| REGNREGENERON PHARMACEUTICALS, INC. | 228,086 | $175.7M |
| GILDGILEAD SCIENCES, INC. | 1,067,837 | $148.3M |
| INCYIncyte Corp. | 638,242 | $59.7M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,051,317 | $57.9M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 147,533 | $48.5M |
| MRNAModerna, Inc. | 710,640 | $36.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 606,224 | $34.2M |
| INSMINSMED Inc | 169,162 | $27.7M |
| EXELEXELIXIS, INC. | 624,023 | $26.8M |
| BBIOBridgeBio Pharma, Inc. | 351,719 | $26.1M |
| SNYSanofi | 527,185 | $25.4M |
| LGNDLigand Pharmaceuticals Incorporated | 121,151 | $24.2M |
| PTCTPTC THERAPEUTICS, INC. | 335,439 | $22.9M |
| GMABGenmab A/S | 797,068 | $21.4M |
| ROIVRoivant Sciences Ltd. | 707,171 | $19.6M |
| COGTCogent Biosciences, Inc. | 374,868 | $14.4M |
| TERNTerns Pharmaceuticals, Inc. | 244,898 | $12.9M |
| TEVATeva Pharmaceutical Industries Limited | 393,588 | $11.7M |
| CYTKCYTOKINETICS INC | 174,029 | $11.5M |
| INVAInnoviva, Inc. | 469,519 | $10.9M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 173,995 | $10.9M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 129,065 | $10.8M |
| ANIPANI PHARMACEUTICALS INC | 138,941 | $10.7M |
| JAZZJazz Pharmaceuticals plc | 55,214 | $10.4M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 115,712 | $10.1M |
| RVMDREVOLUTION MEDICINES, INC. | 99,117 | $9.6M |
| NUVLNuvalent, Inc. | 92,502 | $9.5M |
| NKTRNEKTAR THERAPEUTICS | 106,248 | $7.6M |
| ABVXAbivax SA | 65,273 | $7.3M |
| TVTXTravere Therapeutics, Inc. | 234,265 | $7.0M |
| ONCBeOne Medicines Ltd. | 23,447 | $6.9M |
| TGTXTG THERAPEUTICS, INC. | 199,652 | $6.6M |
| ADMAADMA BIOLOGICS, INC. | 711,693 | $6.4M |
| AXSMAxsome Therapeutics, Inc. | 35,718 | $6.0M |
| APGEApogee Therapeutics, Inc. | 58,484 | $4.9M |
| IONSIONIS PHARMACEUTICALS INC | 62,919 | $4.7M |
| VRDNViridian Therapeutics, Inc.\DE | 234,551 | $4.6M |
| VCELVericel Corp | 138,286 | $4.4M |
| PTGXProtagonist Therapeutics, Inc | 40,376 | $4.3M |
| ANNXAnnexon, Inc. | 711,380 | $3.9M |
| ADPTAdaptive Biotechnologies Corp | 274,416 | $3.8M |
| ALMSALUMIS INC. | 162,180 | $3.6M |
| BEAMBeam Therapeutics Inc. | 144,722 | $3.4M |
| ORICOric Pharmaceuticals, Inc. | 263,059 | $3.3M |
| LQDALiquidia Corp | 86,890 | $3.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 57,776 | $3.0M |
| HROWHARROW, INC. | 79,989 | $2.8M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 84,385 | $2.7M |
| FBRXForte Biosciences, Inc. | 91,772 | $2.4M |
| DFTXDefinium Therapeutics Inc. | 119,464 | $2.3M |
| ORKAOruka Therapeutics, Inc. | 45,459 | $2.2M |
| XERSXeris Biopharma Holdings, Inc. | 384,195 | $2.2M |
| PCVXVaxcyte, Inc. | 38,179 | $2.2M |
| SLNOSOLENO THERAPEUTICS INC | 58,692 | $2.0M |
| SIONSionna Therapeutics, Inc. | 48,419 | $1.9M |
| APLSApellis Pharmaceuticals, Inc. | 44,757 | $1.8M |
| LBRXLB PHARMACEUTICALS INC | 72,067 | $1.8M |
| RCUSArcus Biosciences, Inc. | 80,833 | $1.7M |
| PVLAPALVELLA THERAPEUTICS, INC. | 13,527 | $1.7M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 251,653 | $1.6M |
