| REGNREGENERON PHARMACEUTICALS, INC. | 2,065,064 | $1.60B |
| GILDGILEAD SCIENCES, INC. | 7,833,564 | $1.09B |
| EXELEXELIXIS, INC. | 3,782,734 | $162.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 322,232 | $106.6M |
| SNYSanofi | 1,911,226 | $92.1M |
| INSMINSMED Inc | 534,750 | $87.4M |
| TEVATeva Pharmaceutical Industries Limited | 2,741,023 | $82.6M |
| JAZZJazz Pharmaceuticals plc | 346,148 | $65.4M |
| ONCBeOne Medicines Ltd. | 196,429 | $58.3M |
| AXSMAxsome Therapeutics, Inc. | 335,737 | $56.7M |
| ADMAADMA BIOLOGICS, INC. | 6,098,225 | $54.9M |
| MRNAModerna, Inc. | 1,078,194 | $54.8M |
| ROIVRoivant Sciences Ltd. | 1,955,046 | $54.2M |
| IONSIONIS PHARMACEUTICALS INC | 648,496 | $48.7M |
| ARGXARGENX SE | 66,241 | $48.4M |
| TGTXTG THERAPEUTICS, INC. | 1,447,078 | $48.1M |
| INCYIncyte Corp. | 491,458 | $46.3M |
| PTCTPTC THERAPEUTICS, INC. | 667,019 | $45.4M |
| BBIOBridgeBio Pharma, Inc. | 562,696 | $41.8M |
| TERNTerns Pharmaceuticals, Inc. | 772,592 | $40.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 705,198 | $39.8M |
| DAWNDay One Biopharmaceuticals, Inc. | 1,823,998 | $39.1M |
| FOLDAMICUS THERAPEUTICS, INC. | 2,300,567 | $33.3M |
| RVMDREVOLUTION MEDICINES, INC. | 340,611 | $33.1M |
| COGTCogent Biosciences, Inc. | 831,602 | $32.0M |
| ARDXARDELYX, INC. | 5,234,683 | $31.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 499,837 | $31.3M |
| ANIPANI PHARMACEUTICALS INC | 402,357 | $30.9M |
| SRRKScholar Rock Holding Corp | 581,654 | $28.6M |
| TVTXTravere Therapeutics, Inc. | 938,569 | $27.9M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 722,348 | $24.4M |
| ANNXAnnexon, Inc. | 4,246,330 | $23.5M |
| CYTKCYTOKINETICS INC | 351,809 | $23.2M |
| ACADACADIA PHARMACEUTICALS INC | 1,036,987 | $23.1M |
| ARQTArcutis Biotherapeutics, Inc. | 902,134 | $21.3M |
| PCVXVaxcyte, Inc. | 320,789 | $18.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 217,482 | $18.3M |
| ADPTAdaptive Biotechnologies Corp | 1,304,160 | $18.1M |
| ANABANAPTYSBIO, INC | 316,065 | $17.5M |
| XERSXeris Biopharma Holdings, Inc. | 2,916,598 | $16.9M |
| ZYMEZymeworks Inc. | 651,662 | $16.3M |
| INVAInnoviva, Inc. | 620,482 | $14.5M |
| PTGXProtagonist Therapeutics, Inc | 127,914 | $13.5M |
| DFTXDefinium Therapeutics Inc. | 698,130 | $13.2M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 3,664,278 | $12.9M |
| NRIXNurix Therapeutics, Inc. | 812,601 | $12.6M |
| VRDNViridian Therapeutics, Inc.\DE | 604,914 | $11.8M |
| CGEMCullinan Therapeutics, Inc. | 805,700 | $11.4M |
| NUVLNuvalent, Inc. | 109,820 | $11.3M |
| RCKTRocket Pharmaceuticals Inc. | 3,128,753 | $11.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 216,047 | $11.2M |
