| GILDGILEAD SCIENCES, INC. | 874,834 | $121.9M |
| REGNREGENERON PHARMACEUTICALS, INC. | 69,854 | $54.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 81,325 | $26.9M |
| INSMINSMED Inc | 122,958 | $20.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 139,598 | $8.7M |
| MRNAModerna, Inc. | 147,589 | $7.5M |
| INCYIncyte Corp. | 76,314 | $7.2M |
| BBIOBridgeBio Pharma, Inc. | 78,932 | $5.8M |
| CYTKCYTOKINETICS INC | 61,177 | $4.0M |
| RVMDREVOLUTION MEDICINES, INC. | 40,628 | $3.8M |
| PCVXVaxcyte, Inc. | 63,826 | $3.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 63,951 | $3.6M |
| PTCTPTC THERAPEUTICS, INC. | 51,068 | $3.5M |
| NUVLNuvalent, Inc. | 32,931 | $3.4M |
| AXSMAxsome Therapeutics, Inc. | 19,452 | $3.3M |
| PTGXProtagonist Therapeutics, Inc | 30,604 | $3.2M |
| JAZZJazz Pharmaceuticals plc | 16,739 | $3.2M |
| SRRKScholar Rock Holding Corp | 61,906 | $3.0M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 34,677 | $3.0M |
| COGTCogent Biosciences, Inc. | 75,970 | $2.9M |
| APGEApogee Therapeutics, Inc. | 34,217 | $2.9M |
| BEAMBeam Therapeutics Inc. | 118,018 | $2.8M |
| TGTXTG THERAPEUTICS, INC. | 79,443 | $2.6M |
| TERNTerns Pharmaceuticals, Inc. | 44,956 | $2.4M |
| FOLDAMICUS THERAPEUTICS, INC. | 161,842 | $2.3M |
| SNYSanofi | 46,620 | $2.2M |
| ARQTArcutis Biotherapeutics, Inc. | 88,484 | $2.1M |
| ACADACADIA PHARMACEUTICALS INC | 86,264 | $1.9M |
| DNLIDenali Therapeutics Inc. | 95,193 | $1.8M |
| LGNDLigand Pharmaceuticals Incorporated | 9,077 | $1.8M |
| SYRESpyre Therapeutics, Inc. | 36,323 | $1.8M |
| IMVTImmunovant, Inc. | 71,801 | $1.8M |
| ONCBeOne Medicines Ltd. | 5,863 | $1.7M |
| NTLAIntellia Therapeutics, Inc. | 133,974 | $1.7M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 19,034 | $1.6M |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 160,462 | $1.5M |
| TVTXTravere Therapeutics, Inc. | 49,448 | $1.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 42,071 | $1.4M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 25,907 | $1.3M |
| IBRXImmunityBio, Inc. | 176,929 | $1.3M |
| EXELEXELIXIS, INC. | 29,199 | $1.2M |
| TNGXTango Therapeutics, Inc. | 59,537 | $1.2M |
| NRIXNurix Therapeutics, Inc. | 77,897 | $1.2M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 394,629 | $1.2M |
| LQDALiquidia Corp | 30,809 | $1.2M |
| ADMAADMA BIOLOGICS, INC. | 127,172 | $1.1M |
| CLDXCelldex Therapeutics, Inc. | 35,339 | $1.1M |
| STOKStoke Therapeutics, Inc. | 33,873 | $1.1M |
| IRONDisc Medicine, Inc. | 16,699 | $1.1M |
| RCUSArcus Biosciences, Inc. | 47,511 | $1.0M |
| ORKAOruka Therapeutics, Inc. | 20,964 | $1.0M |
| ADPTAdaptive Biotechnologies Corp | 70,035 | $972K |
| SLNOSOLENO THERAPEUTICS INC | 29,288 | $963K |