| CNTACentessa Pharmaceuticals plc | 38,812 | $1.5M |
| JBIOJade Biosciences, Inc. | 107,596 | $1.5M |
| FLGTFulgent Genetics Inc. | 93,481 | $1.5M |
| ARQTArcutis Biotherapeutics, Inc. | 62,245 | $1.5M |
| ARVNARVINAS, INC. | 137,185 | $1.5M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 39,710 | $1.3M |
| OCULOCULAR THERAPEUTIX, INC | 152,884 | $1.3M |
| NRIXNurix Therapeutics, Inc. | 81,841 | $1.3M |
| ZYMEZymeworks Inc. | 47,450 | $1.2M |
| IVAInventiva S.A. | 205,639 | $1.1M |
| NUVBNuvation Bio Inc. | 265,700 | $1.1M |
| KALVKalVista Pharmaceuticals, Inc. | 56,192 | $1.1M |
| BIOABioAge Labs, Inc. | 63,256 | $1.1M |
| ARGXARGENX SE | 1,493 | $1.1M |
| ACADACADIA PHARMACEUTICALS INC | 46,935 | $1.0M |
| VKTXViking Therapeutics, Inc. | 31,492 | $1.0M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 100,627 | $978K |
| MAZEMaze Therapeutics, Inc. | 32,526 | $971K |
| RGNXREGENXBIO Inc. | 113,425 | $951K |
| AQSTAquestive Therapeutics, Inc. | 226,163 | $939K |
| KROSKeros Therapeutics, Inc. | 81,311 | $898K |
| NTLAIntellia Therapeutics, Inc. | 59,432 | $762K |
| ANABANAPTYSBIO, INC | 13,288 | $737K |
| KODKodiak Sciences Inc. | 18,629 | $710K |
| IBRXImmunityBio, Inc. | 92,548 | $710K |
| OGNOrganon & Co. | 116,433 | $692K |
| KURAKura Oncology, Inc. | 83,533 | $679K |
| SRRKScholar Rock Holding Corp | 13,740 | $675K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 163,092 | $572K |
| GPCRStructure Therapeutics Inc. | 10,701 | $516K |
| SYRESpyre Therapeutics, Inc. | 9,931 | $501K |
| BCAXBicara Therapeutics Inc. | 19,893 | $396K |
| FOLDAMICUS THERAPEUTICS, INC. | 25,140 | $364K |
| SMMTSummit Therapeutics Inc. | 17,986 | $341K |
| BHVNBiohaven Ltd. | 40,243 | $340K |
| ARDXARDELYX, INC. | 56,286 | $337K |
| DSGNDesign Therapeutics, Inc. | 25,437 | $271K |
| DNLIDenali Therapeutics Inc. | 14,058 | $270K |
| CLDXCelldex Therapeutics, Inc. | 8,491 | $269K |
| TNGXTango Therapeutics, Inc. | 12,840 | $269K |
| DAWNDay One Biopharmaceuticals, Inc. | 11,134 | $239K |
| IMVTImmunovant, Inc. | 8,145 | $202K |
| SIGASIGA TECHNOLOGIES INC | 37,665 | $202K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 64,990 | $200K |
| RCKTRocket Pharmaceuticals Inc. | 54,603 | $195K |
| QUREuniQure N.V. | 10,656 | $174K |
| IRONDisc Medicine, Inc. | 2,634 | $168K |
| TRDAEntrada Therapeutics, Inc. | 11,633 | $147K |
| ALDXAldeyra Therapeutics, Inc. | 84,300 | $142K |
| ALECAlector, Inc. | 66,131 | $142K |
| DNAGinkgo Bioworks Holdings Inc. | 23,095 | $142K |
| RZLTRezolute, Inc. | 46,111 | $141K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 4,581 | $139K |
| STOKStoke Therapeutics, Inc. | 3,622 | $118K |
| ELVNEnliven Therapeutics, Inc. | 3,001 | $118K |
| ABUSArbutus Biopharma Corp | 22,675 | $102K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 4,664 | $101K |
| LENZLENZ Therapeutics, Inc. | 10,934 | $100K |
| OLMAOlema Pharmaceuticals, Inc. | 6,579 | $98K |
| SLSSELLAS Life Sciences Group, Inc. | 18,006 | $76K |
| TVRDTvardi Therapeutics, Inc. | 23,307 | $74K |