| APGEApogee Therapeutics, Inc. | 128,115 | $10.8M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 117,376 | $10.2M |
| ESPREsperion Therapeutics, Inc. | 3,613,709 | $9.9M |
| APLSApellis Pharmaceuticals, Inc. | 220,114 | $8.9M |
| LGNDLigand Pharmaceuticals Incorporated | 42,689 | $8.5M |
| SYRESpyre Therapeutics, Inc. | 153,899 | $7.8M |
| TNGXTango Therapeutics, Inc. | 360,818 | $7.5M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 759,368 | $7.4M |
| ALTAltimmune, Inc. | 2,334,601 | $7.2M |
| ALMSALUMIS INC. | 319,188 | $7.0M |
| IBRXImmunityBio, Inc. | 879,571 | $6.7M |
| VKTXViking Therapeutics, Inc. | 199,003 | $6.5M |
| CLDXCelldex Therapeutics, Inc. | 201,949 | $6.4M |
| BHVNBiohaven Ltd. | 745,748 | $6.3M |
| IMVTImmunovant, Inc. | 241,195 | $6.0M |
| LQDALiquidia Corp | 152,225 | $5.7M |
| DNLIDenali Therapeutics Inc. | 295,586 | $5.7M |
| BEAMBeam Therapeutics Inc. | 232,596 | $5.5M |
| FDMT4D Molecular Therapeutics, Inc. | 561,805 | $5.2M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 162,906 | $5.0M |
| RGNXREGENXBIO Inc. | 582,016 | $4.9M |
| RCUSArcus Biosciences, Inc. | 221,710 | $4.8M |
| SMMTSummit Therapeutics Inc. | 243,992 | $4.6M |
| GERNGERON CORP | 2,931,489 | $4.4M |
| ARVNARVINAS, INC. | 406,340 | $4.3M |
| ORKAOruka Therapeutics, Inc. | 86,938 | $4.3M |
| OLMAOlema Pharmaceuticals, Inc. | 278,990 | $4.2M |
| ELVNEnliven Therapeutics, Inc. | 105,883 | $4.2M |
| CATXPerspective Therapeutics, Inc. | 910,221 | $3.8M |
| KODKodiak Sciences Inc. | 95,292 | $3.6M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 1,164,603 | $3.6M |
| STOKStoke Therapeutics, Inc. | 108,617 | $3.5M |
| SLNOSOLENO THERAPEUTICS INC | 104,738 | $3.5M |
| OCULOCULAR THERAPEUTIX, INC | 411,080 | $3.5M |
| IRONDisc Medicine, Inc. | 51,380 | $3.3M |
| VCELVericel Corp | 101,644 | $3.3M |
| NTLAIntellia Therapeutics, Inc. | 240,817 | $3.1M |
| LRMRLarimar Therapeutics, Inc. | 674,915 | $3.0M |
| KROSKeros Therapeutics, Inc. | 262,075 | $2.9M |
| SLDBSolid Biosciences Inc. | 400,292 | $2.9M |
| SLSSELLAS Life Sciences Group, Inc. | 670,974 | $2.8M |
| OGNOrganon & Co. | 468,931 | $2.8M |
| PVLAPALVELLA THERAPEUTICS, INC. | 20,834 | $2.6M |
| HROWHARROW, INC. | 65,504 | $2.3M |
| TRDAEntrada Therapeutics, Inc. | 175,648 | $2.2M |
| NUVBNuvation Bio Inc. | 514,117 | $2.2M |
| KALVKalVista Pharmaceuticals, Inc. | 106,864 | $2.2M |
| PGENPRECIGEN, INC. | 534,011 | $2.1M |
| ORICOric Pharmaceuticals, Inc. | 153,022 | $1.9M |
| MAZEMaze Therapeutics, Inc. | 63,360 | $1.9M |
| SVRASavara Inc | 343,553 | $1.9M |
| ZVRAZEVRA THERAPEUTICS, INC. | 192,588 | $1.8M |
| FLGTFulgent Genetics Inc. | 104,049 | $1.7M |
