| GILDGILEAD SCIENCES, INC. | 5,282,196 | $736.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 313,093 | $241.9M |
| SNYSanofi | 2,356,559 | $113.5M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 220,623 | $73.0M |
| MRNAModerna, Inc. | 932,269 | $47.4M |
| INSMINSMED Inc | 275,731 | $45.1M |
| TEVATeva Pharmaceutical Industries Limited | 1,400,671 | $42.2M |
| ROIVRoivant Sciences Ltd. | 1,415,848 | $39.2M |
| RVMDREVOLUTION MEDICINES, INC. | 383,179 | $37.3M |
| TERNTerns Pharmaceuticals, Inc. | 669,601 | $35.3M |
| INCYIncyte Corp. | 367,095 | $34.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 379,606 | $31.9M |
| BBIOBridgeBio Pharma, Inc. | 423,888 | $31.5M |
| IONSIONIS PHARMACEUTICALS INC | 289,874 | $21.8M |
| EXELEXELIXIS, INC. | 504,289 | $21.6M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 380,397 | $21.0M |
| ABUSArbutus Biopharma Corp | 4,316,095 | $19.4M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,338,482 | $19.4M |
| GRFSGrifols S.A. | 2,104,594 | $16.9M |
| IBRXImmunityBio, Inc. | 1,890,100 | $14.5M |
| KALVKalVista Pharmaceuticals, Inc. | 537,061 | $10.8M |
| ABVXAbivax SA | 90,775 | $10.1M |
| INVAInnoviva, Inc. | 430,879 | $10.0M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 314,792 | $9.6M |
| ONCBeOne Medicines Ltd. | 25,222 | $7.5M |
| TVTXTravere Therapeutics, Inc. | 248,861 | $7.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 115,343 | $7.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 122,838 | $6.9M |
| AXSMAxsome Therapeutics, Inc. | 34,261 | $5.8M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 109,114 | $5.6M |
| CYTKCYTOKINETICS INC | 79,159 | $5.2M |
| ANIPANI PHARMACEUTICALS INC | 67,447 | $5.2M |
| JAZZJazz Pharmaceuticals plc | 26,808 | $5.1M |
| ALMSALUMIS INC. | 222,658 | $4.9M |
| APGEApogee Therapeutics, Inc. | 50,396 | $4.2M |
| ORKAOruka Therapeutics, Inc. | 85,737 | $4.2M |
| CMPXCompass Therapeutics, Inc. | 790,041 | $4.2M |
| ARGXARGENX SE | 5,500 | $4.0M |
| APLSApellis Pharmaceuticals, Inc. | 98,327 | $4.0M |
| TGTXTG THERAPEUTICS, INC. | 116,657 | $3.9M |
| PTCTPTC THERAPEUTICS, INC. | 53,079 | $3.6M |
| ESPREsperion Therapeutics, Inc. | 1,301,911 | $3.6M |
| AQSTAquestive Therapeutics, Inc. | 799,163 | $3.3M |
| NUVLNuvalent, Inc. | 30,844 | $3.2M |
| QUREuniQure N.V. | 167,732 | $2.7M |
| MANEVeradermics Incorporated | 36,911 | $2.3M |
| NKTRNEKTAR THERAPEUTICS | 32,356 | $2.3M |
| SYRESpyre Therapeutics, Inc. | 45,786 | $2.3M |
| VKTXViking Therapeutics, Inc. | 70,279 | $2.3M |
| FLGTFulgent Genetics Inc. | 141,011 | $2.2M |
| IRONDisc Medicine, Inc. | 33,267 | $2.1M |
| SRRKScholar Rock Holding Corp | 43,051 | $2.1M |
| CGEMCullinan Therapeutics, Inc. | 140,295 | $2.0M |
| VRDNViridian Therapeutics, Inc.\DE | 100,598 | $2.0M |
| PGENPRECIGEN, INC. | 491,696 | $1.9M |
| NTLAIntellia Therapeutics, Inc. | 147,242 | $1.9M |
| PCVXVaxcyte, Inc. | 31,988 | $1.9M |
| VCELVericel Corp | 56,889 | $1.8M |
| SLNOSOLENO THERAPEUTICS INC | 54,219 | $1.8M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 52,438 | $1.8M |
