| GILDGILEAD SCIENCES, INC. | 33,992,410 | $4.63B |
| INSMINSMED Inc | 24,150,499 | $3.70B |
| REGNREGENERON PHARMACEUTICALS, INC. | 4,311,806 | $3.23B |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 6,323,752 | $2.00B |
| NUVLNuvalent, Inc. | 3,088,349 | $298.7M |
| SNYSanofi | 5,600,731 | $261.7M |
| JAZZJazz Pharmaceuticals plc | 1,204,353 | $220.6M |
| TEVATeva Pharmaceutical Industries Limited | 6,762,744 | $191.7M |
| IONSIONIS PHARMACEUTICALS INC | 2,363,567 | $171.4M |
| TERNTerns Pharmaceuticals, Inc. | 2,869,728 | $151.8M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 1,553,644 | $120.0M |
| FOLDAMICUS THERAPEUTICS, INC. | 6,749,190 | $97.4M |
| BBIOBridgeBio Pharma, Inc. | 1,312,259 | $91.0M |
| APGEApogee Therapeutics, Inc. | 1,110,470 | $87.4M |
| IRONDisc Medicine, Inc. | 1,371,480 | $83.4M |
| DAWNDay One Biopharmaceuticals, Inc. | 3,134,753 | $67.1M |
| ABVXAbivax SA | 635,066 | $64.5M |
| MRNAModerna, Inc. | 1,317,601 | $63.5M |
| MANEVeradermics Incorporated | 976,166 | $59.4M |
| RDYDR REDDYS LABORATORIES LTD | 4,371,378 | $58.8M |
| CYTKCYTOKINETICS INC | 903,805 | $56.9M |
| PCVXVaxcyte, Inc. | 1,008,314 | $55.4M |
| SIONSionna Therapeutics, Inc. | 1,465,014 | $53.7M |
| INCYIncyte Corp. | 497,042 | $44.9M |
| SYRESpyre Therapeutics, Inc. | 979,299 | $44.5M |
| AXSMAxsome Therapeutics, Inc. | 270,160 | $43.4M |
| QUREuniQure N.V. | 2,837,466 | $41.8M |
| ROIVRoivant Sciences Ltd. | 1,537,519 | $40.6M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 683,068 | $39.4M |
| APLSApellis Pharmaceuticals, Inc. | 2,047,927 | $35.0M |
| EXELEXELIXIS, INC. | 810,849 | $34.0M |
| LBRXLB PHARMACEUTICALS INC | 1,427,568 | $33.2M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 578,828 | $31.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 557,836 | $30.6M |
| RVMDREVOLUTION MEDICINES, INC. | 301,393 | $27.9M |
| RGNXREGENXBIO Inc. | 3,483,800 | $27.1M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 884,228 | $25.9M |
| ZURAZura Bio Ltd | 4,458,851 | $25.3M |
| PTCTPTC THERAPEUTICS, INC. | 346,017 | $22.7M |
| ONCBeOne Medicines Ltd. | 77,538 | $22.0M |
| GRFSGrifols S.A. | 2,701,572 | $20.4M |
| VRDNViridian Therapeutics, Inc.\DE | 1,059,864 | $19.6M |
| MLTXMoonLake Immunotherapeutics | 1,088,514 | $18.4M |
| ALMSALUMIS INC. | 861,575 | $17.4M |
| PTGXProtagonist Therapeutics, Inc | 172,990 | $17.3M |
| LGNDLigand Pharmaceuticals Incorporated | 86,274 | $16.6M |
| ANIPANI PHARMACEUTICALS INC | 220,166 | $16.2M |
| NKTRNEKTAR THERAPEUTICS | 240,102 | $15.7M |
| VKTXViking Therapeutics, Inc. | 485,703 | $14.5M |
| CNTACentessa Pharmaceuticals plc | 477,597 | $13.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 250,735 | $12.4M |
| BEAMBeam Therapeutics Inc. | 551,355 | $12.1M |
| VCELVericel Corp | 326,430 | $10.0M |
| IBRXImmunityBio, Inc. | 1,489,509 | $9.9M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 343,613 | $9.5M |
| GPCRStructure Therapeutics Inc. | 212,803 | $9.4M |
| COGTCogent Biosciences, Inc. | 262,704 | $9.3M |
| ARGXARGENX SE | 13,005 | $9.2M |
