| GILDGILEAD SCIENCES, INC. | 1,624,637 | $226.4M |
| JAZZJazz Pharmaceuticals plc | 365,451 | $69.1M |
| REGNREGENERON PHARMACEUTICALS, INC. | 88,871 | $68.7M |
| INSMINSMED Inc | 152,366 | $24.9M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 74,920 | $24.8M |
| INCYIncyte Corp. | 210,788 | $19.8M |
| TEVATeva Pharmaceutical Industries Limited | 595,032 | $17.9M |
| MRNAModerna, Inc. | 160,161 | $8.1M |
| RVMDREVOLUTION MEDICINES, INC. | 68,018 | $6.6M |
| EXELEXELIXIS, INC. | 146,446 | $6.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 89,808 | $5.1M |
| BBIOBridgeBio Pharma, Inc. | 65,987 | $4.9M |
| IONSIONIS PHARMACEUTICALS INC | 60,239 | $4.5M |
| ROIVRoivant Sciences Ltd. | 160,016 | $4.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 48,372 | $3.0M |
| CYTKCYTOKINETICS INC | 45,573 | $3.0M |
| PCVXVaxcyte, Inc. | 45,568 | $2.6M |
| BEAMBeam Therapeutics Inc. | 102,129 | $2.4M |
| DNLIDenali Therapeutics Inc. | 111,694 | $2.1M |
| PTCTPTC THERAPEUTICS, INC. | 26,965 | $1.8M |
| FOLDAMICUS THERAPEUTICS, INC. | 118,081 | $1.7M |
| AXSMAxsome Therapeutics, Inc. | 9,404 | $1.6M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 30,079 | $1.6M |
| VKTXViking Therapeutics, Inc. | 46,786 | $1.5M |
| SRRKScholar Rock Holding Corp | 29,178 | $1.4M |
| PTGXProtagonist Therapeutics, Inc | 13,412 | $1.4M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 15,598 | $1.4M |
| APGEApogee Therapeutics, Inc. | 15,916 | $1.3M |
| TGTXTG THERAPEUTICS, INC. | 40,211 | $1.3M |
| LQDALiquidia Corp | 34,093 | $1.3M |
| APLSApellis Pharmaceuticals, Inc. | 27,921 | $1.1M |
| TVTXTravere Therapeutics, Inc. | 37,560 | $1.1M |
| RCUSArcus Biosciences, Inc. | 51,024 | $1.1M |
| NUVLNuvalent, Inc. | 10,492 | $1.1M |
| ARQTArcutis Biotherapeutics, Inc. | 42,131 | $993K |
| ZYMEZymeworks Inc. | 39,355 | $985K |
| CLDXCelldex Therapeutics, Inc. | 30,677 | $973K |
| ADMAADMA BIOLOGICS, INC. | 99,004 | $892K |
| NTLAIntellia Therapeutics, Inc. | 69,324 | $889K |
| COGTCogent Biosciences, Inc. | 22,857 | $880K |
| ACADACADIA PHARMACEUTICALS INC | 38,947 | $867K |
| DAWNDay One Biopharmaceuticals, Inc. | 40,315 | $864K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 23,620 | $799K |
| TERNTerns Pharmaceuticals, Inc. | 15,146 | $798K |
| ARVNARVINAS, INC. | 73,853 | $783K |
| VRDNViridian Therapeutics, Inc.\DE | 37,462 | $733K |
| KNSAKiniksa Pharmaceuticals International, plc | 15,111 | $728K |
| SYRESpyre Therapeutics, Inc. | 13,955 | $704K |
| ADPTAdaptive Biotechnologies Corp | 49,622 | $689K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 20,921 | $670K |
| RLAYRelay Therapeutics, Inc. | 66,739 | $664K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 214,851 | $660K |
| INVAInnoviva, Inc. | 27,729 | $646K |
| NRIXNurix Therapeutics, Inc. | 40,928 | $634K |
| LGNDLigand Pharmaceuticals Incorporated | 3,121 | $623K |
| ARDXARDELYX, INC. | 103,494 | $620K |
| IBRXImmunityBio, Inc. | 80,269 | $616K |
| VCELVericel Corp | 19,049 | $613K |
| IMVTImmunovant, Inc. | 23,830 | $592K |
| ABUSArbutus Biopharma Corp | 125,233 | $564K |
| XERSXeris Biopharma Holdings, Inc. | 93,302 | $541K |
| OGNOrganon & Co. | 90,134 | $540K |
| ANABANAPTYSBIO, INC | 9,599 | $532K |
