4M |
| PCVXVaxcyte, Inc. | 4,440,519 | $258.0M |
| COGTCogent Biosciences, Inc. | 5,663,543 | $218.0M |
| NUVLNuvalent, Inc. | 2,035,831 | $208.6M |
| SRRKScholar Rock Holding Corp | 4,031,317 | $198.2M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 2,271,851 | $197.6M |
| FOLDAMICUS THERAPEUTICS, INC. | 12,893,897 | $186.4M |
| ACADACADIA PHARMACEUTICALS INC | 8,332,771 | $185.5M |
| APGEApogee Therapeutics, Inc. | 2,162,964 | $182.1M |
| AXSMAxsome Therapeutics, Inc. | 986,809 | $166.8M |
| LGNDLigand Pharmaceuticals Incorporated | 778,856 | $155.5M |
| ARQTArcutis Biotherapeutics, Inc. | 6,296,197 | $148.3M |
| TVTXTravere Therapeutics, Inc. | 4,959,988 | $147.4M |
| VKTXViking Therapeutics, Inc. | 4,395,557 | $143.0M |
| IBRXImmunityBio, Inc. | 17,708,103 | $135.8M |
| BEAMBeam Therapeutics Inc. | 5,699,265 | $135.8M |
| SMMTSummit Therapeutics Inc. | 7,028,160 | $133.3M |
| SYRESpyre Therapeutics, Inc. | 2,607,031 | $131.5M |
| ADMAADMA BIOLOGICS, INC. | 14,084,205 | $126.9M |
| DNLIDenali Therapeutics Inc. | 6,272,001 | $120.4M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 2,288,127 | $118.3M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 1,398,913 | $117.4M |
| RCUSArcus Biosciences, Inc. | 5,412,901 | $116.9M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 3,364,879 | $113.7M |
| TERNTerns Pharmaceuticals, Inc. | 2,139,662 | $112.8M |
| IMVTImmunovant, Inc. | 4,537,929 | $112.7M |
| IRONDisc Medicine, Inc. | 1,698,244 | $108.6M |
| VCELVericel Corp | 3,152,130 | $101.4M |
| TNGXTango Therapeutics, Inc. | 4,651,894 | $97.3M |
| VRDNViridian Therapeutics, Inc.\DE | 4,672,885 | $91.4M |
| SLNOSOLENO THERAPEUTICS INC | 2,680,802 | $89.8M |
| CLDXCelldex Therapeutics, Inc. | 2,804,168 | $88.9M |
| NTLAIntellia Therapeutics, Inc. | 6,922,676 | $88.7M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 28,490,638 | $87.5M |
| KODKodiak Sciences Inc. | 2,250,920 | $85.8M |
| ARDXARDELYX, INC. | 13,604,307 | $81.5M |
| NRIXNurix Therapeutics, Inc. | 5,141,195 | $79.7M |
| ORKAOruka Therapeutics, Inc. | 1,613,461 | $79.1M |
| STOKStoke Therapeutics, Inc. | 2,276,512 | $74.1M |
| INVAInnoviva, Inc. | 3,060,377 | $71.3M |
| LQDALiquidia Corp | 1,881,599 | $71.0M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 2,181,901 | $66.3M |
| DAWNDay One Biopharmaceuticals, Inc. | 2,869,876 | $61.5M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 17,448,108 | $61.2M |
| OGNOrganon & Co. | 9,956,774 | $59.6M |
| ANIPANI PHARMACEUTICALS INC | 771,587 | $59.3M |
| OLMAOlema Pharmaceuticals, Inc. | 3,937,831 | $58.7M |
| PVLAPALVELLA THERAPEUTICS, INC. | 458,999 | $57.2M |
| BHVNBiohaven Ltd. | 6,618,803 | $56.0M |
