| GILDGILEAD SCIENCES, INC. | 5,647,122 | $787.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 7,506,786 | $414.3M |
| IONSIONIS PHARMACEUTICALS INC | 3,801,815 | $285.5M |
| REGNREGENERON PHARMACEUTICALS, INC. | 351,171 | $271.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 791,515 | $261.9M |
| SNYSanofi | 3,155,080 | $152.0M |
| RDYDR REDDYS LABORATORIES LTD | 9,984,082 | $138.3M |
| INCYIncyte Corp. | 1,054,123 | $99.2M |
| INSMINSMED Inc | 523,101 | $85.5M |
| MRNAModerna, Inc. | 999,340 | $50.8M |
| RVMDREVOLUTION MEDICINES, INC. | 371,743 | $36.2M |
| EXELEXELIXIS, INC. | 694,131 | $29.8M |
| TEVATeva Pharmaceutical Industries Limited | 963,824 | $29.0M |
| VCELVericel Corp | 882,162 | $28.4M |
| ARGXARGENX SE | 32,917 | $24.0M |
| LGNDLigand Pharmaceuticals Incorporated | 111,543 | $22.3M |
| ONCBeOne Medicines Ltd. | 70,391 | $20.9M |
| ANIPANI PHARMACEUTICALS INC | 213,919 | $16.5M |
| VKTXViking Therapeutics, Inc. | 397,968 | $13.0M |
| IBRXImmunityBio, Inc. | 1,486,049 | $11.4M |
| BBIOBridgeBio Pharma, Inc. | 142,407 | $10.6M |
| JAZZJazz Pharmaceuticals plc | 45,251 | $8.6M |
| ADMAADMA BIOLOGICS, INC. | 929,326 | $8.4M |
| GRFSGrifols S.A. | 785,703 | $6.3M |
| NTLAIntellia Therapeutics, Inc. | 465,499 | $6.0M |
| APLSApellis Pharmaceuticals, Inc. | 126,701 | $5.1M |
| ACADACADIA PHARMACEUTICALS INC | 223,155 | $5.0M |
| TERNTerns Pharmaceuticals, Inc. | 78,912 | $4.2M |
| GMABGenmab A/S | 150,135 | $4.0M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 68,309 | $3.9M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 61,316 | $3.8M |
| ROIVRoivant Sciences Ltd. | 110,041 | $3.0M |
| NUVLNuvalent, Inc. | 23,569 | $2.4M |
| AXSMAxsome Therapeutics, Inc. | 13,645 | $2.3M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 625,035 | $2.2M |
| COGTCogent Biosciences, Inc. | 56,260 | $2.2M |
| DFTXDefinium Therapeutics Inc. | 97,192 | $1.8M |
| OGNOrganon & Co. | 299,663 | $1.8M |
| QUREuniQure N.V. | 107,888 | $1.8M |
| ABVXAbivax SA | 15,123 | $1.7M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 19,064 | $1.6M |
| ABCLAbCellera Biologics Inc. | 394,753 | $1.4M |
| CMPSCOMPASS Pathways plc | 244,526 | $1.4M |
| IMCRImmunocore Holdings plc | 44,714 | $1.3M |
| TGTXTG THERAPEUTICS, INC. | 37,252 | $1.2M |
| ZYMEZymeworks Inc. | 47,360 | $1.2M |
| CYTKCYTOKINETICS INC | 17,692 | $1.2M |
| NKTRNEKTAR THERAPEUTICS | 16,181 | $1.2M |
| BHVNBiohaven Ltd. | 122,452 | $1.0M |
| TVTXTravere Therapeutics, Inc. | 33,352 | $990K |
| LENZLENZ Therapeutics, Inc. | 95,235 | $870K |
| ADPTAdaptive Biotechnologies Corp | 46,470 | $645K |
| ABSIAbsci Corporation | 175,085 | $525K |
