| REGNREGENERON PHARMACEUTICALS, INC. | 448,371 | $346.4M |
| GILDGILEAD SCIENCES, INC. | 1,966,938 | $274.1M |
| MRNAModerna, Inc. | 4,317,219 | $219.3M |
| ARGXARGENX SE | 177,836 | $129.9M |
| INSMINSMED Inc | 604,600 | $98.9M |
| BBIOBridgeBio Pharma, Inc. | 1,307,176 | $97.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,698,298 | $93.7M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 280,965 | $93.0M |
| ROIVRoivant Sciences Ltd. | 2,516,353 | $69.7M |
| PTCTPTC THERAPEUTICS, INC. | 920,476 | $62.7M |
| CYTKCYTOKINETICS INC | 854,374 | $56.3M |
| ONCBeOne Medicines Ltd. | 184,356 | $54.7M |
| RDYDR REDDYS LABORATORIES LTD | 3,183,971 | $44.1M |
| EXELEXELIXIS, INC. | 973,207 | $41.7M |
| RVMDREVOLUTION MEDICINES, INC. | 422,443 | $41.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 650,599 | $40.8M |
| INCYIncyte Corp. | 405,530 | $38.2M |
| SNYSanofi | 775,423 | $37.4M |
| IONSIONIS PHARMACEUTICALS INC | 479,460 | $36.0M |
| SRRKScholar Rock Holding Corp | 723,875 | $35.6M |
| AXSMAxsome Therapeutics, Inc. | 188,146 | $31.8M |
| TGTXTG THERAPEUTICS, INC. | 957,026 | $31.8M |
| KNSAKiniksa Pharmaceuticals International, plc | 647,731 | $31.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,864,602 | $27.0M |
| TEVATeva Pharmaceutical Industries Limited | 877,568 | $26.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 448,768 | $25.4M |
| APLSApellis Pharmaceuticals, Inc. | 584,192 | $23.5M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 247,876 | $21.6M |
| PTGXProtagonist Therapeutics, Inc | 194,530 | $20.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 235,748 | $19.8M |
| ARQTArcutis Biotherapeutics, Inc. | 812,146 | $19.1M |
| APGEApogee Therapeutics, Inc. | 220,099 | $18.5M |
| VKTXViking Therapeutics, Inc. | 540,499 | $17.6M |
| ADMAADMA BIOLOGICS, INC. | 1,905,472 | $17.2M |
| BEAMBeam Therapeutics Inc. | 700,647 | $16.7M |
| SLNOSOLENO THERAPEUTICS INC | 432,535 | $14.5M |
| NUVLNuvalent, Inc. | 140,592 | $14.4M |
| COGTCogent Biosciences, Inc. | 343,082 | $13.2M |
| BHVNBiohaven Ltd. | 1,544,338 | $13.1M |
| PCVXVaxcyte, Inc. | 224,518 | $13.0M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 327,457 | $11.1M |
| NKTRNEKTAR THERAPEUTICS | 121,539 | $8.7M |
| IMVTImmunovant, Inc. | 334,557 | $8.3M |
| RCUSArcus Biosciences, Inc. | 381,856 | $8.2M |
| IRONDisc Medicine, Inc. | 127,737 | $8.2M |
| NTLAIntellia Therapeutics, Inc. | 579,430 | $7.4M |
| DAWNDay One Biopharmaceuticals, Inc. | 337,767 | $7.2M |
| LGNDLigand Pharmaceuticals Incorporated | 34,915 | $7.0M |
| AVTXAvalo Therapeutics, Inc. | 422,781 | $6.3M |
| GMABGenmab A/S | 227,587 | $6.1M |
| CLDXCelldex Therapeutics, Inc. | 175,788 | $5.6M |
