| EXELEXELIXIS, INC. | 13,726,993 | $588.8M |
| INCYIncyte Corp. | 3,651,532 | $343.7M |
| GILDGILEAD SCIENCES, INC. | 2,152,528 | $300.0M |
| JAZZJazz Pharmaceuticals plc | 819,374 | $154.9M |
| GMABGenmab A/S | 4,414,550 | $118.4M |
| RDYDR REDDYS LABORATORIES LTD | 7,859,728 | $108.9M |
| INVAInnoviva, Inc. | 4,055,632 | $94.5M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 1,705,222 | $88.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,036,495 | $65.0M |
| TVTXTravere Therapeutics, Inc. | 1,966,779 | $58.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 1,024,871 | $57.9M |
| REGNREGENERON PHARMACEUTICALS, INC. | 66,802 | $51.6M |
| MRNAModerna, Inc. | 881,200 | $44.8M |
| ACADACADIA PHARMACEUTICALS INC | 1,724,196 | $38.4M |
| APLSApellis Pharmaceuticals, Inc. | 935,958 | $37.7M |
| PTCTPTC THERAPEUTICS, INC. | 533,300 | $36.3M |
| DAWNDay One Biopharmaceuticals, Inc. | 1,296,984 | $27.8M |
| AXSMAxsome Therapeutics, Inc. | 164,300 | $27.8M |
| COGTCogent Biosciences, Inc. | 706,268 | $27.2M |
| BBIOBridgeBio Pharma, Inc. | 365,772 | $27.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,872,893 | $27.1M |
| IONSIONIS PHARMACEUTICALS INC | 305,549 | $22.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 258,011 | $22.4M |
| ONCBeOne Medicines Ltd. | 65,456 | $19.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 311,292 | $17.2M |
| SLNOSOLENO THERAPEUTICS INC | 447,300 | $15.0M |
| ANIPANI PHARMACEUTICALS INC | 186,102 | $14.3M |
| KURAKura Oncology, Inc. | 1,582,568 | $12.9M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,942,413 | $12.4M |
| BEAMBeam Therapeutics Inc. | 513,578 | $12.2M |
| ADMAADMA BIOLOGICS, INC. | 1,262,634 | $11.4M |
| TGTXTG THERAPEUTICS, INC. | 340,900 | $11.3M |
| KODKodiak Sciences Inc. | 294,300 | $11.2M |
| ARQTArcutis Biotherapeutics, Inc. | 440,999 | $10.4M |
| OCULOCULAR THERAPEUTIX, INC | 1,147,982 | $9.7M |
| RCUSArcus Biosciences, Inc. | 424,700 | $9.2M |
| NUVLNuvalent, Inc. | 89,000 | $9.1M |
| TERNTerns Pharmaceuticals, Inc. | 169,034 | $8.9M |
| ARDXARDELYX, INC. | 1,272,441 | $7.6M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 2,400,605 | $7.4M |
| CNTACentessa Pharmaceuticals plc | 185,000 | $7.3M |
| RLAYRelay Therapeutics, Inc. | 673,599 | $6.7M |
| CCCCC4 Therapeutics, Inc. | 2,461,815 | $6.5M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 607,515 | $5.9M |
| FDMT4D Molecular Therapeutics, Inc. | 578,265 | $5.4M |
| ABCLAbCellera Biologics Inc. | 1,510,629 | $5.3M |
| MLTXMoonLake Immunotherapeutics | 276,772 | $5.2M |
| ANABANAPTYSBIO, INC | 90,900 | $5.0M |
| KROSKeros Therapeutics, Inc. | 453,482 | $5.0M |
| IMCRImmunocore Holdings plc | 164,000 | $4.9M |
| CMPSCOMPASS Pathways plc | 865,354 | $4.8M |
