| LLYELI LILLY & Co | 7,072,021 | $6.50B |
| JNJJOHNSON & JOHNSON | 19,628,113 | $4.80B |
| ABBVAbbVie Inc. | 14,161,606 | $3.08B |
| MRKMerck & Co., Inc. | 20,414,819 | $2.46B |
| UNHUnitedHealth Group Incorporated Common Stock (DE) | 7,442,890 | $2.01B |
| GILDGILEAD SCIENCES, INC. | 13,199,103 | $1.84B |
| AMGNAMGEN INC | 4,784,982 | $1.68B |
| BMYBRISTOL MYERS SQUIBB CO | 22,719,320 | $1.38B |
| VRTXVERTEX PHARMACEUTICALS INC / MA | 3,057,396 | $1.37B |
| ABTABBOTT LABORATORIES | 13,198,740 | $1.36B |
| PFEPFIZER INC | 34,522,932 | $969.4M |
| PMPhilip Morris International Inc | 5,577,426 | $922.2M |
| MCKMcKesson Corporation | 892,826 | $772.6M |
| ELVElevance Health Inc. | 2,518,615 | $737.3M |
| GMOptec International, Inc. | 8,458,105 | $630.1M |
| REGNREGENERON PHARMACEUTICALS, INC. | 723,621 | $559.1M |
| ZTSZoetis Inc. | 4,398,351 | $519.9M |
| CORCencora Inc. | 1,616,563 | $507.8M |
| CAHCardinal Health Inc. | 2,322,438 | $490.8M |
| IDXXIDEXX LABORATORIES INC /DE | 871,789 | $489.8M |
| IQVIQVIA Holdings Inc. | 1,499,267 | $255.7M |
| BIIBBIOGEN INC. | 1,377,568 | $252.5M |
| WSTWest Pharmaceutical Services Inc. | 902,764 | $226.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 677,519 | $224.2M |
| INSMINSMED Inc | 1,215,025 | $198.7M |
| GEHCGE HealthCare Technologies Inc. | 2,521,213 | $179.5M |
| DGXQuest Diagnostics Incorporated | 846,603 | $165.9M |
| GHGuardant Health Inc. | 1,623,511 | $150.0M |
| RPRXRoyalty Pharma plc | 3,095,766 | $148.5M |
| INCYIncyte Corp. | 1,540,913 | $145.0M |
| ZBHZimmer Biomet Holdings Inc. | 1,470,220 | $132.9M |
| UTHRUNITED THERAPEUTICS Corp | 207,309 | $122.9M |
| IONSIONIS PHARMACEUTICALS INC | 1,475,632 | $110.8M |
| AZNASTRAZENECA PLC | 452,905 | $89.3M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,330,996 | $83.5M |
| MRNAModerna, Inc. | 1,620,574 | $82.3M |
| NBIXNEUROCRINE BIOSCIENCES INC | 571,719 | $75.3M |
| KYMRKymera Therapeutics, Inc. | 875,872 | $73.0M |
| CGONCG Oncology, Inc. | 1,064,966 | $72.1M |
| BNTXBioNTech SE | 783,995 | $69.7M |
| MEDPMedpace Holdings Inc. | 140,807 | $67.6M |
| VTRSViatris Inc | 3,964,630 | $53.6M |
| RVMDREVOLUTION MEDICINES, INC. | 500,595 | $48.7M |
| ROIVRoivant Sciences Ltd. | 1,741,480 | $48.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 850,819 | $48.1M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 541,450 | $47.1M |
| LGNDLigand Pharmaceuticals Incorporated | 212,888 | $42.5M |
| BEAMBeam Therapeutics Inc. | 1,653,714 | $39.4M |
| TWSTTwist Bioscience Corp | 823,976 | $39.2M |
| CRLCHARLES RIVER LABORATORIES INTERNATIONAL, INC. | 218,913 | $37.8M |