| STOKStoke Therapeutics, Inc. | 265,473 | $8.4M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 2,500,624 | $8.3M |
| INVAInnoviva, Inc. | 350,571 | $8.0M |
| TVTXTravere Therapeutics, Inc. | 288,551 | $8.0M |
| CCCCC4 Therapeutics, Inc. | 3,223,054 | $7.6M |
| SRRKScholar Rock Holding Corp | 174,419 | $7.5M |
| FLGTFulgent Genetics Inc. | 460,363 | $7.2M |
| LQDALiquidia Corp | 195,116 | $6.9M |
| NTLAIntellia Therapeutics, Inc. | 548,491 | $6.4M |
| DNLIDenali Therapeutics Inc. | 323,989 | $5.9M |
| GMABGenmab A/S | 222,607 | $5.7M |
| ACADACADIA PHARMACEUTICALS INC | 263,091 | $5.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 107,017 | $4.9M |
| CLDXCelldex Therapeutics, Inc. | 164,778 | $4.9M |
| TGTXTG THERAPEUTICS, INC. | 150,523 | $4.7M |
| ADMAADMA BIOLOGICS, INC. | 512,926 | $4.7M |
| DFTXDefinium Therapeutics Inc. | 264,545 | $4.6M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 151,558 | $4.5M |
| CMPXCompass Therapeutics, Inc. | 847,702 | $4.3M |
| BHVNBiohaven Ltd. | 503,565 | $4.1M |
| UPBUpstream Bio, Inc. | 463,001 | $4.1M |
| CGEMCullinan Therapeutics, Inc. | 297,231 | $4.0M |
| ORICOric Pharmaceuticals, Inc. | 323,584 | $3.9M |
| OCULOCULAR THERAPEUTIX, INC | 520,663 | $3.9M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 1,330,553 | $3.8M |
| FDMT4D Molecular Therapeutics, Inc. | 415,655 | $3.6M |
| XERSXeris Biopharma Holdings, Inc. | 612,479 | $3.4M |
| BCAXBicara Therapeutics Inc. | 177,408 | $3.4M |
| ADPTAdaptive Biotechnologies Corp | 259,176 | $3.3M |
| ZVRAZEVRA THERAPEUTICS, INC. | 378,932 | $3.3M |
| SPRYARS Pharmaceuticals, Inc. | 382,801 | $3.0M |
| PGENPRECIGEN, INC. | 873,283 | $2.8M |
| ZYMEZymeworks Inc. | 114,072 | $2.8M |
| BIOABioAge Labs, Inc. | 173,570 | $2.7M |
| RCKTRocket Pharmaceuticals Inc. | 796,224 | $2.7M |
| AVTXAvalo Therapeutics, Inc. | 194,391 | $2.7M |
| KODKodiak Sciences Inc. | 79,708 | $2.7M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 31,938 | $2.5M |
| ARQTArcutis Biotherapeutics, Inc. | 112,954 | $2.4M |
| ARDXARDELYX, INC. | 430,136 | $2.4M |
| IMVTImmunovant, Inc. | 96,882 | $2.3M |
| NUVBNuvation Bio Inc. | 539,162 | $2.2M |
| SANASana Biotechnology, Inc. | 785,834 | $2.1M |
| OLMAOlema Pharmaceuticals, Inc. | 142,762 | $1.9M |
| ESPREsperion Therapeutics, Inc. | 685,666 | $1.8M |
| SLDBSolid Biosciences Inc. | 276,412 | $1.8M |
| OGNOrganon & Co. | 298,326 | $1.7M |
| TECXTectonic Therapeutic, Inc. | 58,870 | $1.7M |
| MAZEMaze Therapeutics, Inc. | 58,446 | $1.7M |
| RCUSArcus Biosciences, Inc. | 80,817 | $1.7M |
| ALVOAlvotech | 504,201 | $1.7M |
| ANNXAnnexon, Inc. | 323,894 | $1.6M |
| SLNOSOLENO THERAPEUTICS INC | 51,480 | $1.6M |
| ARVNARVINAS, INC. | 143,313 | $1.5M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 53,962 | $1.4M |
| LRMRLarimar Therapeutics, Inc. | 331,818 | $1.4M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 220,724 | $1.4M |
| IMTXImmatics N.V. | 140,465 | $1.3M |
| TNGXTango Therapeutics, Inc. | 67,326 | $1.3M |
| NGNENeurogene Inc. | 64,922 | $1.3M |
| HROWHARROW, INC. | 36,393 | $1.2M |
| AUTLAutolus Therapeutics plc | 935,403 | $1.2M |