| IMVTImmunovant, Inc. | 192,500 | $4.8M |
| CGEMCullinan Therapeutics, Inc. | 324,111 | $4.6M |
| BCYCBICYCLE THERAPEUTICS PLC | 979,300 | $4.5M |
| ZNTLZentalis Pharmaceuticals, Inc. | 1,938,145 | $4.5M |
| ESPREsperion Therapeutics, Inc. | 1,620,100 | $4.4M |
| ASRTAssertio Holdings, Inc. | 228,599 | $4.4M |
| DSGNDesign Therapeutics, Inc. | 408,200 | $4.3M |
| SANASana Biotechnology, Inc. | 1,451,200 | $4.2M |
| VRDNViridian Therapeutics, Inc.\DE | 203,100 | $4.0M |
| FATEFATE THERAPEUTICS INC | 2,974,683 | $3.6M |
| SVRASavara Inc | 652,672 | $3.6M |
| BDTXBlack Diamond Therapeutics, Inc. | 1,643,747 | $3.5M |
| LCTXLineage Cell Therapeutics, Inc. | 2,125,100 | $3.4M |
| LRMRLarimar Therapeutics, Inc. | 739,942 | $3.3M |
| ADPTAdaptive Biotechnologies Corp | 239,800 | $3.3M |
| INSMINSMED Inc | 20,300 | $3.3M |
| SGMTSagimet Biosciences Inc. | 625,469 | $3.3M |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 346,998 | $3.3M |
| PCVXVaxcyte, Inc. | 54,734 | $3.2M |
| AUTLAutolus Therapeutics plc | 2,299,499 | $3.2M |
| ANNXAnnexon, Inc. | 544,300 | $3.0M |
| NKTRNEKTAR THERAPEUTICS | 41,781 | $3.0M |
| HROWHARROW, INC. | 84,579 | $3.0M |
| SPROSpero Therapeutics, Inc. | 1,189,235 | $2.8M |
| ALECAlector, Inc. | 1,287,691 | $2.8M |
| GPCRStructure Therapeutics Inc. | 55,800 | $2.7M |
| GERNGERON CORP | 1,799,521 | $2.7M |
| PLXProtalix BioTherapeutics, Inc. | 1,224,800 | $2.7M |
| XERSXeris Biopharma Holdings, Inc. | 452,860 | $2.6M |
| RGNXREGENXBIO Inc. | 305,286 | $2.6M |
| TRDAEntrada Therapeutics, Inc. | 202,084 | $2.6M |
| SIGASIGA TECHNOLOGIES INC | 475,013 | $2.5M |
| ORGOOrganogenesis Holdings Inc. | 1,068,538 | $2.5M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,600,500 | $2.5M |
| OVIDOvid Therapeutics Inc. | 1,104,300 | $2.5M |
| TENXTENAX THERAPEUTICS, INC. | 152,600 | $2.4M |
| STROSUTRO BIOPHARMA, INC. | 97,824 | $2.4M |
| BIOABioAge Labs, Inc. | 138,588 | $2.4M |
| NUVBNuvation Bio Inc. | 559,180 | $2.4M |
| LYELLyell Immunopharma, Inc. | 116,411 | $2.3M |
| PLRXPLIANT THERAPEUTICS, INC. | 1,852,842 | $2.3M |
| RCKTRocket Pharmaceuticals Inc. | 637,174 | $2.3M |
| PVLAPALVELLA THERAPEUTICS, INC. | 17,970 | $2.2M |
| PROKPROKIDNEY CORP. | 1,250,794 | $2.2M |
| VYGRVoyager Therapeutics, Inc. | 578,024 | $2.2M |
| IRONDisc Medicine, Inc. | 31,820 | $2.0M |
| LITSLite Strategy, Inc. | 1,744,700 | $2.0M |
| BMEABiomea Fusion, Inc. | 1,312,798 | $2.0M |
| HCMHUTCHMED (China) Limited | 132,062 | $2.0M |
| JBIOJade Biosciences, Inc. | 135,039 | $1.9M |
| ZURAZura Bio Ltd | 313,300 | $1.9M |
| CNTNCanton Strategic Holdings, Inc. | 562,000 | $1.8M |
| NRIXNurix Therapeutics, Inc. | 118,000 | $1.8M |
| AVTXAvalo Therapeutics, Inc. | 120,114 | $1.8M |