| PCVXVaxcyte, Inc. | 8,551 | $496K |
| RNAAtrium Therapeutics Inc. | 35,698 | $477K |
| MESOMesoblast Limited | 26,266 | $404K |
| BEAMBeam Therapeutics Inc. | 16,825 | $401K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 11,790 | $399K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 11,314 | $362K |
| FBRXForte Biosciences, Inc. | 13,389 | $346K |
| HROWHARROW, INC. | 8,490 | $300K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 29,901 | $281K |
| PTCTPTC THERAPEUTICS, INC. | 3,863 | $263K |
| KZIAKAZIA THERAPEUTICS LTD | 34,340 | $255K |
| XERSXeris Biopharma Holdings, Inc. | 43,610 | $253K |
| OPKOPKO HEALTH, INC. | 219,994 | $251K |
| INVAInnoviva, Inc. | 10,061 | $235K |
| ANABANAPTYSBIO, INC | 4,219 | $234K |
| OCULOCULAR THERAPEUTIX, INC | 26,554 | $225K |
| SRRKScholar Rock Holding Corp | 4,331 | $213K |
| ELVNEnliven Therapeutics, Inc. | 5,424 | $212K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 3,837 | $198K |
| PTGXProtagonist Therapeutics, Inc | 1,599 | $169K |
| SYRESpyre Therapeutics, Inc. | 3,250 | $164K |
| DMACDiaMedica Therapeutics Inc. | 23,343 | $157K |
| ORKAOruka Therapeutics, Inc. | 3,172 | $155K |
| SLNOSOLENO THERAPEUTICS INC | 4,659 | $155K |
| DNLIDenali Therapeutics Inc. | 7,535 | $145K |
| SMMTSummit Therapeutics Inc. | 7,422 | $141K |
| DSGNDesign Therapeutics, Inc. | 11,366 | $121K |
| VRDNViridian Therapeutics, Inc.\DE | 6,218 | $121K |
| AQSTAquestive Therapeutics, Inc. | 28,951 | $120K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 3,695 | $112K |
| RCUSArcus Biosciences, Inc. | 4,758 | $102K |
| FOLDAMICUS THERAPEUTICS, INC. | 5,754 | $83K |
| KODKodiak Sciences Inc. | 2,135 | $81K |
| ALTAltimmune, Inc. | 25,317 | $78K |
| KURAKura Oncology, Inc. | 9,149 | $74K |
| BCYCBICYCLE THERAPEUTICS PLC | 14,470 | $67K |
| ADAGAdagene Inc. | 16,850 | $66K |
| MAZEMaze Therapeutics, Inc. | 2,029 | $61K |
| HRMYHarmony Biosciences Holdings, Inc. | 2,131 | $60K |
| IMVTImmunovant, Inc. | 2,401 | $60K |
| KALVKalVista Pharmaceuticals, Inc. | 2,917 | $59K |
| NRIXNurix Therapeutics, Inc. | 3,687 | $58K |
| CGEMCullinan Therapeutics, Inc. | 4,044 | $58K |
| NBTXNanobiotix S.A. | 1,825 | $56K |
| KROSKeros Therapeutics, Inc. | 4,867 | $54K |
| GERNGERON CORP | 34,388 | $52K |
| LQDALiquidia Corp | 1,317 | $50K |
| CNTACentessa Pharmaceuticals plc | 1,164 | $46K |
| PGENPRECIGEN, INC. | 10,714 | $41K |
| ATAIAtai Beckley N.V. | 11,557 | $41K |
| DAWNDay One Biopharmaceuticals, Inc. | 1,911 | $41K |
| HCMHUTCHMED (China) Limited | 2,660 | $40K |
| GYREGYRE THERAPEUTICS, INC. | 5,605 | $39K |
| ARDXARDELYX, INC. | 6,344 | $38K |
