| JAZZJazz Pharmaceuticals plc | 1,262,511 | $238.7M |
| INSMINSMED Inc | 1,157,786 | $189.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 3,315,973 | $171.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 3,010,308 | $170.1M |
| SNYSanofi | 3,440,654 | $165.8M |
| GILDGILEAD SCIENCES, INC. | 1,180,760 | $164.6M |
| TERNTerns Pharmaceuticals, Inc. | 3,011,558 | $158.8M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 447,887 | $148.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 7,908,459 | $114.4M |
| ARDXARDELYX, INC. | 17,842,370 | $106.9M |
| APLSApellis Pharmaceuticals, Inc. | 2,256,802 | $90.8M |
| IONSIONIS PHARMACEUTICALS INC | 1,051,506 | $79.0M |
| ABVXAbivax SA | 605,992 | $67.5M |
| ONCBeOne Medicines Ltd. | 204,846 | $60.8M |
| TEVATeva Pharmaceutical Industries Limited | 1,893,845 | $57.0M |
| INVAInnoviva, Inc. | 2,279,451 | $53.1M |
| ARGXARGENX SE | 72,365 | $52.8M |
| MRNAModerna, Inc. | 1,019,208 | $51.8M |
| REGNREGENERON PHARMACEUTICALS, INC. | 62,730 | $48.5M |
| SPRYARS Pharmaceuticals, Inc. | 5,982,919 | $48.0M |
| BBIOBridgeBio Pharma, Inc. | 633,283 | $47.0M |
| COGTCogent Biosciences, Inc. | 1,192,406 | $45.9M |
| ANIPANI PHARMACEUTICALS INC | 592,013 | $45.5M |
| DAWNDay One Biopharmaceuticals, Inc. | 1,927,557 | $41.3M |
| OGNOrganon & Co. | 6,781,535 | $40.6M |
| GRFSGrifols S.A. | 5,005,532 | $40.1M |
| EXELEXELIXIS, INC. | 934,809 | $40.1M |
| CLDXCelldex Therapeutics, Inc. | 1,253,532 | $39.8M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 451,825 | $39.3M |
| KALVKalVista Pharmaceuticals, Inc. | 1,912,146 | $38.5M |
| IMCRImmunocore Holdings plc | 1,237,403 | $37.3M |
| RVMDREVOLUTION MEDICINES, INC. | 377,332 | $36.7M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 9,414,292 | $33.0M |
| ADMAADMA BIOLOGICS, INC. | 3,434,449 | $30.9M |
| NKTRNEKTAR THERAPEUTICS | 404,277 | $29.1M |
| CNTACentessa Pharmaceuticals plc | 722,121 | $28.7M |
| RLMDRELMADA THERAPEUTICS, INC. | 3,907,265 | $27.2M |
| KNSAKiniksa Pharmaceuticals International, plc | 564,420 | $27.2M |
| HRMYHarmony Biosciences Holdings, Inc. | 954,359 | $26.7M |
| ANABANAPTYSBIO, INC | 475,572 | $26.4M |
| OCGNOcugen, Inc. | 13,727,192 | $24.8M |
| DNLIDenali Therapeutics Inc. | 1,257,950 | $24.2M |
| ROIVRoivant Sciences Ltd. | 803,801 | $22.3M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 261,962 | $22.0M |
| SRZNSurrozen Inc. | 731,138 | $21.3M |
| GMABGenmab A/S | 792,293 | $21.3M |
| SLNOSOLENO THERAPEUTICS INC | 606,513 | $20.3M |
| CMPSCOMPASS Pathways plc | 3,138,522 | $17.4M |
| CTMXCytomX Therapeutics, Inc. | 3,660,190 | $17.2M |
| PCVXVaxcyte, Inc. | 293,695 | $17.1M |
| CATXPerspective Therapeutics, Inc. | 4,046,640 | $16.9M |
| IVAInventiva S.A. | 2,987,613 | $16.6M |
| LRMRLarimar Therapeutics, Inc. | 3,625,278 | $16.3M |
| INCYIncyte Corp. | 172,915 | $16.3M |
| DFTXDefinium Therapeutics Inc. | 846,896 | $16.0M |
| IMMXImmix Biopharma, Inc. | 1,750,200 | $15.9M |