| RDYDR REDDYS LABORATORIES LTD | 4,026,207 | $55.8M |
| ANABANAPTYSBIO, INC | 992,445 | $55.0M |
| ORICOric Pharmaceuticals, Inc. | 3,702,196 | $46.9M |
| DFTXDefinium Therapeutics Inc. | 2,471,873 | $46.7M |
| GERNGERON CORP | 30,497,183 | $45.4M |
| ADPTAdaptive Biotechnologies Corp | 3,227,245 | $44.8M |
| ELVNEnliven Therapeutics, Inc. | 1,091,106 | $42.8M |
| PGENPRECIGEN, INC. | 10,890,124 | $42.1M |
| OCULOCULAR THERAPEUTIX, INC | 4,708,419 | $39.9M |
| ALMSALUMIS INC. | 1,801,812 | $39.7M |
| KALVKalVista Pharmaceuticals, Inc. | 1,955,844 | $39.4M |
| ANNXAnnexon, Inc. | 6,919,255 | $38.3M |
| QUREuniQure N.V. | 2,260,512 | $37.0M |
| KURAKura Oncology, Inc. | 4,511,891 | $36.7M |
| SVRASavara Inc | 6,707,684 | $36.6M |
| CGEMCullinan Therapeutics, Inc. | 2,544,115 | $36.2M |
| SLSSELLAS Life Sciences Group, Inc. | 8,396,356 | $35.5M |
| CMPXCompass Therapeutics, Inc. | 6,694,976 | $35.4M |
| SANASana Biotechnology, Inc. | 10,538,086 | $30.3M |
| SIONSionna Therapeutics, Inc. | 756,227 | $30.3M |
| HROWHARROW, INC. | 855,047 | $30.1M |
| SPRYARS Pharmaceuticals, Inc. | 3,644,966 | $29.3M |
| NUVBNuvation Bio Inc. | 6,784,927 | $29.1M |
| ZBIOZenas BioPharma, Inc. | 1,470,923 | $28.8M |
| ABUSArbutus Biopharma Corp | 6,342,510 | $28.5M |
| BCAXBicara Therapeutics Inc. | 1,419,388 | $28.2M |
| XERSXeris Biopharma Holdings, Inc. | 4,658,174 | $27.0M |
| CTMXCytomX Therapeutics, Inc. | 5,663,408 | $26.6M |
| ZYMEZymeworks Inc. | 1,011,777 | $25.3M |
| FDMT4D Molecular Therapeutics, Inc. | 2,707,875 | $25.2M |
| RGNXREGENXBIO Inc. | 2,731,485 | $22.9M |
| ALTAltimmune, Inc. | 7,145,550 | $22.0M |
| ABSIAbsci Corporation | 7,324,858 | $22.0M |
| ARVNARVINAS, INC. | 1,828,472 | $19.4M |
| ESPREsperion Therapeutics, Inc. | 7,055,794 | $19.3M |
| MAZEMaze Therapeutics, Inc. | 636,722 | $19.0M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 1,938,498 | $18.8M |
| NKTRNEKTAR THERAPEUTICS | 244,727 | $17.6M |
| OCGNOcugen, Inc. | 9,670,191 | $17.5M |
| RCKTRocket Pharmaceuticals Inc. | 4,485,989 | $16.1M |
| BIOABioAge Labs, Inc. | 850,894 | $14.9M |
| ZVRAZEVRA THERAPEUTICS, INC. | 1,561,569 | $14.6M |
| AVXLANAVEX LIFE SCIENCES CORP. | 4,512,028 | $13.9M |
| CATXPerspective Therapeutics, Inc. | 3,132,670 | $13.1M |
| LBRXLB PHARMACEUTICALS INC | 504,373 | $12.4M |
| OPKOPKO HEALTH, INC. | 9,501,377 | $10.8M |
| AQSTAquestive Therapeutics, Inc. | 2,546,191 | $10.6M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 456,927 | $9.9M |
| JBIOJade Biosciences, Inc. | 655,690 | $9.2M |
| IVVDInvivyd, Inc. | 6,935,648 | $9.0M |
| FLGTFulgent Genetics Inc. | 529,399 | $8.4M |
| DNAGinkgo Bioworks Holdings Inc. | 1,346,659 | $8.3M |
| SLDBSolid Biosciences Inc. | 1,125,487 | $8.1M |