| ABEOABEONA THERAPEUTICS INC. | 266,497 | $1.1M |
| SMMTSummit Therapeutics Inc. | 64,554 | $1.1M |
| VYGRVoyager Therapeutics, Inc. | 276,867 | $1.1M |
| ORKAOruka Therapeutics, Inc. | 22,620 | $1.0M |
| PLRXPLIANT THERAPEUTICS, INC. | 861,823 | $1.0M |
| ELVNEnliven Therapeutics, Inc. | 20,820 | $762K |
| NRIXNurix Therapeutics, Inc. | 50,357 | $739K |
| KRROKorro Bio, Inc. | 68,500 | $704K |
| CBIOCRESCENT BIOPHARMA, INC. | 41,004 | $681K |
| ATAIAtai Beckley N.V. | 192,514 | $655K |
| ANABANAPTYSBIO, INC | 11,645 | $645K |
| PVLAPALVELLA THERAPEUTICS, INC. | 5,519 | $611K |
| OPKOPKO HEALTH, INC. | 508,484 | $559K |
| PHVSPharvaris N.V. | 20,005 | $546K |
| TLXTelix Pharmaceuticals Limited | 57,348 | $514K |
| ABSIAbsci Corporation | 166,590 | $460K |
| ZBIOZenas BioPharma, Inc. | 25,109 | $458K |
| GERNGERON CORP | 291,838 | $411K |
| SVRASavara Inc | 80,709 | $408K |
| KURAKura Oncology, Inc. | 52,572 | $406K |
| KALVKalVista Pharmaceuticals, Inc. | 22,026 | $404K |
| KROSKeros Therapeutics, Inc. | 37,680 | $402K |
| ABUSArbutus Biopharma Corp | 87,049 | $374K |
| ALTAltimmune, Inc. | 127,498 | $367K |
| SLSSELLAS Life Sciences Group, Inc. | 81,824 | $328K |
| AQSTAquestive Therapeutics, Inc. | 64,438 | $260K |
| ABCLAbCellera Biologics Inc. | 77,618 | $255K |
| GHRSGH Research PLC | 18,853 | $246K |
| ZNTLZentalis Pharmaceuticals, Inc. | 113,126 | $242K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 25,967 | $240K |
| JBIOJade Biosciences, Inc. | 15,863 | $210K |
| TRDAEntrada Therapeutics, Inc. | 14,847 | $175K |
| RNAAtrium Therapeutics Inc. | 12,038 | $163K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 8,199 | $161K |
| MPLTMapLight Therapeutics, Inc. | 7,869 | $147K |
| DSGNDesign Therapeutics, Inc. | 14,134 | $147K |
| AVXLANAVEX LIFE SCIENCES CORP. | 50,169 | $141K |
| CTMXCytomX Therapeutics, Inc. | 30,741 | $136K |
| SIGASIGA TECHNOLOGIES INC | 25,186 | $132K |
| TENXTENAX THERAPEUTICS, INC. | 9,418 | $132K |
| NBPNovaBridge Biosciences | 57,489 | $129K |
| XOMAXOMA Royalty Corporation | 3,992 | $121K |
| CATXPerspective Therapeutics, Inc. | 29,241 | $112K |
| CADLCandel Therapeutics, Inc. | 24,863 | $111K |
| DNAGinkgo Bioworks Holdings Inc. | 19,026 | $104K |
| IMCRImmunocore Holdings plc | 3,521 | $103K |
| DMACDiaMedica Therapeutics Inc. | 14,316 | $95K |
| LENZLENZ Therapeutics, Inc. | 10,883 | $90K |
| RZLTRezolute, Inc. | 31,455 | $90K |
| CHRSCoherus Oncology, Inc. | 53,156 | $85K |
| ALECAlector, Inc. | 37,379 | $76K |
| FENCFENNEC PHARMACEUTICALS INC. | 11,859 | $68K |
| TNXPTonix Pharmaceuticals Holding Corp. | 5,524 | $66K |
| PLXProtalix BioTherapeutics, Inc. | 31,685 | $66K |
| ORGOOrganogenesis Holdings Inc. | 27,989 | $64K |
| PHGEBiomX Inc. | 14,135 | $63K |
| MDWDMediWound Ltd. | 3,971 | $61K |
| CMPSCOMPASS Pathways plc | 9,949 | $52K |
| FATEFATE THERAPEUTICS INC | 44,888 | $51K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 65,106 | $49K |
| NVCTNuvectis Pharma, Inc. | 6,472 | $48K |
| MESOMesoblast Limited | 3,289 | $47K |
| HUMAHumacyte Inc. | 80,932 | $46K |
| BCYCBICYCLE THERAPEUTICS PLC | 9,873 | $43K |
