| GILDGILEAD SCIENCES, INC. | 6,628,441 | $923.8M |
| SNYSanofi | 3,415,115 | $164.5M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 342,763 | $113.4M |
| REGNREGENERON PHARMACEUTICALS, INC. | 142,021 | $109.7M |
| INSMINSMED Inc | 597,384 | $97.7M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,405,498 | $77.6M |
| EXELEXELIXIS, INC. | 687,304 | $29.5M |
| ARGXARGENX SE | 38,104 | $27.8M |
| INCYIncyte Corp. | 255,022 | $24.0M |
| LGNDLigand Pharmaceuticals Incorporated | 84,901 | $17.0M |
| ONCBeOne Medicines Ltd. | 52,063 | $15.5M |
| TEVATeva Pharmaceutical Industries Limited | 487,018 | $14.7M |
| IONSIONIS PHARMACEUTICALS INC | 189,853 | $14.3M |
| JAZZJazz Pharmaceuticals plc | 68,488 | $12.9M |
| TGTXTG THERAPEUTICS, INC. | 332,720 | $11.1M |
| AXSMAxsome Therapeutics, Inc. | 61,405 | $10.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 158,398 | $9.9M |
| BBIOBridgeBio Pharma, Inc. | 132,540 | $9.8M |
| GMABGenmab A/S | 319,592 | $8.6M |
| GRFSGrifols S.A. | 1,053,433 | $8.4M |
| ROIVRoivant Sciences Ltd. | 263,965 | $7.3M |
| MRNAModerna, Inc. | 143,765 | $7.3M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 2,071,524 | $7.3M |
| CYTKCYTOKINETICS INC | 74,342 | $4.9M |
| ZYMEZymeworks Inc. | 189,636 | $4.7M |
| ARQTArcutis Biotherapeutics, Inc. | 197,810 | $4.7M |
| AQSTAquestive Therapeutics, Inc. | 1,034,644 | $4.3M |
| NTLAIntellia Therapeutics, Inc. | 333,897 | $4.3M |
| OGNOrganon & Co. | 700,599 | $4.2M |
| TERNTerns Pharmaceuticals, Inc. | 79,557 | $4.2M |
| COGTCogent Biosciences, Inc. | 106,660 | $4.1M |
| VKTXViking Therapeutics, Inc. | 121,340 | $3.9M |
| IBRXImmunityBio, Inc. | 514,721 | $3.9M |
| ANNXAnnexon, Inc. | 698,739 | $3.9M |
| TECXTectonic Therapeutic, Inc. | 112,664 | $3.5M |
| RVMDREVOLUTION MEDICINES, INC. | 34,241 | $3.3M |
| PTGXProtagonist Therapeutics, Inc | 30,072 | $3.2M |
| BEAMBeam Therapeutics Inc. | 132,249 | $3.2M |
| PCVXVaxcyte, Inc. | 53,106 | $3.1M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 34,108 | $3.0M |
| KODKodiak Sciences Inc. | 77,137 | $2.9M |
| ACIUAC Immune SA | 1,004,284 | $2.8M |
| NUVLNuvalent, Inc. | 26,310 | $2.7M |
| VCELVericel Corp | 83,475 | $2.7M |
| TVTXTravere Therapeutics, Inc. | 89,406 | $2.7M |
| ACADACADIA PHARMACEUTICALS INC | 118,525 | $2.6M |
| FLGTFulgent Genetics Inc. | 147,135 | $2.3M |
| CCCCC4 Therapeutics, Inc. | 867,911 | $2.3M |
| SMMTSummit Therapeutics Inc. | 120,301 | $2.3M |
| IMCRImmunocore Holdings plc | 75,473 | $2.3M |
| DNLIDenali Therapeutics Inc. | 107,657 | $2.1M |
| PTCTPTC THERAPEUTICS, INC. | 30,327 | $2.1M |