| ACADACADIA PHARMACEUTICALS INC | 705,461 | $15.7M |
| ATAIAtai Beckley N.V. | 4,364,096 | $15.4M |
| STOKStoke Therapeutics, Inc. | 472,141 | $15.4M |
| ADPTAdaptive Biotechnologies Corp | 1,081,366 | $15.0M |
| ELVNEnliven Therapeutics, Inc. | 345,318 | $13.5M |
| ALMSALUMIS INC. | 606,284 | $13.4M |
| VYGRVoyager Therapeutics, Inc. | 3,428,571 | $13.2M |
| GHRSGH Research PLC | 937,898 | $13.2M |
| XERSXeris Biopharma Holdings, Inc. | 2,265,974 | $13.1M |
| QUREuniQure N.V. | 792,756 | $13.0M |
| KURAKura Oncology, Inc. | 1,565,143 | $12.7M |
| AVTXAvalo Therapeutics, Inc. | 835,484 | $12.5M |
| BHVNBiohaven Ltd. | 1,447,886 | $12.2M |
| DMRADamora Therapeutics, Inc. | 471,646 | $12.2M |
| IRDOpus Genetics, Inc. | 2,630,432 | $12.0M |
| PVLAPALVELLA THERAPEUTICS, INC. | 93,646 | $11.7M |
| SABSSAB BIOTHERAPEUTICS, INC. | 3,032,697 | $11.6M |
| RCKTRocket Pharmaceuticals Inc. | 3,118,124 | $11.2M |
| GERNGERON CORP | 7,321,522 | $10.9M |
| IBRXImmunityBio, Inc. | 1,420,244 | $10.9M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 356,354 | $10.8M |
| MLTXMoonLake Immunotherapeutics | 576,092 | $10.7M |
| ALTAltimmune, Inc. | 3,258,191 | $10.0M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 303,848 | $9.7M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,477,519 | $9.4M |
| ZBIOZenas BioPharma, Inc. | 476,818 | $9.3M |
| LYELLyell Immunopharma, Inc. | 458,905 | $9.2M |
| ZURAZura Bio Ltd | 1,508,063 | $9.0M |
| TNGXTango Therapeutics, Inc. | 425,644 | $8.9M |
| LCTXLineage Cell Therapeutics, Inc. | 5,561,374 | $8.8M |
| FBRXForte Biosciences, Inc. | 337,983 | $8.8M |
| CLYMClimb Bio, Inc. | 1,276,260 | $8.7M |
| TENXTENAX THERAPEUTICS, INC. | 533,889 | $8.5M |
| NRIXNurix Therapeutics, Inc. | 546,297 | $8.5M |
| UPBUpstream Bio, Inc. | 937,323 | $8.4M |
| VKTXViking Therapeutics, Inc. | 250,525 | $8.2M |
| GPCRStructure Therapeutics Inc. | 168,931 | $8.1M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 2,612,277 | $8.0M |
| LENZLENZ Therapeutics, Inc. | 869,257 | $8.0M |
| APGEApogee Therapeutics, Inc. | 92,592 | $7.8M |
| MANEVeradermics Incorporated | 123,220 | $7.8M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 4,944,731 | $7.7M |
| ANTXAN2 Therapeutics, Inc. | 2,222,502 | $7.6M |
| BIOABioAge Labs, Inc. | 430,463 | $7.5M |
| SYRESpyre Therapeutics, Inc. | 146,639 | $7.4M |
| ALVOAlvotech | 2,122,596 | $7.3M |
| ANNXAnnexon, Inc. | 1,238,678 | $6.9M |
| TRDAEntrada Therapeutics, Inc. | 519,356 | $6.6M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 233,650 | $6.5M |
| CYTKCYTOKINETICS INC | 97,959 | $6.5M |
| XOMAXOMA Royalty Corporation | 204,920 | $6.4M |
| FLGTFulgent Genetics Inc. | 401,819 | $6.4M |
| DMACDiaMedica Therapeutics Inc. | 935,592 | $6.3M |
| ARVNARVINAS, INC. | 576,352 | $6.1M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 7,630,527 | $6.1M |
| CBIOCRESCENT BIOPHARMA, INC. | 323,553 | $5.9M |
| SLNSilence Therapeutics Plc | 1,074,191 | $5.7M |
| SIONSionna Therapeutics, Inc. | 140,641 | $5.6M |