| ACIUAC Immune SA | 624,367 | $1.7M |
| ALMSALUMIS INC. | 75,167 | $1.7M |
| ACETAdicet Bio, Inc. | 232,591 | $1.6M |
| OKUROnKure Therapeutics, Inc. | 377,250 | $1.6M |
| KRROKorro Bio, Inc. | 136,227 | $1.5M |
| CLYMClimb Bio, Inc. | 217,300 | $1.5M |
| WHWKWhitehawk Therapeutics, Inc. | 428,622 | $1.5M |
| ALXOALX ONCOLOGY HOLDINGS INC | 732,599 | $1.5M |
| ALDXAldeyra Therapeutics, Inc. | 863,187 | $1.5M |
| SRZNSurrozen Inc. | 49,126 | $1.4M |
| RLYBRallybio Corp | 156,527 | $1.4M |
| KZRKezar Life Sciences, Inc. | 188,426 | $1.4M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 1,718,300 | $1.4M |
| BHVNBiohaven Ltd. | 160,952 | $1.4M |
| ELTXElicio Therapeutics, Inc. | 121,631 | $1.3M |
| RLMDRELMADA THERAPEUTICS, INC. | 167,200 | $1.2M |
| GRCEGrace Therapeutics, Inc. | 243,910 | $1.1M |
| INOINOVIO PHARMACEUTICALS, INC. | 643,777 | $1.1M |
| IVVDInvivyd, Inc. | 846,265 | $1.1M |
| MGXMetagenomi Therapeutics, Inc. | 787,900 | $1.1M |
| IMUXIMMUNIC, INC. | 919,164 | $1.0M |
| AGENAGENUS INC | 285,646 | $954K |
| SGMOQSANGAMO THERAPEUTICS, INC | 3,836,665 | $947K |
| PRLDPrelude Therapeutics Inc | 275,200 | $941K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 101,900 | $912K |
| SLDBSolid Biosciences Inc. | 124,272 | $895K |
| NGNENeurogene Inc. | 43,400 | $875K |
| AVXLANAVEX LIFE SCIENCES CORP. | 276,800 | $850K |
| CGTXCOGNITION THERAPEUTICS INC | 1,117,136 | $848K |
| CSBRCHAMPIONS ONCOLOGY, INC. | 145,539 | $837K |
| ANVSAnnovis Bio, Inc. | 347,600 | $775K |
| ALGSAligos Therapeutics, Inc. | 100,450 | $746K |
| ABEOABEONA THERAPEUTICS INC. | 161,082 | $722K |
| ANTXAN2 Therapeutics, Inc. | 198,800 | $680K |
| NBPNovaBridge Biosciences | 272,412 | $670K |
| LONALeonaBio, Inc. | 64,222 | $660K |
| LSTALISATA THERAPEUTICS, INC. | 131,715 | $660K |
| DNAGinkgo Bioworks Holdings Inc. | 100,456 | $616K |
| ONCYONCOLYTICS BIOTECH INC | 715,838 | $608K |
| RVMDREVOLUTION MEDICINES, INC. | 6,200 | $603K |
| TAOXTAO Synergies Inc. | 101,800 | $579K |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 725,120 | $576K |
| ATOSATOSSA THERAPEUTICS, INC. | 109,007 | $573K |
| CHRSCoherus Oncology, Inc. | 331,700 | $561K |
| UPBUpstream Bio, Inc. | 62,100 | $559K |
| FLNAFilana Therapeutics Inc. | 326,759 | $552K |
| ORMPORAMED PHARMACEUTICALS INC. | 147,700 | $502K |
| RZLTRezolute, Inc. | 157,711 | $481K |
| CNTXContext Therapeutics Inc. | 182,999 | $479K |
| MAZEMaze Therapeutics, Inc. | 15,800 | $472K |
| ATNMActinium Pharmaceuticals, Inc. | 471,600 | $469K |
| CBIOCRESCENT BIOPHARMA, INC. | 24,262 | $446K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 15,651 | $434K |
| HOWLWerewolf Therapeutics, Inc. | 516,218 | $430K |
| RNACCartesian Therapeutics, Inc. | 67,300 | $414K |
