| GILDGILEAD SCIENCES, INC. | 2,236,312 | $311.7M |
| REGNREGENERON PHARMACEUTICALS, INC. | 157,781 | $121.9M |
| INCYIncyte Corp. | 693,665 | $65.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 195,277 | $64.6M |
| INSMINSMED Inc | 272,615 | $44.6M |
| JAZZJazz Pharmaceuticals plc | 164,542 | $31.1M |
| EXELEXELIXIS, INC. | 723,931 | $31.0M |
| ROIVRoivant Sciences Ltd. | 1,113,266 | $30.8M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 522,125 | $29.5M |
| MRNAModerna, Inc. | 560,359 | $28.5M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 404,436 | $25.4M |
| CYTKCYTOKINETICS INC | 369,575 | $24.4M |
| RVMDREVOLUTION MEDICINES, INC. | 179,942 | $17.5M |
| PTGXProtagonist Therapeutics, Inc | 157,413 | $16.6M |
| BBIOBridgeBio Pharma, Inc. | 205,785 | $15.3M |
| PTCTPTC THERAPEUTICS, INC. | 212,462 | $14.5M |
| IONSIONIS PHARMACEUTICALS INC | 173,440 | $13.0M |
| TGTXTG THERAPEUTICS, INC. | 385,339 | $12.8M |
| LGNDLigand Pharmaceuticals Incorporated | 56,800 | $11.3M |
| APLSApellis Pharmaceuticals, Inc. | 275,540 | $11.1M |
| PCVXVaxcyte, Inc. | 158,841 | $9.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 169,275 | $8.7M |
| AXSMAxsome Therapeutics, Inc. | 51,619 | $8.7M |
| ACADACADIA PHARMACEUTICALS INC | 355,461 | $7.9M |
| TEVATeva Pharmaceutical Industries Limited | 236,269 | $7.1M |
| COGTCogent Biosciences, Inc. | 175,276 | $6.7M |
| NUVLNuvalent, Inc. | 63,867 | $6.5M |
| TERNTerns Pharmaceuticals, Inc. | 123,334 | $6.5M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 69,858 | $6.1M |
| ADMAADMA BIOLOGICS, INC. | 627,945 | $5.7M |
| SRRKScholar Rock Holding Corp | 112,501 | $5.5M |
| FOLDAMICUS THERAPEUTICS, INC. | 376,187 | $5.4M |
| RCUSArcus Biosciences, Inc. | 241,492 | $5.2M |
| INVAInnoviva, Inc. | 199,898 | $4.7M |
| VCELVericel Corp | 141,559 | $4.6M |
| SYRESpyre Therapeutics, Inc. | 85,121 | $4.3M |
| APGEApogee Therapeutics, Inc. | 48,678 | $4.1M |
| VKTXViking Therapeutics, Inc. | 120,102 | $3.9M |
| ARQTArcutis Biotherapeutics, Inc. | 161,131 | $3.8M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 45,186 | $3.8M |
| DNLIDenali Therapeutics Inc. | 184,248 | $3.5M |
| ANIPANI PHARMACEUTICALS INC | 41,745 | $3.2M |
| RDYDR REDDYS LABORATORIES LTD | 231,733 | $3.2M |
| TVTXTravere Therapeutics, Inc. | 103,605 | $3.1M |
| LQDALiquidia Corp | 80,000 | $3.0M |
| OGNOrganon & Co. | 491,421 | $2.9M |
| IBRXImmunityBio, Inc. | 362,055 | $2.8M |
| ARGXARGENX SE | 3,752 | $2.7M |
| CLDXCelldex Therapeutics, Inc. | 85,983 | $2.7M |
| BEAMBeam Therapeutics Inc. | 112,239 | $2.7M |
| TNGXTango Therapeutics, Inc. | 126,603 | $2.6M |
| DAWNDay One Biopharmaceuticals, Inc. | 118,557 | $2.5M |
| ADPTAdaptive Biotechnologies Corp | 182,872 | $2.5M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 73,369 | $2.5M |
| SMMTSummit Therapeutics Inc. | 129,542 | $2.5M |
| IMVTImmunovant, Inc. | 97,493 | $2.4M |
| ORKAOruka Therapeutics, Inc. | 46,356 | $2.3M |
| DFTXDefinium Therapeutics Inc. | 119,972 | $2.3M |
| STOKStoke Therapeutics, Inc. | 67,315 | $2.2M |
| SNYSanofi | 44,385 | $2.1M |
| IRONDisc Medicine, Inc. | 33,058 | $2.1M |
| SLNOSOLENO THERAPEUTICS INC | 59,285 | $2.0M |
| ELVNEnliven Therapeutics, Inc. | 50,188 | $2.0M |
| OCULOCULAR THERAPEUTIX, INC | 231,101 | $2.0M |
| VRDNViridian Therapeutics, Inc.\DE | 100,033 | $2.0M |