| LNTHLantheus Holdings, Inc. | 486,498 | $36.9M |
| ELANElanco Animal Health Inc | 1,526,922 | $36.5M |
| HALOHALOZYME THERAPEUTICS, INC. | 528,031 | $34.1M |
| BBIOBridgeBio Pharma, Inc. | 402,948 | $29.9M |
| BAXBaxter International Inc. | 1,769,495 | $29.7M |
| MOHMolina Healthcare Inc | 222,048 | $29.6M |
| RAPPRapport Therapeutics, Inc. | 918,866 | $28.8M |
| JAZZJazz Pharmaceuticals plc | 147,764 | $27.9M |
| PCVXVaxcyte, Inc. | 410,605 | $23.9M |
| DVADaVita Inc. | 151,313 | $23.3M |
| INSPInspire Medical Systems Inc. | 448,787 | $23.1M |
| TECHBIO-TECHNE Corp | 439,373 | $23.0M |
| GMEDGlobus Medical Inc. | 257,538 | $22.2M |
| XENEXenon Pharmaceuticals Inc. | 375,166 | $21.8M |
| CAICaris Life Sciences Inc. | 1,149,133 | $20.5M |
| ARGXARGENX SE | 27,506 | $20.1M |
| NVSNovartis AG | 126,885 | $19.4M |
| RGENREPLIGEN CORP | 163,748 | $19.3M |
| VRDNViridian Therapeutics, Inc.\DE | 888,298 | $17.4M |
| AXSMAxsome Therapeutics, Inc. | 94,937 | $16.0M |
| CYTKCYTOKINETICS INC | 240,632 | $15.9M |
| ALKSAlkermes plc. | 403,153 | $14.3M |
| NUVLNuvalent, Inc. | 122,187 | $12.5M |
| MDGLMADRIGAL PHARMACEUTICALS, INC. | 23,796 | $12.5M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 4,023,398 | $12.4M |
| PRAXPraxis Precision Medicines, Inc. | 38,145 | $12.3M |
| PTGXProtagonist Therapeutics, Inc | 107,437 | $11.3M |
| MMSIMerit Medical Systems Inc. | 155,578 | $10.7M |
| SYRESpyre Therapeutics, Inc. | 207,314 | $10.5M |
| ICUIICU Medical Inc. | 79,421 | $10.3M |
| KRYSKrystal Biotech, Inc. | 36,937 | $9.5M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 285,285 | $9.1M |
| CORTCORCEPT THERAPEUTICS INC | 217,468 | $8.8M |
| PVLAPALVELLA THERAPEUTICS, INC. | 69,901 | $8.7M |
| PTCTPTC THERAPEUTICS, INC. | 126,963 | $8.6M |
| RIOTRiot Platforms, Inc. | 683,903 | $8.5M |
| CRNXCrinetics Pharmaceuticals, Inc. | 230,128 | $8.4M |
| VKTXViking Therapeutics, Inc. | 253,894 | $8.3M |
| FOLDAMICUS THERAPEUTICS, INC. | 557,170 | $8.1M |
| ZYMEZymeworks Inc. | 319,385 | $8.0M |
| VERAVera Therapeutics, Inc. | 197,769 | $8.0M |
| ALHCAlignment Healthcare Inc. | 450,528 | $7.9M |
| TGTXTG THERAPEUTICS, INC. | 235,477 | $7.8M |
| CRSPCRISPR Therapeutics AG | 157,396 | $7.5M |
| APLSApellis Pharmaceuticals, Inc. | 179,953 | $7.2M |
| IRONDisc Medicine, Inc. | 110,890 | $7.1M |
| CPRXCATALYST PHARMACEUTICALS, INC. | 280,889 | $7.0M |
| ACLXArcellx, Inc. | 57,289 | $6.6M |
| ACHCAcadia Healthcare Company Inc. | 275,313 | $6.4M |
| COGTCogent Biosciences, Inc. | 165,510 | $6.4M |
| SHCSotera Health Company | 437,582 | $6.3M |