| ANABANAPTYSBIO, INC | 96,971 | $5.4M |
| VRDNViridian Therapeutics, Inc.\DE | 266,399 | $5.2M |
| ANIPANI PHARMACEUTICALS INC | 63,645 | $4.9M |
| ABVXAbivax SA | 40,362 | $4.5M |
| MLTXMoonLake Immunotherapeutics | 239,838 | $4.5M |
| ARDXARDELYX, INC. | 698,744 | $4.2M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 424,596 | $4.1M |
| TERNTerns Pharmaceuticals, Inc. | 67,695 | $3.6M |
| PVLAPALVELLA THERAPEUTICS, INC. | 27,781 | $3.5M |
| NRIXNurix Therapeutics, Inc. | 223,363 | $3.5M |
| AQSTAquestive Therapeutics, Inc. | 809,007 | $3.4M |
| VCELVericel Corp | 104,287 | $3.4M |
| TVTXTravere Therapeutics, Inc. | 109,382 | $3.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 61,983 | $3.2M |
| JAZZJazz Pharmaceuticals plc | 15,794 | $3.0M |
| CTMXCytomX Therapeutics, Inc. | 606,275 | $2.8M |
| TRDAEntrada Therapeutics, Inc. | 181,148 | $2.3M |
| STOKStoke Therapeutics, Inc. | 56,128 | $1.8M |
| INVAInnoviva, Inc. | 76,514 | $1.8M |
| SIONSionna Therapeutics, Inc. | 40,570 | $1.6M |
| HCMHUTCHMED (China) Limited | 106,504 | $1.6M |
| ACADACADIA PHARMACEUTICALS INC | 70,812 | $1.6M |
| SLDBSolid Biosciences Inc. | 217,196 | $1.6M |
| XERSXeris Biopharma Holdings, Inc. | 262,787 | $1.5M |
| ANNXAnnexon, Inc. | 255,371 | $1.4M |
| GRFSGrifols S.A. | 172,722 | $1.4M |
| ALTAltimmune, Inc. | 435,078 | $1.3M |
| SVRASavara Inc | 240,600 | $1.3M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 373,139 | $1.3M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 37,450 | $1.2M |
| UPBUpstream Bio, Inc. | 126,000 | $1.1M |
| ADPTAdaptive Biotechnologies Corp | 81,382 | $1.1M |
| KODKodiak Sciences Inc. | 29,126 | $1.1M |
| ZNTLZentalis Pharmaceuticals, Inc. | 471,438 | $1.1M |
| DNAGinkgo Bioworks Holdings Inc. | 172,716 | $1.1M |
| IMTXImmatics N.V. | 104,023 | $1.0M |
| RCKTRocket Pharmaceuticals Inc. | 269,206 | $964K |
| SYRESpyre Therapeutics, Inc. | 18,630 | $940K |
| SMMTSummit Therapeutics Inc. | 49,040 | $930K |
| NUVBNuvation Bio Inc. | 205,454 | $881K |
| OGNOrganon & Co. | 145,445 | $871K |
| IBRXImmunityBio, Inc. | 109,477 | $840K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 90,819 | $813K |
| BCAXBicara Therapeutics Inc. | 40,396 | $803K |
| SLNSilence Therapeutics Plc | 147,668 | $778K |
| ALMSALUMIS INC. | 35,146 | $774K |
| DNLIDenali Therapeutics Inc. | 39,893 | $766K |
| MPLTMapLight Therapeutics, Inc. | 37,301 | $758K |
| ZYMEZymeworks Inc. | 28,119 | $704K |
| TNGXTango Therapeutics, Inc. | 30,625 | $641K |
| OCULOCULAR THERAPEUTIX, INC | 75,152 | $637K |
| GERNGERON CORP | 426,698 | $636K |
| LQDALiquidia Corp | 14,691 | $554K |
| BIOABioAge Labs, Inc. | 31,558 | $552K |
| ORKAOruka Therapeutics, Inc. | 10,928 | $536K |
