| GILDGILEAD SCIENCES, INC. | 486,271 | $67.8M |
| REGNREGENERON PHARMACEUTICALS, INC. | 18,226 | $14.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 220,565 | $12.2M |
| SNYSanofi | 122,947 | $5.9M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 12,322 | $4.1M |
| MRNAModerna, Inc. | 69,883 | $3.6M |
| INCYIncyte Corp. | 33,976 | $3.2M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 37,360 | $3.1M |
| TEVATeva Pharmaceutical Industries Limited | 95,610 | $2.9M |
| ARGXARGENX SE | 3,796 | $2.8M |
| APLSApellis Pharmaceuticals, Inc. | 54,474 | $2.2M |
| IRONDisc Medicine, Inc. | 25,292 | $1.6M |
| INSMINSMED Inc | 8,910 | $1.5M |
| RDYDR REDDYS LABORATORIES LTD | 99,650 | $1.4M |
| JAZZJazz Pharmaceuticals plc | 5,707 | $1.1M |
| IONSIONIS PHARMACEUTICALS INC | 13,545 | $1.0M |
| PCVXVaxcyte, Inc. | 14,956 | $869K |
| EXELEXELIXIS, INC. | 19,896 | $853K |
| BMRNBIOMARIN PHARMACEUTICAL INC | 14,589 | $824K |
| GMABGenmab A/S | 28,595 | $767K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 14,548 | $752K |
| ROIVRoivant Sciences Ltd. | 26,138 | $724K |
| RVMDREVOLUTION MEDICINES, INC. | 6,775 | $659K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 6,938 | $603K |
| CYTKCYTOKINETICS INC | 8,577 | $565K |
| BBIOBridgeBio Pharma, Inc. | 6,682 | $496K |
| OGNOrganon & Co. | 78,257 | $469K |
| LGNDLigand Pharmaceuticals Incorporated | 2,342 | $468K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 7,312 | $458K |
| INVAInnoviva, Inc. | 18,636 | $434K |
| PTGXProtagonist Therapeutics, Inc | 3,998 | $421K |
| ABVXAbivax SA | 3,766 | $419K |
| ARQTArcutis Biotherapeutics, Inc. | 17,597 | $415K |
| TGTXTG THERAPEUTICS, INC. | 11,817 | $393K |
| ONCBeOne Medicines Ltd. | 1,321 | $392K |
| AXSMAxsome Therapeutics, Inc. | 2,080 | $352K |
| VCELVericel Corp | 9,493 | $305K |
| IBRXImmunityBio, Inc. | 39,030 | $299K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 9,119 | $292K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 28,386 | $276K |
| VKTXViking Therapeutics, Inc. | 7,956 | $259K |
| LQDALiquidia Corp | 6,339 | $239K |
| NUVLNuvalent, Inc. | 2,110 | $216K |
| PTCTPTC THERAPEUTICS, INC. | 3,128 | $213K |
| ADPTAdaptive Biotechnologies Corp | 14,737 | $205K |
| AVXLANAVEX LIFE SCIENCES CORP. | 62,092 | $191K |
| DNLIDenali Therapeutics Inc. | 9,220 | $177K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 4,940 | $167K |
| RCUSArcus Biosciences, Inc. | 7,577 | $164K |
| ORKAOruka Therapeutics, Inc. | 3,186 | $156K |
| DFTXDefinium Therapeutics Inc. | 7,620 | $144K |
| GPCRStructure Therapeutics Inc. | 2,854 | $138K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 5,585 | $121K |
| ADMAADMA BIOLOGICS, INC. | 12,940 | $117K |
| TERNTerns Pharmaceuticals, Inc. | 2,060 | $109K |
| NGNENeurogene Inc. | 5,047 | $102K |
| ORICOric Pharmaceuticals, Inc. | 8,010 | $101K |
