| GILDGILEAD SCIENCES, INC. | 13,199,103 | $1.84B |
| REGNREGENERON PHARMACEUTICALS, INC. | 723,621 | $559.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 677,519 | $224.2M |
| INSMINSMED Inc | 1,215,025 | $198.7M |
| INCYIncyte Corp. | 1,540,913 | $145.0M |
| IONSIONIS PHARMACEUTICALS INC | 1,475,632 | $110.8M |
| DNLIDenali Therapeutics Inc. | 4,432,314 | $85.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,330,996 | $83.5M |
| MRNAModerna, Inc. | 1,620,574 | $82.3M |
| EXELEXELIXIS, INC. | 1,292,017 | $55.4M |
| RVMDREVOLUTION MEDICINES, INC. | 500,595 | $48.7M |
| ROIVRoivant Sciences Ltd. | 1,741,480 | $48.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 850,819 | $48.1M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 541,450 | $47.1M |
| LGNDLigand Pharmaceuticals Incorporated | 212,888 | $42.5M |
| BEAMBeam Therapeutics Inc. | 1,653,714 | $39.4M |
| BBIOBridgeBio Pharma, Inc. | 402,948 | $29.9M |
| JAZZJazz Pharmaceuticals plc | 147,764 | $27.9M |
| ABCLAbCellera Biologics Inc. | 7,575,476 | $26.4M |
| PCVXVaxcyte, Inc. | 410,605 | $23.9M |
| ARGXARGENX SE | 27,506 | $20.1M |
| VRDNViridian Therapeutics, Inc.\DE | 888,298 | $17.4M |
| AXSMAxsome Therapeutics, Inc. | 94,937 | $16.0M |
| CYTKCYTOKINETICS INC | 240,632 | $15.9M |
| NUVLNuvalent, Inc. | 122,187 | $12.5M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 4,023,398 | $12.4M |
| PTGXProtagonist Therapeutics, Inc | 107,437 | $11.3M |
| SYRESpyre Therapeutics, Inc. | 207,314 | $10.5M |
| CLLSCellectis S.A. | 3,178,620 | $10.1M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 285,285 | $9.1M |
| PVLAPALVELLA THERAPEUTICS, INC. | 69,901 | $8.7M |
| PTCTPTC THERAPEUTICS, INC. | 126,963 | $8.6M |
| VKTXViking Therapeutics, Inc. | 253,894 | $8.3M |
| FOLDAMICUS THERAPEUTICS, INC. | 557,170 | $8.1M |
| ZYMEZymeworks Inc. | 319,385 | $8.0M |
| TGTXTG THERAPEUTICS, INC. | 235,477 | $7.8M |
| APLSApellis Pharmaceuticals, Inc. | 179,953 | $7.2M |
| IRONDisc Medicine, Inc. | 110,890 | $7.1M |
| COGTCogent Biosciences, Inc. | 165,510 | $6.4M |
| ARQTArcutis Biotherapeutics, Inc. | 237,171 | $5.6M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 107,856 | $5.6M |
| BHVNBiohaven Ltd. | 618,180 | $5.2M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 60,435 | $5.1M |
| SRRKScholar Rock Holding Corp | 102,912 | $5.1M |
| TERNTerns Pharmaceuticals, Inc. | 94,646 | $5.0M |
| APGEApogee Therapeutics, Inc. | 56,352 | $4.7M |
| OGNOrganon & Co. | 778,905 | $4.7M |
| ACADACADIA PHARMACEUTICALS INC | 206,884 | $4.6M |
| LQDALiquidia Corp | 116,614 | $4.4M |
| IBRXImmunityBio, Inc. | 532,675 | $4.1M |
| TVTXTravere Therapeutics, Inc. | 137,025 | $4.1M |
| HRMYHarmony Biosciences Holdings, Inc. | 141,540 | $4.0M |
| XERSXeris Biopharma Holdings, Inc. | 668,074 | $3.9M |
| CLDXCelldex Therapeutics, Inc. | 120,807 | $3.8M |
| ABUSArbutus Biopharma Corp | 838,210 | $3.8M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 110,679 | $3.7M |
| SPRYARS Pharmaceuticals, Inc. | 464,681 | $3.7M |
| NTLAIntellia Therapeutics, Inc. | 283,958 | $3.6M |
| ADMAADMA BIOLOGICS, INC. | 393,651 | $3.5M |
| IMVTImmunovant, Inc. | 141,728 | $3.5M |
| RCUSArcus Biosciences, Inc. | 158,292 | $3.4M |
| VCELVericel Corp | 100,071 | $3.2M |
| INVAInnoviva, Inc. | 134,571 | $3.1M |
| ADPTAdaptive Biotechnologies Corp | 222,524 | $3.1M |
| DAWNDay One Biopharmaceuticals, Inc. | 136,991 | $2.9M |
| ELVNEnliven Therapeutics, Inc. | 67,475 | $2.6M |
| ARDXARDELYX, INC. | 440,674 | $2.6M |
| OCULOCULAR THERAPEUTIX, INC | 308,906 | $2.6M |
| ANIPANI PHARMACEUTICALS INC | 32,782 | $2.5M |
| NKTRNEKTAR THERAPEUTICS | 34,025 | $2.4M |
| NRIXNurix Therapeutics, Inc. | 157,350 | $2.4M |
| SLNOSOLENO THERAPEUTICS INC | 71,986 | $2.4M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 76,377 | $2.3M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 40,423 | $2.2M |
