| BBIOBridgeBio Pharma, Inc. | 1,757,672 | $130.5M |
| GILDGILEAD SCIENCES, INC. | 666,637 | $92.9M |
| TGTXTG THERAPEUTICS, INC. | 2,041,669 | $67.8M |
| EXELEXELIXIS, INC. | 1,087,030 | $46.6M |
| TEVATeva Pharmaceutical Industries Limited | 1,464,638 | $44.1M |
| JAZZJazz Pharmaceuticals plc | 223,615 | $42.3M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 661,399 | $36.5M |
| LQDALiquidia Corp | 795,884 | $30.0M |
| ROIVRoivant Sciences Ltd. | 1,020,707 | $28.3M |
| ARGXARGENX SE | 38,438 | $28.1M |
| SRRKScholar Rock Holding Corp | 560,084 | $27.5M |
| ADMAADMA BIOLOGICS, INC. | 3,051,943 | $27.5M |
| VKTXViking Therapeutics, Inc. | 748,949 | $24.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 685,240 | $23.2M |
| ONCBeOne Medicines Ltd. | 75,953 | $22.6M |
| ACADACADIA PHARMACEUTICALS INC | 803,265 | $17.9M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 566,081 | $17.2M |
| PCVXVaxcyte, Inc. | 252,877 | $14.7M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 4,173,886 | $14.7M |
| IONSIONIS PHARMACEUTICALS INC | 191,818 | $14.4M |
| VCELVericel Corp | 409,930 | $13.2M |
| ABVXAbivax SA | 94,141 | $10.5M |
| QUREuniQure N.V. | 635,995 | $10.4M |
| DAWNDay One Biopharmaceuticals, Inc. | 475,436 | $10.2M |
| ADPTAdaptive Biotechnologies Corp | 682,182 | $9.5M |
| TVTXTravere Therapeutics, Inc. | 302,280 | $9.0M |
| MLTXMoonLake Immunotherapeutics | 453,625 | $8.5M |
| NKTRNEKTAR THERAPEUTICS | 112,652 | $8.1M |
| NUVLNuvalent, Inc. | 77,138 | $7.9M |
| ARDXARDELYX, INC. | 1,179,379 | $7.1M |
| PGENPRECIGEN, INC. | 1,821,790 | $7.1M |
| OCULOCULAR THERAPEUTIX, INC | 804,589 | $6.8M |
| ARQTArcutis Biotherapeutics, Inc. | 283,623 | $6.7M |
| OCGNOcugen, Inc. | 3,678,655 | $6.7M |
| ELVNEnliven Therapeutics, Inc. | 163,519 | $6.4M |
| IMCRImmunocore Holdings plc | 204,368 | $6.2M |
| ZYMEZymeworks Inc. | 226,967 | $5.7M |
| IBRXImmunityBio, Inc. | 704,232 | $5.4M |
| KURAKura Oncology, Inc. | 663,350 | $5.4M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 165,201 | $5.3M |
| NTLAIntellia Therapeutics, Inc. | 384,957 | $4.9M |
| DFTXDefinium Therapeutics Inc. | 260,241 | $4.9M |
| ANABANAPTYSBIO, INC | 86,038 | $4.8M |
| CTMXCytomX Therapeutics, Inc. | 997,510 | $4.7M |
| FOLDAMICUS THERAPEUTICS, INC. | 298,632 | $4.3M |
| AQSTAquestive Therapeutics, Inc. | 1,030,050 | $4.3M |
| XERSXeris Biopharma Holdings, Inc. | 725,616 | $4.2M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 2,665,938 | $4.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 5,374 | $4.2M |
| CCCCC4 Therapeutics, Inc. | 1,246,896 | $3.3M |