| DSGNDesign Therapeutics, Inc. | 50,272 | $535K |
| GPCRStructure Therapeutics Inc. | 10,879 | $524K |
| IMCRImmunocore Holdings plc | 16,936 | $511K |
| CCCCC4 Therapeutics, Inc. | 190,348 | $501K |
| TENXTENAX THERAPEUTICS, INC. | 30,647 | $490K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 154,101 | $473K |
| FLGTFulgent Genetics Inc. | 29,424 | $468K |
| DFTXDefinium Therapeutics Inc. | 23,356 | $441K |
| ABCLAbCellera Biologics Inc. | 125,322 | $437K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 14,000 | $426K |
| CGEMCullinan Therapeutics, Inc. | 29,543 | $420K |
| ESPREsperion Therapeutics, Inc. | 152,340 | $417K |
| JBIOJade Biosciences, Inc. | 28,624 | $402K |
| ARVNARVINAS, INC. | 36,229 | $384K |
| ELVNEnliven Therapeutics, Inc. | 9,627 | $377K |
| OLMAOlema Pharmaceuticals, Inc. | 21,670 | $323K |
| KURAKura Oncology, Inc. | 37,447 | $304K |
| CBIOCRESCENT BIOPHARMA, INC. | 15,694 | $288K |
| HROWHARROW, INC. | 8,006 | $282K |
| PRQRProQR Therapeutics N.V. | 172,349 | $279K |
| ORICOric Pharmaceuticals, Inc. | 21,101 | $267K |
| VYGRVoyager Therapeutics, Inc. | 65,253 | $252K |
| KALVKalVista Pharmaceuticals, Inc. | 11,974 | $241K |
| PGENPRECIGEN, INC. | 60,348 | $234K |
| SRZNSurrozen Inc. | 7,325 | $213K |
| MISTMilestone Pharmaceuticals Inc. | 176,504 | $210K |
| CLYMClimb Bio, Inc. | 29,128 | $200K |
| SLSSELLAS Life Sciences Group, Inc. | 47,016 | $199K |
| ZBIOZenas BioPharma, Inc. | 9,999 | $195K |
| MAZEMaze Therapeutics, Inc. | 6,475 | $193K |
| CMPXCompass Therapeutics, Inc. | 35,768 | $189K |
| ABUSArbutus Biopharma Corp | 41,561 | $187K |
| RGNXREGENXBIO Inc. | 21,707 | $182K |
| NBPNovaBridge Biosciences | 73,102 | $180K |
| SANASana Biotechnology, Inc. | 57,118 | $165K |
| SPRYARS Pharmaceuticals, Inc. | 20,141 | $162K |
| DMRADamora Therapeutics, Inc. | 6,194 | $160K |
| QUREuniQure N.V. | 8,734 | $143K |
| ABSIAbsci Corporation | 47,212 | $142K |
| IMUXIMMUNIC, INC. | 121,850 | $135K |
| CLLSCellectis S.A. | 41,000 | $130K |
| FDMT4D Molecular Therapeutics, Inc. | 13,283 | $124K |
| SGMTSagimet Biosciences Inc. | 23,066 | $121K |
| ZVRAZEVRA THERAPEUTICS, INC. | 12,864 | $120K |
| TLXTelix Pharmaceuticals Limited | 12,000 | $115K |
| RNAAtrium Therapeutics Inc. | 8,267 | $111K |
| NBTXNanobiotix S.A. | 3,559 | $110K |
| ANTXAN2 Therapeutics, Inc. | 30,078 | $103K |
| OPKOPKO HEALTH, INC. | 89,732 | $102K |
| LBRXLB PHARMACEUTICALS INC | 4,052 | $100K |
| CNTACentessa Pharmaceuticals plc | 2,482 | $99K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 10,489 | $98K |
| CATXPerspective Therapeutics, Inc. | 21,661 | $90K |
| FBRXForte Biosciences, Inc. | 3,436 | $89K |
| AVXLANAVEX LIFE SCIENCES CORP. | 28,413 | $87K |