| GHRSGH Research PLC | 2,590 | $36K |
| GPCRStructure Therapeutics Inc. | 722 | $35K |
| SANASana Biotechnology, Inc. | 12,285 | $35K |
| ARQTArcutis Biotherapeutics, Inc. | 1,383 | $32K |
| XOMAXOMA Royalty Corporation | 1,002 | $31K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 3,171 | $30K |
| ABEOABEONA THERAPEUTICS INC. | 6,500 | $29K |
| SGMTSagimet Biosciences Inc. | 5,576 | $29K |
| LSTALISATA THERAPEUTICS, INC. | 5,912 | $29K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 4,320 | $28K |
| VERUVERU INC. | 12,239 | $27K |
| CELUCelularity Inc. | 18,000 | $24K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 1,079 | $23K |
| LONALeonaBio, Inc. | 2,225 | $23K |
| SPRYARS Pharmaceuticals, Inc. | 2,616 | $21K |
| NUVBNuvation Bio Inc. | 4,654 | $20K |
| SLDBSolid Biosciences Inc. | 2,666 | $19K |
| CATXPerspective Therapeutics, Inc. | 4,500 | $19K |
| APGEApogee Therapeutics, Inc. | 211 | $18K |
| SLSSELLAS Life Sciences Group, Inc. | 4,171 | $18K |
| SRZNSurrozen Inc. | 625 | $18K |
| CLDXCelldex Therapeutics, Inc. | 502 | $16K |
| PVLAPALVELLA THERAPEUTICS, INC. | 128 | $16K |
| PLXProtalix BioTherapeutics, Inc. | 7,568 | $16K |
| ALGSAligos Therapeutics, Inc. | 2,125 | $16K |
| OLMAOlema Pharmaceuticals, Inc. | 1,000 | $15K |
| ALECAlector, Inc. | 7,047 | $15K |
| STOKStoke Therapeutics, Inc. | 458 | $15K |
| AVXLANAVEX LIFE SCIENCES CORP. | 4,727 | $15K |
| ASRTAssertio Holdings, Inc. | 789 | $15K |
| ZVRAZEVRA THERAPEUTICS, INC. | 1,515 | $13K |
| HUMAHumacyte Inc. | 20,821 | $13K |
| HINDVyome Holdings, Inc | 5,856 | $13K |
| KNSAKiniksa Pharmaceuticals International, plc | 249 | $12K |
| SIGASIGA TECHNOLOGIES INC | 2,246 | $12K |
| FLGTFulgent Genetics Inc. | 728 | $11K |
| ACETAdicet Bio, Inc. | 1,699 | $11K |
| SCLXSCILEX HOLDING CO | 1,596 | $11K |
| NVCTNuvectis Pharma, Inc. | 1,264 | $10K |
| FDMT4D Molecular Therapeutics, Inc. | 979 | $9K |
| EDSAEdesa Biotech, Inc. | 1,659 | $9K |
| PRLDPrelude Therapeutics Inc | 2,331 | $8K |
| MISTMilestone Pharmaceuticals Inc. | 6,698 | $8K |
| CRDFCardiff Oncology, Inc. | 5,202 | $8K |
| TNGXTango Therapeutics, Inc. | 350 | $7K |
| FATEFATE THERAPEUTICS INC | 5,894 | $7K |
| OVIDOvid Therapeutics Inc. | 3,310 | $7K |
| ESLAEstrella Immunopharma Inc. | 6,600 | $7K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 2,595 | $7K |
| DRTSAlpha Tau Medical Ltd. | 1,000 | $7K |
| ANNXAnnexon, Inc. | 1,160 | $6K |
| LYELLyell Immunopharma, Inc. | 251 | $6K |
| HURATuHURA Biosciences, Inc./NV | 3,263 | $6K |
| INOINOVIO PHARMACEUTICALS, INC. | 3,782 | $6K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 62 | $5K |