| ALMSALUMIS INC. | 86,718 | $1.9M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 33,775 | $1.9M |
| ANABANAPTYSBIO, INC | 33,180 | $1.8M |
| VRDNViridian Therapeutics, Inc.\DE | 93,204 | $1.8M |
| QUREuniQure N.V. | 103,446 | $1.7M |
| SYRESpyre Therapeutics, Inc. | 33,208 | $1.7M |
| KROSKeros Therapeutics, Inc. | 151,040 | $1.7M |
| ADMAADMA BIOLOGICS, INC. | 179,470 | $1.6M |
| SRRKScholar Rock Holding Corp | 32,690 | $1.6M |
| FOLDAMICUS THERAPEUTICS, INC. | 111,070 | $1.6M |
| OVIDOvid Therapeutics Inc. | 713,625 | $1.6M |
| APGEApogee Therapeutics, Inc. | 16,527 | $1.4M |
| DAWNDay One Biopharmaceuticals, Inc. | 56,429 | $1.2M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 13,787 | $1.2M |
| ADPTAdaptive Biotechnologies Corp | 81,795 | $1.1M |
| CLDXCelldex Therapeutics, Inc. | 35,158 | $1.1M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 21,524 | $1.1M |
| LQDALiquidia Corp | 25,653 | $968K |
| OCULOCULAR THERAPEUTIX, INC | 112,766 | $955K |
| SLSSELLAS Life Sciences Group, Inc. | 225,707 | $955K |
| IRONDisc Medicine, Inc. | 14,690 | $939K |
| TNGXTango Therapeutics, Inc. | 41,972 | $878K |
| NRIXNurix Therapeutics, Inc. | 56,137 | $870K |
| ARDXARDELYX, INC. | 143,039 | $857K |
| IMVTImmunovant, Inc. | 33,222 | $825K |
| NUVBNuvation Bio Inc. | 189,910 | $815K |
| BHVNBiohaven Ltd. | 93,041 | $787K |
| PGENPRECIGEN, INC. | 201,963 | $782K |
| CMPSCOMPASS Pathways plc | 140,387 | $776K |
| RCUSArcus Biosciences, Inc. | 35,725 | $772K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 22,763 | $770K |
| DFTXDefinium Therapeutics Inc. | 39,973 | $755K |
| ORKAOruka Therapeutics, Inc. | 14,831 | $727K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 236,916 | $727K |
| PVLAPALVELLA THERAPEUTICS, INC. | 5,824 | $726K |
| SLNOSOLENO THERAPEUTICS INC | 20,751 | $695K |
| OLMAOlema Pharmaceuticals, Inc. | 46,433 | $692K |
| GERNGERON CORP | 460,729 | $686K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 21,424 | $651K |
| STOKStoke Therapeutics, Inc. | 19,869 | $647K |
| INVAInnoviva, Inc. | 27,558 | $642K |
| ANIPANI PHARMACEUTICALS INC | 7,634 | $587K |
| ARVNARVINAS, INC. | 53,663 | $569K |
| ELVNEnliven Therapeutics, Inc. | 14,291 | $560K |
| HROWHARROW, INC. | 15,251 | $538K |
| ORMPORAMED PHARMACEUTICALS INC. | 157,586 | $536K |
| HRMYHarmony Biosciences Holdings, Inc. | 18,034 | $505K |
| ORICOric Pharmaceuticals, Inc. | 39,108 | $495K |
| KALVKalVista Pharmaceuticals, Inc. | 23,927 | $482K |
| SVRASavara Inc | 86,929 | $475K |
| RGNXREGENXBIO Inc. | 50,502 | $423K |
| KNSAKiniksa Pharmaceuticals International, plc | 8,368 | $403K |