| RVMDREVOLUTION MEDICINES, INC. | 33,603 | $3.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 57,327 | $3.0M |
| ABCLAbCellera Biologics Inc. | 847,883 | $3.0M |
| CLDXCelldex Therapeutics, Inc. | 90,321 | $2.9M |
| GMABGenmab A/S | 98,432 | $2.6M |
| AVTXAvalo Therapeutics, Inc. | 173,320 | $2.6M |
| LGNDLigand Pharmaceuticals Incorporated | 12,906 | $2.6M |
| LRMRLarimar Therapeutics, Inc. | 554,007 | $2.5M |
| SVRASavara Inc | 430,967 | $2.4M |
| RCUSArcus Biosciences, Inc. | 107,979 | $2.3M |
| RCKTRocket Pharmaceuticals Inc. | 623,354 | $2.2M |
| AVXLANAVEX LIFE SCIENCES CORP. | 725,003 | $2.2M |
| ARVNARVINAS, INC. | 199,908 | $2.1M |
| STOKStoke Therapeutics, Inc. | 64,349 | $2.1M |
| IMVTImmunovant, Inc. | 84,312 | $2.1M |
| ZVRAZEVRA THERAPEUTICS, INC. | 221,058 | $2.1M |
| MRNAModerna, Inc. | 39,463 | $2.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 5,902 | $2.0M |
| BHVNBiohaven Ltd. | 228,444 | $1.9M |
| CMPSCOMPASS Pathways plc | 341,821 | $1.9M |
| INSMINSMED Inc | 11,401 | $1.9M |
| ZURAZura Bio Ltd | 278,890 | $1.7M |
| RZLTRezolute, Inc. | 543,363 | $1.7M |
| ALDXAldeyra Therapeutics, Inc. | 968,891 | $1.6M |
| OVIDOvid Therapeutics Inc. | 735,429 | $1.6M |
| CNTACentessa Pharmaceuticals plc | 40,968 | $1.6M |
| LCTXLineage Cell Therapeutics, Inc. | 993,208 | $1.6M |
| RLMDRELMADA THERAPEUTICS, INC. | 221,969 | $1.5M |
| MESOMesoblast Limited | 98,786 | $1.5M |
| ASRTAssertio Holdings, Inc. | 79,436 | $1.5M |
| FBRXForte Biosciences, Inc. | 57,933 | $1.5M |
| KRROKorro Bio, Inc. | 115,704 | $1.3M |
| LYELLyell Immunopharma, Inc. | 63,893 | $1.3M |
| OPKOPKO HEALTH, INC. | 1,114,375 | $1.3M |
| VRDNViridian Therapeutics, Inc.\DE | 60,815 | $1.2M |
| CLYMClimb Bio, Inc. | 171,375 | $1.2M |
| GERNGERON CORP | 771,971 | $1.2M |
| ZNTLZentalis Pharmaceuticals, Inc. | 490,339 | $1.1M |
| CNTXContext Therapeutics Inc. | 436,931 | $1.1M |
| HCMHUTCHMED (China) Limited | 76,514 | $1.1M |
| DSGNDesign Therapeutics, Inc. | 103,902 | $1.1M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 107,926 | $1.0M |
| ANTXAN2 Therapeutics, Inc. | 303,649 | $1.0M |
| BCYCBICYCLE THERAPEUTICS PLC | 218,115 | $1.0M |
| IVVDInvivyd, Inc. | 773,352 | $1.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 15,775 | $989K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 34,499 | $957K |
| RGNXREGENXBIO Inc. | 105,548 | $884K |
| ALECAlector, Inc. | 399,464 | $859K |
| FATEFATE THERAPEUTICS INC | 646,979 | $776K |
| INCYIncyte Corp. | 8,243 | $776K |
| GRCEGrace Therapeutics, Inc. | 167,097 | $774K |
| IMUXIMMUNIC, INC. | 659,153 | $732K |
| IRDOpus Genetics, Inc. | 158,103 | $719K |
