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| AZNASTRAZENECA PLC | 5,501,992 | $1.09B |
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| MCKMcKesson Corporation | 712,800 | $616.8M |
| PFEPFIZER INC | 15,342,187 | $430.8M |
| ABTABBOTT LABORATORIES | 3,936,707 | $404.2M |
| BMYBRISTOL MYERS SQUIBB CO | 6,082,207 | $368.9M |
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| IONSIONIS PHARMACEUTICALS INC | 339,874 | $25.5M |
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| ABUSArbutus Biopharma Corp | 4,316,095 | $19.4M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,338,482 | $19.4M |
| CYTKCYTOKINETICS INC | 267,659 | $17.6M |
| QGENQIAGEN N.V. | 429,006 | $17.2M |
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| CORTCORCEPT THERAPEUTICS INC | 174,578 | $7.0M |
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| ANIPANI PHARMACEUTICALS INC | 67,447 | $5.2M |
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| COLLCOLLEGIUM PHARMACEUTICAL, INC | 71,949 | $2.4M |
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| BCRXBIOCRYST PHARMACEUTICALS INC | 133,597 | $1.3M |
| OCULOCULAR THERAPEUTIX, INC | 148,977 | $1.3M |
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| LGNDLigand Pharmaceuticals Incorporated | 6,008 | $1.2M |
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| KYTXKyverna Therapeutics, Inc. | 136,375 | $1.2M |
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| RYTMRHYTHM PHARMACEUTICALS, INC. | 10,652 | $926K |
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| MLYSMineralys Therapeutics, Inc. | 33,877 | $918K |
| GENBGenerate Biomedicines Inc. | 70,894 | $886K |
| AVIRAtea Pharmaceuticals, Inc. | 160,946 | $866K |
| ARRYARRAY BIOPHARMA INC | 118,134 | $854K |
| CCCCC4 Therapeutics, Inc. | 317,877 | $836K |
| ADPTAdaptive Biotechnologies Corp | 59,443 | $825K |
| XERSXeris Biopharma Holdings, Inc. | 138,553 | $804K |
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| JANXJanux Therapeutics, Inc. | 55,988 | $778K |
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| TBPHTheravance Biopharma, Inc. | 46,376 | $753K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 27,050 | $751K |
| DFTXDefinium Therapeutics Inc. | 39,683 | $750K |
| MDXGMiMedx Group Inc | 187,459 | $740K |
| SIONSionna Therapeutics, Inc. | 18,385 | $737K |
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| NATRNATURES SUNSHINE PRODUCTS INC | 29,990 | $719K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 21,780 | $697K |
| ARQTArcutis Biotherapeutics, Inc. | 28,965 | $682K |
| FULCFulcrum Therapeutics, Inc. | 88,458 | $678K |
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| IMTXImmatics N.V. | 64,654 | $636K |
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| RLMDRELMADA THERAPEUTICS, INC. | 88,953 | $619K |
| ACADACADIA PHARMACEUTICALS INC | 27,803 | $619K |
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| OFIXOrthofix Medical Inc. Common Stock (DE) | 35,987 | $413K |
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| RIGLRIGEL PHARMACEUTICALS INC | 15,198 | $411K |