| DSGNDesign Therapeutics, Inc. | 659,575 | $7.0M |
| MPLTMapLight Therapeutics, Inc. | 339,116 | $6.9M |
| TRDAEntrada Therapeutics, Inc. | 533,798 | $6.7M |
| TECXTectonic Therapeutic, Inc. | 213,505 | $6.6M |
| UPBUpstream Bio, Inc. | 705,350 | $6.3M |
| NGNENeurogene Inc. | 313,005 | $6.3M |
| KROSKeros Therapeutics, Inc. | 561,730 | $6.2M |
| XOMAXOMA Royalty Corporation | 193,148 | $6.1M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 917,590 | $5.9M |
| SIGASIGA TECHNOLOGIES INC | 1,011,938 | $5.4M |
| RZLTRezolute, Inc. | 1,771,841 | $5.4M |
| GRFSGrifols S.A. | 646,207 | $5.2M |
| DMRADamora Therapeutics, Inc. | 183,922 | $4.8M |
| MANEVeradermics Incorporated | 74,400 | $4.7M |
| HCMHUTCHMED (China) Limited | 304,829 | $4.6M |
| IMTXImmatics N.V. | 456,998 | $4.5M |
| DMACDiaMedica Therapeutics Inc. | 644,211 | $4.4M |
| PHVSPharvaris N.V. | 152,945 | $4.3M |
| ABEOABEONA THERAPEUTICS INC. | 957,328 | $4.3M |
| LRMRLarimar Therapeutics, Inc. | 911,326 | $4.1M |
| ATAIAtai Beckley N.V. | 1,144,355 | $4.1M |
| CADLCandel Therapeutics, Inc. | 818,558 | $4.0M |
| ALECAlector, Inc. | 1,865,526 | $4.0M |
| CHRSCoherus Oncology, Inc. | 2,325,859 | $3.9M |
| ARGXARGENX SE | 5,113 | $3.7M |
| KNSAKiniksa Pharmaceuticals International, plc | 76,633 | $3.7M |
| LENZLENZ Therapeutics, Inc. | 402,225 | $3.7M |
| VYGRVoyager Therapeutics, Inc. | 948,226 | $3.7M |
| ORGOOrganogenesis Holdings Inc. | 1,525,108 | $3.6M |
| RNAAtrium Therapeutics Inc. | 257,086 | $3.4M |
| TNXPTonix Pharmaceuticals Holding Corp. | 230,607 | $3.2M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 3,843,672 | $3.1M |
| IMCRImmunocore Holdings plc | 97,940 | $3.0M |
| FATEFATE THERAPEUTICS INC | 2,263,173 | $2.7M |
| ABCLAbCellera Biologics Inc. | 730,213 | $2.5M |
| RLMDRELMADA THERAPEUTICS, INC. | 357,040 | $2.5M |
| MDWDMediWound Ltd. | 143,770 | $2.3M |
| GPCRStructure Therapeutics Inc. | 47,581 | $2.3M |
| FENCFENNEC PHARMACEUTICALS INC. | 359,055 | $2.2M |
| PLXProtalix BioTherapeutics, Inc. | 972,815 | $2.1M |
| ONCBeOne Medicines Ltd. | 7,065 | $2.1M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 226,278 | $2.0M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 63,090 | $2.0M |
| CRDFCardiff Oncology, Inc. | 1,186,947 | $1.9M |
| ALDXAldeyra Therapeutics, Inc. | 1,124,710 | $1.9M |
| HUMAHumacyte Inc. | 3,043,929 | $1.8M |
| IMMXImmix Biopharma, Inc. | 191,910 | $1.7M |
| LCTXLineage Cell Therapeutics, Inc. | 1,090,111 | $1.7M |
| XFORX4 Pharmaceuticals, Inc | 403,534 | $1.7M |
| KRROKorro Bio, Inc. | 140,341 | $1.6M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 56,689 | $1.6M |