| SLDBSolid Biosciences Inc. | 96,993 | $698K |
| STROSUTRO BIOPHARMA, INC. | 27,760 | $692K |
| AXSMAxsome Therapeutics, Inc. | 4,078 | $689K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 73,193 | $687K |
| ORICOric Pharmaceuticals, Inc. | 53,037 | $672K |
| PRLDPrelude Therapeutics Inc | 192,963 | $660K |
| DNLIDenali Therapeutics Inc. | 32,147 | $617K |
| EDSAEdesa Biotech, Inc. | 115,721 | $605K |
| GALTGALECTIN THERAPEUTICS INC | 194,868 | $544K |
| TENXTENAX THERAPEUTICS, INC. | 33,628 | $538K |
| DRTSAlpha Tau Medical Ltd. | 75,539 | $534K |
| SLNSilence Therapeutics Plc | 100,927 | $532K |
| WHWKWhitehawk Therapeutics, Inc. | 151,110 | $521K |
| KROSKeros Therapeutics, Inc. | 44,457 | $491K |
| PROKPROKIDNEY CORP. | 264,285 | $473K |
| TRDAEntrada Therapeutics, Inc. | 37,213 | $470K |
| XOMAXOMA Royalty Corporation | 14,519 | $455K |
| PLRXPLIANT THERAPEUTICS, INC. | 356,794 | $450K |
| BMEABiomea Fusion, Inc. | 275,655 | $422K |
| CYTKCYTOKINETICS INC | 6,097 | $402K |
| IVAInventiva S.A. | 69,434 | $385K |
| SANASana Biotechnology, Inc. | 132,715 | $382K |
| TERNTerns Pharmaceuticals, Inc. | 7,231 | $381K |
| FLNAFilana Therapeutics Inc. | 225,164 | $381K |
| PTGXProtagonist Therapeutics, Inc | 3,607 | $380K |
| VYGRVoyager Therapeutics, Inc. | 97,963 | $378K |
| FDMT4D Molecular Therapeutics, Inc. | 39,694 | $370K |
| SLNOSOLENO THERAPEUTICS INC | 11,002 | $368K |
| ESPREsperion Therapeutics, Inc. | 124,140 | $340K |
| AUTLAutolus Therapeutics plc | 245,785 | $339K |
| CGEMCullinan Therapeutics, Inc. | 22,812 | $324K |
| IMMXImmix Biopharma, Inc. | 35,164 | $320K |
| ORGOOrganogenesis Holdings Inc. | 129,333 | $307K |
| DMRADamora Therapeutics, Inc. | 11,420 | $296K |
| BMRNBIOMARIN PHARMACEUTICAL INC | 5,133 | $290K |
| ARMPArmata Pharmaceuticals, Inc. | 27,998 | $287K |
| CGTXCOGNITION THERAPEUTICS INC | 370,140 | $281K |
| SIGASIGA TECHNOLOGIES INC | 52,080 | $279K |
| RNAAtrium Therapeutics Inc. | 19,955 | $267K |
| ANNXAnnexon, Inc. | 47,120 | $261K |
| ARTVArtiva Biotherapeutics, Inc. | 39,496 | $254K |
| ACETAdicet Bio, Inc. | 37,084 | $253K |
| ABSIAbsci Corporation | 83,364 | $250K |
| SPROSpero Therapeutics, Inc. | 106,345 | $249K |
| COGTCogent Biosciences, Inc. | 5,483 | $211K |
| SRZNSurrozen Inc. | 7,091 | $207K |
| MGXMetagenomi Therapeutics, Inc. | 151,440 | $203K |
| ACXPAcurx Pharmaceuticals, Inc. | 54,642 | $203K |
| BDTXBlack Diamond Therapeutics, Inc. | 94,831 | $202K |
| LGVNLongeveron Inc. | 185,656 | $193K |
| ALXOALX ONCOLOGY HOLDINGS INC | 95,101 | $191K |
| NRIXNurix Therapeutics, Inc. | 12,273 | $190K |
| MISTMilestone Pharmaceuticals Inc. | 159,669 | $190K |
