| GILDGILEAD SCIENCES, INC. | 254,507 | $35.5M |
| BBIOBridgeBio Pharma, Inc. | 217,084 | $16.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 46,653 | $15.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 225,955 | $12.5M |
| LGNDLigand Pharmaceuticals Incorporated | 58,150 | $11.6M |
| REGNREGENERON PHARMACEUTICALS, INC. | 12,238 | $9.5M |
| TGTXTG THERAPEUTICS, INC. | 271,608 | $9.0M |
| SNYSanofi | 181,936 | $8.8M |
| ABUSArbutus Biopharma Corp | 1,348,127 | $6.1M |
| VCELVericel Corp | 183,360 | $5.9M |
| CYTKCYTOKINETICS INC | 50,872 | $3.4M |
| GALTGALECTIN THERAPEUTICS INC | 1,122,670 | $3.1M |
| INSMINSMED Inc | 18,657 | $3.1M |
| EXELEXELIXIS, INC. | 67,923 | $2.9M |
| INCYIncyte Corp. | 27,091 | $2.5M |
| VKTXViking Therapeutics, Inc. | 76,987 | $2.5M |
| TEVATeva Pharmaceutical Industries Limited | 80,772 | $2.4M |
| DMACDiaMedica Therapeutics Inc. | 319,675 | $2.2M |
| GPCRStructure Therapeutics Inc. | 44,416 | $2.1M |
| MRNAModerna, Inc. | 40,197 | $2.0M |
| RVMDREVOLUTION MEDICINES, INC. | 20,939 | $2.0M |
| ADPTAdaptive Biotechnologies Corp | 135,994 | $1.9M |
| RLAYRelay Therapeutics, Inc. | 186,123 | $1.9M |
| MAZEMaze Therapeutics, Inc. | 59,943 | $1.8M |
| HROWHARROW, INC. | 35,058 | $1.2M |
| ABCLAbCellera Biologics Inc. | 348,978 | $1.2M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 35,950 | $1.1M |
| JAZZJazz Pharmaceuticals plc | 5,723 | $1.1M |
| AXSMAxsome Therapeutics, Inc. | 5,468 | $924K |
| PGENPRECIGEN, INC. | 222,368 | $861K |
| IBRXImmunityBio, Inc. | 101,316 | $777K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 10,914 | $684K |
| OGNOrganon & Co. | 110,499 | $662K |
| IONSIONIS PHARMACEUTICALS INC | 8,710 | $654K |
| CNTNCanton Strategic Holdings, Inc. | 189,801 | $621K |
| ARGXARGENX SE | 711 | $519K |
| RDYDR REDDYS LABORATORIES LTD | 37,250 | $516K |
| PCVXVaxcyte, Inc. | 8,870 | $515K |
| OCULOCULAR THERAPEUTIX, INC | 51,495 | $436K |
| ELVNEnliven Therapeutics, Inc. | 10,032 | $393K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 107,099 | $376K |
| STOKStoke Therapeutics, Inc. | 10,312 | $336K |
| XERSXeris Biopharma Holdings, Inc. | 54,756 | $318K |
| NKTRNEKTAR THERAPEUTICS | 4,393 | $316K |
| DNLIDenali Therapeutics Inc. | 16,413 | $315K |
| MLTXMoonLake Immunotherapeutics | 15,905 | $296K |
| ADMAADMA BIOLOGICS, INC. | 30,651 | $276K |
| NTLAIntellia Therapeutics, Inc. | 19,985 | $256K |
| BMRNBIOMARIN PHARMACEUTICAL INC | 4,428 | $250K |
| ESPREsperion Therapeutics, Inc. | 84,434 | $231K |
| ACADACADIA PHARMACEUTICALS INC | 10,045 | $224K |
| SLSSELLAS Life Sciences Group, Inc. | 47,272 | $200K |