| GYREGYRE THERAPEUTICS, INC. | 216,326 | $1.5M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 964,038 | $1.5M |
| LYELLyell Immunopharma, Inc. | 72,522 | $1.5M |
| FBRXForte Biosciences, Inc. | 54,821 | $1.4M |
| STROSUTRO BIOPHARMA, INC. | 52,118 | $1.3M |
| NVCTNuvectis Pharma, Inc. | 166,516 | $1.3M |
| RNACCartesian Therapeutics, Inc. | 200,337 | $1.2M |
| SNYSanofi | 24,276 | $1.2M |
| ZURAZura Bio Ltd | 194,963 | $1.2M |
| OVIDOvid Therapeutics Inc. | 520,283 | $1.2M |
| AVTXAvalo Therapeutics, Inc. | 71,654 | $1.1M |
| MLTXMoonLake Immunotherapeutics | 56,490 | $1.1M |
| CCCCC4 Therapeutics, Inc. | 382,973 | $1.0M |
| PROKPROKIDNEY CORP. | 556,845 | $997K |
| HURATuHURA Biosciences, Inc./NV | 512,913 | $918K |
| NBPNovaBridge Biosciences | 370,107 | $910K |
| IRDOpus Genetics, Inc. | 199,953 | $910K |
| CLYMClimb Bio, Inc. | 132,000 | $904K |
| SRZNSurrozen Inc. | 27,726 | $808K |
| AARDAardvark Therapeutics, Inc. | 199,322 | $751K |
| GALTGALECTIN THERAPEUTICS INC | 258,432 | $721K |
| CBIOCRESCENT BIOPHARMA, INC. | 39,067 | $718K |
| SGMTSagimet Biosciences Inc. | 128,788 | $673K |
| CNTNCanton Strategic Holdings, Inc. | 201,871 | $660K |
| CAMPCamp4 Therapeutics Corp | 146,900 | $648K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 68,872 | $647K |
| IMUXIMMUNIC, INC. | 565,645 | $628K |
| CNTXContext Therapeutics Inc. | 233,507 | $612K |
| ZNTLZentalis Pharmaceuticals, Inc. | 249,690 | $584K |
| ABVXAbivax SA | 5,007 | $558K |
| WHWKWhitehawk Therapeutics, Inc. | 160,382 | $553K |
| ELTXElicio Therapeutics, Inc. | 50,620 | $541K |
| ASRTAssertio Holdings, Inc. | 27,772 | $529K |
| AGENAGENUS INC | 156,183 | $522K |
| ARMPArmata Pharmaceuticals, Inc. | 50,800 | $520K |
| INOINOVIO PHARMACEUTICALS, INC. | 296,310 | $516K |
| SPROSpero Therapeutics, Inc. | 214,751 | $503K |
| PRLDPrelude Therapeutics Inc | 138,231 | $473K |
| TENXTENAX THERAPEUTICS, INC. | 28,990 | $464K |
| BDTXBlack Diamond Therapeutics, Inc. | 213,513 | $455K |
| CMPSCOMPASS Pathways plc | 80,442 | $445K |
| PLYXPolaryx Therapeutics Inc. | 58,104 | $439K |
| SGMOQSANGAMO THERAPEUTICS, INC | 1,694,783 | $418K |
| ANIXAnixa Biosciences Inc | 159,040 | $410K |
| FLNAFilana Therapeutics Inc. | 239,987 | $406K |
| ANTXAN2 Therapeutics, Inc. | 115,202 | $394K |
| ALXOALX ONCOLOGY HOLDINGS INC | 175,828 | $353K |
| PLRXPLIANT THERAPEUTICS, INC. | 253,418 | $319K |
| BMEABiomea Fusion, Inc. | 208,015 | $318K |
| TVRDTvardi Therapeutics, Inc. | 97,231 | $309K |
| RGCRegencell Bioscience Holdings Ltd | 11,851 | $301K |
| SABSSAB BIOTHERAPEUTICS, INC. | 74,231 | $284K |
| MNOVMEDICINOVA INC | 193,698 | $265K |
| ACETAdicet Bio, Inc. | 36,222 | $247K |
| CGTXCOGNITION THERAPEUTICS INC | 314,483 | $239K |