| NUVBNuvation Bio Inc. | 512,161 | $2.2M |
| PHVSPharvaris N.V. | 77,646 | $2.2M |
| KNSAKiniksa Pharmaceuticals International, plc | 44,525 | $2.1M |
| STOKStoke Therapeutics, Inc. | 58,185 | $1.9M |
| GERNGERON CORP | 1,271,014 | $1.9M |
| ALMSALUMIS INC. | 82,074 | $1.8M |
| HROWHARROW, INC. | 50,967 | $1.8M |
| TEVATeva Pharmaceutical Industries Limited | 57,244 | $1.7M |
| ANABANAPTYSBIO, INC | 30,727 | $1.7M |
| KODKodiak Sciences Inc. | 43,751 | $1.7M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 474,099 | $1.7M |
| FLGTFulgent Genetics Inc. | 101,303 | $1.6M |
| TNGXTango Therapeutics, Inc. | 75,717 | $1.6M |
| SMMTSummit Therapeutics Inc. | 79,696 | $1.5M |
| SNYSanofi | 30,508 | $1.5M |
| MLTXMoonLake Immunotherapeutics | 74,162 | $1.4M |
| PGENPRECIGEN, INC. | 354,559 | $1.4M |
| QUREuniQure N.V. | 82,633 | $1.4M |
| ARVNARVINAS, INC. | 110,974 | $1.2M |
| KURAKura Oncology, Inc. | 124,153 | $1.0M |
| CGEMCullinan Therapeutics, Inc. | 67,656 | $961K |
| ATAIAtai Beckley N.V. | 266,000 | $942K |
| CTMXCytomX Therapeutics, Inc. | 189,400 | $890K |
| GMABGenmab A/S | 32,644 | $876K |
| ORKAOruka Therapeutics, Inc. | 16,902 | $829K |
| OPKOPKO HEALTH, INC. | 674,848 | $769K |
| CMPXCompass Therapeutics, Inc. | 139,642 | $739K |
| ANNXAnnexon, Inc. | 130,647 | $724K |
| KALVKalVista Pharmaceuticals, Inc. | 34,743 | $699K |
| ORICOric Pharmaceuticals, Inc. | 54,239 | $687K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 31,820 | $687K |
| SANASana Biotechnology, Inc. | 231,706 | $667K |
| ONCBeOne Medicines Ltd. | 2,137 | $635K |
| DNAGinkgo Bioworks Holdings Inc. | 64,577 | $396K |
| OLMAOlema Pharmaceuticals, Inc. | 25,025 | $373K |
| RDYDR REDDYS LABORATORIES LTD | 23,462 | $325K |
| ZBIOZenas BioPharma, Inc. | 15,523 | $303K |
| SVRASavara Inc | 52,718 | $288K |
| LENZLENZ Therapeutics, Inc. | 25,788 | $236K |
| DFTXDefinium Therapeutics Inc. | 2,413 | $46K |
| RNACCartesian Therapeutics, Inc. | 4,533 | $28K |
| ZVRAZEVRA THERAPEUTICS, INC. | 2,118 | $20K |
| SLDBSolid Biosciences Inc. | 2,133 | $15K |
| ABEOABEONA THERAPEUTICS INC. | 3,412 | $15K |
| KROSKeros Therapeutics, Inc. | 1,366 | $15K |
| RGNXREGENXBIO Inc. | 1,700 | $14K |
| ALTAltimmune, Inc. | 4,154 | $13K |
| MAZEMaze Therapeutics, Inc. | 427 | $13K |
| GLSIGreenwich LifeSciences, Inc. | 521 | $13K |
| DSGNDesign Therapeutics, Inc. | 1,143 | $12K |
| BCAXBicara Therapeutics Inc. | 610 | $12K |
| TECXTectonic Therapeutic, Inc. | 382 | $12K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 1,224 | $11K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,710 | $11K |
| XOMAXOMA Royalty Corporation | 283 | $9K |
| RNAAtrium Therapeutics Inc. | 612 | $8K |
| ALDXAldeyra Therapeutics, Inc. | 4,825 | $8K |
| GRFSGrifols S.A. | 940 | $8K |
| JBIOJade Biosciences, Inc. | 493 | $7K |
| FDMT4D Molecular Therapeutics, Inc. | 691 | $6K |
| NGNENeurogene Inc. | 292 | $6K |
| IMCRImmunocore Holdings plc | 185 | $6K |
| TRDAEntrada Therapeutics, Inc. | 435 | $5K |
| UPBUpstream Bio, Inc. | 588 | $5K |
| SIONSionna Therapeutics, Inc. | 116 | $5K |
| SIGASIGA TECHNOLOGIES INC | 625 | $3K |
| KRROKorro Bio, Inc. | 225 | $3K |
| VYGRVoyager Therapeutics, Inc. | 595 | $2K |
| AQSTAquestive Therapeutics, Inc. | 542 | $2K |
| TNXPTonix Pharmaceuticals Holding Corp. | 141 | $2K |
| FENCFENNEC PHARMACEUTICALS INC. | 303 | $2K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 2,078 | $2K |
| MDWDMediWound Ltd. | 101 | $2K |
| DMACDiaMedica Therapeutics Inc. | 203 | $1K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 131 | $1K |
| FATEFATE THERAPEUTICS INC | 815 | $978 |
| AGENAGENUS INC | 285 | $952 |
| RCKTRocket Pharmaceuticals Inc. | 261 | $934 |
| AVXLANAVEX LIFE SCIENCES CORP. | 222 | $682 |
| CADLCandel Therapeutics, Inc. | 138 | $676 |
| BDTXBlack Diamond Therapeutics, Inc. | 275 | $586 |
| BIOABioAge Labs, Inc. | 7 | $122 |