| ALNYALNYLAM PHARMACEUTICALS, INC. | 426,723 | $141.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 162,814 | $125.8M |
| IONSIONIS PHARMACEUTICALS INC | 695,276 | $52.2M |
| BBIOBridgeBio Pharma, Inc. | 556,324 | $41.3M |
| GILDGILEAD SCIENCES, INC. | 206,207 | $28.7M |
| ARQTArcutis Biotherapeutics, Inc. | 1,103,490 | $26.0M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,705,829 | $24.7M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 262,968 | $22.9M |
| ONCBeOne Medicines Ltd. | 74,124 | $22.0M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 359,702 | $20.3M |
| AXSMAxsome Therapeutics, Inc. | 114,102 | $19.3M |
| APLSApellis Pharmaceuticals, Inc. | 449,796 | $18.1M |
| TGTXTG THERAPEUTICS, INC. | 513,813 | $17.1M |
| ANABANAPTYSBIO, INC | 267,703 | $14.8M |
| TERNTerns Pharmaceuticals, Inc. | 275,350 | $14.5M |
| LENZLENZ Therapeutics, Inc. | 1,506,499 | $13.8M |
| RNACCartesian Therapeutics, Inc. | 2,238,486 | $13.8M |
| ARGXARGENX SE | 18,679 | $13.6M |
| RVMDREVOLUTION MEDICINES, INC. | 120,769 | $11.7M |
| SMMTSummit Therapeutics Inc. | 613,877 | $11.6M |
| OLMAOlema Pharmaceuticals, Inc. | 738,552 | $11.0M |
| MRNAModerna, Inc. | 212,709 | $10.8M |
| NUVLNuvalent, Inc. | 104,801 | $10.7M |
| DAWNDay One Biopharmaceuticals, Inc. | 415,706 | $8.9M |
| COGTCogent Biosciences, Inc. | 226,259 | $8.7M |
| OCULOCULAR THERAPEUTIX, INC | 980,757 | $8.3M |
| ACADACADIA PHARMACEUTICALS INC | 370,458 | $8.2M |
| NKTRNEKTAR THERAPEUTICS | 107,385 | $7.7M |
| KNSAKiniksa Pharmaceuticals International, plc | 158,093 | $7.6M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 208,888 | $7.1M |
| INSMINSMED Inc | 39,316 | $6.4M |
| SLNOSOLENO THERAPEUTICS INC | 185,337 | $6.2M |
| LQDALiquidia Corp | 161,689 | $6.1M |
| TVTXTravere Therapeutics, Inc. | 200,111 | $5.9M |
| QUREuniQure N.V. | 345,983 | $5.7M |
| TECXTectonic Therapeutic, Inc. | 164,419 | $5.1M |
| TEVATeva Pharmaceutical Industries Limited | 167,580 | $5.0M |
| OGNOrganon & Co. | 831,424 | $5.0M |
| ANIPANI PHARMACEUTICALS INC | 63,538 | $4.9M |
| ARDXARDELYX, INC. | 697,284 | $4.2M |
| SNYSanofi | 113,857 | $3.9M |
| TNGXTango Therapeutics, Inc. | 178,915 | $3.7M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 1,032,168 | $3.6M |
| XERSXeris Biopharma Holdings, Inc. | 614,550 | $3.6M |
| NRIXNurix Therapeutics, Inc. | 224,535 | $3.5M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 62,711 | $3.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 38,738 | $3.3M |
| APGEApogee Therapeutics, Inc. | 38,348 | $3.2M |
| RNAAtrium Therapeutics Inc. | 231,466 | $3.1M |
| KALVKalVista Pharmaceuticals, Inc. | 143,966 | $2.9M |
| PHVSPharvaris N.V. | 96,384 | $2.7M |