| MIRMMirum Pharmaceuticals, Inc. | 66,629 | $6.2M |
| SRPTSarepta Therapeutics, Inc. | 276,955 | $6.0M |
| PBHPrestige Consumer Healthcare Inc. | 99,251 | $5.9M |
| IDYAIDEAYA Biosciences, Inc. | 175,151 | $5.8M |
| ARQTArcutis Biotherapeutics, Inc. | 237,171 | $5.6M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 107,856 | $5.6M |
| BHVNBiohaven Ltd. | 618,180 | $5.2M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 60,435 | $5.1M |
| SRRKScholar Rock Holding Corp | 102,912 | $5.1M |
| TERNTerns Pharmaceuticals, Inc. | 94,646 | $5.0M |
| APGEApogee Therapeutics, Inc. | 56,352 | $4.7M |
| RAREUltragenyx Pharmaceutical Inc. | 223,048 | $4.7M |
| OGNOrganon & Co. | 778,905 | $4.7M |
| OSCROscar Health Inc. | 406,391 | $4.7M |
| ACADACADIA PHARMACEUTICALS INC | 206,884 | $4.6M |
| PRGOPERRIGO Co plc | 428,278 | $4.6M |
| LQDALiquidia Corp | 116,614 | $4.4M |
| TARSTarsus Pharmaceuticals, Inc. | 62,706 | $4.4M |
| DYNDyne Therapeutics, Inc. | 239,285 | $4.3M |
| PBIPROVENTION BIO, INC. | 389,369 | $4.3M |
| ERASErasca, Inc. | 259,007 | $4.2M |
| IMNMImmunome Inc. | 187,011 | $4.1M |
| IBRXImmunityBio, Inc. | 532,675 | $4.1M |
| TVTXTravere Therapeutics, Inc. | 137,025 | $4.1M |
| HRMYHarmony Biosciences Holdings, Inc. | 141,540 | $4.0M |
| XERSXeris Biopharma Holdings, Inc. | 668,074 | $3.9M |
| CLDXCelldex Therapeutics, Inc. | 120,807 | $3.8M |
| ABUSArbutus Biopharma Corp | 838,210 | $3.8M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 110,679 | $3.7M |
| SPRYARS Pharmaceuticals, Inc. | 464,681 | $3.7M |
| NTLAIntellia Therapeutics, Inc. | 283,958 | $3.6M |
| EWTXEdgewise Therapeutics, Inc. | 114,720 | $3.6M |
| PGNYProgyny Inc. | 211,087 | $3.6M |
| ADMAADMA BIOLOGICS, INC. | 393,651 | $3.5M |
| IMVTImmunovant, Inc. | 141,728 | $3.5M |
| BCRXBIOCRYST PHARMACEUTICALS INC | 368,978 | $3.5M |
| SNDXSyndax Pharmaceuticals Inc | 149,797 | $3.5M |
| AUPHAurinia Pharmaceuticals Inc. | 233,256 | $3.5M |
| PRCTPROCEPT BioRobotics Corporation | 136,738 | $3.4M |
| RCUSArcus Biosciences, Inc. | 158,292 | $3.4M |
| NEOGNEOGEN CORP | 359,796 | $3.3M |
| QDELQuidelOrtho Corp | 196,961 | $3.2M |
| VCELVericel Corp | 100,071 | $3.2M |
| INVAInnoviva, Inc. | 134,571 | $3.1M |
| ADPTAdaptive Biotechnologies Corp | 222,524 | $3.1M |
| MNKDMANNKIND CORP | 1,232,642 | $3.0M |
| AVNSAvanos Medical Inc. | 210,160 | $2.9M |
| DAWNDay One Biopharmaceuticals, Inc. | 136,991 | $2.9M |
| PAHCPHIBRO ANIMAL HEALTH CORP | 50,176 | $2.8M |
| HLFHerbalife Ltd. | 182,555 | $2.7M |
| NEONeoGenomics Inc. | 359,913 | $2.7M |
