| GILDGILEAD SCIENCES, INC. | 856,921 | $119.4M |
| AXSMAxsome Therapeutics, Inc. | 131,414 | $22.2M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 228,508 | $12.6M |
| TEVATeva Pharmaceutical Industries Limited | 181,965 | $5.5M |
| REGNREGENERON PHARMACEUTICALS, INC. | 5,628 | $4.3M |
| SNYSanofi | 87,155 | $4.2M |
| GMABGenmab A/S | 95,548 | $2.6M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 7,381 | $2.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 34,683 | $2.2M |
| ARGXARGENX SE | 2,823 | $2.1M |
| RDYDR REDDYS LABORATORIES LTD | 146,928 | $2.0M |
| ADPTAdaptive Biotechnologies Corp | 116,456 | $1.6M |
| EXELEXELIXIS, INC. | 32,111 | $1.4M |
| INSMINSMED Inc | 7,377 | $1.2M |
| VCELVericel Corp | 34,178 | $1.1M |
| BBIOBridgeBio Pharma, Inc. | 11,083 | $823K |
| MRNAModerna, Inc. | 13,480 | $685K |
| INCYIncyte Corp. | 5,626 | $530K |
| ONCBeOne Medicines Ltd. | 1,708 | $507K |
| COGTCogent Biosciences, Inc. | 12,210 | $470K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 14,433 | $439K |
| PTGXProtagonist Therapeutics, Inc | 3,914 | $413K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 4,722 | $396K |
| IONSIONIS PHARMACEUTICALS INC | 5,047 | $379K |
| JAZZJazz Pharmaceuticals plc | 1,971 | $373K |
| RVMDREVOLUTION MEDICINES, INC. | 3,828 | $372K |
| BEAMBeam Therapeutics Inc. | 14,672 | $350K |
| NUVLNuvalent, Inc. | 2,770 | $284K |
| TERNTerns Pharmaceuticals, Inc. | 5,190 | $274K |
| CYTKCYTOKINETICS INC | 4,050 | $267K |
| VKTXViking Therapeutics, Inc. | 7,623 | $248K |
| LGNDLigand Pharmaceuticals Incorporated | 1,211 | $242K |
| ORKAOruka Therapeutics, Inc. | 4,865 | $239K |
| BMRNBIOMARIN PHARMACEUTICAL INC | 3,673 | $207K |
| GRFSGrifols S.A. | 23,703 | $190K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 5,474 | $175K |
| DAREDare Bioscience, Inc. | 91,370 | $166K |
| ROIVRoivant Sciences Ltd. | 5,833 | $162K |
| NKTRNEKTAR THERAPEUTICS | 1,916 | $138K |
| SRRKScholar Rock Holding Corp | 2,549 | $125K |
| PCVXVaxcyte, Inc. | 1,642 | $95K |
| SLDBSolid Biosciences Inc. | 13,218 | $95K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 1,840 | $95K |
| TGTXTG THERAPEUTICS, INC. | 2,797 | $93K |
| ANABANAPTYSBIO, INC | 1,635 | $91K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 1,041 | $91K |
| IBRXImmunityBio, Inc. | 10,501 | $81K |
| SVRASavara Inc | 14,252 | $78K |
| OGNOrganon & Co. | 12,916 | $77K |
| IRONDisc Medicine, Inc. | 1,185 | $76K |
| PTCTPTC THERAPEUTICS, INC. | 1,037 | $71K |
| APGEApogee Therapeutics, Inc. | 748 | $63K |
| VRDNViridian Therapeutics, Inc.\DE | 2,905 | $57K |