| VRDNViridian Therapeutics, Inc.\DE | 48,195 | $932K |
| VCELVericel Corp | 27,856 | $889K |
| DAWNDay One Biopharmaceuticals, Inc. | 40,964 | $878K |
| DFTXDefinium Therapeutics Inc. | 46,193 | $873K |
| KODKodiak Sciences Inc. | 22,833 | $848K |
| ARDXARDELYX, INC. | 141,281 | $834K |
| INVAInnoviva, Inc. | 35,182 | $820K |
| OCULOCULAR THERAPEUTIX, INC | 88,170 | $747K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 24,841 | $744K |
| ELVNEnliven Therapeutics, Inc. | 18,449 | $723K |
| ALMSALUMIS INC. | 32,160 | $708K |
| QUREuniQure N.V. | 42,836 | $690K |
| ANIPANI PHARMACEUTICALS INC | 8,866 | $682K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 188,914 | $657K |
| OLMAOlema Pharmaceuticals, Inc. | 42,074 | $613K |
| ZYMEZymeworks Inc. | 23,373 | $585K |
| BHVNBiohaven Ltd. | 69,636 | $584K |
| ANABANAPTYSBIO, INC | 10,486 | $581K |
| HRMYHarmony Biosciences Holdings, Inc. | 20,532 | $575K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 17,865 | $572K |
| PVLAPALVELLA THERAPEUTICS, INC. | 4,688 | $570K |
| ABVXAbivax SA | 5,013 | $558K |
| HROWHARROW, INC. | 14,774 | $521K |
| ORICOric Pharmaceuticals, Inc. | 39,188 | $493K |
| RGNXREGENXBIO Inc. | 58,350 | $486K |
| NUVBNuvation Bio Inc. | 113,020 | $485K |
| GERNGERON CORP | 318,809 | $470K |
| IXHLIncannex Healthcare Inc. | 149,857 | $450K |
| SVRASavara Inc | 81,286 | $438K |
| KALVKalVista Pharmaceuticals, Inc. | 22,005 | $436K |
| XERSXeris Biopharma Holdings, Inc. | 73,870 | $428K |
| CGEMCullinan Therapeutics, Inc. | 30,151 | $425K |
| ANNXAnnexon, Inc. | 76,257 | $414K |
| SLSSELLAS Life Sciences Group, Inc. | 98,289 | $412K |
| SANASana Biotechnology, Inc. | 143,510 | $408K |
| PGENPRECIGEN, INC. | 107,107 | $400K |
| FLGTFulgent Genetics Inc. | 24,640 | $392K |
| CMPXCompass Therapeutics, Inc. | 74,084 | $389K |
| KURAKura Oncology, Inc. | 47,335 | $381K |
| RCKTRocket Pharmaceuticals Inc. | 105,594 | $377K |
| MAZEMaze Therapeutics, Inc. | 12,416 | $371K |
| SIONSionna Therapeutics, Inc. | 9,185 | $363K |
| ABUSArbutus Biopharma Corp | 79,466 | $356K |
| BCAXBicara Therapeutics Inc. | 17,666 | $349K |
| SMMTSummit Therapeutics Inc. | 18,357 | $312K |
| IONSIONIS PHARMACEUTICALS INC | 4,273 | $310K |
| ESPREsperion Therapeutics, Inc. | 112,469 | $308K |
| SPRYARS Pharmaceuticals, Inc. | 35,867 | $286K |
| ROIVRoivant Sciences Ltd. | 10,805 | $285K |
| ZBIOZenas BioPharma, Inc. | 14,386 | $277K |
| ARVNARVINAS, INC. | 26,062 | $276K |
| VKTXViking Therapeutics, Inc. | 8,937 | $267K |
| BIOABioAge Labs, Inc. | 14,155 | $248K |
| ZVRAZEVRA THERAPEUTICS, INC. | 26,093 | $243K |
| ABSIAbsci Corporation | 82,259 | $243K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 24,639 | $238K |
| FDMT4D Molecular Therapeutics, Inc. | 25,809 | $237K |