| ELVNEnliven Therapeutics, Inc. | 67,475 | $2.6M |
| ARDXARDELYX, INC. | 440,674 | $2.6M |
| OCULOCULAR THERAPEUTIX, INC | 308,906 | $2.6M |
| ARRYARRAY BIOPHARMA INC | 359,654 | $2.6M |
| ANIPANI PHARMACEUTICALS INC | 32,782 | $2.5M |
| NKTRNEKTAR THERAPEUTICS | 34,025 | $2.4M |
| NRIXNurix Therapeutics, Inc. | 157,350 | $2.4M |
| SLNOSOLENO THERAPEUTICS INC | 71,986 | $2.4M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 76,377 | $2.3M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 40,423 | $2.2M |
| NUVBNuvation Bio Inc. | 512,161 | $2.2M |
| PHVSPharvaris N.V. | 77,646 | $2.2M |
| AMLXAmylyx Pharmaceuticals, Inc. | 157,089 | $2.2M |
| MLYSMineralys Therapeutics, Inc. | 79,537 | $2.2M |
| KNSAKiniksa Pharmaceuticals International, plc | 44,525 | $2.1M |
| NVAXNOVAVAX INC | 261,266 | $2.1M |
| RLAYRelay Therapeutics, Inc. | 210,468 | $2.1M |
| STOKStoke Therapeutics, Inc. | 58,185 | $1.9M |
| GERNGERON CORP | 1,271,014 | $1.9M |
| TRVITrevi Therapeutics, Inc. | 154,168 | $1.8M |
| ICLRICON plc | 16,564 | $1.8M |
| NVONovo Nordisk A/S | 49,637 | $1.8M |
| ALMSALUMIS INC. | 82,074 | $1.8M |
| COLLCOLLEGIUM PHARMACEUTICAL, INC | 52,192 | $1.7M |
| TEVATeva Pharmaceutical Industries Limited | 57,244 | $1.7M |
| ANABANAPTYSBIO, INC | 30,727 | $1.7M |
| PCRXPacira BioSciences, Inc. | 74,070 | $1.7M |
| KODKodiak Sciences Inc. | 43,751 | $1.7M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 474,099 | $1.7M |
| WVEWave Life Sciences Ltd. | 225,114 | $1.6M |
| FLGTFulgent Genetics Inc. | 101,303 | $1.6M |
| CSTLCastle Biosciences Inc. | 64,964 | $1.6M |
| TNGXTango Therapeutics, Inc. | 75,717 | $1.6M |
| SMMTSummit Therapeutics Inc. | 79,696 | $1.5M |
| SNYSanofi | 30,508 | $1.5M |
| XNCRXencor Inc | 121,342 | $1.5M |
| MLTXMoonLake Immunotherapeutics | 74,162 | $1.4M |
| PGENPRECIGEN, INC. | 354,559 | $1.4M |
| QUREuniQure N.V. | 82,633 | $1.4M |
| TLRYTilray Brands, Inc. | 196,335 | $1.3M |
| JANXJanux Therapeutics, Inc. | 87,757 | $1.2M |
| CLOVClover Health Investments Corp. | 681,795 | $1.2M |
| TSHATaysha Gene Therapies, Inc. | 265,795 | $1.2M |
| ARVNARVINAS, INC. | 110,974 | $1.2M |
| VIRVir Biotechnology, Inc. | 130,503 | $1.2M |
| CRMDCorMedix Inc. | 171,882 | $1.2M |
| AMPHAmphastar Pharmaceuticals, Inc. | 55,375 | $1.1M |
| MYGNMYRIAD GENETICS INC | 233,748 | $1.1M |
| TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) | 56,108 | $1.0M |
| KURAKura Oncology, Inc. | 124,153 | $1.0M |
| CGEMCullinan Therapeutics, Inc. | 67,656 | $961K |
| ATAIAtai Beckley N.V. | 266,000 | $942K |
| CTMXCytomX Therapeutics, Inc. | 189,400 | $890K |