| APLSApellis Pharmaceuticals, Inc. | 1,380 | $56K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 16,940 | $52K |
| AVTXAvalo Therapeutics, Inc. | 3,387 | $51K |
| SLNOSOLENO THERAPEUTICS INC | 1,339 | $45K |
| KNSAKiniksa Pharmaceuticals International, plc | 913 | $44K |
| MLTXMoonLake Immunotherapeutics | 2,323 | $43K |
| FOLDAMICUS THERAPEUTICS, INC. | 2,438 | $35K |
| KURAKura Oncology, Inc. | 4,332 | $35K |
| TECXTectonic Therapeutic, Inc. | 1,136 | $35K |
| SMMTSummit Therapeutics Inc. | 1,850 | $35K |
| DMACDiaMedica Therapeutics Inc. | 4,522 | $31K |
| ANIPANI PHARMACEUTICALS INC | 394 | $30K |
| ARDXARDELYX, INC. | 5,058 | $30K |
| MANEVeradermics Incorporated | 470 | $30K |
| DNAGinkgo Bioworks Holdings Inc. | 4,633 | $28K |
| TVTXTravere Therapeutics, Inc. | 915 | $27K |
| IVVDInvivyd, Inc. | 20,500 | $27K |
| CLDXCelldex Therapeutics, Inc. | 772 | $24K |
| QUREuniQure N.V. | 1,402 | $23K |
| ZBIOZenas BioPharma, Inc. | 994 | $19K |
| INVAInnoviva, Inc. | 795 | $19K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 542 | $18K |
| RGNXREGENXBIO Inc. | 2,178 | $18K |
| ESLAEstrella Immunopharma Inc. | 16,904 | $18K |
| AVXLANAVEX LIFE SCIENCES CORP. | 5,670 | $17K |
| DNLIDenali Therapeutics Inc. | 902 | $17K |
| BHVNBiohaven Ltd. | 2,018 | $17K |
| KALVKalVista Pharmaceuticals, Inc. | 708 | $14K |
| SPRYARS Pharmaceuticals, Inc. | 1,519 | $12K |
| GERNGERON CORP | 8,000 | $12K |
| WHWKWhitehawk Therapeutics, Inc. | 3,333 | $11K |
| ALMSALUMIS INC. | 464 | $10K |
| ABSIAbsci Corporation | 3,274 | $10K |
| ZVRAZEVRA THERAPEUTICS, INC. | 1,034 | $10K |
| AQSTAquestive Therapeutics, Inc. | 2,283 | $9K |
| ARVNARVINAS, INC. | 881 | $9K |
| DAWNDay One Biopharmaceuticals, Inc. | 414 | $9K |
| IMVTImmunovant, Inc. | 356 | $9K |
| ZYMEZymeworks Inc. | 352 | $9K |
| RCUSArcus Biosciences, Inc. | 403 | $9K |
| STOKStoke Therapeutics, Inc. | 265 | $9K |
| HCMHUTCHMED (China) Limited | 573 | $9K |
| HROWHARROW, INC. | 227 | $8K |
| IMCRImmunocore Holdings plc | 264 | $8K |
| OLMAOlema Pharmaceuticals, Inc. | 511 | $8K |
| NTLAIntellia Therapeutics, Inc. | 583 | $7K |
| ABUSArbutus Biopharma Corp | 1,588 | $7K |
| CGEMCullinan Therapeutics, Inc. | 502 | $7K |
| NUVBNuvation Bio Inc. | 1,581 | $7K |
| ELVNEnliven Therapeutics, Inc. | 167 | $7K |
| RCKTRocket Pharmaceuticals Inc. | 1,824 | $7K |
| MESOMesoblast Limited | 410 | $6K |
| MGXMetagenomi Therapeutics, Inc. | 4,500 | $6K |
| ABVXAbivax SA | 51 | $6K |
| UPBUpstream Bio, Inc. | 590 | $5K |
| LRMRLarimar Therapeutics, Inc. | 1,175 | $5K |
| ADMAADMA BIOLOGICS, INC. | 575 | $5K |