| DFTXDefinium Therapeutics Inc. | 10,559 | $200K |
| SVRASavara Inc | 35,926 | $196K |
| ROIVRoivant Sciences Ltd. | 7,000 | $194K |
| AQSTAquestive Therapeutics, Inc. | 44,811 | $186K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 56,326 | $173K |
| SRRKScholar Rock Holding Corp | 3,482 | $171K |
| ANIPANI PHARMACEUTICALS INC | 2,138 | $164K |
| GERNGERON CORP | 109,753 | $164K |
| NUVBNuvation Bio Inc. | 37,507 | $161K |
| PLRXPLIANT THERAPEUTICS, INC. | 114,924 | $145K |
| TERNTerns Pharmaceuticals, Inc. | 2,624 | $138K |
| BEAMBeam Therapeutics Inc. | 5,507 | $131K |
| ARQTArcutis Biotherapeutics, Inc. | 5,453 | $128K |
| PTGXProtagonist Therapeutics, Inc | 1,197 | $126K |
| MRKRMarker Therapeutics, Inc. | 93,121 | $121K |
| AVXLANAVEX LIFE SCIENCES CORP. | 38,640 | $119K |
| ARDXARDELYX, INC. | 19,797 | $119K |
| ANABANAPTYSBIO, INC | 2,046 | $113K |
| XOMAXOMA Royalty Corporation | 3,444 | $108K |
| APLSApellis Pharmaceuticals, Inc. | 2,615 | $105K |
| SMMTSummit Therapeutics Inc. | 5,398 | $102K |
| ONCBeOne Medicines Ltd. | 315 | $94K |
| BCAXBicara Therapeutics Inc. | 4,489 | $89K |
| APGEApogee Therapeutics, Inc. | 1,010 | $85K |
| KNSAKiniksa Pharmaceuticals International, plc | 1,739 | $84K |
| GHRSGH Research PLC | 5,925 | $83K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 939 | $82K |
| COGTCogent Biosciences, Inc. | 2,109 | $81K |
| CMPXCompass Therapeutics, Inc. | 14,678 | $78K |
| CTMXCytomX Therapeutics, Inc. | 16,471 | $77K |
| ARVNARVINAS, INC. | 7,246 | $77K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 11,669 | $75K |
| BHVNBiohaven Ltd. | 8,451 | $71K |
| INVAInnoviva, Inc. | 3,013 | $70K |
| ABSIAbsci Corporation | 22,897 | $69K |
| SANASana Biotechnology, Inc. | 23,772 | $68K |
| GMABGenmab A/S | 2,526 | $68K |
| AGENAGENUS INC | 20,014 | $67K |
| KZIAKAZIA THERAPEUTICS LTD | 8,744 | $65K |
| ALTAltimmune, Inc. | 20,678 | $64K |
| LONALeonaBio, Inc. | 6,180 | $64K |
| LCTXLineage Cell Therapeutics, Inc. | 38,290 | $60K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 1,786 | $60K |
| ZVRAZEVRA THERAPEUTICS, INC. | 6,377 | $59K |
| SLNOSOLENO THERAPEUTICS INC | 1,626 | $54K |
| OPKOPKO HEALTH, INC. | 47,667 | $54K |
| FLNAFilana Therapeutics Inc. | 31,241 | $53K |
| IMTXImmatics N.V. | 5,175 | $51K |
| CMPSCOMPASS Pathways plc | 8,697 | $48K |
| IMVTImmunovant, Inc. | 1,875 | $47K |
| IMCRImmunocore Holdings plc | 1,524 | $46K |
| KODKodiak Sciences Inc. | 1,200 | $46K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 1,942 | $42K |
| SIGASIGA TECHNOLOGIES INC | 7,621 | $41K |
| TVTXTravere Therapeutics, Inc. | 1,361 | $40K |