| ACADACADIA PHARMACEUTICALS INC | 4,303 | $96K |
| ZBIOZenas BioPharma, Inc. | 4,767 | $93K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 25,052 | $88K |
| KNSAKiniksa Pharmaceuticals International, plc | 1,765 | $85K |
| ANIPANI PHARMACEUTICALS INC | 1,043 | $80K |
| IMVTImmunovant, Inc. | 2,902 | $72K |
| ORMPORAMED PHARMACEUTICALS INC. | 21,200 | $72K |
| GRFSGrifols S.A. | 8,961 | $72K |
| RADXRadiopharm Theranostics Limited | 16,000 | $69K |
| HRMYHarmony Biosciences Holdings, Inc. | 2,232 | $63K |
| SRRKScholar Rock Holding Corp | 1,270 | $62K |
| CMPXCompass Therapeutics, Inc. | 11,038 | $58K |
| COGTCogent Biosciences, Inc. | 1,433 | $55K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 16,832 | $52K |
| KODKodiak Sciences Inc. | 1,236 | $47K |
| NTLAIntellia Therapeutics, Inc. | 3,552 | $46K |
| OPKOPKO HEALTH, INC. | 37,000 | $42K |
| KURAKura Oncology, Inc. | 4,824 | $39K |
| NUVBNuvation Bio Inc. | 8,824 | $38K |
| ARVNARVINAS, INC. | 3,558 | $38K |
| SGMOQSANGAMO THERAPEUTICS, INC | 150,000 | $37K |
| BMEABiomea Fusion, Inc. | 24,000 | $37K |
| BIOABioAge Labs, Inc. | 2,073 | $36K |
| SANASana Biotechnology, Inc. | 12,043 | $35K |
| BEAMBeam Therapeutics Inc. | 1,262 | $30K |
| RCKTRocket Pharmaceuticals Inc. | 8,310 | $30K |
| SABSSAB BIOTHERAPEUTICS, INC. | 7,700 | $29K |
| ZYMEZymeworks Inc. | 987 | $25K |
| SMMTSummit Therapeutics Inc. | 1,243 | $24K |
| DSGNDesign Therapeutics, Inc. | 1,816 | $19K |
| NRSNNeuroSense Therapeutics Ltd. | 21,150 | $16K |
| CLDXCelldex Therapeutics, Inc. | 485 | $15K |
| TRDAEntrada Therapeutics, Inc. | 1,141 | $14K |
| GERNGERON CORP | 9,614 | $14K |
| FDMT4D Molecular Therapeutics, Inc. | 1,462 | $14K |
| CLNNClene Inc. | 2,735 | $13K |
| ONCYONCOLYTICS BIOTECH INC | 15,055 | $13K |
| RNAAtrium Therapeutics Inc. | 943 | $13K |
| FLGTFulgent Genetics Inc. | 720 | $11K |
| OCGNOcugen, Inc. | 5,231 | $9K |
| KRROKorro Bio, Inc. | 830 | $9K |
| APGEApogee Therapeutics, Inc. | 110 | $9K |
| ALMSALUMIS INC. | 417 | $9K |
| FOLDAMICUS THERAPEUTICS, INC. | 625 | $9K |
| ABUSArbutus Biopharma Corp | 1,869 | $8K |
| SVRASavara Inc | 1,525 | $8K |
| OLMAOlema Pharmaceuticals, Inc. | 551 | $8K |
| ANIXAnixa Biosciences Inc | 3,039 | $8K |
| BCAXBicara Therapeutics Inc. | 383 | $8K |
| XFORX4 Pharmaceuticals, Inc | 1,759 | $7K |
| NRIXNurix Therapeutics, Inc. | 450 | $7K |
| CNTNCanton Strategic Holdings, Inc. | 2,000 | $7K |
| ANNXAnnexon, Inc. | 1,132 | $6K |
| SYRESpyre Therapeutics, Inc. | 123 | $6K |
| XERSXeris Biopharma Holdings, Inc. | 1,053 | $6K |
| ANABANAPTYSBIO, INC | 109 | $6K |
| BHVNBiohaven Ltd. | 713 | $6K |
| TVTXTravere Therapeutics, Inc. | 179 | $5K |
| OCULOCULAR THERAPEUTIX, INC | 609 | $5K |
| OTLKOutlook Therapeutics, Inc. | 25,000 | $5K |
| SIGASIGA TECHNOLOGIES INC | 955 | $5K |
| NBPNovaBridge Biosciences | 2,000 | $5K |
| SLDBSolid Biosciences Inc. | 682 | $5K |