| KODKodiak Sciences Inc. | 71,056 | $2.7M |
| NTLAIntellia Therapeutics, Inc. | 209,983 | $2.7M |
| ALMSALUMIS INC. | 114,198 | $2.5M |
| SRRKScholar Rock Holding Corp | 49,955 | $2.5M |
| DFTXDefinium Therapeutics Inc. | 125,522 | $2.4M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 230,920 | $2.2M |
| ZYMEZymeworks Inc. | 83,146 | $2.1M |
| MLTXMoonLake Immunotherapeutics | 110,217 | $2.1M |
| IRONDisc Medicine, Inc. | 31,709 | $2.0M |
| CNTACentessa Pharmaceuticals plc | 50,606 | $2.0M |
| ESPREsperion Therapeutics, Inc. | 700,153 | $1.9M |
| HROWHARROW, INC. | 50,119 | $1.8M |
| ZVRAZEVRA THERAPEUTICS, INC. | 182,864 | $1.7M |
| ADPTAdaptive Biotechnologies Corp | 121,986 | $1.7M |
| ATAIAtai Beckley N.V. | 469,693 | $1.7M |
| PVLAPALVELLA THERAPEUTICS, INC. | 13,067 | $1.6M |
| BHVNBiohaven Ltd. | 177,678 | $1.5M |
| RCUSArcus Biosciences, Inc. | 66,674 | $1.4M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 43,021 | $1.4M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 25,524 | $1.3M |
| LGNDLigand Pharmaceuticals Incorporated | 6,394 | $1.3M |
| AVTXAvalo Therapeutics, Inc. | 81,285 | $1.2M |
| ORKAOruka Therapeutics, Inc. | 24,463 | $1.2M |
| ABSIAbsci Corporation | 391,290 | $1.2M |
| EXELEXELIXIS, INC. | 27,072 | $1.2M |
| CTMXCytomX Therapeutics, Inc. | 241,215 | $1.1M |
| GPCRStructure Therapeutics Inc. | 22,646 | $1.1M |
| IVVDInvivyd, Inc. | 819,968 | $1.1M |
| MANEVeradermics Incorporated | 16,610 | $1.0M |
| AQSTAquestive Therapeutics, Inc. | 249,482 | $1.0M |
| BIOABioAge Labs, Inc. | 55,520 | $971K |
| SVRASavara Inc | 170,819 | $933K |
| GMABGenmab A/S | 34,533 | $927K |
| SPRYARS Pharmaceuticals, Inc. | 114,273 | $918K |
| DSGNDesign Therapeutics, Inc. | 86,117 | $916K |
| VRDNViridian Therapeutics, Inc.\DE | 43,909 | $859K |
| ZBIOZenas BioPharma, Inc. | 42,874 | $838K |
| FLGTFulgent Genetics Inc. | 52,534 | $835K |
| OCGNOcugen, Inc. | 434,009 | $786K |
| ADMAADMA BIOLOGICS, INC. | 83,226 | $750K |
| ORGOOrganogenesis Holdings Inc. | 311,182 | $738K |
| KURAKura Oncology, Inc. | 88,603 | $720K |
| CATXPerspective Therapeutics, Inc. | 169,147 | $705K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 859,958 | $688K |
| RGCRegencell Bioscience Holdings Ltd | 26,613 | $677K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 23,804 | $661K |
| JBIOJade Biosciences, Inc. | 44,650 | $627K |
| SGMTSagimet Biosciences Inc. | 118,620 | $620K |
| SIONSionna Therapeutics, Inc. | 15,217 | $610K |
| DMRADamora Therapeutics, Inc. | 23,458 | $608K |
| FDMT4D Molecular Therapeutics, Inc. | 62,513 | $582K |
| FBRXForte Biosciences, Inc. | 20,755 | $538K |
| NUVBNuvation Bio Inc. | 124,944 | $536K |
| MESOMesoblast Limited | 34,042 | $524K |