| CHRSCoherus Oncology, Inc. | 3,080 | $5K |
| IMAImageneBio, Inc. | 1,000 | $5K |
| ALXOALX ONCOLOGY HOLDINGS INC | 1,879 | $4K |
| PMNProMIS Neurosciences Inc. | 268 | $4K |
| MDWDMediWound Ltd. | 236 | $4K |
| ACOGAlpha Cognition Inc. | 679 | $4K |
| ARVNARVINAS, INC. | 294 | $4K |
| SVRASavara Inc | 504 | $3K |
| CTMXCytomX Therapeutics, Inc. | 742 | $3K |
| IVVDInvivyd, Inc. | 2,318 | $3K |
| LRMRLarimar Therapeutics, Inc. | 757 | $3K |
| VYGRVoyager Therapeutics, Inc. | 647 | $3K |
| CADLCandel Therapeutics, Inc. | 600 | $3K |
| GALTGALECTIN THERAPEUTICS INC | 1,067 | $3K |
| IMUXIMMUNIC, INC. | 3,005 | $3K |
| ANIXAnixa Biosciences Inc | 1,088 | $3K |
| GRCEGrace Therapeutics, Inc. | 543 | $3K |
| ATOSATOSSA THERAPEUTICS, INC. | 644 | $3K |
| FLNAFilana Therapeutics Inc. | 1,553 | $3K |
| RGNXREGENXBIO Inc. | 272 | $2K |
| PLRXPLIANT THERAPEUTICS, INC. | 997 | $2K |
| MLTXMoonLake Immunotherapeutics | 84 | $2K |
| ALMSALUMIS INC. | 88 | $2K |
| OCSOculis Holding AG | 65 | $2K |
| PHVSPharvaris N.V. | 81 | $2K |
| BCAXBicara Therapeutics Inc. | 80 | $2K |
| ESPREsperion Therapeutics, Inc. | 831 | $2K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,551 | $2K |
| OCGNOcugen, Inc. | 1,196 | $2K |
| ALDXAldeyra Therapeutics, Inc. | 1,368 | $2K |
| AVTXAvalo Therapeutics, Inc. | 216 | $2K |
| NGNENeurogene Inc. | 112 | $2K |
| ACIUAC Immune SA | 860 | $2K |
| KZRKezar Life Sciences, Inc. | 322 | $2K |
| RGCRegencell Bioscience Holdings Ltd | 69 | $2K |
| IRONDisc Medicine, Inc. | 24 | $2K |
| RLAYRelay Therapeutics, Inc. | 146 | $1K |
| KYNBKYNTRA BIO INC. | 137 | $1K |
| SGMOQSANGAMO THERAPEUTICS, INC | 4,519 | $1K |
| SIONSionna Therapeutics, Inc. | 30 | $1K |
| MANEVeradermics Incorporated | 8 | $1K |
| ALVOAlvotech | 160 | $1K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 154 | $1K |
| JBIOJade Biosciences, Inc. | 71 | $1K |
| IMMXImmix Biopharma, Inc. | 59 | $1K |
| CCCCC4 Therapeutics, Inc. | 680 | $1K |
| CBIOCRESCENT BIOPHARMA, INC. | 51 | $1K |
| RLMDRELMADA THERAPEUTICS, INC. | 95 | $1K |
| AARDAardvark Therapeutics, Inc. | 180 | $1K |
| MENSJyong Biotech Ltd. | 266 | $1K |
| KLRSKalaris Therapeutics, Inc. | 103 | $1K |
| TNXPTonix Pharmaceuticals Holding Corp. | 59 | $1K |
| WHWKWhitehawk Therapeutics, Inc. | 177 | $1K |
| BDTXBlack Diamond Therapeutics, Inc. | 699 | $1K |
| ORMPORAMED PHARMACEUTICALS INC. | 174 | $1K |
| KRROKorro Bio, Inc. | 104 | $1K |
| CRVOCervoMed Inc. | 283 | $1K |
| OKUROnKure Therapeutics, Inc. | 230 | $1K |
| VTGNVistagen Therapeutics, Inc. | 2,127 | $1K |
| PHGEBiomX Inc. | 251 | $1K |
| REVBREVELATION BIOSCIENCES, INC. | 747 | $1K |