| TECXTectonic Therapeutic, Inc. | 2,816 | $87K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 3,778 | $82K |
| KROSKeros Therapeutics, Inc. | 6,904 | $76K |
| XOMAXOMA Royalty Corporation | 2,193 | $69K |
| ELTXElicio Therapeutics, Inc. | 6,344 | $68K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 9,667 | $62K |
| RNACCartesian Therapeutics, Inc. | 9,950 | $61K |
| RLMDRELMADA THERAPEUTICS, INC. | 8,320 | $58K |
| SIGASIGA TECHNOLOGIES INC | 10,323 | $55K |
| LRMRLarimar Therapeutics, Inc. | 12,226 | $55K |
| LCTXLineage Cell Therapeutics, Inc. | 34,810 | $55K |
| NGNENeurogene Inc. | 2,694 | $54K |
| RZLTRezolute, Inc. | 17,803 | $54K |
| CADLCandel Therapeutics, Inc. | 10,529 | $52K |
| DMACDiaMedica Therapeutics Inc. | 7,523 | $51K |
| ALDXAldeyra Therapeutics, Inc. | 29,815 | $50K |
| CHRSCoherus Oncology, Inc. | 26,434 | $45K |
| LENZLENZ Therapeutics, Inc. | 4,848 | $44K |
| ABEOABEONA THERAPEUTICS INC. | 9,888 | $44K |
| ZURAZura Bio Ltd | 7,335 | $44K |
| ALECAlector, Inc. | 20,027 | $43K |
| LYELLyell Immunopharma, Inc. | 2,097 | $42K |
| ORGOOrganogenesis Holdings Inc. | 17,324 | $41K |
| PYPDPolyPid Ltd. | 9,177 | $40K |
| TNXPTonix Pharmaceuticals Holding Corp. | 2,862 | $39K |
| PHVSPharvaris N.V. | 1,389 | $39K |
| EVOEvotec SE | 15,279 | $38K |
| FENCFENNEC PHARMACEUTICALS INC. | 6,197 | $38K |
| PLXProtalix BioTherapeutics, Inc. | 17,343 | $38K |
| IVVDInvivyd, Inc. | 26,044 | $34K |
| MDWDMediWound Ltd. | 2,058 | $33K |
| GALTGALECTIN THERAPEUTICS INC | 11,816 | $33K |
| GRCEGrace Therapeutics, Inc. | 7,100 | $33K |
| FATEFATE THERAPEUTICS INC | 25,715 | $31K |
| NVCTNuvectis Pharma, Inc. | 3,542 | $27K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 17,550 | $27K |
| ATAIAtai Beckley N.V. | 7,562 | $27K |
| KRROKorro Bio, Inc. | 2,354 | $27K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 32,454 | $26K |
| IMMXImmix Biopharma, Inc. | 2,774 | $25K |
| ALVOAlvotech | 6,981 | $24K |
| HUMAHumacyte Inc. | 39,135 | $24K |
| ATHEAlterity Therapeutics Limited | 6,809 | $24K |
| MESOMesoblast Limited | 1,421 | $22K |
| CRDFCardiff Oncology, Inc. | 13,076 | $21K |
| OCGNOcugen, Inc. | 11,023 | $20K |
| XFORX4 Pharmaceuticals, Inc | 4,756 | $20K |
| GHRSGH Research PLC | 1,310 | $18K |
| GYREGYRE THERAPEUTICS, INC. | 2,571 | $18K |
| HURATuHURA Biosciences, Inc./NV | 9,510 | $17K |
| ADAGAdagene Inc. | 3,700 | $15K |
| CMMBChemomab Therapeutics Ltd. | 8,425 | $13K |
| AARDAardvark Therapeutics, Inc. | 3,234 | $12K |
| CMPSCOMPASS Pathways plc | 2,019 | $11K |
| IFRXInflaRx N.V. | 10,600 | $9K |
| KZIAKAZIA THERAPEUTICS LTD | 1,081 | $8K |
| PPBTPURPLE BIOTECH LTD. | 1,957 | $8K |
| PROKPROKIDNEY CORP. | 4,121 | $7K |
