| JAZZJazz Pharmaceuticals plc | 249,174 | $47.1M |
| SNYSanofi | 562,921 | $27.1M |
| PTCTPTC THERAPEUTICS, INC. | 384,672 | $26.2M |
| ACADACADIA PHARMACEUTICALS INC | 1,027,357 | $22.9M |
| REGNREGENERON PHARMACEUTICALS, INC. | 28,520 | $22.0M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 372,197 | $21.0M |
| GILDGILEAD SCIENCES, INC. | 104,165 | $14.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 173,438 | $8.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 128,795 | $7.1M |
| BBIOBridgeBio Pharma, Inc. | 53,621 | $4.0M |
| INCYIncyte Corp. | 37,120 | $3.5M |
| SYRESpyre Therapeutics, Inc. | 64,002 | $3.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 6,437 | $2.1M |
| ONCBeOne Medicines Ltd. | 6,377 | $1.9M |
| VKTXViking Therapeutics, Inc. | 57,156 | $1.9M |
| NTLAIntellia Therapeutics, Inc. | 141,523 | $1.8M |
| ROIVRoivant Sciences Ltd. | 54,257 | $1.5M |
| INSMINSMED Inc | 7,429 | $1.2M |
| MRNAModerna, Inc. | 20,578 | $1.0M |
| DFTXDefinium Therapeutics Inc. | 55,206 | $1.0M |
| APLSApellis Pharmaceuticals, Inc. | 20,634 | $830K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 261,513 | $803K |
| TNGXTango Therapeutics, Inc. | 36,340 | $760K |
| ARGXARGENX SE | 936 | $684K |
| LENZLENZ Therapeutics, Inc. | 73,340 | $671K |
| RDYDR REDDYS LABORATORIES LTD | 47,612 | $659K |
| ATAIAtai Beckley N.V. | 179,000 | $634K |
| AXSMAxsome Therapeutics, Inc. | 3,722 | $629K |
| PCVXVaxcyte, Inc. | 9,879 | $574K |
| PTGXProtagonist Therapeutics, Inc | 4,828 | $509K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 14,875 | $503K |
| DNLIDenali Therapeutics Inc. | 25,935 | $498K |
| VCELVericel Corp | 14,440 | $465K |
| ARQTArcutis Biotherapeutics, Inc. | 19,597 | $462K |
| GMABGenmab A/S | 16,073 | $431K |
| TEVATeva Pharmaceutical Industries Limited | 14,043 | $423K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 4,844 | $421K |
| ARDXARDELYX, INC. | 57,430 | $344K |
| HRMYHarmony Biosciences Holdings, Inc. | 12,061 | $338K |
| IONSIONIS PHARMACEUTICALS INC | 4,155 | $312K |
| ABUSArbutus Biopharma Corp | 63,000 | $284K |
| RCUSArcus Biosciences, Inc. | 12,929 | $279K |
| RGNXREGENXBIO Inc. | 31,502 | $264K |
| TGTXTG THERAPEUTICS, INC. | 7,321 | $243K |
| RCKTRocket Pharmaceuticals Inc. | 67,826 | $243K |
| TVTXTravere Therapeutics, Inc. | 8,109 | $241K |
| ADPTAdaptive Biotechnologies Corp | 17,263 | $240K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 55,468 | $195K |
| CYTKCYTOKINETICS INC | 2,869 | $189K |
| FDMT4D Molecular Therapeutics, Inc. | 17,854 | $166K |
| EXELEXELIXIS, INC. | 3,862 | $166K |
| RVMDREVOLUTION MEDICINES, INC. | 1,681 | $163K |
| ALTAltimmune, Inc. | 46,370 | $143K |
| LGNDLigand Pharmaceuticals Incorporated | 608 | $121K |
| GPCRStructure Therapeutics Inc. | 2,220 | $107K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 1,944 | $100K |