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| PEPGPepGen Inc. | 45,130 | $80K |
| GNLXGENELUX Corp | 32,756 | $79K |
| BMEABiomea Fusion, Inc. | 51,606 | $79K |
| MRVIMARAVAI LIFESCIENCES HOLDINGS, INC. | 27,656 | $78K |
| AURAAura Biosciences, Inc. | 11,540 | $77K |
| SIGASIGA TECHNOLOGIES INC | 14,316 | $77K |
| LPCNLipocine Inc. | 9,412 | $75K |
| LRMRLarimar Therapeutics, Inc. | 16,373 | $74K |
| BBNXBeta Bionics Inc. | 7,344 | $74K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 91,394 | $73K |
| PYXSPyxis Oncology, Inc. | 49,825 | $73K |
| ABOSAcumen Pharmaceuticals, Inc. | 30,679 | $72K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 3,339 | $72K |
| FLNAFilana Therapeutics Inc. | 42,379 | $72K |
| ORMPORAMED PHARMACEUTICALS INC. | 19,966 | $68K |
| UTMDUtah Medical Products Inc. | 1,092 | $68K |
| ZLABZai Lab Ltd | 3,531 | $66K |
| CATXPerspective Therapeutics, Inc. | 15,049 | $63K |
| GHRSGH Research PLC | 4,394 | $62K |
| XOMAXOMA Royalty Corporation | 1,965 | $62K |
| NXTCNextCure, Inc. | 5,626 | $60K |
| RCKTRocket Pharmaceuticals Inc. | 16,578 | $59K |
| MCRBSeres Therapeutics, Inc. | 6,507 | $58K |
| BTMDbiote Corp. | 42,719 | $58K |
| GMABGenmab A/S | 2,139 | $57K |
| CADLCandel Therapeutics, Inc. | 11,699 | $57K |
| NTHINEONC TECHNOLOGIES HOLDINGS, INC. | 8,062 | $57K |
| NGNENeurogene Inc. | 2,751 | $55K |
| SRZNSurrozen Inc. | 1,888 | $55K |
| IMAImageneBio, Inc. | 10,959 | $55K |
| GUTSFractyl Health Inc. | 116,048 | $53K |
| NAGENiagen Bioscience, Inc. | 11,945 | $53K |
| CRBUCaribou Biosciences, Inc. | 26,713 | $51K |
| DNAGinkgo Bioworks Holdings Inc. | 7,978 | $49K |
| EVMNEvommune, Inc. | 1,978 | $45K |
| OABIOmniAb Inc. | 28,760 | $45K |
| DMACDiaMedica Therapeutics Inc. | 6,487 | $44K |
| KMDAKAMADA LTD | 5,260 | $44K |
| TMCITreace Medical Concepts Inc. | 36,436 | $44K |
| AGLagilon health inc. | 5,463 | $43K |
| ELDNEledon Pharmaceuticals, Inc. | 13,816 | $43K |
| KPTIKaryopharm Therapeutics Inc. | 7,424 | $41K |
| BNTCBenitec Biopharma Inc. | 3,835 | $41K |
| FENCFENNEC PHARMACEUTICALS INC. | 6,273 | $39K |
| KRMDKORU Medical Systems Inc. Common Stock (DE) | 8,466 | $37K |
| IKTInhibikase Therapeutics, Inc. | 21,348 | $36K |
| ATYRaTYR PHARMA INC | 45,123 | $35K |
| ACHAccendra Health Inc. | 15,278 | $35K |
| PMVPPMV Pharmaceuticals, Inc. | 27,536 | $34K |
| TILInstil Bio, Inc. | 4,135 | $34K |
| LYELLyell Immunopharma, Inc. | 1,671 | $34K |
| LFCRLIFECORE BIOMEDICAL, INC. DE | 8,864 | $33K |
| MDWDMediWound Ltd. | 2,034 | $33K |
| PLXProtalix BioTherapeutics, Inc. | 14,822 | $32K |
| INNVINNOVUS PHARMACEUTICALS, INC. | 3,994 | $32K |
| DTILPRECISION BIOSCIENCES INC | 5,579 | $31K |
| KLRSKalaris Therapeutics, Inc. | 5,280 | $30K |
| PRLDPrelude Therapeutics Inc | 8,600 | $29K |
| RNAAtrium Therapeutics Inc. | 2,095 | $28K |
| GLSIGreenwich LifeSciences, Inc. | 1,159 | $28K |
| SNWVSANUWAVE Health Inc. | 1,455 | $25K |
| HUMAHumacyte Inc. | 40,147 | $24K |
| NVCTNuvectis Pharma, Inc. | 3,121 | $24K |
| TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) | 1,241 | $23K |
| TLSITriSalus Life Sciences Inc. | 5,741 | $23K |
| DERMJourney Medical Corp | 4,622 | $22K |
