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| REGNREGENERON PHARMACEUTICALS, INC. | 812,236 | $627.6M |
| MRNAModerna, Inc. | 9,086,404 | $461.6M |
| IONSIONIS PHARMACEUTICALS INC | 5,857,629 | $439.8M |
| BBIOBridgeBio Pharma, Inc. | 3,120,631 | $231.7M |
| RVMDREVOLUTION MEDICINES, INC. | 1,558,807 | $151.6M |
| VKTXViking Therapeutics, Inc. | 4,432,142 | $144.2M |
| EXELEXELIXIS, INC. | 2,206,212 | $94.6M |
| ARGXARGENX SE | 109,121 | $79.7M |
| NKTRNEKTAR THERAPEUTICS | 930,741 | $67.0M |
| GMABGenmab A/S | 2,339,432 | $62.8M |
| NTLAIntellia Therapeutics, Inc. | 4,705,901 | $60.3M |
| AXSMAxsome Therapeutics, Inc. | 322,778 | $54.6M |
| TGTXTG THERAPEUTICS, INC. | 1,542,312 | $51.2M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 13,687,433 | $48.0M |
| TVTXTravere Therapeutics, Inc. | 1,508,259 | $44.8M |
| QUREuniQure N.V. | 2,675,871 | $43.8M |
| INCYIncyte Corp. | 415,914 | $39.1M |
| INSMINSMED Inc | 237,017 | $38.8M |
| ABCLAbCellera Biologics Inc. | 10,562,065 | $36.9M |
| INVAInnoviva, Inc. | 1,484,264 | $34.6M |
| IBRXImmunityBio, Inc. | 4,385,500 | $33.6M |
| IMCRImmunocore Holdings plc | 1,021,265 | $30.8M |
| BEAMBeam Therapeutics Inc. | 1,210,853 | $28.9M |
| ESPREsperion Therapeutics, Inc. | 9,458,779 | $25.9M |
| ANABANAPTYSBIO, INC | 465,083 | $25.8M |
| ARDXARDELYX, INC. | 4,274,043 | $25.6M |
| APGEApogee Therapeutics, Inc. | 281,386 | $23.7M |
| DFTXDefinium Therapeutics Inc. | 1,201,610 | $22.7M |
| LQDALiquidia Corp | 563,233 | $21.3M |
| APLSApellis Pharmaceuticals, Inc. | 521,965 | $21.0M |
| MLTXMoonLake Immunotherapeutics | 1,122,312 | $20.9M |
| KNSAKiniksa Pharmaceuticals International, plc | 420,914 | $20.3M |
| ARVNARVINAS, INC. | 1,832,114 | $19.4M |
| ADMAADMA BIOLOGICS, INC. | 2,092,133 | $18.9M |
| OGNOrganon & Co. | 3,137,020 | $18.8M |
| CYTKCYTOKINETICS INC | 285,008 | $18.8M |
| SMMTSummit Therapeutics Inc. | 981,185 | $18.6M |
| OLMAOlema Pharmaceuticals, Inc. | 1,169,421 | $17.4M |
| ACADACADIA PHARMACEUTICALS INC | 775,121 | $17.3M |
| VCELVericel Corp | 485,012 | $15.6M |
| OCULOCULAR THERAPEUTIX, INC | 1,830,159 | $15.5M |
| ALMSALUMIS INC. | 658,115 | $14.5M |
| CMPSCOMPASS Pathways plc | 2,583,499 | $14.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 271,228 | $14.0M |
| CTMXCytomX Therapeutics, Inc. | 2,710,156 | $12.7M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 4,066,315 | $12.5M |
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| NUVBNuvation Bio Inc. | 2,684,089 | $11.5M |
| FOLDAMICUS THERAPEUTICS, INC. | 781,741 | $11.3M |
| XERSXeris Biopharma Holdings, Inc. | 1,924,202 | $11.2M |
| TEVATeva Pharmaceutical Industries Limited | 366,791 | $11.0M |
| NUVLNuvalent, Inc. | 102,118 | $10.5M |