| KZIAKAZIA THERAPEUTICS LTD | 12,700 | $94K |
| CRDFCardiff Oncology, Inc. | 56,500 | $92K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,318 | $83K |
| NRIXNurix Therapeutics, Inc. | 5,318 | $82K |
| IMVTImmunovant, Inc. | 3,316 | $82K |
| AQSTAquestive Therapeutics, Inc. | 18,804 | $78K |
| APGEApogee Therapeutics, Inc. | 887 | $75K |
| ALGSAligos Therapeutics, Inc. | 10,000 | $74K |
| TERNTerns Pharmaceuticals, Inc. | 1,381 | $73K |
| SRRKScholar Rock Holding Corp | 1,428 | $70K |
| NUVBNuvation Bio Inc. | 15,236 | $65K |
| BEAMBeam Therapeutics Inc. | 2,532 | $60K |
| ARVNARVINAS, INC. | 5,665 | $60K |
| COGTCogent Biosciences, Inc. | 1,468 | $57K |
| AVXLANAVEX LIFE SCIENCES CORP. | 18,094 | $56K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 5,613 | $55K |
| CMPXCompass Therapeutics, Inc. | 10,182 | $54K |
| DNAGinkgo Bioworks Holdings Inc. | 8,337 | $51K |
| OCULOCULAR THERAPEUTIX, INC | 5,957 | $50K |
| SGMTSagimet Biosciences Inc. | 9,000 | $47K |
| IBRXImmunityBio, Inc. | 6,020 | $46K |
| MESOMesoblast Limited | 3,000 | $46K |
| ZURAZura Bio Ltd | 7,500 | $45K |
| SPRYARS Pharmaceuticals, Inc. | 5,454 | $44K |
| GERNGERON CORP | 27,996 | $42K |
| TENXTENAX THERAPEUTICS, INC. | 2,501 | $40K |
| SANASana Biotechnology, Inc. | 13,765 | $40K |
| DSGNDesign Therapeutics, Inc. | 3,684 | $39K |
| CLDXCelldex Therapeutics, Inc. | 1,151 | $37K |
| NUVLNuvalent, Inc. | 336 | $34K |
| VRDNViridian Therapeutics, Inc.\DE | 1,663 | $33K |
| ADMAADMA BIOLOGICS, INC. | 3,425 | $31K |
| GRFSGrifols S.A. | 3,281 | $26K |
| FOLDAMICUS THERAPEUTICS, INC. | 1,786 | $26K |
| EVOEvotec SE | 10,219 | $26K |
| RLAYRelay Therapeutics, Inc. | 2,263 | $23K |
| LQDALiquidia Corp | 573 | $22K |
| SLSSELLAS Life Sciences Group, Inc. | 5,000 | $21K |
| SLDBSolid Biosciences Inc. | 2,589 | $19K |
| ANABANAPTYSBIO, INC | 326 | $18K |
| ONCYONCOLYTICS BIOTECH INC | 20,939 | $18K |
| XERSXeris Biopharma Holdings, Inc. | 2,964 | $17K |
| PDSBPDS Biotechnology Corp | 27,664 | $17K |
| OGNOrganon & Co. | 2,626 | $16K |
| STOKStoke Therapeutics, Inc. | 481 | $16K |
| ORGOOrganogenesis Holdings Inc. | 6,487 | $15K |
| MISTMilestone Pharmaceuticals Inc. | 12,500 | $15K |
| CGTXCOGNITION THERAPEUTICS INC | 19,231 | $15K |
| HCMHUTCHMED (China) Limited | 963 | $14K |
| KALVKalVista Pharmaceuticals, Inc. | 665 | $13K |
| CATXPerspective Therapeutics, Inc. | 3,000 | $13K |
| GALTGALECTIN THERAPEUTICS INC | 4,386 | $12K |
| KURAKura Oncology, Inc. | 1,500 | $12K |
| BCAXBicara Therapeutics Inc. | 601 | $12K |
| SLNOSOLENO THERAPEUTICS INC | 344 | $12K |
| TECXTectonic Therapeutic, Inc. | 370 | $11K |
| OLMAOlema Pharmaceuticals, Inc. | 746 | $11K |
| PGENPRECIGEN, INC. | 2,697 | $10K |
| SIONSionna Therapeutics, Inc. | 241 | $10K |