| AVXLANAVEX LIFE SCIENCES CORP. | 538,277 | $1.7M |
| KNSAKiniksa Pharmaceuticals International, plc | 34,152 | $1.6M |
| RCUSArcus Biosciences, Inc. | 74,977 | $1.6M |
| PTGXProtagonist Therapeutics, Inc | 14,405 | $1.5M |
| RZLTRezolute, Inc. | 495,462 | $1.5M |
| LENZLENZ Therapeutics, Inc. | 151,387 | $1.4M |
| ZNTLZentalis Pharmaceuticals, Inc. | 591,217 | $1.4M |
| ADMAADMA BIOLOGICS, INC. | 143,862 | $1.3M |
| OCULOCULAR THERAPEUTIX, INC | 148,977 | $1.3M |
| KURAKura Oncology, Inc. | 154,393 | $1.3M |
| LQDALiquidia Corp | 32,807 | $1.2M |
| COGTCogent Biosciences, Inc. | 31,261 | $1.2M |
| LGNDLigand Pharmaceuticals Incorporated | 6,008 | $1.2M |
| BEAMBeam Therapeutics Inc. | 47,638 | $1.1M |
| BHVNBiohaven Ltd. | 125,822 | $1.1M |
| ZURAZura Bio Ltd | 169,833 | $1.0M |
| DNLIDenali Therapeutics Inc. | 52,084 | $1.0M |
| IMCRImmunocore Holdings plc | 30,909 | $932K |
| SMMTSummit Therapeutics Inc. | 49,103 | $931K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 10,652 | $926K |
| GPCRStructure Therapeutics Inc. | 19,188 | $925K |
| CCCCC4 Therapeutics, Inc. | 317,877 | $836K |
| ADPTAdaptive Biotechnologies Corp | 59,443 | $825K |
| XERSXeris Biopharma Holdings, Inc. | 138,553 | $804K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 27,050 | $751K |
| DFTXDefinium Therapeutics Inc. | 39,683 | $750K |
| SIONSionna Therapeutics, Inc. | 18,385 | $737K |
| NBPNovaBridge Biosciences | 299,299 | $736K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 21,780 | $697K |
| ARQTArcutis Biotherapeutics, Inc. | 28,965 | $682K |
| SPRYARS Pharmaceuticals, Inc. | 84,169 | $676K |
| CTMXCytomX Therapeutics, Inc. | 142,412 | $669K |
| DAWNDay One Biopharmaceuticals, Inc. | 30,163 | $647K |
| IMTXImmatics N.V. | 64,654 | $636K |
| LCTXLineage Cell Therapeutics, Inc. | 393,309 | $621K |
| RLMDRELMADA THERAPEUTICS, INC. | 88,953 | $619K |
| ACADACADIA PHARMACEUTICALS INC | 27,803 | $619K |
| ARVNARVINAS, INC. | 56,357 | $597K |
| ALTAltimmune, Inc. | 192,871 | $594K |
| DSGNDesign Therapeutics, Inc. | 55,790 | $594K |
| ZBIOZenas BioPharma, Inc. | 29,610 | $579K |
| BCAXBicara Therapeutics Inc. | 28,823 | $573K |
| DMRADamora Therapeutics, Inc. | 22,034 | $571K |
| RGNXREGENXBIO Inc. | 67,427 | $565K |
| CBIOCRESCENT BIOPHARMA, INC. | 30,189 | $555K |
| MLTXMoonLake Immunotherapeutics | 27,602 | $515K |
| BIOABioAge Labs, Inc. | 28,240 | $494K |
| NUVBNuvation Bio Inc. | 114,491 | $491K |
| IMMXImmix Biopharma, Inc. | 51,768 | $472K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 153,271 | $471K |
| ELVNEnliven Therapeutics, Inc. | 11,830 | $464K |
| ZYMEZymeworks Inc. | 18,374 | $460K |
| TNGXTango Therapeutics, Inc. | 21,670 | $453K |
| RLAYRelay Therapeutics, Inc. | 45,267 | $450K |
| CLDXCelldex Therapeutics, Inc. | 13,975 | $443K |
| KODKodiak Sciences Inc. | 11,305 | $431K |
| SLDBSolid Biosciences Inc. | 58,877 | $424K |
| OCGNOcugen, Inc. | 230,618 | $417K |
| ANABANAPTYSBIO, INC | 7,440 | $413K |