| CMPSCOMPASS Pathways plc | 3,863 | $21K |
| ALXOALX ONCOLOGY HOLDINGS INC | 10,515 | $21K |
| INMBInmune Bio, Inc. | 18,646 | $21K |
| RNACCartesian Therapeutics, Inc. | 3,307 | $20K |
| MESOMesoblast Limited | 1,282 | $20K |
| SKINThe Beauty Health Company | 21,358 | $19K |
| LUCDLucid Diagnostics Inc. | 16,453 | $19K |
| CRDFCardiff Oncology, Inc. | 11,666 | $19K |
| TKNOAlpha Teknova, Inc. | 6,442 | $19K |
| TCRXTScan Therapeutics, Inc. | 17,080 | $17K |
| ALDXAldeyra Therapeutics, Inc. | 9,906 | $17K |
| HURATuHURA Biosciences, Inc./NV | 9,241 | $17K |
| GYREGYRE THERAPEUTICS, INC. | 2,300 | $16K |
| ACIUAC Immune SA | 5,791 | $16K |
| SLNSilence Therapeutics Plc | 2,937 | $15K |
| FTLFFITLIFE BRANDS, INC. | 1,023 | $15K |
| AARDAardvark Therapeutics, Inc. | 3,621 | $14K |
| XFORX4 Pharmaceuticals, Inc | 2,814 | $12K |
| MENSJyong Biotech Ltd. | 5,189 | $11K |
| AUTLAutolus Therapeutics plc | 8,074 | $11K |
| SKYESkye Bioscience, Inc. | 18,089 | $11K |
| HOWLWerewolf Therapeutics, Inc. | 13,235 | $11K |
| BCYCBICYCLE THERAPEUTICS PLC | 2,357 | $11K |
| SRTSSensus Healthcare Inc. | 2,738 | $11K |
| RCELAvita Medical Inc. | 2,682 | $10K |
| STIMNeuronetics Inc. | 6,504 | $9K |
| IRDOpus Genetics, Inc. | 1,900 | $9K |
| QNRXQuoin Pharmaceuticals, Ltd. | 1,300 | $9K |
| ACRVAcrivon Therapeutics, Inc. | 5,940 | $8K |
| RANIRani Therapeutics Holdings, Inc. | 10,246 | $8K |
| TNYATenaya Therapeutics, Inc. | 10,777 | $7K |
| ACTUACTUATE THERAPEUTICS, INC. | 2,176 | $6K |
| GLPGGalapagos NV | 178 | $5K |
| PHGEBiomX Inc. | 1,316 | $5K |
| HELPCYBIN INC. | 862 | $4K |
| PALIPALISADE BIO, INC. | 2,230 | $4K |
| SGPSpyGlass Pharma Inc. | 140 | $4K |
| STROSUTRO BIOPHARMA, INC. | 139 | $3K |
| EIKNEikon Therapeutics Inc. | 318 | $3K |
| SXTP60 DEGREES PHARMACEUTICALS, INC. | 1,856 | $3K |
| CGCCanopy Growth Corp | 3,203 | $3K |
| TVRDTvardi Therapeutics, Inc. | 946 | $3K |
| VORVor Biopharma Inc. | 136 | $2K |
| IXHLIncannex Healthcare Inc. | 750 | $2K |
| WHWKWhitehawk Therapeutics, Inc. | 647 | $2K |
| PMIPicard Medical Inc. | 2,091 | $2K |
| SABSSAB BIOTHERAPEUTICS, INC. | 496 | $2K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 212 | $2K |
| PASGPassage BIO, Inc. | 212 | $2K |
| MDXHMDxHealth SA | 694 | $2K |
| ARMPArmata Pharmaceuticals, Inc. | 154 | $2K |
| ADAGAdagene Inc. | 400 | $2K |
| VTVTvTv Therapeutics Inc. | 36 | $1K |
| ACXPAcurx Pharmaceuticals, Inc. | 380 | $1K |
| ANTXAN2 Therapeutics, Inc. | 400 | $1K |
| TVGNTevogen Bio Holdings Inc. | 249 | $1K |
| INOINOVIO PHARMACEUTICALS, INC. | 506 | $880 |
| NERVMinerva Neurosciences, Inc. | 146 | $880 |
| MREOMereo BioPharma Group plc | 2,496 | $824 |
| CLLSCellectis S.A. | 224 | $710 |
| CRONCronos Group Inc. | 155 | $389 |
| CRDLCardiol Therapeutics Inc. | 200 | $270 |
| IMMPImmutep Limited | 258 | $91 |
| DYAIDYADIC INTERNATIONAL INC | 72 | $59 |
| PLRXPLIANT THERAPEUTICS, INC. | 34 | $43 |
| COEPCoeptis Therapeutics Holdings Inc. | 3 | $34 |
| KZRKezar Life Sciences, Inc. | 1 | $7 |
| OVIDOvid Therapeutics Inc. | 1 | $2 |
| OGIORGANIGRAM GLOBAL INC. | 1 | $1 |
| SGMOSANGAMO THERAPEUTICS, INC | 1 | $0 |