| CRDFCardiff Oncology, Inc. | 26,724 | $41K |
| ALDXAldeyra Therapeutics, Inc. | 23,158 | $39K |
| SLNSilence Therapeutics Plc | 7,636 | $38K |
| GYREGYRE THERAPEUTICS, INC. | 5,181 | $35K |
| DRTSAlpha Tau Medical Ltd. | 5,020 | $33K |
| SRZNSurrozen Inc. | 1,119 | $31K |
| HURATuHURA Biosciences, Inc./NV | 17,704 | $31K |
| ANVSAnnovis Bio, Inc. | 14,900 | $30K |
| GALTGALECTIN THERAPEUTICS INC | 11,043 | $28K |
| LYELLyell Immunopharma, Inc. | 1,468 | $28K |
| MNOVMEDICINOVA INC | 20,576 | $28K |
| RNACCartesian Therapeutics, Inc. | 4,413 | $26K |
| IVVDInvivyd, Inc. | 21,534 | $26K |
| CNTXContext Therapeutics Inc. | 10,422 | $26K |
| AARDAardvark Therapeutics, Inc. | 6,617 | $24K |
| IMMXImmix Biopharma, Inc. | 2,537 | $22K |
| ORMPORAMED PHARMACEUTICALS INC. | 6,389 | $21K |
| RLYBRallybio Corp | 2,497 | $20K |
| RGCRegencell Bioscience Holdings Ltd | 845 | $20K |
| ACIUAC Immune SA | 7,640 | $20K |
| OCGNOcugen, Inc. | 10,876 | $19K |
| LCTXLineage Cell Therapeutics, Inc. | 10,944 | $16K |
| MENSJyong Biotech Ltd. | 5,679 | $11K |
| SGMTSagimet Biosciences Inc. | 2,318 | $11K |
| BDTXBlack Diamond Therapeutics, Inc. | 4,638 | $9K |
| INOINOVIO PHARMACEUTICALS, INC. | 5,485 | $9K |
| HCMHUTCHMED (China) Limited | 638 | $9K |
| TVRDTvardi Therapeutics, Inc. | 2,565 | $8K |
| ALGSAligos Therapeutics, Inc. | 674 | $4K |
| LPCNLipocine Inc. | 392 | $3K |
| ADAGAdagene Inc. | 712 | $3K |
| GRMLGreenland Mines Ltd | 9,429 | $3K |
| NNVCNANOVIRICIDES, INC. | 3,000 | $3K |
| IXHLIncannex Healthcare Inc. | 825 | $3K |
| MGXMetagenomi Therapeutics, Inc. | 1,596 | $2K |
| ATOSATOSSA THERAPEUTICS, INC. | 383 | $2K |
| HOWLWerewolf Therapeutics, Inc. | 2,096 | $2K |
| ASRTAssertio Holdings, Inc. | 88 | $2K |
| VERUVERU INC. | 717 | $2K |
| ATNMActinium Pharmaceuticals, Inc. | 1,494 | $1K |
| IMAImageneBio, Inc. | 293 | $1K |
| AGENAGENUS INC | 382 | $1K |
| PROKPROKIDNEY CORP. | 756 | $1K |
| ONCYONCOLYTICS BIOTECH INC | 1,277 | $1K |
| HYFTMindWalk Holdings Corp. | 1,000 | $1K |
| KZRKezar Life Sciences, Inc. | 109 | $812 |
| SPROSpero Therapeutics, Inc. | 236 | $529 |
| PRQRProQR Therapeutics N.V. | 283 | $427 |
| PLURPluri Inc. | 125 | $420 |
| IMUXIMMUNIC, INC. | 407 | $419 |
| AYTUAYTU BIOPHARMA, INC | 154 | $405 |
| WHWKWhitehawk Therapeutics, Inc. | 121 | $397 |
| SABSSAB BIOTHERAPEUTICS, INC. | 87 | $329 |
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| CLYMClimb Bio, Inc. | 46 | $301 |
| IFRXInflaRx N.V. | 335 | $279 |
| KLRSKalaris Therapeutics, Inc. | 50 | $265 |
| EVOEvotec SE | 100 | $236 |
| FBRXForte Biosciences, Inc. | 8 | $211 |
| PRLDPrelude Therapeutics Inc | 62 | $190 |
| ALXOALX ONCOLOGY HOLDINGS INC | 99 | $189 |
| BOLTBolt Biotherapeutics, Inc. | 42 | $179 |
| OKUROnKure Therapeutics, Inc. | 45 | $171 |
| SGMOQSANGAMO THERAPEUTICS, INC | 489 | $150 |
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| CYPHCYPHERPUNK TECHNOLOGIES INC. | 227 | $142 |
| XFORX4 Pharmaceuticals, Inc | 33 | $132 |
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| LONALeonaBio, Inc. | 12 | $111 |
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