| CAMPCamp4 Therapeutics Corp | 236 | $1K |
| IMMPImmutep Limited | 1,801 | $1K |
| RCKTRocket Pharmaceuticals Inc. | 313 | $1K |
| STROSUTRO BIOPHARMA, INC. | 12 | $0 |
| ABUSArbutus Biopharma Corp | 109 | $0 |
| ZNTLZentalis Pharmaceuticals, Inc. | 98 | $0 |
| DMRADamora Therapeutics, Inc. | 7 | $0 |
| CMPXCompass Therapeutics, Inc. | 6 | $0 |
| PROKPROKIDNEY CORP. | 190 | $0 |
| DNAGinkgo Bioworks Holdings Inc. | 142 | $0 |
| ORGOOrganogenesis Holdings Inc. | 48 | $0 |
| ASMBASSEMBLY BIOSCIENCES, INC. | 16 | $0 |
| TRDAEntrada Therapeutics, Inc. | 25 | $0 |
| LCTXLineage Cell Therapeutics, Inc. | 408 | $0 |
| CLYMClimb Bio, Inc. | 79 | $0 |
| XFORX4 Pharmaceuticals, Inc | 115 | $0 |
| IRDOpus Genetics, Inc. | 5 | $0 |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 143 | $0 |
| RNACCartesian Therapeutics, Inc. | 70 | $0 |
| SABSSAB BIOTHERAPEUTICS, INC. | 1 | $0 |
| ELTXElicio Therapeutics, Inc. | 23 | $0 |
| PRQRProQR Therapeutics N.V. | 308 | $0 |
| AGENAGENUS INC | 49 | $0 |
| CTORCITIUS ONCOLOGY, INC. | 186 | $0 |
| BMEABiomea Fusion, Inc. | 234 | $0 |
| TENXTENAX THERAPEUTICS, INC. | 4 | $0 |
| MGXMetagenomi Therapeutics, Inc. | 314 | $0 |
| LPCNLipocine Inc. | 50 | $0 |
| ELUTELUTIA INC. | 242 | $0 |
| JSPRJasper Therapeutics Inc. | 120 | $0 |
| PLURPluri Inc. | 125 | $0 |
| ABVCABVC BIOPHARMA, INC. | 17 | $0 |
| TVRDTvardi Therapeutics, Inc. | 85 | $0 |
| OTLKOutlook Therapeutics, Inc. | 85 | $0 |
| ATNMActinium Pharmaceuticals, Inc. | 45 | $0 |
| PDSBPDS Biotechnology Corp | 75 | $0 |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 75 | $0 |
| BCTXBriaCell Therapeutics Corp. | 100 | $0 |
| CUECue Biopharma, Inc. | 75 | $0 |
| DAREDare Bioscience, Inc. | 59 | $0 |
| SKYESkye Bioscience, Inc. | 127 | $0 |
| AYTUAYTU BIOPHARMA, INC | 36 | $0 |
| FBLGFibroBiologics, Inc. | 186 | $0 |
| QNTMQuantum Biopharma Ltd. | 19 | $0 |
| COCPCocrystal Pharma, Inc. | 51 | $0 |
| TPSTTempest Therapeutics, Inc. | 27 | $0 |
| PULMPulmatrix, Inc. | 7 | $0 |
| IMNNImunon, Inc. | 1 | $0 |
| BIVIBIOVIE INC. | 205 | $0 |
| RNAZTranscode Therapeutics, Inc. | 8 | $0 |
| QNCXQuince Therapeutics, Inc. | 3,291 | $0 |
| TOVXTheriva Biologics, Inc. | 1 | $0 |
| VIVSVivoSim Labs, INC. | 2 | $0 |
| GOVXGeoVax Labs, Inc. | 1 | $0 |
| CMNDClearmind Medicine Inc. | 14 | $0 |
| QNRXQuoin Pharmaceuticals, Ltd. | 11 | $0 |
| SLNSilence Therapeutics Plc | 16 | $0 |
| AAPGASCENTAGE PHARMA GROUP INTERNATIONAL | 6 | $0 |
| NBPNovaBridge Biosciences | 99 | $0 |
| RDHLRedHill Biopharma Ltd. | 1 | $0 |
| PPBTPURPLE BIOTECH LTD. | 10 | $0 |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 100 | $0 |
| TAOXTAO Synergies Inc. | 18 | $0 |