| BHVNBiohaven Ltd. | 1,186,714 | $10.0M |
| AVXLANAVEX LIFE SCIENCES CORP. | 3,247,888 | $10.0M |
| ONCBeOne Medicines Ltd. | 33,543 | $10.0M |
| SRRKScholar Rock Holding Corp | 178,672 | $8.8M |
| GPCRStructure Therapeutics Inc. | 181,415 | $8.7M |
| ABSIAbsci Corporation | 2,898,766 | $8.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 251,636 | $8.5M |
| CCCCC4 Therapeutics, Inc. | 3,035,634 | $8.0M |
| ALTAltimmune, Inc. | 2,478,900 | $7.6M |
| ANIPANI PHARMACEUTICALS INC | 96,809 | $7.4M |
| CGEMCullinan Therapeutics, Inc. | 522,047 | $7.4M |
| ATAIAtai Beckley N.V. | 1,975,552 | $7.0M |
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| ARQTArcutis Biotherapeutics, Inc. | 234,307 | $5.5M |
| ZBIOZenas BioPharma, Inc. | 275,056 | $5.4M |
| FLGTFulgent Genetics Inc. | 322,189 | $5.1M |
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| RGNXREGENXBIO Inc. | 554,892 | $4.6M |
| LENZLENZ Therapeutics, Inc. | 500,997 | $4.6M |
| CLDXCelldex Therapeutics, Inc. | 137,015 | $4.3M |
| CATXPerspective Therapeutics, Inc. | 1,003,474 | $4.2M |
| FATEFATE THERAPEUTICS INC | 3,466,786 | $4.2M |
| OCGNOcugen, Inc. | 2,251,282 | $4.1M |
| KROSKeros Therapeutics, Inc. | 363,835 | $4.0M |
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| CHRSCoherus Oncology, Inc. | 2,302,001 | $3.9M |
| KODKodiak Sciences Inc. | 99,468 | $3.8M |
| JAZZJazz Pharmaceuticals plc | 19,600 | $3.7M |
| TNGXTango Therapeutics, Inc. | 173,132 | $3.6M |
| PHVSPharvaris N.V. | 126,076 | $3.6M |
| SANASana Biotechnology, Inc. | 1,198,579 | $3.5M |
| FLNAFilana Therapeutics Inc. | 1,988,814 | $3.4M |
| ALXOALX ONCOLOGY HOLDINGS INC | 1,587,833 | $3.2M |
| PRLDPrelude Therapeutics Inc | 923,626 | $3.2M |
| KALVKalVista Pharmaceuticals, Inc. | 153,459 | $3.1M |
| KURAKura Oncology, Inc. | 357,955 | $2.9M |
| TERNTerns Pharmaceuticals, Inc. | 54,366 | $2.9M |
| RLMDRELMADA THERAPEUTICS, INC. | 408,095 | $2.8M |
| PLRXPLIANT THERAPEUTICS, INC. | 2,253,138 | $2.8M |
| GERNGERON CORP | 1,889,468 | $2.8M |
| OVIDOvid Therapeutics Inc. | 1,256,869 | $2.8M |
| MISTMilestone Pharmaceuticals Inc. | 2,317,176 | $2.8M |
| ALECAlector, Inc. | 1,279,306 | $2.8M |
| ANNXAnnexon, Inc. | 471,391 | $2.6M |
| IVVDInvivyd, Inc. | 1,969,659 | $2.6M |
| RZLTRezolute, Inc. | 830,588 | $2.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 44,475 | $2.5M |
| RNAAtrium Therapeutics Inc. | 178,560 | $2.4M |
| CNTACentessa Pharmaceuticals plc | 59,844 | $2.4M |
| VYGRVoyager Therapeutics, Inc. | 615,660 | $2.4M |
| SIGASIGA TECHNOLOGIES INC | 433,661 | $2.3M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 35,800 | $2.2M |
| LRMRLarimar Therapeutics, Inc. | 475,612 | $2.1M |
| CBIOCRESCENT BIOPHARMA, INC. | 115,828 | $2.1M |