| KALVKalVista Pharmaceuticals, Inc. | 2,006 | $40K |
| GRFSGrifols S.A. | 4,598 | $37K |
| VERUVERU INC. | 16,618 | $37K |
| IMMXImmix Biopharma, Inc. | 4,000 | $36K |
| JSPRJasper Therapeutics Inc. | 40,850 | $36K |
| PTCTPTC THERAPEUTICS, INC. | 502 | $34K |
| AUTLAutolus Therapeutics plc | 24,574 | $34K |
| HUMAHumacyte Inc. | 54,838 | $33K |
| NUVLNuvalent, Inc. | 321 | $33K |
| STROSUTRO BIOPHARMA, INC. | 1,280 | $32K |
| CADLCandel Therapeutics, Inc. | 6,374 | $31K |
| QNTMQuantum Biopharma Ltd. | 6,375 | $31K |
| CLDXCelldex Therapeutics, Inc. | 952 | $30K |
| NRIXNurix Therapeutics, Inc. | 1,928 | $30K |
| SABSSAB BIOTHERAPEUTICS, INC. | 7,775 | $30K |
| SPRYARS Pharmaceuticals, Inc. | 3,692 | $30K |
| CNTXContext Therapeutics Inc. | 10,500 | $28K |
| FOLDAMICUS THERAPEUTICS, INC. | 1,896 | $27K |
| FLGTFulgent Genetics Inc. | 1,657 | $26K |
| LQDALiquidia Corp | 688 | $26K |
| DNAGinkgo Bioworks Holdings Inc. | 4,185 | $26K |
| SYRESpyre Therapeutics, Inc. | 498 | $25K |
| RCUSArcus Biosciences, Inc. | 1,107 | $24K |
| CLYMClimb Bio, Inc. | 3,400 | $23K |
| KROSKeros Therapeutics, Inc. | 2,052 | $23K |
| MESOMesoblast Limited | 1,469 | $23K |
| IMUXIMMUNIC, INC. | 20,000 | $22K |
| ZYMEZymeworks Inc. | 882 | $22K |
| BTAIBioXcel Therapeutics, Inc. | 16,214 | $22K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 410 | $21K |
| TNXPTonix Pharmaceuticals Holding Corp. | 1,455 | $20K |
| ATNMActinium Pharmaceuticals, Inc. | 19,865 | $20K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 232 | $19K |
| IXHLIncannex Healthcare Inc. | 6,376 | $19K |
| ORGOOrganogenesis Holdings Inc. | 7,528 | $18K |
| IRONDisc Medicine, Inc. | 275 | $18K |
| VRDNViridian Therapeutics, Inc.\DE | 830 | $16K |
| NBTXNanobiotix S.A. | 500 | $15K |
| ORMPORAMED PHARMACEUTICALS INC. | 4,324 | $15K |
| RGNXREGENXBIO Inc. | 1,718 | $14K |
| CELUCelularity Inc. | 10,000 | $13K |
| ZBIOZenas BioPharma, Inc. | 677 | $13K |
| OCGNOcugen, Inc. | 7,055 | $13K |
| CCCCC4 Therapeutics, Inc. | 4,544 | $12K |
| ATAIAtai Beckley N.V. | 3,372 | $12K |
| QUREuniQure N.V. | 703 | $11K |
| HCMHUTCHMED (China) Limited | 764 | $11K |
| SLDBSolid Biosciences Inc. | 1,463 | $11K |
| ALVOAlvotech | 3,040 | $10K |
| VYGRVoyager Therapeutics, Inc. | 2,645 | $10K |
| MDWDMediWound Ltd. | 626 | $10K |
| IRDOpus Genetics, Inc. | 2,200 | $10K |
| LENZLENZ Therapeutics, Inc. | 1,075 | $10K |
| ORICOric Pharmaceuticals, Inc. | 759 | $10K |
| CLNNClene Inc. | 1,926 | $9K |
| ABVXAbivax SA | 85 | $9K |
| BMEABiomea Fusion, Inc. | 6,000 | $9K |
| KURAKura Oncology, Inc. | 1,101 | $9K |