| VYGRVoyager Therapeutics, Inc. | 101,722 | $393K |
| GPCRStructure Therapeutics Inc. | 7,818 | $377K |
| DRTSAlpha Tau Medical Ltd. | 49,300 | $349K |
| APLSApellis Pharmaceuticals, Inc. | 8,592 | $346K |
| XERSXeris Biopharma Holdings, Inc. | 58,307 | $338K |
| ABVXAbivax SA | 2,896 | $322K |
| ALDXAldeyra Therapeutics, Inc. | 189,729 | $321K |
| MAZEMaze Therapeutics, Inc. | 10,369 | $310K |
| BCAXBicara Therapeutics Inc. | 14,977 | $298K |
| CGEMCullinan Therapeutics, Inc. | 20,939 | $298K |
| ALTAltimmune, Inc. | 95,907 | $295K |
| AUTLAutolus Therapeutics plc | 207,856 | $287K |
| ESLAEstrella Immunopharma Inc. | 264,388 | $280K |
| MESOMesoblast Limited | 18,093 | $278K |
| MGXMetagenomi Therapeutics, Inc. | 202,138 | $271K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 27,337 | $266K |
| ABUSArbutus Biopharma Corp | 58,709 | $264K |
| KURAKura Oncology, Inc. | 31,471 | $256K |
| ESPREsperion Therapeutics, Inc. | 92,880 | $254K |
| CMPXCompass Therapeutics, Inc. | 47,740 | $253K |
| ZVRAZEVRA THERAPEUTICS, INC. | 26,205 | $244K |
| SPRYARS Pharmaceuticals, Inc. | 30,385 | $244K |
| AVXLANAVEX LIFE SCIENCES CORP. | 79,445 | $244K |
| CNTACentessa Pharmaceuticals plc | 6,000 | $238K |
| SIONSionna Therapeutics, Inc. | 5,894 | $236K |
| MLTXMoonLake Immunotherapeutics | 12,520 | $233K |
| SLDBSolid Biosciences Inc. | 32,281 | $232K |
| SANASana Biotechnology, Inc. | 75,682 | $218K |
| LBRXLB PHARMACEUTICALS INC | 8,623 | $213K |
| BIOABioAge Labs, Inc. | 11,406 | $199K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 9,195 | $199K |
| MDWDMediWound Ltd. | 11,787 | $190K |
| OPKOPKO HEALTH, INC. | 162,609 | $185K |
| ABSIAbsci Corporation | 61,259 | $184K |
| ZBIOZenas BioPharma, Inc. | 8,885 | $174K |
| FDMT4D Molecular Therapeutics, Inc. | 18,309 | $170K |
| JBIOJade Biosciences, Inc. | 12,046 | $169K |
| UPBUpstream Bio, Inc. | 18,402 | $166K |
| RDYDR REDDYS LABORATORIES LTD | 11,406 | $158K |
| IMMXImmix Biopharma, Inc. | 17,149 | $156K |
| RNAAtrium Therapeutics Inc. | 11,416 | $153K |
| MPLTMapLight Therapeutics, Inc. | 7,163 | $146K |
| OCGNOcugen, Inc. | 77,901 | $141K |
| RCKTRocket Pharmaceuticals Inc. | 39,260 | $141K |
| TRDAEntrada Therapeutics, Inc. | 11,011 | $139K |
| DNAGinkgo Bioworks Holdings Inc. | 21,609 | $132K |
| LENZLENZ Therapeutics, Inc. | 13,972 | $128K |
| XOMAXOMA Royalty Corporation | 3,865 | $121K |
| FATEFATE THERAPEUTICS INC | 100,975 | $121K |
| TNXPTonix Pharmaceuticals Holding Corp. | 8,629 | $119K |
| DMACDiaMedica Therapeutics Inc. | 15,966 | $108K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 16,273 | $104K |