| GALTGALECTIN THERAPEUTICS INC | 147,900 | $413K |
| IMAImageneBio, Inc. | 81,696 | $408K |
| VCELVericel Corp | 12,600 | $405K |
| ARMPArmata Pharmaceuticals, Inc. | 38,496 | $394K |
| KLRSKalaris Therapeutics, Inc. | 66,151 | $382K |
| XBIOXenetic Biosciences, Inc. | 137,440 | $368K |
| DMACDiaMedica Therapeutics Inc. | 52,523 | $356K |
| IRDOpus Genetics, Inc. | 73,209 | $333K |
| BOLTBolt Biotherapeutics, Inc. | 77,225 | $312K |
| LPCNLipocine Inc. | 38,497 | $308K |
| LQDALiquidia Corp | 8,100 | $306K |
| TVRDTvardi Therapeutics, Inc. | 92,100 | $293K |
| GHRSGH Research PLC | 20,614 | $290K |
| FLGTFulgent Genetics Inc. | 18,000 | $286K |
| DRTSAlpha Tau Medical Ltd. | 40,457 | $286K |
| AARDAardvark Therapeutics, Inc. | 70,792 | $267K |
| HYFTMindWalk Holdings Corp. | 232,480 | $263K |
| MNOVMEDICINOVA INC | 189,900 | $260K |
| AYTUAYTU BIOPHARMA, INC | 93,723 | $256K |
| CRVOCervoMed Inc. | 63,904 | $252K |
| SCLXSCILEX HOLDING CO | 36,864 | $246K |
| MRKRMarker Therapeutics, Inc. | 175,294 | $228K |
| ALVOAlvotech | 63,200 | $217K |
| KYNBKYNTRA BIO INC. | 27,481 | $186K |
| TLPHTALPHERA, INC. | 237,755 | $178K |
| VTGNVistagen Therapeutics, Inc. | 291,300 | $166K |
| CRDFCardiff Oncology, Inc. | 101,253 | $164K |
| LTRNLantern Pharma Inc. | 116,000 | $159K |
| ANIXAnixa Biosciences Inc | 61,173 | $158K |
| JSPRJasper Therapeutics Inc. | 177,500 | $156K |
| MISTMilestone Pharmaceuticals Inc. | 129,705 | $154K |
| VERUVERU INC. | 69,250 | $153K |
| EVAXEvaxion A/S | 39,225 | $146K |
| PULMPulmatrix, Inc. | 109,148 | $141K |
| ADAGAdagene Inc. | 34,533 | $135K |
| PDSBPDS Biotechnology Corp | 220,800 | $134K |
| IGCIGC Pharma, Inc. | 483,975 | $127K |
| COCPCocrystal Pharma, Inc. | 123,928 | $125K |
| OPKOPKO HEALTH, INC. | 109,543 | $125K |
| NNVCNANOVIRICIDES, INC. | 134,900 | $123K |
| BIVIBIOVIE INC. | 67,918 | $95K |
| ABVCABVC BIOPHARMA, INC. | 95,100 | $92K |
| ELUTELUTIA INC. | 82,716 | $87K |
| BRNSBarinthus Biotherapeutics plc. | 151,000 | $86K |
| BCABBioAtla, Inc. | 510,514 | $82K |
| PYPDPolyPid Ltd. | 18,596 | $81K |
| KTTAPasithea Therapeutics Corp. | 93,399 | $69K |
| CALCCalciMedica, Inc. | 128,075 | $69K |
| ESLAEstrella Immunopharma Inc. | 62,795 | $67K |
| PLURPluri Inc. | 19,424 | $66K |
| CADLCandel Therapeutics, Inc. | 12,780 | $63K |
| OTLKOutlook Therapeutics, Inc. | 255,157 | $53K |
| CUECue Biopharma, Inc. | 213,828 | $49K |
| PMCBPharmaCyte Biotech, Inc. | 56,500 | $38K |
| RNTXRein Therapeutics, Inc. | 24,500 | $32K |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 43,002 | $31K |
| FBLGFibroBiologics, Inc. | 15,997 | $21K |
| DAREDare Bioscience, Inc. | 10,195 | $19K |
| BCDABioCardia, Inc. | 13,900 | $17K |
| CPHICHINA PHARMA HOLDINGS, INC. | 11,418 | $7K |