| HROWHARROW, INC. | 11,603 | $409K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 40,862 | $397K |
| VYGRVoyager Therapeutics, Inc. | 100,091 | $386K |
| NRIXNurix Therapeutics, Inc. | 24,180 | $375K |
| ARDXARDELYX, INC. | 62,397 | $374K |
| IMVTImmunovant, Inc. | 14,900 | $370K |
| TRDAEntrada Therapeutics, Inc. | 28,676 | $362K |
| JBIOJade Biosciences, Inc. | 24,660 | $346K |
| FBRXForte Biosciences, Inc. | 13,268 | $344K |
| CLYMClimb Bio, Inc. | 48,936 | $335K |
| CHRSCoherus Oncology, Inc. | 195,473 | $330K |
| STOKStoke Therapeutics, Inc. | 10,119 | $329K |
| GALTGALECTIN THERAPEUTICS INC | 111,848 | $312K |
| GERNGERON CORP | 205,967 | $307K |
| MAZEMaze Therapeutics, Inc. | 9,262 | $276K |
| CNTACentessa Pharmaceuticals plc | 6,922 | $275K |
| TENXTENAX THERAPEUTICS, INC. | 16,698 | $267K |
| PROKPROKIDNEY CORP. | 146,284 | $262K |
| KROSKeros Therapeutics, Inc. | 23,157 | $256K |
| PVLAPALVELLA THERAPEUTICS, INC. | 1,991 | $248K |
| ABSIAbsci Corporation | 82,523 | $248K |
| FDMT4D Molecular Therapeutics, Inc. | 25,437 | $237K |
| MNOVMEDICINOVA INC | 162,900 | $223K |
| UPBUpstream Bio, Inc. | 24,720 | $222K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 63,180 | $222K |
| AVTXAvalo Therapeutics, Inc. | 14,642 | $219K |
| OLMAOlema Pharmaceuticals, Inc. | 13,998 | $209K |
| TECXTectonic Therapeutic, Inc. | 6,706 | $207K |
| AGENAGENUS INC | 59,345 | $198K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 20,782 | $195K |
| OGNOrganon & Co. | 32,441 | $194K |
| KZIAKAZIA THERAPEUTICS LTD | 23,999 | $179K |
| ABCLAbCellera Biologics Inc. | 49,474 | $173K |
| ACETAdicet Bio, Inc. | 25,000 | $170K |
| IVVDInvivyd, Inc. | 126,742 | $165K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 105,487 | $165K |
| OPKOPKO HEALTH, INC. | 138,300 | $158K |
| ORICOric Pharmaceuticals, Inc. | 12,429 | $157K |
| CAMPCamp4 Therapeutics Corp | 34,693 | $153K |
| SVRASavara Inc | 27,874 | $152K |
| ZVRAZEVRA THERAPEUTICS, INC. | 15,445 | $144K |
| SGMTSagimet Biosciences Inc. | 27,429 | $143K |
| BDTXBlack Diamond Therapeutics, Inc. | 67,279 | $143K |
| SLSSELLAS Life Sciences Group, Inc. | 32,412 | $137K |
| ATAIAtai Beckley N.V. | 38,218 | $135K |
| ANNXAnnexon, Inc. | 24,291 | $135K |
| PHVSPharvaris N.V. | 4,368 | $123K |
| ABEOABEONA THERAPEUTICS INC. | 27,248 | $122K |
| MPLTMapLight Therapeutics, Inc. | 5,789 | $118K |
| LBRXLB PHARMACEUTICALS INC | 4,530 | $112K |
| OKUROnKure Therapeutics, Inc. | 25,000 | $104K |
| ALECAlector, Inc. | 42,591 | $92K |
| SANASana Biotechnology, Inc. | 31,580 | $91K |
| TNXPTonix Pharmaceuticals Holding Corp. | 6,549 | $90K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 13,988 | $89K |
| FATEFATE THERAPEUTICS INC | 72,996 | $88K |
| ORGOOrganogenesis Holdings Inc. | 36,052 | $85K |
| ALVOAlvotech | 23,832 | $82K |
| BMEABiomea Fusion, Inc. | 51,606 | $79K |
| SIGASIGA TECHNOLOGIES INC | 14,316 | $77K |
| LPCNLipocine Inc. | 9,412 | $75K |