| ACIUAC Immune SA | 2,410 | $7K |
| AUTLAutolus Therapeutics plc | 4,582 | $6K |
| BCYCBICYCLE THERAPEUTICS PLC | 1,016 | $5K |
| TVRDTvardi Therapeutics, Inc. | 1,426 | $5K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 149 | $4K |
| MENSJyong Biotech Ltd. | 1,881 | $4K |
| KLRSKalaris Therapeutics, Inc. | 652 | $4K |
| BDTXBlack Diamond Therapeutics, Inc. | 1,712 | $4K |
| SABSSAB BIOTHERAPEUTICS, INC. | 889 | $3K |
| STROSUTRO BIOPHARMA, INC. | 111 | $3K |
| OVIDOvid Therapeutics Inc. | 992 | $2K |
| BMEABiomea Fusion, Inc. | 1,053 | $2K |
| OKUROnKure Therapeutics, Inc. | 281 | $1K |
| RLYBRallybio Corp | 120 | $1K |
| ALXOALX ONCOLOGY HOLDINGS INC | 466 | $934 |
| PLRXPLIANT THERAPEUTICS, INC. | 657 | $828 |
| FLNAFilana Therapeutics Inc. | 425 | $718 |
| WHWKWhitehawk Therapeutics, Inc. | 202 | $697 |
| KZRKezar Life Sciences, Inc. | 89 | $660 |
| HOWLWerewolf Therapeutics, Inc. | 790 | $658 |
| INOINOVIO PHARMACEUTICALS, INC. | 352 | $612 |
| LITSLite Strategy, Inc. | 462 | $536 |
| IMMPImmutep Limited | 1,500 | $526 |
| ATOSATOSSA THERAPEUTICS, INC. | 98 | $515 |
| MGXMetagenomi Therapeutics, Inc. | 307 | $411 |
| PDSBPDS Biotechnology Corp | 648 | $392 |
| CRVOCervoMed Inc. | 91 | $359 |
| ACETAdicet Bio, Inc. | 50 | $340 |
| KYNBKYNTRA BIO INC. | 50 | $339 |
| PRLDPrelude Therapeutics Inc | 95 | $325 |
| AGENAGENUS INC | 96 | $321 |
| GLMDGalmed Pharmaceuticals Ltd. | 600 | $294 |
| LONALeonaBio, Inc. | 23 | $236 |
| ATNMActinium Pharmaceuticals, Inc. | 237 | $236 |
| INKTMiNK Therapeutics, Inc. | 16 | $168 |
| CAMPCamp4 Therapeutics Corp | 36 | $159 |
| CELUCelularity Inc. | 99 | $132 |
| JSPRJasper Therapeutics Inc. | 141 | $124 |
| IMAImageneBio, Inc. | 24 | $120 |
| SCLXSCILEX HOLDING CO | 18 | $120 |
| CLNNClene Inc. | 23 | $113 |
| TLPHTALPHERA, INC. | 136 | $102 |
| CTXRCitius Pharmaceuticals, Inc. | 107 | $96 |
| CUECue Biopharma, Inc. | 415 | $95 |
| SPROSpero Therapeutics, Inc. | 40 | $94 |
| FBLGFibroBiologics, Inc. | 66 | $87 |
| BTAIBioXcel Therapeutics, Inc. | 59 | $79 |
| BCABBioAtla, Inc. | 472 | $76 |
| SGMOQSANGAMO THERAPEUTICS, INC | 266 | $66 |
| OTLKOutlook Therapeutics, Inc. | 305 | $63 |
| AYTUAYTU BIOPHARMA, INC | 23 | $63 |
| MRKRMarker Therapeutics, Inc. | 23 | $30 |
| ALGSAligos Therapeutics, Inc. | 3 | $22 |
| XCUREXICURE, INC. | 4 | $17 |
| VERUVERU INC. | 7 | $15 |
| VTGNVistagen Therapeutics, Inc. | 13 | $7 |
| TPSTTempest Therapeutics, Inc. | 3 | $5 |
| DWTXDogwood Therapeutics, Inc. | 2 | $4 |
| SERSerina Therapeutics, Inc. | 2 | $4 |
| MBIOMUSTANG BIO, INC. | 6 | $4 |
| ELUTELUTIA INC. | 3 | $3 |
| BIVIBIOVIE INC. | 2 | $3 |
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| QNCXQuince Therapeutics, Inc. | 8 | $1 |