| CATXPerspective Therapeutics, Inc. | 23,491 | $98K |
| DSGNDesign Therapeutics, Inc. | 9,027 | $96K |
| LRMRLarimar Therapeutics, Inc. | 20,228 | $91K |
| NGNENeurogene Inc. | 4,268 | $86K |
| RZLTRezolute, Inc. | 27,434 | $84K |
| CADLCandel Therapeutics, Inc. | 16,593 | $81K |
| SIGASIGA TECHNOLOGIES INC | 15,038 | $80K |
| ABEOABEONA THERAPEUTICS INC. | 16,702 | $75K |
| ALECAlector, Inc. | 34,526 | $74K |
| FENCFENNEC PHARMACEUTICALS INC. | 10,897 | $67K |
| PDSBPDS Biotechnology Corp | 110,500 | $67K |
| CHRSCoherus Oncology, Inc. | 38,639 | $65K |
| CRDFCardiff Oncology, Inc. | 38,406 | $62K |
| ORGOOrganogenesis Holdings Inc. | 24,797 | $59K |
| PLXProtalix BioTherapeutics, Inc. | 26,522 | $58K |
| OKUROnKure Therapeutics, Inc. | 13,500 | $56K |
| ABCLAbCellera Biologics Inc. | 15,900 | $55K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 66,543 | $53K |
| SGMTSagimet Biosciences Inc. | 9,274 | $48K |
| NVCTNuvectis Pharma, Inc. | 5,619 | $43K |
| KZRKezar Life Sciences, Inc. | 5,796 | $43K |
| HUMAHumacyte Inc. | 62,673 | $38K |
| ANVSAnnovis Bio, Inc. | 14,307 | $32K |
| AGENAGENUS INC | 9,363 | $31K |
| HURATuHURA Biosciences, Inc./NV | 17,444 | $31K |
| CTMXCytomX Therapeutics, Inc. | 6,595 | $31K |
| ANIXAnixa Biosciences Inc | 12,000 | $31K |
| GYREGYRE THERAPEUTICS, INC. | 4,290 | $30K |
| KRROKorro Bio, Inc. | 2,589 | $29K |
| CLNNClene Inc. | 5,927 | $29K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 900 | $29K |
| LCTXLineage Cell Therapeutics, Inc. | 17,937 | $28K |
| RNACCartesian Therapeutics, Inc. | 3,980 | $24K |
| NKTRNEKTAR THERAPEUTICS | 327 | $24K |
| ATAIAtai Beckley N.V. | 6,535 | $23K |
| LPCNLipocine Inc. | 2,706 | $22K |
| ATNMActinium Pharmaceuticals, Inc. | 19,800 | $20K |
| AARDAardvark Therapeutics, Inc. | 4,707 | $18K |
| GHRSGH Research PLC | 1,250 | $18K |
| GALTGALECTIN THERAPEUTICS INC | 6,299 | $18K |
| IRDOpus Genetics, Inc. | 3,785 | $17K |
| ALVOAlvotech | 5,000 | $17K |
| VERUVERU INC. | 7,005 | $15K |
| FLNAFilana Therapeutics Inc. | 8,421 | $14K |
| FBRXForte Biosciences, Inc. | 502 | $13K |
| PHVSPharvaris N.V. | 450 | $13K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 7,760 | $12K |
| CELZCREATIVE MEDICAL TECHNOLOGY HOLDINGS, INC. | 5,000 | $10K |
| CLLSCellectis S.A. | 3,150 | $10K |
| IMNNImunon, Inc. | 3,342 | $10K |
| SGMOQSANGAMO THERAPEUTICS, INC | 38,330 | $9K |
| ACXPAcurx Pharmaceuticals, Inc. | 2,300 | $9K |
| GRCEGrace Therapeutics, Inc. | 1,800 | $8K |
| TVRDTvardi Therapeutics, Inc. | 2,266 | $7K |
| COCPCocrystal Pharma, Inc. | 7,039 | $7K |