| NRIXNurix Therapeutics, Inc. | 123,367 | $1.9M |
| ZYMEZymeworks Inc. | 75,399 | $1.9M |
| ALMSALUMIS INC. | 84,292 | $1.9M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 603,759 | $1.9M |
| KODKodiak Sciences Inc. | 47,958 | $1.8M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 520,130 | $1.8M |
| NTLAIntellia Therapeutics, Inc. | 136,588 | $1.8M |
| ARDXARDELYX, INC. | 291,840 | $1.7M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 52,083 | $1.6M |
| ANABANAPTYSBIO, INC | 23,848 | $1.3M |
| HROWHARROW, INC. | 37,190 | $1.3M |
| NUVBNuvation Bio Inc. | 303,881 | $1.3M |
| OLMAOlema Pharmaceuticals, Inc. | 84,350 | $1.3M |
| BHVNBiohaven Ltd. | 136,883 | $1.2M |
| PVLAPALVELLA THERAPEUTICS, INC. | 9,129 | $1.1M |
| XERSXeris Biopharma Holdings, Inc. | 191,067 | $1.1M |
| GMABGenmab A/S | 39,562 | $1.1M |
| GERNGERON CORP | 700,101 | $1.0M |
| ORICOric Pharmaceuticals, Inc. | 79,063 | $1.0M |
| CGEMCullinan Therapeutics, Inc. | 67,516 | $959K |
| KALVKalVista Pharmaceuticals, Inc. | 47,469 | $956K |
| MAZEMaze Therapeutics, Inc. | 31,513 | $941K |
| ANNXAnnexon, Inc. | 159,670 | $885K |
| SVRASavara Inc | 157,142 | $858K |
| ARVNARVINAS, INC. | 80,492 | $853K |
| KURAKura Oncology, Inc. | 104,815 | $852K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 15,163 | $837K |
| SLSSELLAS Life Sciences Group, Inc. | 194,198 | $821K |
| BCAXBicara Therapeutics Inc. | 40,747 | $810K |
| ABUSArbutus Biopharma Corp | 178,785 | $805K |
| CMPXCompass Therapeutics, Inc. | 147,016 | $778K |
| PGENPRECIGEN, INC. | 197,407 | $764K |
| ESPREsperion Therapeutics, Inc. | 276,401 | $757K |
| SIONSionna Therapeutics, Inc. | 18,308 | $734K |
| ZVRAZEVRA THERAPEUTICS, INC. | 68,071 | $634K |
| BIOABioAge Labs, Inc. | 35,320 | $618K |
| SLDBSolid Biosciences Inc. | 82,103 | $591K |
| SPRYARS Pharmaceuticals, Inc. | 72,257 | $580K |
| SANASana Biotechnology, Inc. | 198,696 | $572K |
| JBIOJade Biosciences, Inc. | 40,551 | $570K |
| OPKOPKO HEALTH, INC. | 497,240 | $567K |
| AQSTAquestive Therapeutics, Inc. | 136,539 | $567K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 55,367 | $538K |
| ZBIOZenas BioPharma, Inc. | 26,813 | $524K |
| RGNXREGENXBIO Inc. | 60,487 | $507K |
| FDMT4D Molecular Therapeutics, Inc. | 54,101 | $504K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 22,902 | $494K |
| ABSIAbsci Corporation | 160,608 | $482K |
| ALTAltimmune, Inc. | 155,671 | $479K |
| TRDAEntrada Therapeutics, Inc. | 35,938 | $454K |
| KROSKeros Therapeutics, Inc. | 40,176 | $444K |
| TECXTectonic Therapeutic, Inc. | 14,027 | $434K |
| FLGTFulgent Genetics Inc. | 27,145 | $432K |
| LBRXLB PHARMACEUTICALS INC | 17,103 | $422K |
| MPLTMapLight Therapeutics, Inc. | 20,368 | $414K |
| RCKTRocket Pharmaceuticals Inc. | 110,196 | $394K |
| DSGNDesign Therapeutics, Inc. | 34,860 | $371K |
| UPBUpstream Bio, Inc. | 41,203 | $371K |
| XOMAXOMA Royalty Corporation | 11,705 | $367K |
| KNSAKiniksa Pharmaceuticals International, plc | 7,286 | $351K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 53,036 | $339K |
| AVXLANAVEX LIFE SCIENCES CORP. | 106,138 | $326K |
| CATXPerspective Therapeutics, Inc. | 77,090 | $321K |
| DNAGinkgo Bioworks Holdings Inc. | 50,283 | $308K |
| LRMRLarimar Therapeutics, Inc. | 62,685 | $282K |
| NGNENeurogene Inc. | 13,892 | $280K |
| SIGASIGA TECHNOLOGIES INC | 51,142 | $274K |