| ZVRAZEVRA THERAPEUTICS, INC. | 590,269 | $5.5M |
| IRONDisc Medicine, Inc. | 83,259 | $5.3M |
| STROSUTRO BIOPHARMA, INC. | 210,378 | $5.2M |
| CADLCandel Therapeutics, Inc. | 1,060,086 | $5.2M |
| PHVSPharvaris N.V. | 181,946 | $5.1M |
| XFORX4 Pharmaceuticals, Inc | 1,210,514 | $5.0M |
| CGEMCullinan Therapeutics, Inc. | 346,582 | $4.9M |
| NUVBNuvation Bio Inc. | 1,122,180 | $4.8M |
| RZLTRezolute, Inc. | 1,517,679 | $4.6M |
| SANASana Biotechnology, Inc. | 1,591,030 | $4.6M |
| IVVDInvivyd, Inc. | 3,511,581 | $4.6M |
| ABCLAbCellera Biologics Inc. | 1,294,574 | $4.5M |
| SGMTSagimet Biosciences Inc. | 862,303 | $4.5M |
| CMPXCompass Therapeutics, Inc. | 846,220 | $4.5M |
| ALECAlector, Inc. | 1,979,226 | $4.3M |
| IMUXIMMUNIC, INC. | 3,779,922 | $4.2M |
| NGNENeurogene Inc. | 204,809 | $4.1M |
| TGTXTG THERAPEUTICS, INC. | 122,587 | $4.1M |
| PROKPROKIDNEY CORP. | 2,271,577 | $4.1M |
| ALXOALX ONCOLOGY HOLDINGS INC | 1,988,559 | $4.0M |
| CNTXContext Therapeutics Inc. | 1,424,374 | $3.7M |
| CCCCC4 Therapeutics, Inc. | 1,393,342 | $3.7M |
| ABSIAbsci Corporation | 1,197,369 | $3.6M |
| AXSMAxsome Therapeutics, Inc. | 20,758 | $3.5M |
| LBRXLB PHARMACEUTICALS INC | 136,966 | $3.4M |
| OVIDOvid Therapeutics Inc. | 1,496,518 | $3.3M |
| BCAXBicara Therapeutics Inc. | 156,702 | $3.1M |
| TNXPTonix Pharmaceuticals Holding Corp. | 219,673 | $3.0M |
| ZNTLZentalis Pharmaceuticals, Inc. | 1,289,822 | $3.0M |
| DNAGinkgo Bioworks Holdings Inc. | 487,957 | $3.0M |
| ABUSArbutus Biopharma Corp | 642,448 | $2.9M |
| VRDNViridian Therapeutics, Inc.\DE | 140,595 | $2.8M |
| OLMAOlema Pharmaceuticals, Inc. | 182,935 | $2.7M |
| ARMPArmata Pharmaceuticals, Inc. | 257,992 | $2.6M |
| SLDBSolid Biosciences Inc. | 363,675 | $2.6M |
| BTAIBioXcel Therapeutics, Inc. | 1,936,760 | $2.6M |
| RNAAtrium Therapeutics Inc. | 190,859 | $2.6M |
| SIGASIGA TECHNOLOGIES INC | 466,324 | $2.5M |
| INOINOVIO PHARMACEUTICALS, INC. | 1,410,845 | $2.5M |
| SMMTSummit Therapeutics Inc. | 126,273 | $2.4M |
| RGNXREGENXBIO Inc. | 285,174 | $2.4M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 265,954 | $2.4M |
| JBIOJade Biosciences, Inc. | 160,051 | $2.2M |
| GALTGALECTIN THERAPEUTICS INC | 798,434 | $2.2M |
| ACIUAC Immune SA | 792,657 | $2.2M |
| IMTXImmatics N.V. | 215,721 | $2.1M |
| ABEOABEONA THERAPEUTICS INC. | 425,426 | $1.9M |
| NUVLNuvalent, Inc. | 18,057 | $1.8M |
| MISTMilestone Pharmaceuticals Inc. | 1,544,325 | $1.8M |
| TECXTectonic Therapeutic, Inc. | 58,348 | $1.8M |
| RNACCartesian Therapeutics, Inc. | 284,317 | $1.7M |
| ALDXAldeyra Therapeutics, Inc. | 995,243 | $1.7M |
| ESPREsperion Therapeutics, Inc. | 604,345 | $1.7M |
| PLRXPLIANT THERAPEUTICS, INC. | 1,180,518 | $1.5M |
| JSPRJasper Therapeutics Inc. | 1,617,531 | $1.4M |
| BCYCBICYCLE THERAPEUTICS PLC | 283,986 | $1.3M |
| PRLDPrelude Therapeutics Inc | 382,737 | $1.3M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 55,817 | $1.2M |
| KROSKeros Therapeutics, Inc. | 106,858 | $1.2M |
