| GILDGILEAD SCIENCES, INC. | 1,440,817 | $200.8M |
| REGNREGENERON PHARMACEUTICALS, INC. | 117,369 | $90.7M |
| INSMINSMED Inc | 293,546 | $48.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 728,504 | $40.2M |
| ARGXARGENX SE | 39,437 | $28.8M |
| IONSIONIS PHARMACEUTICALS INC | 350,414 | $26.3M |
| LGNDLigand Pharmaceuticals Incorporated | 119,839 | $23.9M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 65,424 | $21.6M |
| GRFSGrifols S.A. | 2,452,728 | $19.7M |
| TGTXTG THERAPEUTICS, INC. | 401,846 | $13.3M |
| RVMDREVOLUTION MEDICINES, INC. | 124,709 | $12.1M |
| BBIOBridgeBio Pharma, Inc. | 162,001 | $12.0M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 125,207 | $10.9M |
| KNSAKiniksa Pharmaceuticals International, plc | 209,617 | $10.1M |
| ANIPANI PHARMACEUTICALS INC | 124,100 | $9.5M |
| HROWHARROW, INC. | 268,515 | $9.5M |
| MRNAModerna, Inc. | 176,800 | $9.0M |
| INCYIncyte Corp. | 93,241 | $8.8M |
| TVTXTravere Therapeutics, Inc. | 293,357 | $8.7M |
| COGTCogent Biosciences, Inc. | 223,216 | $8.6M |
| AXSMAxsome Therapeutics, Inc. | 50,113 | $8.5M |
| TERNTerns Pharmaceuticals, Inc. | 160,597 | $8.5M |
| RDYDR REDDYS LABORATORIES LTD | 588,706 | $8.2M |
| PCVXVaxcyte, Inc. | 121,320 | $7.0M |
| ROIVRoivant Sciences Ltd. | 249,637 | $6.9M |
| IMCRImmunocore Holdings plc | 211,140 | $6.4M |
| SLNOSOLENO THERAPEUTICS INC | 185,317 | $6.2M |
| ARQTArcutis Biotherapeutics, Inc. | 256,628 | $6.0M |
| JAZZJazz Pharmaceuticals plc | 31,694 | $6.0M |
| EXELEXELIXIS, INC. | 138,842 | $6.0M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 95,997 | $5.4M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 47,972 | $4.0M |
| NUVLNuvalent, Inc. | 33,460 | $3.4M |
| ACADACADIA PHARMACEUTICALS INC | 153,053 | $3.4M |
| APLSApellis Pharmaceuticals, Inc. | 84,451 | $3.4M |
| SIGASIGA TECHNOLOGIES INC | 590,761 | $3.2M |
| ONCBeOne Medicines Ltd. | 10,486 | $3.1M |
| CYTKCYTOKINETICS INC | 46,719 | $3.1M |
| KODKodiak Sciences Inc. | 69,860 | $2.7M |
| PVLAPALVELLA THERAPEUTICS, INC. | 21,142 | $2.6M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 41,879 | $2.6M |
| DNLIDenali Therapeutics Inc. | 128,119 | $2.5M |
| QUREuniQure N.V. | 147,549 | $2.4M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 44,472 | $2.3M |
| APGEApogee Therapeutics, Inc. | 25,971 | $2.2M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 2,576,716 | $2.1M |
| PTCTPTC THERAPEUTICS, INC. | 28,915 | $2.0M |
| PTGXProtagonist Therapeutics, Inc | 18,382 | $1.9M |
| SRRKScholar Rock Holding Corp | 39,333 | $1.9M |
| ADPTAdaptive Biotechnologies Corp | 136,731 | $1.9M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 51,707 | $1.7M |