| SERSerina Therapeutics, Inc. | 3,606 | $7K |
| PRQRProQR Therapeutics N.V. | 4,000 | $6K |
| NBTXNanobiotix S.A. | 200 | $6K |
| BTAIBioXcel Therapeutics, Inc. | 4,319 | $6K |
| ONCYONCOLYTICS BIOTECH INC | 6,602 | $6K |
| ELUTELUTIA INC. | 5,000 | $5K |
| ALGSAligos Therapeutics, Inc. | 700 | $5K |
| INOINOVIO PHARMACEUTICALS, INC. | 2,869 | $5K |
| IMTXImmatics N.V. | 464 | $5K |
| CELUCelularity Inc. | 2,500 | $3K |
| TTRXTurn Therapeutics Inc. | 1,000 | $3K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 300 | $3K |
| LYELLyell Immunopharma, Inc. | 125 | $3K |
| CGTXCOGNITION THERAPEUTICS INC | 3,050 | $2K |
| LTRNLantern Pharma Inc. | 1,475 | $2K |
| ASRTAssertio Holdings, Inc. | 100 | $2K |
| ATOSATOSSA THERAPEUTICS, INC. | 296 | $2K |
| INTSINTENSITY THERAPEUTICS, INC. | 200 | $1K |
| TLSATiziana Life Sciences Ltd | 1,000 | $1K |
| IMUXIMMUNIC, INC. | 900 | $999 |
| BCYCBICYCLE THERAPEUTICS PLC | 200 | $928 |
| TLPHTALPHERA, INC. | 983 | $734 |
| PLURPluri Inc. | 185 | $628 |
| CUECue Biopharma, Inc. | 2,563 | $589 |
| OTLKOutlook Therapeutics, Inc. | 2,480 | $510 |
| QNTMQuantum Biopharma Ltd. | 100 | $477 |
| RNAZTranscode Therapeutics, Inc. | 55 | $474 |
| SPROSpero Therapeutics, Inc. | 200 | $468 |
| SCLXSCILEX HOLDING CO | 69 | $460 |
| JSPRJasper Therapeutics Inc. | 500 | $438 |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 44 | $410 |
| CANFCan-Fite BioPharma Ltd. | 125 | $388 |
| AYTUAYTU BIOPHARMA, INC | 127 | $347 |
| RLYBRallybio Corp | 37 | $332 |
| IVVDInvivyd, Inc. | 250 | $325 |
| MRKRMarker Therapeutics, Inc. | 232 | $302 |
| IMAImageneBio, Inc. | 41 | $205 |
| VIVSVivoSim Labs, INC. | 111 | $158 |
| CODXCo-Diagnostics Inc. | 81 | $151 |
| PTNPALATIN TECHNOLOGIES INC | 8 | $139 |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 150 | $109 |
| AEONAEON Biopharma, Inc. | 90 | $89 |
| PLRXPLIANT THERAPEUTICS, INC. | 50 | $63 |
| GOVXGeoVax Labs, Inc. | 31 | $43 |
| BIVIBIOVIE INC. | 27 | $38 |
| LITSLite Strategy, Inc. | 25 | $29 |
| RNTXRein Therapeutics, Inc. | 20 | $26 |
| MIRAMIRA PHARMACEUTICALS, INC. | 23 | $25 |
| GLMDGalmed Pharmaceuticals Ltd. | 43 | $21 |
| PCSAProcessa Pharmaceuticals, Inc. | 6 | $15 |
| FBLGFibroBiologics, Inc. | 10 | $13 |
| ADILADIAL PHARMACEUTICALS, INC. | 6 | $11 |
| ARMPArmata Pharmaceuticals, Inc. | 1 | $5 |
| CALCCalciMedica, Inc. | 10 | $5 |
| BCTXBriaCell Therapeutics Corp. | 1 | $4 |
| SILOSilo Pharma, Inc. | 10 | $4 |
| BMEABiomea Fusion, Inc. | 1 | $2 |
| ENVBEnveric Biosciences, Inc. | 1 | $2 |
| ZNTLZentalis Pharmaceuticals, Inc. | 1 | $1 |
| DAREDare Bioscience, Inc. | 0 | $0 |