| ALTAltimmune, Inc. | 1,552 | $5K |
| HROWHARROW, INC. | 132 | $5K |
| TNGXTango Therapeutics, Inc. | 212 | $4K |
| TAOXTAO Synergies Inc. | 750 | $4K |
| VRDNViridian Therapeutics, Inc.\DE | 207 | $4K |
| PRLDPrelude Therapeutics Inc | 1,171 | $4K |
| KROSKeros Therapeutics, Inc. | 349 | $4K |
| PVLAPALVELLA THERAPEUTICS, INC. | 30 | $4K |
| LBRXLB PHARMACEUTICALS INC | 145 | $4K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 513 | $3K |
| FENCFENNEC PHARMACEUTICALS INC. | 510 | $3K |
| HUMAHumacyte Inc. | 5,101 | $3K |
| KALVKalVista Pharmaceuticals, Inc. | 149 | $3K |
| FLNAFilana Therapeutics Inc. | 1,681 | $3K |
| ACIUAC Immune SA | 1,000 | $3K |
| ZVRAZEVRA THERAPEUTICS, INC. | 282 | $3K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,461 | $2K |
| VYGRVoyager Therapeutics, Inc. | 582 | $2K |
| DNAGinkgo Bioworks Holdings Inc. | 359 | $2K |
| OVIDOvid Therapeutics Inc. | 903 | $2K |
| ARDXARDELYX, INC. | 298 | $2K |
| FATEFATE THERAPEUTICS INC | 1,480 | $2K |
| MAZEMaze Therapeutics, Inc. | 58 | $2K |
| SLNOSOLENO THERAPEUTICS INC | 50 | $2K |
| TVRDTvardi Therapeutics, Inc. | 519 | $2K |
| STROSUTRO BIOPHARMA, INC. | 62 | $2K |
| ABSIAbsci Corporation | 492 | $1K |
| STOKStoke Therapeutics, Inc. | 44 | $1K |
| BIVIBIOVIE INC. | 1,000 | $1K |
| JBIOJade Biosciences, Inc. | 95 | $1K |
| SLSSELLAS Life Sciences Group, Inc. | 289 | $1K |
| MISTMilestone Pharmaceuticals Inc. | 1,000 | $1K |
| CRDFCardiff Oncology, Inc. | 707 | $1K |
| CMPSCOMPASS Pathways plc | 200 | $1K |
| VERUVERU INC. | 500 | $1K |
| RGNXREGENXBIO Inc. | 115 | $964 |
| CATXPerspective Therapeutics, Inc. | 221 | $922 |
| DAWNDay One Biopharmaceuticals, Inc. | 41 | $879 |
| ELVNEnliven Therapeutics, Inc. | 22 | $862 |
| TECXTectonic Therapeutic, Inc. | 26 | $804 |
| ANVSAnnovis Bio, Inc. | 360 | $803 |
| XOMAXOMA Royalty Corporation | 25 | $784 |
| CADLCandel Therapeutics, Inc. | 154 | $754 |
| CAPRCAPRICOR THERAPEUTICS, INC. | 24 | $730 |
| IVVDInvivyd, Inc. | 502 | $652 |
| SIONSionna Therapeutics, Inc. | 16 | $641 |
| ALDXAldeyra Therapeutics, Inc. | 369 | $624 |
| HURATuHURA Biosciences, Inc./NV | 340 | $609 |
| RZLTRezolute, Inc. | 182 | $555 |
| INOINOVIO PHARMACEUTICALS, INC. | 300 | $522 |
| ABEOABEONA THERAPEUTICS INC. | 86 | $385 |
| SPRYARS Pharmaceuticals, Inc. | 32 | $257 |
| CGEMCullinan Therapeutics, Inc. | 18 | $256 |
| GLSIGreenwich LifeSciences, Inc. | 10 | $240 |
| MLTXMoonLake Immunotherapeutics | 12 | $224 |
| RNACCartesian Therapeutics, Inc. | 36 | $221 |
| ALXOALX ONCOLOGY HOLDINGS INC | 100 | $201 |
| NVCTNuvectis Pharma, Inc. | 23 | $178 |
| DMACDiaMedica Therapeutics Inc. | 19 | $129 |
| AARDAardvark Therapeutics, Inc. | 28 | $106 |
| LENZLENZ Therapeutics, Inc. | 11 | $101 |
| LRMRLarimar Therapeutics, Inc. | 17 | $77 |
| PLXProtalix BioTherapeutics, Inc. | 20 | $43 |
| AQSTAquestive Therapeutics, Inc. | 10 | $42 |