| TNGXTango Therapeutics, Inc. | 425 | $9K |
| ALMSALUMIS INC. | 343 | $8K |
| TLXTelix Pharmaceuticals Limited | 756 | $7K |
| ASRTAssertio Holdings, Inc. | 376 | $7K |
| HOWLWerewolf Therapeutics, Inc. | 8,625 | $7K |
| ANNXAnnexon, Inc. | 1,269 | $7K |
| ONCYONCOLYTICS BIOTECH INC | 8,200 | $7K |
| NNVCNANOVIRICIDES, INC. | 7,650 | $7K |
| ABEOABEONA THERAPEUTICS INC. | 1,431 | $6K |
| CTORCITIUS ONCOLOGY, INC. | 10,125 | $6K |
| RGCRegencell Bioscience Holdings Ltd | 227 | $6K |
| RCKTRocket Pharmaceuticals Inc. | 1,592 | $6K |
| WHWKWhitehawk Therapeutics, Inc. | 1,639 | $6K |
| CGEMCullinan Therapeutics, Inc. | 384 | $5K |
| LRMRLarimar Therapeutics, Inc. | 1,211 | $5K |
| DAWNDay One Biopharmaceuticals, Inc. | 229 | $5K |
| HURATuHURA Biosciences, Inc./NV | 2,700 | $5K |
| ORKAOruka Therapeutics, Inc. | 97 | $5K |
| OLMAOlema Pharmaceuticals, Inc. | 317 | $5K |
| PMNProMIS Neurosciences Inc. | 360 | $5K |
| MGXMetagenomi Therapeutics, Inc. | 2,891 | $4K |
| ARMPArmata Pharmaceuticals, Inc. | 357 | $4K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 372 | $4K |
| UPBUpstream Bio, Inc. | 389 | $4K |
| DSGNDesign Therapeutics, Inc. | 306 | $3K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 3,861 | $3K |
| ATOSATOSSA THERAPEUTICS, INC. | 587 | $3K |
| PTNPALATIN TECHNOLOGIES INC | 169 | $3K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 100 | $3K |
| CHRSCoherus Oncology, Inc. | 1,538 | $3K |
| TPSTTempest Therapeutics, Inc. | 1,529 | $2K |
| PVLAPALVELLA THERAPEUTICS, INC. | 20 | $2K |
| LYELLyell Immunopharma, Inc. | 124 | $2K |
| CTXRCitius Pharmaceuticals, Inc. | 2,735 | $2K |
| PHIOPhio Pharmaceuticals Corp. | 2,000 | $2K |
| CGTXCOGNITION THERAPEUTICS INC | 3,200 | $2K |
| VTGNVistagen Therapeutics, Inc. | 4,133 | $2K |
| BIOABioAge Labs, Inc. | 134 | $2K |
| MIRAMIRA PHARMACEUTICALS, INC. | 2,000 | $2K |
| CATXPerspective Therapeutics, Inc. | 500 | $2K |
| LGVNLongeveron Inc. | 2,000 | $2K |
| PYPDPolyPid Ltd. | 467 | $2K |
| DRTSAlpha Tau Medical Ltd. | 280 | $2K |
| SERSerina Therapeutics, Inc. | 1,001 | $2K |
| RNACCartesian Therapeutics, Inc. | 302 | $2K |
| BDTXBlack Diamond Therapeutics, Inc. | 857 | $2K |
| INOINOVIO PHARMACEUTICALS, INC. | 1,038 | $2K |
| SGMOQSANGAMO THERAPEUTICS, INC | 6,980 | $2K |
| PROKPROKIDNEY CORP. | 950 | $2K |
| OTLKOutlook Therapeutics, Inc. | 7,303 | $2K |
| KRROKorro Bio, Inc. | 135 | $2K |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 1,850 | $1K |
| CANFCan-Fite BioPharma Ltd. | 450 | $1K |
| AYTUAYTU BIOPHARMA, INC | 462 | $1K |
| TAOXTAO Synergies Inc. | 220 | $1K |
| KYNBKYNTRA BIO INC. | 180 | $1K |