| GMABGenmab A/S | 32,644 | $876K |
| URGNUroGen Pharma Ltd. | 47,419 | $853K |
| MDXGMiMedx Group Inc | 210,333 | $831K |
| ORKAOruka Therapeutics, Inc. | 16,902 | $829K |
| OPKOPKO HEALTH, INC. | 674,848 | $769K |
| CMPXCompass Therapeutics, Inc. | 139,642 | $739K |
| ANNXAnnexon, Inc. | 130,647 | $724K |
| KALVKalVista Pharmaceuticals, Inc. | 34,743 | $699K |
| ORICOric Pharmaceuticals, Inc. | 54,239 | $687K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 31,820 | $687K |
| SANASana Biotechnology, Inc. | 231,706 | $667K |
| ONCBeOne Medicines Ltd. | 2,137 | $635K |
| PHATPhathom Pharmaceuticals, Inc. | 55,788 | $620K |
| DNAGinkgo Bioworks Holdings Inc. | 64,577 | $396K |
| OLMAOlema Pharmaceuticals, Inc. | 25,025 | $373K |
| RDYDR REDDYS LABORATORIES LTD | 23,462 | $325K |
| GLUEMonte Rosa Therapeutics, Inc. | 19,279 | $317K |
| TBPHTheravance Biopharma, Inc. | 19,441 | $316K |
| ZBIOZenas BioPharma, Inc. | 15,523 | $303K |
| TYRATyra Biosciences, Inc. | 7,832 | $300K |
| PRMEPrime Medicine, Inc. | 85,300 | $297K |
| FMSFresenius Medical Care AG American Depositary Shares (Each representing 1/2 of an Ordinary Share) | 12,784 | $288K |
| SVRASavara Inc | 52,718 | $288K |
| AVBPArriVent BioPharma, Inc. | 11,357 | $262K |
| QGENQIAGEN N.V. | 6,343 | $254K |
| LENZLENZ Therapeutics, Inc. | 25,788 | $236K |
| MBXMBX Biosciences, Inc. | 7,238 | $216K |
| CRVSCorvus Pharmaceuticals, Inc. | 6,116 | $89K |
| DFTXDefinium Therapeutics Inc. | 2,413 | $46K |
| INDVIndivior Pharmaceuticals, Inc. | 1,450 | $44K |
| VMDViemed Healthcare Inc. | 4,305 | $40K |
| CLPTClearPoint Neuro Inc. | 3,665 | $33K |
| AURAAura Biosciences, Inc. | 4,517 | $30K |
| RNACCartesian Therapeutics, Inc. | 4,533 | $28K |
| UTMDUtah Medical Products Inc. | 393 | $24K |
| ZVRAZEVRA THERAPEUTICS, INC. | 2,118 | $20K |
| SLDBSolid Biosciences Inc. | 2,133 | $15K |
| ABEOABEONA THERAPEUTICS INC. | 3,412 | $15K |
| KROSKeros Therapeutics, Inc. | 1,366 | $15K |
| RIGLRIGEL PHARMACEUTICALS INC | 536 | $14K |
| RGNXREGENXBIO Inc. | 1,700 | $14K |
| ARCTArcturus Therapeutics Holdings Inc. | 1,787 | $14K |
| FHTXFoghorn Therapeutics Inc. | 2,876 | $14K |
| OFIXOrthofix Medical Inc. Common Stock (DE) | 1,190 | $14K |
| ALTAltimmune, Inc. | 4,154 | $13K |
| NATRNATURES SUNSHINE PRODUCTS INC | 532 | $13K |
| MAZEMaze Therapeutics, Inc. | 427 | $13K |
| MGTXMeiraGTx Holdings plc | 1,464 | $13K |
| GLSIGreenwich LifeSciences, Inc. | 521 | $13K |
| AVIRAtea Pharmaceuticals, Inc. | 2,319 | $12K |
| DSGNDesign Therapeutics, Inc. | 1,143 | $12K |
| BCAXBicara Therapeutics Inc. | 610 | $12K |