| CMPXCompass Therapeutics, Inc. | 290,972 | $1.5M |
| DSGNDesign Therapeutics, Inc. | 126,815 | $1.3M |
| ZBIOZenas BioPharma, Inc. | 67,770 | $1.3M |
| TNXPTonix Pharmaceuticals Holding Corp. | 94,561 | $1.3M |
| KNSAKiniksa Pharmaceuticals International, plc | 26,948 | $1.3M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 23,472 | $1.3M |
| KURAKura Oncology, Inc. | 151,863 | $1.2M |
| SPRYARS Pharmaceuticals, Inc. | 150,696 | $1.2M |
| ABUSArbutus Biopharma Corp | 259,017 | $1.2M |
| DNAGinkgo Bioworks Holdings Inc. | 181,749 | $1.1M |
| AQSTAquestive Therapeutics, Inc. | 253,465 | $1.1M |
| ABSIAbsci Corporation | 342,689 | $1.0M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 45,435 | $981K |
| OPKOPKO HEALTH, INC. | 846,993 | $966K |
| SIONSionna Therapeutics, Inc. | 23,734 | $951K |
| SANASana Biotechnology, Inc. | 326,972 | $942K |
| BCAXBicara Therapeutics Inc. | 43,984 | $875K |
| BIOABioAge Labs, Inc. | 48,688 | $852K |
| UPBUpstream Bio, Inc. | 75,536 | $680K |
| JBIOJade Biosciences, Inc. | 46,236 | $650K |
| ATAIAtai Beckley N.V. | 177,123 | $627K |
| MLTXMoonLake Immunotherapeutics | 33,417 | $623K |
| LBRXLB PHARMACEUTICALS INC | 22,966 | $566K |
| SIGASIGA TECHNOLOGIES INC | 100,899 | $540K |
| DMACDiaMedica Therapeutics Inc. | 79,110 | $536K |
| AVXLANAVEX LIFE SCIENCES CORP. | 169,156 | $519K |
| NGNENeurogene Inc. | 25,210 | $508K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 79,101 | $505K |
| PHVSPharvaris N.V. | 17,007 | $480K |
| MPLTMapLight Therapeutics, Inc. | 23,089 | $469K |
| CADLCandel Therapeutics, Inc. | 93,158 | $456K |
| VYGRVoyager Therapeutics, Inc. | 117,100 | $452K |
| ORGOOrganogenesis Holdings Inc. | 188,745 | $447K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 526,293 | $421K |
| FATEFATE THERAPEUTICS INC | 339,073 | $407K |
| XOMAXOMA Royalty Corporation | 12,706 | $399K |
| FENCFENNEC PHARMACEUTICALS INC. | 60,948 | $375K |
| TECXTectonic Therapeutic, Inc. | 12,033 | $372K |
| LENZLENZ Therapeutics, Inc. | 40,190 | $368K |
| CHRSCoherus Oncology, Inc. | 210,379 | $356K |
| RNAAtrium Therapeutics Inc. | 25,307 | $338K |
| ALECAlector, Inc. | 154,930 | $333K |
| RZLTRezolute, Inc. | 97,686 | $298K |
| ABEOABEONA THERAPEUTICS INC. | 56,719 | $254K |
| RNACCartesian Therapeutics, Inc. | 37,451 | $230K |
| HUMAHumacyte Inc. | 349,435 | $212K |
| CRDFCardiff Oncology, Inc. | 130,346 | $211K |
| PLXProtalix BioTherapeutics, Inc. | 90,188 | $196K |
| MDWDMediWound Ltd. | 10,799 | $174K |
| NVCTNuvectis Pharma, Inc. | 16,749 | $129K |
| HURATuHURA Biosciences, Inc./NV | 33,575 | $60K |
| AARDAardvark Therapeutics, Inc. | 15,312 | $58K |
| ALDXAldeyra Therapeutics, Inc. | 21,266 | $36K |