| SCLXSCILEX HOLDING CO | 35,376 | $236K |
| ATOSATOSSA THERAPEUTICS, INC. | 39,761 | $209K |
| KZRKezar Life Sciences, Inc. | 27,093 | $201K |
| EDSAEdesa Biotech, Inc. | 37,979 | $199K |
| LPCNLipocine Inc. | 22,407 | $179K |
| ANVSAnnovis Bio, Inc. | 77,735 | $173K |
| LONALeonaBio, Inc. | 16,337 | $168K |
| MGXMetagenomi Therapeutics, Inc. | 120,427 | $161K |
| GHRSGH Research PLC | 11,049 | $155K |
| KLRSKalaris Therapeutics, Inc. | 26,510 | $153K |
| CSBRCHAMPIONS ONCOLOGY, INC. | 26,203 | $151K |
| CLNNClene Inc. | 29,801 | $147K |
| BCYCBICYCLE THERAPEUTICS PLC | 30,512 | $142K |
| KYNBKYNTRA BIO INC. | 20,284 | $138K |
| LITSLite Strategy, Inc. | 115,021 | $133K |
| LSTALISATA THERAPEUTICS, INC. | 25,348 | $127K |
| ATNMActinium Pharmaceuticals, Inc. | 126,215 | $126K |
| BTAIBioXcel Therapeutics, Inc. | 92,118 | $123K |
| VERUVERU INC. | 55,004 | $122K |
| AUTLAutolus Therapeutics plc | 83,540 | $115K |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 140,113 | $111K |
| TAOXTAO Synergies Inc. | 19,300 | $110K |
| HOWLWerewolf Therapeutics, Inc. | 119,168 | $99K |
| RNTXRein Therapeutics, Inc. | 75,904 | $99K |
| CRVOCervoMed Inc. | 20,527 | $81K |
| PDSBPDS Biotechnology Corp | 133,333 | $81K |
| CELUCelularity Inc. | 57,830 | $77K |
| ABVCABVC BIOPHARMA, INC. | 72,800 | $71K |
| VTGNVistagen Therapeutics, Inc. | 121,114 | $69K |
| GRMLGreenland Mines Ltd | 196,400 | $65K |
| OKUROnKure Therapeutics, Inc. | 13,462 | $56K |
| IGCIGC Pharma, Inc. | 200,799 | $53K |
| MIRAMIRA PHARMACEUTICALS, INC. | 49,100 | $53K |
| NNVCNANOVIRICIDES, INC. | 54,206 | $49K |
| LGVNLongeveron Inc. | 45,380 | $47K |
| SKYESkye Bioscience, Inc. | 75,326 | $46K |
| ESLAEstrella Immunopharma Inc. | 43,252 | $46K |
| DAREDare Bioscience, Inc. | 23,515 | $43K |
| CUECue Biopharma, Inc. | 179,353 | $41K |
| JSPRJasper Therapeutics Inc. | 44,699 | $39K |
| OTLKOutlook Therapeutics, Inc. | 163,102 | $34K |
| LTRNLantern Pharma Inc. | 23,652 | $32K |
| MRKRMarker Therapeutics, Inc. | 20,948 | $27K |
| CTORCITIUS ONCOLOGY, INC. | 42,900 | $27K |
| MISTMilestone Pharmaceuticals Inc. | 22,331 | $27K |
| QNCXQuince Therapeutics, Inc. | 248,011 | $25K |
| SERSerina Therapeutics, Inc. | 12,758 | $25K |
| BCABBioAtla, Inc. | 151,377 | $24K |
| CTXRCitius Pharmaceuticals, Inc. | 23,271 | $21K |
| COCPCocrystal Pharma, Inc. | 20,543 | $21K |
| PULMPulmatrix, Inc. | 13,945 | $18K |
| TLPHTALPHERA, INC. | 22,182 | $17K |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 19,160 | $14K |
| ELUTELUTIA INC. | 11,969 | $13K |
| MEDSDataMeds AI, Inc. | 124,600 | $12K |
| CALCCalciMedica, Inc. | 17,073 | $9K |
| SILOSilo Pharma, Inc. | 12,500 | $4K |
| LIMNLIMINATUS PHARMA, INC. | 19,000 | $3K |