| VKTXViking Therapeutics, Inc. | 51,963 | $1.7M |
| ELVNEnliven Therapeutics, Inc. | 38,648 | $1.5M |
| BHVNBiohaven Ltd. | 160,251 | $1.4M |
| ADMAADMA BIOLOGICS, INC. | 148,374 | $1.3M |
| FOLDAMICUS THERAPEUTICS, INC. | 88,516 | $1.3M |
| STOKStoke Therapeutics, Inc. | 39,158 | $1.3M |
| SYRESpyre Therapeutics, Inc. | 22,265 | $1.1M |
| OCULOCULAR THERAPEUTIX, INC | 124,672 | $1.1M |
| VCELVericel Corp | 31,918 | $1.0M |
| SMMTSummit Therapeutics Inc. | 53,777 | $1.0M |
| ABVXAbivax SA | 8,672 | $966K |
| VRDNViridian Therapeutics, Inc.\DE | 44,375 | $868K |
| LQDALiquidia Corp | 21,924 | $827K |
| OGNOrganon & Co. | 121,873 | $730K |
| BEAMBeam Therapeutics Inc. | 30,629 | $730K |
| IBRXImmunityBio, Inc. | 93,418 | $717K |
| CLDXCelldex Therapeutics, Inc. | 22,237 | $705K |
| TNGXTango Therapeutics, Inc. | 33,476 | $700K |
| IMVTImmunovant, Inc. | 25,655 | $637K |
| ORKAOruka Therapeutics, Inc. | 12,200 | $598K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 17,800 | $570K |
| RCUSArcus Biosciences, Inc. | 26,054 | $563K |
| DFTXDefinium Therapeutics Inc. | 29,600 | $559K |
| IRONDisc Medicine, Inc. | 8,576 | $548K |
| DAWNDay One Biopharmaceuticals, Inc. | 24,732 | $530K |
| NRIXNurix Therapeutics, Inc. | 31,595 | $490K |
| INVAInnoviva, Inc. | 19,992 | $466K |
| ARDXARDELYX, INC. | 75,544 | $453K |
| ZYMEZymeworks Inc. | 17,371 | $435K |
| NTLAIntellia Therapeutics, Inc. | 32,656 | $419K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 13,000 | $395K |
| ALMSALUMIS INC. | 17,867 | $394K |
| ANABANAPTYSBIO, INC | 6,988 | $388K |
| ZVRAZEVRA THERAPEUTICS, INC. | 38,349 | $357K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 97,901 | $344K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 107,475 | $330K |
| NUVBNuvation Bio Inc. | 68,728 | $295K |
| OLMAOlema Pharmaceuticals, Inc. | 18,868 | $281K |
| GERNGERON CORP | 171,453 | $255K |
| XERSXeris Biopharma Holdings, Inc. | 43,422 | $252K |
| MAZEMaze Therapeutics, Inc. | 8,200 | $245K |
| ORICOric Pharmaceuticals, Inc. | 18,429 | $233K |
| SIONSionna Therapeutics, Inc. | 5,300 | $212K |
| ARVNARVINAS, INC. | 19,415 | $206K |
| KALVKalVista Pharmaceuticals, Inc. | 9,964 | $201K |
| SVRASavara Inc | 36,555 | $200K |
| CGEMCullinan Therapeutics, Inc. | 12,918 | $184K |
| KURAKura Oncology, Inc. | 21,595 | $176K |
| ESPREsperion Therapeutics, Inc. | 63,900 | $175K |
| SLSSELLAS Life Sciences Group, Inc. | 39,000 | $165K |
| ANNXAnnexon, Inc. | 29,568 | $164K |
| CMPXCompass Therapeutics, Inc. | 30,407 | $161K |
| ABUSArbutus Biopharma Corp | 35,268 | $159K |
| LBRXLB PHARMACEUTICALS INC | 6,100 | $150K |
| BCAXBicara Therapeutics Inc. | 7,500 | $149K |
| PGENPRECIGEN, INC. | 38,038 | $147K |