| GERNGERON CORP | 49,047 | $73K |
| MDWDMediWound Ltd. | 4,483 | $72K |
| RDYDR REDDYS LABORATORIES LTD | 4,902 | $68K |
| SLDBSolid Biosciences Inc. | 8,888 | $64K |
| MLTXMoonLake Immunotherapeutics | 3,426 | $64K |
| CRVOCervoMed Inc. | 16,090 | $63K |
| ABEOABEONA THERAPEUTICS INC. | 14,054 | $63K |
| CGEMCullinan Therapeutics, Inc. | 4,272 | $61K |
| SVRASavara Inc | 10,797 | $59K |
| ESPREsperion Therapeutics, Inc. | 21,483 | $59K |
| CMPXCompass Therapeutics, Inc. | 10,900 | $58K |
| ZBIOZenas BioPharma, Inc. | 2,721 | $53K |
| RNAAtrium Therapeutics Inc. | 3,839 | $51K |
| ALTAltimmune, Inc. | 16,092 | $50K |
| PGENPRECIGEN, INC. | 12,425 | $48K |
| ZVRAZEVRA THERAPEUTICS, INC. | 5,111 | $48K |
| SPRYARS Pharmaceuticals, Inc. | 5,140 | $41K |
| OPKOPKO HEALTH, INC. | 31,816 | $36K |
| CATXPerspective Therapeutics, Inc. | 8,477 | $35K |
| ABSIAbsci Corporation | 11,021 | $33K |
| UPBUpstream Bio, Inc. | 3,647 | $33K |
| NGNENeurogene Inc. | 1,607 | $32K |
| SANASana Biotechnology, Inc. | 11,066 | $32K |
| FDMT4D Molecular Therapeutics, Inc. | 3,143 | $29K |
| MPLTMapLight Therapeutics, Inc. | 1,337 | $27K |
| PLXProtalix BioTherapeutics, Inc. | 12,250 | $27K |
| TECXTectonic Therapeutic, Inc. | 851 | $26K |
| XOMAXOMA Royalty Corporation | 819 | $26K |
| CHRSCoherus Oncology, Inc. | 14,230 | $24K |
| KRROKorro Bio, Inc. | 2,115 | $24K |
| AVXLANAVEX LIFE SCIENCES CORP. | 6,340 | $19K |
| RGCRegencell Bioscience Holdings Ltd | 760 | $19K |
| CADLCandel Therapeutics, Inc. | 3,700 | $18K |
| DMACDiaMedica Therapeutics Inc. | 2,671 | $18K |
| FENCFENNEC PHARMACEUTICALS INC. | 2,862 | $18K |
| SGMOQSANGAMO THERAPEUTICS, INC | 68,778 | $17K |
| LRMRLarimar Therapeutics, Inc. | 3,589 | $16K |
| VYGRVoyager Therapeutics, Inc. | 4,054 | $16K |
| ORGOOrganogenesis Holdings Inc. | 5,657 | $13K |
| FLNAFilana Therapeutics Inc. | 7,320 | $12K |
| TNXPTonix Pharmaceuticals Holding Corp. | 870 | $12K |
| FATEFATE THERAPEUTICS INC | 9,731 | $12K |
| GRFSGrifols S.A. | 1,424 | $11K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 12,671 | $10K |
| CRDFCardiff Oncology, Inc. | 5,135 | $8K |
| NVCTNuvectis Pharma, Inc. | 1,066 | $8K |
| GYREGYRE THERAPEUTICS, INC. | 1,124 | $8K |
| HUMAHumacyte Inc. | 11,179 | $7K |
| HURATuHURA Biosciences, Inc./NV | 3,464 | $6K |
| KNSAKiniksa Pharmaceuticals International, plc | 122 | $6K |
| MGXMetagenomi Therapeutics, Inc. | 4,179 | $6K |
| RNACCartesian Therapeutics, Inc. | 849 | $5K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 446 | $4K |
| XFORX4 Pharmaceuticals, Inc | 729 | $3K |
| AARDAardvark Therapeutics, Inc. | 469 | $2K |
| AGENAGENUS INC | 433 | $1K |
| WHWKWhitehawk Therapeutics, Inc. | 386 | $1K |
| OCGNOcugen, Inc. | 521 | $943 |
| IMCRImmunocore Holdings plc | 30 | $905 |
| HCMHUTCHMED (China) Limited | 42 | $628 |
| CLYMClimb Bio, Inc. | 79 | $541 |
| BDTXBlack Diamond Therapeutics, Inc. | 250 | $533 |
| GALTGALECTIN THERAPEUTICS INC | 142 | $396 |
| MISTMilestone Pharmaceuticals Inc. | 125 | $149 |
| ATAIAtai Beckley N.V. | 23 | $81 |