| ALTAltimmune, Inc. | 77,292 | $235K |
| TEVATeva Pharmaceutical Industries Limited | 7,714 | $232K |
| LBRXLB PHARMACEUTICALS INC | 9,170 | $226K |
| OPKOPKO HEALTH, INC. | 197,906 | $226K |
| APLSApellis Pharmaceuticals, Inc. | 12,788 | $219K |
| JBIOJade Biosciences, Inc. | 14,961 | $210K |
| SLDBSolid Biosciences Inc. | 28,024 | $202K |
| AQSTAquestive Therapeutics, Inc. | 47,783 | $198K |
| MPLTMapLight Therapeutics, Inc. | 9,061 | $184K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 8,428 | $182K |
| TRDAEntrada Therapeutics, Inc. | 13,577 | $171K |
| TECXTectonic Therapeutic, Inc. | 5,215 | $161K |
| KROSKeros Therapeutics, Inc. | 13,891 | $153K |
| AVXLANAVEX LIFE SCIENCES CORP. | 49,802 | $150K |
| XOMAXOMA Royalty Corporation | 4,600 | $144K |
| CATXPerspective Therapeutics, Inc. | 34,841 | $143K |
| UPBUpstream Bio, Inc. | 15,608 | $140K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 20,635 | $132K |
| RNAAtrium Therapeutics Inc. | 9,488 | $127K |
| DSGNDesign Therapeutics, Inc. | 11,363 | $121K |
| DNAGinkgo Bioworks Holdings Inc. | 19,651 | $120K |
| DMACDiaMedica Therapeutics Inc. | 16,158 | $109K |
| NGNENeurogene Inc. | 5,307 | $107K |
| SIGASIGA TECHNOLOGIES INC | 19,526 | $104K |
| LRMRLarimar Therapeutics, Inc. | 23,091 | $104K |
| RZLTRezolute, Inc. | 33,957 | $104K |
| CADLCandel Therapeutics, Inc. | 21,073 | $103K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,829 | $101K |
| ABEOABEONA THERAPEUTICS INC. | 20,760 | $93K |
| ALECAlector, Inc. | 42,661 | $92K |
| SGMOQSANGAMO THERAPEUTICS, INC | 361,277 | $89K |
| TNXPTonix Pharmaceuticals Holding Corp. | 6,383 | $88K |
| LENZLENZ Therapeutics, Inc. | 9,371 | $86K |
| VYGRVoyager Therapeutics, Inc. | 22,127 | $85K |
| CHRSCoherus Oncology, Inc. | 50,445 | $85K |
| FENCFENNEC PHARMACEUTICALS INC. | 13,621 | $84K |
| ORGOOrganogenesis Holdings Inc. | 32,482 | $77K |
| MDWDMediWound Ltd. | 4,648 | $75K |
| PLXProtalix BioTherapeutics, Inc. | 34,062 | $74K |
| CTMXCytomX Therapeutics, Inc. | 16,683 | $74K |
| FATEFATE THERAPEUTICS INC | 53,619 | $64K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 73,125 | $59K |
| NVCTNuvectis Pharma, Inc. | 7,368 | $57K |
| CRDFCardiff Oncology, Inc. | 29,467 | $48K |
| HUMAHumacyte Inc. | 73,878 | $45K |
| ALDXAldeyra Therapeutics, Inc. | 25,815 | $44K |
| GYREGYRE THERAPEUTICS, INC. | 5,617 | $39K |
| KRROKorro Bio, Inc. | 3,214 | $36K |
| HURATuHURA Biosciences, Inc./NV | 20,140 | $36K |
| OCGNOcugen, Inc. | 19,680 | $34K |
| RNACCartesian Therapeutics, Inc. | 5,253 | $32K |
| IVVDInvivyd, Inc. | 21,307 | $25K |
| AARDAardvark Therapeutics, Inc. | 6,065 | $23K |
| DMRADamora Therapeutics, Inc. | 353 | $9K |
| TVRDTvardi Therapeutics, Inc. | 2,356 | $7K |