| CNTNCanton Strategic Holdings, Inc. | 359,183 | $1.2M |
| ARQTArcutis Biotherapeutics, Inc. | 49,333 | $1.2M |
| DSGNDesign Therapeutics, Inc. | 108,928 | $1.2M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 32,144 | $1.1M |
| WHWKWhitehawk Therapeutics, Inc. | 309,674 | $1.1M |
| KZRKezar Life Sciences, Inc. | 142,050 | $1.1M |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 107,800 | $1.0M |
| AGMBAgomAb Therapeutics NV | 95,233 | $999K |
| ELTXElicio Therapeutics, Inc. | 92,762 | $992K |
| PMNProMIS Neurosciences Inc. | 77,921 | $990K |
| PLYXPolaryx Therapeutics Inc. | 127,525 | $964K |
| NTLAIntellia Therapeutics, Inc. | 70,559 | $905K |
| MAZEMaze Therapeutics, Inc. | 29,892 | $892K |
| CRVOCervoMed Inc. | 208,908 | $823K |
| RDYDR REDDYS LABORATORIES LTD | 57,035 | $790K |
| KRROKorro Bio, Inc. | 63,606 | $720K |
| SLSSELLAS Life Sciences Group, Inc. | 159,524 | $675K |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 793,948 | $579K |
| ATNMActinium Pharmaceuticals, Inc. | 564,600 | $562K |
| KODKodiak Sciences Inc. | 14,267 | $544K |
| BEAMBeam Therapeutics Inc. | 22,234 | $530K |
| CHRSCoherus Oncology, Inc. | 311,986 | $527K |
| QNRXQuoin Pharmaceuticals, Ltd. | 76,247 | $503K |
| LGVNLongeveron Inc. | 446,725 | $465K |
| VCELVericel Corp | 13,849 | $446K |
| BCABBioAtla, Inc. | 2,756,674 | $444K |
| ORICOric Pharmaceuticals, Inc. | 34,012 | $431K |
| HCMHUTCHMED (China) Limited | 28,014 | $419K |
| CAMPCamp4 Therapeutics Corp | 85,918 | $379K |
| AARDAardvark Therapeutics, Inc. | 98,334 | $371K |
| ATOSATOSSA THERAPEUTICS, INC. | 66,739 | $351K |
| KLRSKalaris Therapeutics, Inc. | 59,534 | $344K |
| VERUVERU INC. | 150,401 | $332K |
| DRTSAlpha Tau Medical Ltd. | 46,445 | $328K |
| LONALeonaBio, Inc. | 31,678 | $326K |
| PRQRProQR Therapeutics N.V. | 194,246 | $315K |
| ASRTAssertio Holdings, Inc. | 16,425 | $313K |
| OCULOCULAR THERAPEUTIX, INC | 34,006 | $288K |
| BDTXBlack Diamond Therapeutics, Inc. | 134,979 | $288K |
| AUTLAutolus Therapeutics plc | 204,728 | $283K |
| QNCXQuince Therapeutics, Inc. | 2,503,717 | $254K |
| EVOEvotec SE | 99,568 | $249K |
| VTGNVistagen Therapeutics, Inc. | 430,404 | $246K |
| PGENPRECIGEN, INC. | 59,817 | $231K |
| MGXMetagenomi Therapeutics, Inc. | 170,104 | $228K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 4,067 | $224K |
| TTRXTurn Therapeutics Inc. | 69,757 | $223K |
| SKYESkye Bioscience, Inc. | 258,200 | $159K |
| AGENAGENUS INC | 43,409 | $145K |
| OKUROnKure Therapeutics, Inc. | 30,499 | $126K |
| FLNAFilana Therapeutics Inc. | 72,588 | $123K |
| HOWLWerewolf Therapeutics, Inc. | 132,050 | $110K |
| AQSTAquestive Therapeutics, Inc. | 25,851 | $107K |
| HUMAHumacyte Inc. | 108,154 | $66K |
| ORMPORAMED PHARMACEUTICALS INC. | 16,018 | $54K |
| CRDFCardiff Oncology, Inc. | 23,029 | $37K |
| MENSJyong Biotech Ltd. | 14,590 | $31K |
| BMEABiomea Fusion, Inc. | 18,335 | $28K |
| IOBTQIO Biotech, Inc. | 194,158 | $11K |
| IMMPImmutep Limited | 20,802 | $7K |