| GILDGILEAD SCIENCES, INC. | 10,464,889 | $1.46B |
| REGNREGENERON PHARMACEUTICALS, INC. | 732,054 | $565.6M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 934,881 | $309.3M |
| INCYIncyte Corp. | 1,543,188 | $145.2M |
| INSMINSMED Inc | 787,079 | $128.7M |
| TEVATeva Pharmaceutical Industries Limited | 3,872,811 | $116.6M |
| ARGXARGENX SE | 150,850 | $110.2M |
| MRNAModerna, Inc. | 750,841 | $38.1M |
| RVMDREVOLUTION MEDICINES, INC. | 341,148 | $33.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 575,186 | $32.5M |
| JAZZJazz Pharmaceuticals plc | 145,528 | $27.5M |
| PTCTPTC THERAPEUTICS, INC. | 343,380 | $23.4M |
| IONSIONIS PHARMACEUTICALS INC | 294,679 | $22.1M |
| BBIOBridgeBio Pharma, Inc. | 284,917 | $21.2M |
| LGNDLigand Pharmaceuticals Incorporated | 97,660 | $19.5M |
| ONCBeOne Medicines Ltd. | 59,812 | $17.8M |
| EXELEXELIXIS, INC. | 395,298 | $17.0M |
| ROIVRoivant Sciences Ltd. | 561,307 | $15.5M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 229,097 | $14.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 423,915 | $14.3M |
| PTGXProtagonist Therapeutics, Inc | 135,367 | $14.3M |
| TVTXTravere Therapeutics, Inc. | 451,056 | $13.4M |
| XERSXeris Biopharma Holdings, Inc. | 1,908,289 | $11.1M |
| ZVRAZEVRA THERAPEUTICS, INC. | 1,163,090 | $10.8M |
| ABUSArbutus Biopharma Corp | 2,401,389 | $10.8M |
| TGTXTG THERAPEUTICS, INC. | 319,703 | $10.6M |
| DNAGinkgo Bioworks Holdings Inc. | 1,661,587 | $10.2M |
| CYTKCYTOKINETICS INC | 151,021 | $10.0M |
| APLSApellis Pharmaceuticals, Inc. | 228,255 | $9.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 135,810 | $7.0M |
| ACADACADIA PHARMACEUTICALS INC | 287,382 | $6.4M |
| PCVXVaxcyte, Inc. | 97,337 | $5.7M |
| ADMAADMA BIOLOGICS, INC. | 602,707 | $5.4M |
| AXSMAxsome Therapeutics, Inc. | 29,398 | $5.0M |
| IMCRImmunocore Holdings plc | 156,143 | $4.7M |
| ADPTAdaptive Biotechnologies Corp | 324,605 | $4.5M |
| INVAInnoviva, Inc. | 187,122 | $4.4M |
| CNTACentessa Pharmaceuticals plc | 110,207 | $4.3M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 47,032 | $4.1M |
| RCUSArcus Biosciences, Inc. | 188,650 | $4.1M |
| OGNOrganon & Co. | 678,043 | $4.1M |
| VCELVericel Corp | 113,681 | $3.7M |
| NUVLNuvalent, Inc. | 34,482 | $3.5M |
| FOLDAMICUS THERAPEUTICS, INC. | 240,554 | $3.5M |
| VKTXViking Therapeutics, Inc. | 96,533 | $3.1M |
| COGTCogent Biosciences, Inc. | 81,243 | $3.1M |
| ANIPANI PHARMACEUTICALS INC | 39,966 | $3.1M |
| LQDALiquidia Corp | 69,640 | $2.6M |
| TERNTerns Pharmaceuticals, Inc. | 46,691 | $2.5M |
| SRRKScholar Rock Holding Corp | 49,914 | $2.5M |
| APGEApogee Therapeutics, Inc. | 27,418 | $2.3M |
| SYRESpyre Therapeutics, Inc. | 44,792 | $2.3M |
| DNLIDenali Therapeutics Inc. | 110,250 | $2.1M |
| ARQTArcutis Biotherapeutics, Inc. | 84,877 | $2.0M |
| BEAMBeam Therapeutics Inc. | 81,912 | $2.0M |