| ONCBeOne Medicines Ltd. | 909 | $270K |
| RZLTRezolute, Inc. | 88,380 | $270K |
| CADLCandel Therapeutics, Inc. | 51,399 | $252K |
| ABEOABEONA THERAPEUTICS INC. | 55,847 | $250K |
| VYGRVoyager Therapeutics, Inc. | 57,566 | $222K |
| ALECAlector, Inc. | 101,327 | $218K |
| CHRSCoherus Oncology, Inc. | 125,101 | $211K |
| LENZLENZ Therapeutics, Inc. | 22,476 | $206K |
| RNAAtrium Therapeutics Inc. | 14,953 | $200K |
| TNXPTonix Pharmaceuticals Holding Corp. | 14,168 | $195K |
| GLSIGreenwich LifeSciences, Inc. | 8,046 | $193K |
| FENCFENNEC PHARMACEUTICALS INC. | 31,298 | $192K |
| ORGOOrganogenesis Holdings Inc. | 80,015 | $190K |
| MDWDMediWound Ltd. | 11,321 | $182K |
| ABVXAbivax SA | 1,441 | $160K |
| FATEFATE THERAPEUTICS INC | 132,308 | $159K |
| DMACDiaMedica Therapeutics Inc. | 22,753 | $154K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 184,549 | $148K |
| MESOMesoblast Limited | 7,809 | $120K |
| CRDFCardiff Oncology, Inc. | 73,896 | $120K |
| ALDXAldeyra Therapeutics, Inc. | 69,205 | $117K |
| KRROKorro Bio, Inc. | 9,850 | $111K |
| HUMAHumacyte Inc. | 174,549 | $106K |
| PLXProtalix BioTherapeutics, Inc. | 45,817 | $99K |
| TLXTelix Pharmaceuticals Limited | 9,823 | $94K |
| IMCRImmunocore Holdings plc | 3,097 | $93K |
| GYREGYRE THERAPEUTICS, INC. | 13,116 | $91K |
| EVAXEvaxion A/S | 21,659 | $81K |
| GRFSGrifols S.A. | 9,573 | $77K |
| RNACCartesian Therapeutics, Inc. | 12,360 | $76K |
| SLNSilence Therapeutics Plc | 13,935 | $73K |
| NBTXNanobiotix S.A. | 2,281 | $70K |
| NVCTNuvectis Pharma, Inc. | 8,657 | $67K |
| CANFCan-Fite BioPharma Ltd. | 20,908 | $65K |
| HCMHUTCHMED (China) Limited | 4,096 | $61K |
| BCYCBICYCLE THERAPEUTICS PLC | 12,571 | $58K |
| AUTLAutolus Therapeutics plc | 34,951 | $48K |
| CLLSCellectis S.A. | 15,085 | $48K |
| NKTRNEKTAR THERAPEUTICS | 600 | $43K |
| CMPSCOMPASS Pathways plc | 7,219 | $40K |
| HURATuHURA Biosciences, Inc./NV | 20,730 | $37K |
| CMMBChemomab Therapeutics Ltd. | 18,366 | $29K |
| AARDAardvark Therapeutics, Inc. | 6,679 | $25K |
| IVAInventiva S.A. | 2,862 | $16K |
| XTLBXTL BIOPHARMACEUTICALS LTD | 5,987 | $14K |
| KZIAKAZIA THERAPEUTICS LTD | 1,402 | $10K |
| TVRDTvardi Therapeutics, Inc. | 3,244 | $10K |
| QNRXQuoin Pharmaceuticals, Ltd. | 1,521 | $10K |
| IMMPImmutep Limited | 22,053 | $8K |
| CCCCC4 Therapeutics, Inc. | 2,716 | $7K |
| ATHEAlterity Therapeutics Limited | 1,970 | $7K |
| BRNSBarinthus Biotherapeutics plc. | 11,685 | $7K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 190 | $5K |
| NCNANuCana plc | 3,722 | $5K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 482 | $5K |
| RDHLRedHill Biopharma Ltd. | 5,116 | $4K |
| PLRXPLIANT THERAPEUTICS, INC. | 2,379 | $3K |
| FLNAFilana Therapeutics Inc. | 1,734 | $3K |
| PPBTPURPLE BIOTECH LTD. | 710 | $3K |
| BMEABiomea Fusion, Inc. | 1,200 | $2K |
| AGENAGENUS INC | 538 | $2K |
| INOINOVIO PHARMACEUTICALS, INC. | 602 | $1K |
| SCNIScinai Immunotherapeutics Ltd. | 1,878 | $1K |
| NEUPNeuphoria Therapeutics Inc. | 202 | $822 |
| ANVSAnnovis Bio, Inc. | 350 | $780 |
| RADXRadiopharm Theranostics Limited | 121 | $519 |
| ADXNAddex Therapeutics Ltd. | 72 | $450 |
| SCLXSCILEX HOLDING CO | 35 | $232 |
| NBPNovaBridge Biosciences | 33 | $81 |
| LXRXLEXICON PHARMACEUTICALS, INC. | 0 | $2 |
| SPRCSciSparc Ltd. | 0 | $0 |