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| VRTXVERTEX PHARMACEUTICALS INC / MA | 1,084,495 | $484.3M |
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| JAZZJazz Pharmaceuticals plc | 346,148 | $65.4M |
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| IONSIONIS PHARMACEUTICALS INC | 648,496 | $48.7M |
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| BCRXBIOCRYST PHARMACEUTICALS INC | 3,819,263 | $36.4M |
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| ANIPANI PHARMACEUTICALS INC | 402,357 | $30.9M |
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| CYTKCYTOKINETICS INC | 351,809 | $23.2M |
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| ACADACADIA PHARMACEUTICALS INC | 1,036,987 | $23.1M |
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| SLNOSOLENO THERAPEUTICS INC | 104,738 | $3.5M |
| OCULOCULAR THERAPEUTIX, INC | 411,080 | $3.5M |
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| ARRYARRAY BIOPHARMA INC | 376,319 | $2.7M |
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