| IBRXImmunityBio, Inc. | 253,692 | $1.9M |
| IMVTImmunovant, Inc. | 74,456 | $1.8M |
| RDYDR REDDYS LABORATORIES LTD | 132,199 | $1.8M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 21,627 | $1.8M |
| CLDXCelldex Therapeutics, Inc. | 55,080 | $1.7M |
| ALVOAlvotech | 504,460 | $1.7M |
| ELVNEnliven Therapeutics, Inc. | 33,083 | $1.3M |
| CMPSCOMPASS Pathways plc | 231,385 | $1.3M |
| IRONDisc Medicine, Inc. | 19,377 | $1.2M |
| ARDXARDELYX, INC. | 206,662 | $1.2M |
| NTLAIntellia Therapeutics, Inc. | 93,645 | $1.2M |
| NKTRNEKTAR THERAPEUTICS | 16,658 | $1.2M |
| KNSAKiniksa Pharmaceuticals International, plc | 24,602 | $1.2M |
| SLNOSOLENO THERAPEUTICS INC | 35,144 | $1.2M |
| VRDNViridian Therapeutics, Inc.\DE | 59,625 | $1.2M |
| DFTXDefinium Therapeutics Inc. | 59,799 | $1.1M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 37,138 | $1.1M |
| ALMSALUMIS INC. | 50,595 | $1.1M |
| OCULOCULAR THERAPEUTIX, INC | 131,162 | $1.1M |
| DAWNDay One Biopharmaceuticals, Inc. | 51,763 | $1.1M |
| NRIXNurix Therapeutics, Inc. | 70,765 | $1.1M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 33,476 | $1.1M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 342,425 | $1.1M |
| STOKStoke Therapeutics, Inc. | 32,048 | $1.0M |
| PVLAPALVELLA THERAPEUTICS, INC. | 7,446 | $928K |
| HROWHARROW, INC. | 24,530 | $865K |
| RLAYRelay Therapeutics, Inc. | 82,056 | $816K |
| BHVNBiohaven Ltd. | 95,987 | $812K |
| ORKAOruka Therapeutics, Inc. | 15,918 | $781K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 220,161 | $773K |
| KODKodiak Sciences Inc. | 20,173 | $769K |
| ANABANAPTYSBIO, INC | 13,831 | $767K |
| PHVSPharvaris N.V. | 26,776 | $756K |
| NUVBNuvation Bio Inc. | 174,172 | $747K |
| TNGXTango Therapeutics, Inc. | 35,375 | $740K |
| CTMXCytomX Therapeutics, Inc. | 141,893 | $667K |
| ZYMEZymeworks Inc. | 26,209 | $656K |
| SMMTSummit Therapeutics Inc. | 31,892 | $605K |
| KURAKura Oncology, Inc. | 71,660 | $583K |
| PGENPRECIGEN, INC. | 125,378 | $485K |
| OLMAOlema Pharmaceuticals, Inc. | 31,665 | $472K |
| ARVNARVINAS, INC. | 43,350 | $460K |
| QUREuniQure N.V. | 27,872 | $456K |
| MANEVeradermics Incorporated | 7,105 | $449K |
| ANNXAnnexon, Inc. | 80,046 | $443K |
| GERNGERON CORP | 296,841 | $442K |
| BCAXBicara Therapeutics Inc. | 22,227 | $442K |
| KALVKalVista Pharmaceuticals, Inc. | 19,787 | $399K |
| CMPXCompass Therapeutics, Inc. | 75,103 | $397K |
| OPKOPKO HEALTH, INC. | 343,474 | $392K |
| SPRYARS Pharmaceuticals, Inc. | 47,885 | $385K |
| MLTXMoonLake Immunotherapeutics | 20,559 | $383K |
| ATAIAtai Beckley N.V. | 105,636 | $374K |
| ORICOric Pharmaceuticals, Inc. | 29,336 | $372K |
| SANASana Biotechnology, Inc. | 126,417 | $364K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 13,992 | $302K |
| FLGTFulgent Genetics Inc. | 18,807 | $299K |