| LRMRLarimar Therapeutics, Inc. | 16,373 | $74K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 91,394 | $73K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 3,339 | $72K |
| FLNAFilana Therapeutics Inc. | 42,379 | $72K |
| ORMPORAMED PHARMACEUTICALS INC. | 19,966 | $68K |
| CATXPerspective Therapeutics, Inc. | 15,049 | $63K |
| GHRSGH Research PLC | 4,394 | $62K |
| XOMAXOMA Royalty Corporation | 1,965 | $62K |
| RCKTRocket Pharmaceuticals Inc. | 16,578 | $59K |
| GMABGenmab A/S | 2,139 | $57K |
| CADLCandel Therapeutics, Inc. | 11,699 | $57K |
| NGNENeurogene Inc. | 2,751 | $55K |
| SRZNSurrozen Inc. | 1,888 | $55K |
| IMAImageneBio, Inc. | 10,959 | $55K |
| DNAGinkgo Bioworks Holdings Inc. | 7,978 | $49K |
| DMACDiaMedica Therapeutics Inc. | 6,487 | $44K |
| FENCFENNEC PHARMACEUTICALS INC. | 6,273 | $39K |
| LYELLyell Immunopharma, Inc. | 1,671 | $34K |
| MDWDMediWound Ltd. | 2,034 | $33K |
| PLXProtalix BioTherapeutics, Inc. | 14,822 | $32K |
| KLRSKalaris Therapeutics, Inc. | 5,280 | $30K |
| PRLDPrelude Therapeutics Inc | 8,600 | $29K |
| RNAAtrium Therapeutics Inc. | 2,095 | $28K |
| HUMAHumacyte Inc. | 40,147 | $24K |
| NVCTNuvectis Pharma, Inc. | 3,121 | $24K |
| CMPSCOMPASS Pathways plc | 3,863 | $21K |
| ALXOALX ONCOLOGY HOLDINGS INC | 10,515 | $21K |
| RNACCartesian Therapeutics, Inc. | 3,307 | $20K |
| MESOMesoblast Limited | 1,282 | $20K |
| CRDFCardiff Oncology, Inc. | 11,666 | $19K |
| ALDXAldeyra Therapeutics, Inc. | 9,906 | $17K |
| HURATuHURA Biosciences, Inc./NV | 9,241 | $17K |
| GYREGYRE THERAPEUTICS, INC. | 2,300 | $16K |
| ACIUAC Immune SA | 5,791 | $16K |
| SLNSilence Therapeutics Plc | 2,937 | $15K |
| AARDAardvark Therapeutics, Inc. | 3,621 | $14K |
| XFORX4 Pharmaceuticals, Inc | 2,814 | $12K |
| MENSJyong Biotech Ltd. | 5,189 | $11K |
| AUTLAutolus Therapeutics plc | 8,074 | $11K |
| SKYESkye Bioscience, Inc. | 18,089 | $11K |
| HOWLWerewolf Therapeutics, Inc. | 13,235 | $11K |
| BCYCBICYCLE THERAPEUTICS PLC | 2,357 | $11K |
| IRDOpus Genetics, Inc. | 1,900 | $9K |
| QNRXQuoin Pharmaceuticals, Ltd. | 1,300 | $9K |
| PHGEBiomX Inc. | 1,316 | $5K |
| STROSUTRO BIOPHARMA, INC. | 139 | $3K |
| TVRDTvardi Therapeutics, Inc. | 946 | $3K |
| IMUXIMMUNIC, INC. | 2,428 | $3K |
| IXHLIncannex Healthcare Inc. | 750 | $2K |
| WHWKWhitehawk Therapeutics, Inc. | 647 | $2K |
| SABSSAB BIOTHERAPEUTICS, INC. | 496 | $2K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 212 | $2K |
| ARMPArmata Pharmaceuticals, Inc. | 154 | $2K |
| ADAGAdagene Inc. | 400 | $2K |
| ACXPAcurx Pharmaceuticals, Inc. | 380 | $1K |
| CUECue Biopharma, Inc. | 6,029 | $1K |
| ANTXAN2 Therapeutics, Inc. | 400 | $1K |
| INOINOVIO PHARMACEUTICALS, INC. | 506 | $880 |
| CLLSCellectis S.A. | 224 | $710 |
| IMMPImmutep Limited | 258 | $91 |
| PLRXPLIANT THERAPEUTICS, INC. | 34 | $43 |
| BOLTBolt Biotherapeutics, Inc. | 6 | $24 |
| ABPOAbpro Holdings, Inc. | 8,333 | $17 |
| KZRKezar Life Sciences, Inc. | 1 | $7 |
| OVIDOvid Therapeutics Inc. | 1 | $2 |
| SGMOQSANGAMO THERAPEUTICS, INC | 1 | $0 |
| QNCXQuince Therapeutics, Inc. | 4 | $0 |