| SLNSilence Therapeutics Plc | 89,469 | $472K |
| IMCRImmunocore Holdings plc | 15,434 | $465K |
| SPROSpero Therapeutics, Inc. | 194,301 | $455K |
| RLMDRELMADA THERAPEUTICS, INC. | 63,426 | $441K |
| OVIDOvid Therapeutics Inc. | 197,971 | $439K |
| INCYIncyte Corp. | 4,444 | $418K |
| MAZEMaze Therapeutics, Inc. | 13,612 | $406K |
| IMMXImmix Biopharma, Inc. | 44,490 | $405K |
| UPBUpstream Bio, Inc. | 44,626 | $402K |
| MISTMilestone Pharmaceuticals Inc. | 336,825 | $401K |
| LYELLyell Immunopharma, Inc. | 19,294 | $387K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 43,190 | $387K |
| OCSOculis Holding AG | 14,447 | $384K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 12,500 | $380K |
| PROKPROKIDNEY CORP. | 211,107 | $378K |
| ANNXAnnexon, Inc. | 67,956 | $376K |
| FENCFENNEC PHARMACEUTICALS INC. | 56,510 | $348K |
| SANASana Biotechnology, Inc. | 118,475 | $341K |
| ASRTAssertio Holdings, Inc. | 17,892 | $341K |
| DNAGinkgo Bioworks Holdings Inc. | 54,930 | $337K |
| CHRSCoherus Oncology, Inc. | 194,405 | $329K |
| SLDBSolid Biosciences Inc. | 44,769 | $322K |
| SLSSELLAS Life Sciences Group, Inc. | 74,751 | $316K |
| SIGASIGA TECHNOLOGIES INC | 58,571 | $313K |
| CLYMClimb Bio, Inc. | 42,974 | $294K |
| IFRXInflaRx N.V. | 301,987 | $270K |
| RDYDR REDDYS LABORATORIES LTD | 19,425 | $269K |
| ZURAZura Bio Ltd | 44,939 | $267K |
| CMPXCompass Therapeutics, Inc. | 50,202 | $266K |
| ARVNARVINAS, INC. | 23,460 | $249K |
| PGENPRECIGEN, INC. | 62,767 | $243K |
| KLRSKalaris Therapeutics, Inc. | 39,773 | $229K |
| LCTXLineage Cell Therapeutics, Inc. | 143,190 | $226K |
| BCAXBicara Therapeutics Inc. | 10,771 | $214K |
| PLRXPLIANT THERAPEUTICS, INC. | 163,215 | $206K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 52,988 | $163K |
| RGNXREGENXBIO Inc. | 16,981 | $142K |
| ABCLAbCellera Biologics Inc. | 31,749 | $111K |
| CCCCC4 Therapeutics, Inc. | 40,664 | $107K |
| TVRDTvardi Therapeutics, Inc. | 32,676 | $104K |
| RCKTRocket Pharmaceuticals Inc. | 28,986 | $104K |
| PLYXPolaryx Therapeutics Inc. | 12,406 | $94K |
| CMPSCOMPASS Pathways plc | 16,293 | $90K |
| RZLTRezolute, Inc. | 29,283 | $89K |
| ZNTLZentalis Pharmaceuticals, Inc. | 30,691 | $72K |
| NBPNovaBridge Biosciences | 23,807 | $59K |
| JSPRJasper Therapeutics Inc. | 64,915 | $57K |
| ALTAltimmune, Inc. | 18,126 | $56K |
| NNVCNANOVIRICIDES, INC. | 58,138 | $53K |
| PRQRProQR Therapeutics N.V. | 31,518 | $51K |
| INOINOVIO PHARMACEUTICALS, INC. | 24,837 | $43K |
| CRDFCardiff Oncology, Inc. | 26,356 | $43K |
| AGENAGENUS INC | 12,373 | $41K |
| BDTXBlack Diamond Therapeutics, Inc. | 15,280 | $33K |
| CGTXCOGNITION THERAPEUTICS INC | 26,546 | $20K |
| ABVCABVC BIOPHARMA, INC. | 10,547 | $10K |