| ELABPMGC Holdings Inc. | 31,594 | $189K |
| IMTXImmatics N.V. | 18,943 | $186K |
| ORMPORAMED PHARMACEUTICALS INC. | 52,540 | $179K |
| LPCNLipocine Inc. | 20,027 | $160K |
| ACIUAC Immune SA | 57,696 | $159K |
| KZRKezar Life Sciences, Inc. | 21,367 | $159K |
| VTGNVistagen Therapeutics, Inc. | 272,811 | $156K |
| XFORX4 Pharmaceuticals, Inc | 37,143 | $153K |
| QNTMQuantum Biopharma Ltd. | 31,501 | $152K |
| PHIOPhio Pharmaceuticals Corp. | 119,189 | $145K |
| HYFTMindWalk Holdings Corp. | 126,552 | $143K |
| AGMBAgomAb Therapeutics NV | 12,794 | $134K |
| MNOVMEDICINOVA INC | 87,085 | $119K |
| ADAGAdagene Inc. | 30,425 | $119K |
| OKUROnKure Therapeutics, Inc. | 26,812 | $111K |
| ARTLARTELO BIOSCIENCES, INC. | 13,079 | $99K |
| CALCCalciMedica, Inc. | 178,515 | $96K |
| PYPDPolyPid Ltd. | 21,642 | $95K |
| SGMTSagimet Biosciences Inc. | 17,187 | $90K |
| KYNBKYNTRA BIO INC. | 12,228 | $83K |
| SERSerina Therapeutics, Inc. | 39,653 | $77K |
| CRVOCervoMed Inc. | 18,246 | $72K |
| HOWLWerewolf Therapeutics, Inc. | 82,836 | $69K |
| CHRSCoherus Oncology, Inc. | 40,494 | $68K |
| ELUTELUTIA INC. | 64,077 | $67K |
| LITSLite Strategy, Inc. | 57,246 | $66K |
| IMAImageneBio, Inc. | 13,210 | $66K |
| CRDFCardiff Oncology, Inc. | 40,105 | $65K |
| PRQRProQR Therapeutics N.V. | 33,289 | $54K |
| INOINOVIO PHARMACEUTICALS, INC. | 30,691 | $53K |
| VERUVERU INC. | 22,807 | $50K |
| MRKRMarker Therapeutics, Inc. | 36,303 | $47K |
| PHGEBiomX Inc. | 11,829 | $44K |
| ONCYONCOLYTICS BIOTECH INC | 42,400 | $43K |
| PLXProtalix BioTherapeutics, Inc. | 17,342 | $38K |
| TOVXTheriva Biologics, Inc. | 177,034 | $35K |
| ATNMActinium Pharmaceuticals, Inc. | 34,299 | $34K |
| BIVIBIOVIE INC. | 22,791 | $32K |
| TLSATiziana Life Sciences Ltd | 24,047 | $28K |
| NNVCNANOVIRICIDES, INC. | 23,755 | $22K |
| NRSNNeuroSense Therapeutics Ltd. | 28,670 | $22K |
| CTXRCitius Pharmaceuticals, Inc. | 22,523 | $20K |
| PULMPulmatrix, Inc. | 14,584 | $19K |
| JSPRJasper Therapeutics Inc. | 21,415 | $19K |
| AEONAEON Biopharma, Inc. | 16,376 | $16K |
| SILOSilo Pharma, Inc. | 44,763 | $16K |
| NCNANuCana plc | 10,511 | $15K |
| MTVAMetaVia Inc. | 10,903 | $13K |
| COCPCocrystal Pharma, Inc. | 12,711 | $13K |
| LIMNLIMINATUS PHARMA, INC. | 71,318 | $12K |
| MEDSDataMeds AI, Inc. | 93,980 | $9K |
| GLMDGalmed Pharmaceuticals Ltd. | 16,445 | $8K |
| SCNXScienture Holdings, Inc. | 27,636 | $8K |
| PMCBPharmaCyte Biotech, Inc. | 11,530 | $8K |
| ENSCEnsysce Biosciences Inc. | 13,570 | $7K |
| BCABBioAtla, Inc. | 23,142 | $4K |
| IMMPImmutep Limited | 10,212 | $4K |
| IOBTQIO Biotech, Inc. | 57,974 | $3K |