| CGEMCullinan Therapeutics, Inc. | 649 | $9K |
| ANNXAnnexon, Inc. | 1,662 | $9K |
| OVIDOvid Therapeutics Inc. | 4,000 | $9K |
| LRMRLarimar Therapeutics, Inc. | 1,959 | $9K |
| ANIPANI PHARMACEUTICALS INC | 113 | $9K |
| LCTXLineage Cell Therapeutics, Inc. | 5,309 | $8K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 270 | $8K |
| FLGTFulgent Genetics Inc. | 512 | $8K |
| ZVRAZEVRA THERAPEUTICS, INC. | 793 | $7K |
| HROWHARROW, INC. | 207 | $7K |
| ORICOric Pharmaceuticals, Inc. | 573 | $7K |
| ESPREsperion Therapeutics, Inc. | 2,611 | $7K |
| CMPSCOMPASS Pathways plc | 1,276 | $7K |
| ABCLAbCellera Biologics Inc. | 2,000 | $7K |
| UPBUpstream Bio, Inc. | 738 | $7K |
| RNTXRein Therapeutics, Inc. | 5,097 | $7K |
| ABSIAbsci Corporation | 2,162 | $6K |
| BHVNBiohaven Ltd. | 747 | $6K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 700 | $6K |
| HUMAHumacyte Inc. | 10,150 | $6K |
| ALMSALUMIS INC. | 256 | $6K |
| ABEOABEONA THERAPEUTICS INC. | 1,250 | $6K |
| ABVXAbivax SA | 50 | $6K |
| TNXPTonix Pharmaceuticals Holding Corp. | 370 | $5K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 793 | $5K |
| KROSKeros Therapeutics, Inc. | 455 | $5K |
| VYGRVoyager Therapeutics, Inc. | 1,227 | $5K |
| ATNMActinium Pharmaceuticals, Inc. | 4,000 | $4K |
| INOINOVIO PHARMACEUTICALS, INC. | 2,037 | $4K |
| SIGASIGA TECHNOLOGIES INC | 630 | $3K |
| BMEABiomea Fusion, Inc. | 2,000 | $3K |
| ACIUAC Immune SA | 1,000 | $3K |
| CALCCalciMedica, Inc. | 5,000 | $3K |
| INVAInnoviva, Inc. | 98 | $2K |
| ANVSAnnovis Bio, Inc. | 1,000 | $2K |
| SGMOQSANGAMO THERAPEUTICS, INC | 7,900 | $2K |
| RNAAtrium Therapeutics Inc. | 142 | $2K |
| ATOSATOSSA THERAPEUTICS, INC. | 353 | $2K |
| ZYMEZymeworks Inc. | 61 | $2K |
| OPKOPKO HEALTH, INC. | 1,053 | $1K |
| IMUXIMMUNIC, INC. | 1,000 | $1K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 1,286 | $1K |
| ELVNEnliven Therapeutics, Inc. | 25 | $980 |
| PLRXPLIANT THERAPEUTICS, INC. | 660 | $832 |
| ALECAlector, Inc. | 367 | $789 |
| SMMTSummit Therapeutics Inc. | 37 | $702 |
| IVVDInvivyd, Inc. | 500 | $650 |
| CHRSCoherus Oncology, Inc. | 324 | $548 |
| LXRXLEXICON PHARMACEUTICALS, INC. | 335 | $523 |
| RGCRegencell Bioscience Holdings Ltd | 20 | $509 |
| VERUVERU INC. | 200 | $442 |
| BDTXBlack Diamond Therapeutics, Inc. | 200 | $426 |
| IMCRImmunocore Holdings plc | 8 | $241 |
| SLNSilence Therapeutics Plc | 45 | $237 |
| QUREuniQure N.V. | 14 | $229 |
| OCGNOcugen, Inc. | 84 | $152 |
| QNTMQuantum Biopharma Ltd. | 30 | $145 |
| XFORX4 Pharmaceuticals, Inc | 33 | $136 |
| INABIN8BIO, INC. | 83 | $123 |
| AYTUAYTU BIOPHARMA, INC | 10 | $27 |
| SKYESkye Bioscience, Inc. | 39 | $24 |
| BCYCBICYCLE THERAPEUTICS PLC | 5 | $23 |
| SCLXSCILEX HOLDING CO | 3 | $20 |
| SERSerina Therapeutics, Inc. | 2 | $4 |
| VIVSVivoSim Labs, INC. | 2 | $3 |