| CGEMCullinan Therapeutics, Inc. | 18,701 | $266K |
| RGCRegencell Bioscience Holdings Ltd | 9,903 | $252K |
| ZBIOZenas BioPharma, Inc. | 10,432 | $204K |
| SVRASavara Inc | 33,613 | $184K |
| GRFSGrifols S.A. | 22,417 | $180K |
| MAZEMaze Therapeutics, Inc. | 5,790 | $173K |
| UPBUpstream Bio, Inc. | 9,609 | $86K |
| RNAAtrium Therapeutics Inc. | 5,657 | $76K |
| LENZLENZ Therapeutics, Inc. | 8,169 | $75K |
| SLSSELLAS Life Sciences Group, Inc. | 15,142 | $64K |
| SIONSionna Therapeutics, Inc. | 1,432 | $57K |
| SIGASIGA TECHNOLOGIES INC | 10,697 | $57K |
| ESPREsperion Therapeutics, Inc. | 20,876 | $57K |
| FENCFENNEC PHARMACEUTICALS INC. | 8,639 | $52K |
| AVXLANAVEX LIFE SCIENCES CORP. | 15,474 | $47K |
| BIOABioAge Labs, Inc. | 2,655 | $46K |
| LBRXLB PHARMACEUTICALS INC | 1,723 | $42K |
| JBIOJade Biosciences, Inc. | 2,805 | $39K |
| BCYCBICYCLE THERAPEUTICS PLC | 9,054 | $39K |
| AQSTAquestive Therapeutics, Inc. | 9,340 | $39K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 3,973 | $39K |
| SLDBSolid Biosciences Inc. | 5,270 | $38K |
| MPLTMapLight Therapeutics, Inc. | 1,805 | $37K |
| ALTAltimmune, Inc. | 11,496 | $35K |
| ABSIAbsci Corporation | 11,741 | $35K |
| FDMT4D Molecular Therapeutics, Inc. | 3,695 | $34K |
| RGNXREGENXBIO Inc. | 4,022 | $34K |
| TRDAEntrada Therapeutics, Inc. | 2,557 | $32K |
| TECXTectonic Therapeutic, Inc. | 1,000 | $31K |
| KROSKeros Therapeutics, Inc. | 2,621 | $29K |
| RCKTRocket Pharmaceuticals Inc. | 7,632 | $27K |
| XOMAXOMA Royalty Corporation | 854 | $27K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 3,564 | $23K |
| CATXPerspective Therapeutics, Inc. | 5,426 | $23K |
| DSGNDesign Therapeutics, Inc. | 2,077 | $22K |
| RZLTRezolute, Inc. | 6,938 | $21K |
| DMACDiaMedica Therapeutics Inc. | 2,986 | $20K |
| NGNENeurogene Inc. | 898 | $18K |
| ALECAlector, Inc. | 8,346 | $18K |
| ABEOABEONA THERAPEUTICS INC. | 3,975 | $18K |
| CADLCandel Therapeutics, Inc. | 3,581 | $18K |
| LRMRLarimar Therapeutics, Inc. | 3,691 | $17K |
| VYGRVoyager Therapeutics, Inc. | 3,969 | $15K |
| MDWDMediWound Ltd. | 919 | $15K |
| TNXPTonix Pharmaceuticals Holding Corp. | 1,053 | $14K |
| ORGOOrganogenesis Holdings Inc. | 6,087 | $14K |
| CHRSCoherus Oncology, Inc. | 8,510 | $14K |
| PLXProtalix BioTherapeutics, Inc. | 6,333 | $14K |
| FATEFATE THERAPEUTICS INC | 10,398 | $12K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 13,930 | $11K |
| CRDFCardiff Oncology, Inc. | 5,709 | $9K |
| HUMAHumacyte Inc. | 15,022 | $9K |
| NVCTNuvectis Pharma, Inc. | 1,172 | $9K |
| HURATuHURA Biosciences, Inc./NV | 4,999 | $9K |
| GYREGYRE THERAPEUTICS, INC. | 1,251 | $9K |
| ALDXAldeyra Therapeutics, Inc. | 4,940 | $8K |
| KRROKorro Bio, Inc. | 526 | $6K |
| RNACCartesian Therapeutics, Inc. | 915 | $6K |
| AARDAardvark Therapeutics, Inc. | 1,143 | $4K |
| TVRDTvardi Therapeutics, Inc. | 421 | $1K |