| SPRYARS Pharmaceuticals, Inc. | 17,707 | $142K |
| TECXTectonic Therapeutic, Inc. | 4,600 | $142K |
| IVAInventiva S.A. | 24,467 | $136K |
| OPKOPKO HEALTH, INC. | 114,301 | $130K |
| FLGTFulgent Genetics Inc. | 8,173 | $130K |
| ZBIOZenas BioPharma, Inc. | 6,200 | $121K |
| FDMT4D Molecular Therapeutics, Inc. | 12,543 | $117K |
| RGNXREGENXBIO Inc. | 13,746 | $115K |
| AQSTAquestive Therapeutics, Inc. | 27,300 | $113K |
| TRDAEntrada Therapeutics, Inc. | 8,877 | $112K |
| SANASana Biotechnology, Inc. | 38,609 | $111K |
| MPLTMapLight Therapeutics, Inc. | 5,300 | $108K |
| JBIOJade Biosciences, Inc. | 7,422 | $104K |
| KROSKeros Therapeutics, Inc. | 9,116 | $101K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 4,652 | $100K |
| BIOABioAge Labs, Inc. | 5,100 | $89K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 8,979 | $87K |
| SNYSanofi | 1,788 | $86K |
| NGNENeurogene Inc. | 4,200 | $85K |
| DNAGinkgo Bioworks Holdings Inc. | 12,300 | $75K |
| RZLTRezolute, Inc. | 24,600 | $75K |
| ABSIAbsci Corporation | 24,700 | $74K |
| XOMAXOMA Royalty Corporation | 2,362 | $74K |
| PLXProtalix BioTherapeutics, Inc. | 31,100 | $67K |
| ALTAltimmune, Inc. | 21,447 | $66K |
| FENCFENNEC PHARMACEUTICALS INC. | 9,753 | $60K |
| MDWDMediWound Ltd. | 3,500 | $56K |
| AVXLANAVEX LIFE SCIENCES CORP. | 18,209 | $56K |
| RCKTRocket Pharmaceuticals Inc. | 15,117 | $54K |
| LENZLENZ Therapeutics, Inc. | 5,793 | $53K |
| SLDBSolid Biosciences Inc. | 7,100 | $51K |
| VYGRVoyager Therapeutics, Inc. | 12,732 | $49K |
| HURATuHURA Biosciences, Inc./NV | 25,500 | $46K |
| CATXPerspective Therapeutics, Inc. | 10,300 | $43K |
| TNXPTonix Pharmaceuticals Holding Corp. | 2,900 | $40K |
| NVCTNuvectis Pharma, Inc. | 5,000 | $39K |
| RNAAtrium Therapeutics Inc. | 2,749 | $37K |
| CHRSCoherus Oncology, Inc. | 20,593 | $35K |
| KRROKorro Bio, Inc. | 3,000 | $34K |
| FATEFATE THERAPEUTICS INC | 28,015 | $34K |
| LRMRLarimar Therapeutics, Inc. | 6,619 | $30K |
| RNACCartesian Therapeutics, Inc. | 3,902 | $24K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 3,600 | $23K |
| ALECAlector, Inc. | 10,310 | $22K |
| DSGNDesign Therapeutics, Inc. | 2,026 | $22K |
| DMACDiaMedica Therapeutics Inc. | 2,781 | $19K |
| GYREGYRE THERAPEUTICS, INC. | 2,700 | $19K |
| ALDXAldeyra Therapeutics, Inc. | 9,598 | $16K |
| AARDAardvark Therapeutics, Inc. | 3,823 | $14K |
| ORGOOrganogenesis Holdings Inc. | 5,792 | $14K |
| TVRDTvardi Therapeutics, Inc. | 3,000 | $10K |
| HUMAHumacyte Inc. | 15,216 | $9K |
| CADLCandel Therapeutics, Inc. | 1,700 | $8K |
| ABEOABEONA THERAPEUTICS INC. | 1,700 | $8K |
| CRDFCardiff Oncology, Inc. | 3,600 | $6K |
| UPBUpstream Bio, Inc. | 100 | $900 |
| SCLXSCILEX HOLDING CO | 1 | $5 |