| CRDFCardiff Oncology, Inc. | 3,109 | $5K |
| BCAXBicara Therapeutics Inc. | 251 | $5K |
| SYRESpyre Therapeutics, Inc. | 97 | $5K |
| PVLAPALVELLA THERAPEUTICS, INC. | 35 | $4K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 1,212 | $4K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 418 | $4K |
| RNAAtrium Therapeutics Inc. | 297 | $4K |
| OCULOCULAR THERAPEUTIX, INC | 468 | $4K |
| NRIXNurix Therapeutics, Inc. | 249 | $4K |
| MISTMilestone Pharmaceuticals Inc. | 3,200 | $4K |
| BIOABioAge Labs, Inc. | 216 | $4K |
| CADLCandel Therapeutics, Inc. | 731 | $4K |
| ACADACADIA PHARMACEUTICALS INC | 157 | $3K |
| ARQTArcutis Biotherapeutics, Inc. | 142 | $3K |
| ESPREsperion Therapeutics, Inc. | 1,030 | $3K |
| ALTAltimmune, Inc. | 890 | $3K |
| ORICOric Pharmaceuticals, Inc. | 173 | $2K |
| PTNPALATIN TECHNOLOGIES INC | 125 | $2K |
| ABCLAbCellera Biologics Inc. | 611 | $2K |
| XOMAXOMA Royalty Corporation | 67 | $2K |
| SIONSionna Therapeutics, Inc. | 51 | $2K |
| SANASana Biotechnology, Inc. | 694 | $2K |
| ZURAZura Bio Ltd | 318 | $2K |
| VERUVERU INC. | 750 | $2K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 59 | $2K |
| RNTXRein Therapeutics, Inc. | 1,250 | $2K |
| HUMAHumacyte Inc. | 2,500 | $2K |
| CATXPerspective Therapeutics, Inc. | 344 | $1K |
| FLGTFulgent Genetics Inc. | 84 | $1K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 200 | $1K |
| TLSATiziana Life Sciences Ltd | 1,000 | $1K |
| LYELLyell Immunopharma, Inc. | 58 | $1K |
| ANIXAnixa Biosciences Inc | 400 | $1K |
| KODKodiak Sciences Inc. | 27 | $1K |
| TNGXTango Therapeutics, Inc. | 48 | $1K |
| TRDAEntrada Therapeutics, Inc. | 70 | $883 |
| LONALeonaBio, Inc. | 81 | $833 |
| LQDALiquidia Corp | 21 | $793 |
| GYREGYRE THERAPEUTICS, INC. | 98 | $683 |
| DSGNDesign Therapeutics, Inc. | 61 | $649 |
| NGNENeurogene Inc. | 30 | $605 |
| GPCRStructure Therapeutics Inc. | 10 | $482 |
| JSPRJasper Therapeutics Inc. | 500 | $438 |
| ANNXAnnexon, Inc. | 77 | $427 |
| CMPXCompass Therapeutics, Inc. | 77 | $407 |
| KROSKeros Therapeutics, Inc. | 35 | $386 |
| SPROSpero Therapeutics, Inc. | 151 | $353 |
| FDMT4D Molecular Therapeutics, Inc. | 35 | $326 |
| MAZEMaze Therapeutics, Inc. | 9 | $269 |
| JBIOJade Biosciences, Inc. | 15 | $211 |
| ORGOOrganogenesis Holdings Inc. | 76 | $180 |
| LENZLENZ Therapeutics, Inc. | 16 | $146 |
| CLNNClene Inc. | 20 | $99 |
| SCLXSCILEX HOLDING CO | 8 | $53 |
| NNVCNANOVIRICIDES, INC. | 43 | $39 |
| CLRBCellectar Biosciences, Inc. | 3 | $8 |
| KYNBKYNTRA BIO INC. | 1 | $7 |
| SGMOQSANGAMO THERAPEUTICS, INC | 11 | $3 |
| BTAIBioXcel Therapeutics, Inc. | 1 | $1 |