| CLYMClimb Bio, Inc. | 310,606 | $2.1M |
| SPROSpero Therapeutics, Inc. | 885,631 | $2.1M |
| COGTCogent Biosciences, Inc. | 53,090 | $2.0M |
| ZURAZura Bio Ltd | 318,186 | $1.9M |
| GILDGILEAD SCIENCES, INC. | 13,500 | $1.9M |
| KRROKorro Bio, Inc. | 165,472 | $1.9M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,199,632 | $1.9M |
| PTCTPTC THERAPEUTICS, INC. | 27,110 | $1.8M |
| BCAXBicara Therapeutics Inc. | 89,881 | $1.8M |
| SLSSELLAS Life Sciences Group, Inc. | 403,165 | $1.7M |
| ADPTAdaptive Biotechnologies Corp | 118,200 | $1.6M |
| STROSUTRO BIOPHARMA, INC. | 65,176 | $1.6M |
| SLNOSOLENO THERAPEUTICS INC | 48,092 | $1.6M |
| SGMOQSANGAMO THERAPEUTICS, INC | 6,270,441 | $1.5M |
| PRQRProQR Therapeutics N.V. | 918,857 | $1.5M |
| ANVSAnnovis Bio, Inc. | 627,659 | $1.4M |
| GALTGALECTIN THERAPEUTICS INC | 467,063 | $1.3M |
| IVAInventiva S.A. | 226,406 | $1.3M |
| FDMT4D Molecular Therapeutics, Inc. | 124,317 | $1.2M |
| SRZNSurrozen Inc. | 39,482 | $1.2M |
| TENXTENAX THERAPEUTICS, INC. | 68,588 | $1.1M |
| RNACCartesian Therapeutics, Inc. | 167,313 | $1.0M |
| AVTXAvalo Therapeutics, Inc. | 64,425 | $962K |
| ORKAOruka Therapeutics, Inc. | 19,364 | $950K |
| WHWKWhitehawk Therapeutics, Inc. | 273,482 | $944K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 30,932 | $940K |
| DAWNDay One Biopharmaceuticals, Inc. | 41,500 | $890K |
| BIOABioAge Labs, Inc. | 46,951 | $821K |
| XOMAXOMA Royalty Corporation | 26,075 | $818K |
| BCYCBICYCLE THERAPEUTICS PLC | 164,800 | $765K |
| LITSLite Strategy, Inc. | 614,442 | $713K |
| SABSSAB BIOTHERAPEUTICS, INC. | 181,185 | $694K |
| VRDNViridian Therapeutics, Inc.\DE | 35,114 | $687K |
| INOINOVIO PHARMACEUTICALS, INC. | 390,384 | $679K |
| MGXMetagenomi Therapeutics, Inc. | 496,767 | $666K |
| SLDBSolid Biosciences Inc. | 92,207 | $664K |
| ASRTAssertio Holdings, Inc. | 33,577 | $640K |
| PROKPROKIDNEY CORP. | 346,382 | $620K |
| AARDAardvark Therapeutics, Inc. | 163,355 | $616K |
| MESOMesoblast Limited | 39,802 | $612K |
| PVLAPALVELLA THERAPEUTICS, INC. | 4,890 | $610K |
| BMEABiomea Fusion, Inc. | 388,696 | $595K |
| AGENAGENUS INC | 170,922 | $571K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 20,550 | $570K |
| TRDAEntrada Therapeutics, Inc. | 44,602 | $563K |
| IRDOpus Genetics, Inc. | 108,641 | $494K |
| ZVRAZEVRA THERAPEUTICS, INC. | 52,436 | $489K |
| CAMPCamp4 Therapeutics Corp | 108,875 | $480K |
| MAZEMaze Therapeutics, Inc. | 15,845 | $473K |
| CADLCandel Therapeutics, Inc. | 93,500 | $458K |
| FBRXForte Biosciences, Inc. | 15,509 | $402K |
| DNAGinkgo Bioworks Holdings Inc. | 63,616 | $390K |
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| RYTMRHYTHM PHARMACEUTICALS, INC. | 4,300 | $374K |