| ZLABZai Lab Ltd | 628 | $12K |
| TECXTectonic Therapeutic, Inc. | 382 | $12K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 1,224 | $11K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,710 | $11K |
| VSTMVerastem, Inc. | 1,852 | $10K |
| ETONEton Pharmaceuticals, Inc. | 368 | $9K |
| XOMAXOMA Royalty Corporation | 283 | $9K |
| RNAAtrium Therapeutics Inc. | 612 | $8K |
| ALDXAldeyra Therapeutics, Inc. | 4,825 | $8K |
| GRFSGrifols S.A. | 940 | $8K |
| CYRXCryoport, Inc. | 908 | $8K |
| SUNSUNSET ISLAND GROUP | 107 | $7K |
| JBIOJade Biosciences, Inc. | 493 | $7K |
| BVSBioventus Inc. | 736 | $7K |
| NPCENeuropace Inc. | 502 | $7K |
| FDMT4D Molecular Therapeutics, Inc. | 691 | $6K |
| NUSNu Skin Enterprises Inc. | 879 | $6K |
| FULCFulcrum Therapeutics, Inc. | 773 | $6K |
| NGNENeurogene Inc. | 292 | $6K |
| OMEROMEROS CORP | 547 | $6K |
| IMCRImmunocore Holdings plc | 185 | $6K |
| TRDAEntrada Therapeutics, Inc. | 435 | $5K |
| UPBUpstream Bio, Inc. | 588 | $5K |
| SIONSionna Therapeutics, Inc. | 116 | $5K |
| INBXInhibrx Biosciences, Inc. | 67 | $5K |
| SEPNSepterna, Inc. | 155 | $4K |
| SIGASIGA TECHNOLOGIES INC | 625 | $3K |
| KMTSKestra Medical Technologies Ltd. | 151 | $3K |
| REPLReplimune Group, Inc. | 388 | $3K |
| KRROKorro Bio, Inc. | 225 | $3K |
| TARAProtara Therapeutics, Inc. | 451 | $2K |
| VYGRVoyager Therapeutics, Inc. | 595 | $2K |
| USNAUSANA HEALTH SCIENCES INC | 131 | $2K |
| AQSTAquestive Therapeutics, Inc. | 542 | $2K |
| TNXPTonix Pharmaceuticals Holding Corp. | 141 | $2K |
| FENCFENNEC PHARMACEUTICALS INC. | 303 | $2K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 2,078 | $2K |
| MDWDMediWound Ltd. | 101 | $2K |
| ATYRaTYR PHARMA INC | 2,011 | $2K |
| DMACDiaMedica Therapeutics Inc. | 203 | $1K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 131 | $1K |
| EBSEmergent BioSolutions Inc. | 146 | $1K |
| EDITEditas Medicine, Inc. | 480 | $1K |
| NAGENiagen Bioscience, Inc. | 264 | $1K |
| FATEFATE THERAPEUTICS INC | 815 | $978 |
| AGENAGENUS INC | 285 | $952 |
| RCKTRocket Pharmaceuticals Inc. | 261 | $934 |
| BBNXBeta Bionics Inc. | 88 | $882 |
| AVXLANAVEX LIFE SCIENCES CORP. | 222 | $682 |
| CADLCandel Therapeutics, Inc. | 138 | $676 |
| BDTXBlack Diamond Therapeutics, Inc. | 275 | $586 |
| SOPHSOPHiA GENETICS SA | 77 | $381 |
| NRCNational Research Corporation Common Stock (Delaware) | 18 | $306 |
| KRMDKORU Medical Systems Inc. Common Stock (DE) | 57 | $246 |
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| MGNXMACROGENICS INC | 55 | $159 |
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