| INTSINTENSITY THERAPEUTICS, INC. | 200 | $1K |
| TLSATiziana Life Sciences Ltd | 1,000 | $1K |
| LPCNLipocine Inc. | 143 | $1K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 663 | $1K |
| ANTXAN2 Therapeutics, Inc. | 300 | $1K |
| LSTALISATA THERAPEUTICS, INC. | 200 | $1K |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 1,219 | $889 |
| EVOEvotec SE | 340 | $850 |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 86 | $807 |
| RNAAtrium Therapeutics Inc. | 58 | $775 |
| FATEFATE THERAPEUTICS INC | 645 | $774 |
| PHGEBiomX Inc. | 200 | $750 |
| SPROSpero Therapeutics, Inc. | 290 | $678 |
| JBIOJade Biosciences, Inc. | 48 | $674 |
| PLXProtalix BioTherapeutics, Inc. | 300 | $651 |
| SCLXSCILEX HOLDING CO | 98 | $639 |
| ACIUAC Immune SA | 221 | $607 |
| FDMT4D Molecular Therapeutics, Inc. | 53 | $493 |
| CBIOCRESCENT BIOPHARMA, INC. | 26 | $477 |
| OKUROnKure Therapeutics, Inc. | 90 | $372 |
| ACXPAcurx Pharmaceuticals, Inc. | 100 | $371 |
| SKYESkye Bioscience, Inc. | 600 | $364 |
| CLLSCellectis S.A. | 100 | $317 |
| LTRNLantern Pharma Inc. | 220 | $301 |
| GYREGYRE THERAPEUTICS, INC. | 38 | $265 |
| ATHEAlterity Therapeutics Limited | 68 | $240 |
| GRMLGreenland Mines Ltd | 650 | $214 |
| TLPHTALPHERA, INC. | 285 | $213 |
| FBLGFibroBiologics, Inc. | 154 | $203 |
| PMCBPharmaCyte Biotech, Inc. | 302 | $200 |
| PLURPluri Inc. | 50 | $170 |
| VIVSVivoSim Labs, INC. | 95 | $131 |
| ANIXAnixa Biosciences Inc | 50 | $129 |
| XCUREXICURE, INC. | 29 | $123 |
| CRVOCervoMed Inc. | 30 | $118 |
| MNOVMEDICINOVA INC | 66 | $90 |
| BCABBioAtla, Inc. | 500 | $80 |
| BIVIBIOVIE INC. | 56 | $77 |
| CUECue Biopharma, Inc. | 300 | $69 |
| TRDAEntrada Therapeutics, Inc. | 5 | $63 |
| CALCCalciMedica, Inc. | 107 | $58 |
| QNCXQuince Therapeutics, Inc. | 550 | $55 |
| BCYCBICYCLE THERAPEUTICS PLC | 10 | $46 |
| RLMDRELMADA THERAPEUTICS, INC. | 5 | $34 |
| IVVDInvivyd, Inc. | 19 | $24 |
| ANVSAnnovis Bio, Inc. | 10 | $22 |
| GDTCCytoMed Therapeutics Ltd | 21 | $21 |
| CODXCo-Diagnostics Inc. | 10 | $18 |
| AVTXAvalo Therapeutics, Inc. | 1 | $14 |
| INKTMiNK Therapeutics, Inc. | 1 | $10 |
| ARTLARTELO BIOSCIENCES, INC. | 1 | $7 |
| TVRDTvardi Therapeutics, Inc. | 2 | $6 |
| IMNNImunon, Inc. | 2 | $5 |
| LITSLite Strategy, Inc. | 2 | $2 |
| CLRBCellectar Biosciences, Inc. | 1 | $2 |
| ASBPAspire Biopharma Holdings Inc. | 2 | $2 |
| SBFMSUNSHINE BIOPHARMA INC. | 2 | $2 |
| GLMDGalmed Pharmaceuticals Ltd. | 5 | $2 |
| BCDABioCardia, Inc. | 1 | $1 |
| MBIOMUSTANG BIO, INC. | 2 | $1 |
| TOVXTheriva Biologics, Inc. | 8 | $1 |
| ADTXAditxt, Inc. | 2 | $0 |