| KALVKalVista Pharmaceuticals, Inc. | 24,296 | $489K |
| NKTRNEKTAR THERAPEUTICS | 6,695 | $482K |
| HROWHARROW, INC. | 12,817 | $452K |
| BHVNBiohaven Ltd. | 51,123 | $433K |
| ELVNEnliven Therapeutics, Inc. | 10,933 | $429K |
| ALMSALUMIS INC. | 18,386 | $405K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 4,824 | $405K |
| DFTXDefinium Therapeutics Inc. | 20,868 | $394K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 12,840 | $390K |
| KURAKura Oncology, Inc. | 46,363 | $377K |
| SLNOSOLENO THERAPEUTICS INC | 10,829 | $363K |
| IRONDisc Medicine, Inc. | 5,640 | $361K |
| MLTXMoonLake Immunotherapeutics | 19,229 | $358K |
| ANIPANI PHARMACEUTICALS INC | 4,285 | $330K |
| STOKStoke Therapeutics, Inc. | 9,582 | $312K |
| OCULOCULAR THERAPEUTIX, INC | 36,056 | $305K |
| QUREuniQure N.V. | 18,564 | $304K |
| ANNXAnnexon, Inc. | 53,867 | $298K |
| PGENPRECIGEN, INC. | 71,764 | $278K |
| CGEMCullinan Therapeutics, Inc. | 19,067 | $271K |
| SVRASavara Inc | 46,854 | $256K |
| SANASana Biotechnology, Inc. | 82,393 | $237K |
| CMPXCompass Therapeutics, Inc. | 43,914 | $232K |
| CTMXCytomX Therapeutics, Inc. | 47,988 | $226K |
| TNGXTango Therapeutics, Inc. | 10,647 | $223K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 63,430 | $223K |
| NUVBNuvation Bio Inc. | 50,230 | $215K |
| ORICOric Pharmaceuticals, Inc. | 15,432 | $196K |
| FLGTFulgent Genetics Inc. | 10,878 | $173K |
| OLMAOlema Pharmaceuticals, Inc. | 11,305 | $169K |
| ATAIAtai Beckley N.V. | 46,375 | $164K |
| GERNGERON CORP | 103,230 | $154K |
| ZBIOZenas BioPharma, Inc. | 6,777 | $132K |
| BCAXBicara Therapeutics Inc. | 6,400 | $127K |
| PHVSPharvaris N.V. | 3,979 | $112K |
| SPRYARS Pharmaceuticals, Inc. | 11,662 | $94K |
| RDYDR REDDYS LABORATORIES LTD | 6,341 | $88K |
| OPKOPKO HEALTH, INC. | 55,140 | $63K |
| LENZLENZ Therapeutics, Inc. | 6,099 | $56K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 747 | $41K |
| ORKAOruka Therapeutics, Inc. | 496 | $24K |
| DNAGinkgo Bioworks Holdings Inc. | 3,700 | $23K |
| KODKodiak Sciences Inc. | 539 | $21K |
| RGNXREGENXBIO Inc. | 2,390 | $20K |
| BIOABioAge Labs, Inc. | 1,082 | $19K |
| TRDAEntrada Therapeutics, Inc. | 1,417 | $18K |
| DSGNDesign Therapeutics, Inc. | 1,594 | $17K |
| SIONSionna Therapeutics, Inc. | 371 | $15K |
| RCKTRocket Pharmaceuticals Inc. | 3,557 | $13K |
| CMPSCOMPASS Pathways plc | 2,192 | $12K |
| ABVXAbivax SA | 105 | $12K |
| MAZEMaze Therapeutics, Inc. | 361 | $11K |
| ESPREsperion Therapeutics, Inc. | 3,864 | $11K |
| GPCRStructure Therapeutics Inc. | 212 | $10K |
| LYELLyell Immunopharma, Inc. | 447 | $9K |
| KROSKeros Therapeutics, Inc. | 699 | $8K |
| IVVDInvivyd, Inc. | 5,157 | $7K |
| UPBUpstream Bio, Inc. | 477 | $4K |
| RNAAtrium Therapeutics Inc. | 49 | $655 |
| SCLXSCILEX HOLDING CO | 44 | $293 |
| MESOMesoblast Limited | 7 | $108 |
| TECXTectonic Therapeutic, Inc. | 3 | $93 |
| AVXLANAVEX LIFE SCIENCES CORP. | 19 | $58 |
| PLRXPLIANT THERAPEUTICS, INC. | 36 | $45 |
| CNTACentessa Pharmaceuticals plc | 1 | $40 |
| ALVOAlvotech | 11 | $38 |
| SKYESkye Bioscience, Inc. | 52 | $32 |
| FDMT4D Molecular Therapeutics, Inc. | 1 | $9 |
| BTAIBioXcel Therapeutics, Inc. | 2 | $3 |