| KYNBKYNTRA BIO INC. | 49,511 | $336K |
| ATNMActinium Pharmaceuticals, Inc. | 337,168 | $336K |
| CRDFCardiff Oncology, Inc. | 206,990 | $335K |
| AYTUAYTU BIOPHARMA, INC | 121,973 | $333K |
| LBRXLB PHARMACEUTICALS INC | 12,720 | $314K |
| RDYDR REDDYS LABORATORIES LTD | 21,800 | $302K |
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| MPLTMapLight Therapeutics, Inc. | 14,098 | $287K |
| PGENPRECIGEN, INC. | 72,800 | $282K |
| NGNENeurogene Inc. | 13,891 | $280K |
| LPCNLipocine Inc. | 33,750 | $270K |
| VTGNVistagen Therapeutics, Inc. | 469,619 | $268K |
| JBIOJade Biosciences, Inc. | 18,251 | $256K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 317,400 | $254K |
| LYELLyell Immunopharma, Inc. | 11,585 | $232K |
| SIONSionna Therapeutics, Inc. | 5,500 | $220K |
| SGMTSagimet Biosciences Inc. | 40,132 | $210K |
| OPKOPKO HEALTH, INC. | 170,000 | $194K |
| KLRSKalaris Therapeutics, Inc. | 30,650 | $177K |
| CMPXCompass Therapeutics, Inc. | 33,100 | $175K |
| DSGNDesign Therapeutics, Inc. | 16,300 | $173K |
| ALGSAligos Therapeutics, Inc. | 23,093 | $172K |
| IFRXInflaRx N.V. | 189,075 | $169K |
| AGMBAgomAb Therapeutics NV | 14,241 | $149K |
| LCTXLineage Cell Therapeutics, Inc. | 88,585 | $140K |
| LONALeonaBio, Inc. | 13,276 | $136K |
| HUMAHumacyte Inc. | 177,536 | $108K |
| ACIUAC Immune SA | 39,091 | $108K |
| OKUROnKure Therapeutics, Inc. | 24,262 | $100K |
| BDTXBlack Diamond Therapeutics, Inc. | 43,300 | $92K |
| ACOGAlpha Cognition Inc. | 15,886 | $87K |
| SLNSilence Therapeutics Plc | 16,203 | $85K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 13,000 | $83K |
| MRKRMarker Therapeutics, Inc. | 61,001 | $79K |
| IMUXIMMUNIC, INC. | 67,186 | $75K |
| SVRASavara Inc | 13,215 | $72K |
| ORGOOrganogenesis Holdings Inc. | 26,997 | $64K |
| XFORX4 Pharmaceuticals, Inc | 13,868 | $57K |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 66,572 | $53K |
| IMMPImmutep Limited | 124,760 | $44K |
| MNOVMEDICINOVA INC | 29,809 | $41K |
| PHIOPhio Pharmaceuticals Corp. | 32,495 | $40K |
| PLXProtalix BioTherapeutics, Inc. | 18,129 | $39K |
| GLMDGalmed Pharmaceuticals Ltd. | 80,177 | $39K |
| ANIXAnixa Biosciences Inc | 14,492 | $37K |
| NRSNNeuroSense Therapeutics Ltd. | 44,445 | $34K |
| DAREDare Bioscience, Inc. | 13,279 | $24K |
| SKYESkye Bioscience, Inc. | 25,684 | $16K |
| KTTAPasithea Therapeutics Corp. | 21,054 | $16K |
| CGTXCOGNITION THERAPEUTICS INC | 19,229 | $15K |
| MBIOMUSTANG BIO, INC. | 16,754 | $12K |
| CTXRCitius Pharmaceuticals, Inc. | 13,138 | $12K |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 10,715 | $8K |
| QNCXQuince Therapeutics, Inc. | 71,223 | $7K |
| GELSGelteq Ltd | 10,052 | $7K |
| TOVXTheriva Biologics, Inc. | 15,441 | $3K |