| GILDGILEAD SCIENCES, INC. | 15,526,336 | $2.16B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,724,478 | $1.33B |
| ARGXARGENX SE | 594,697 | $434.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 1,291,726 | $427.4M |
| INCYIncyte Corp. | 3,870,764 | $364.3M |
| BBIOBridgeBio Pharma, Inc. | 4,592,814 | $341.1M |
| INSMINSMED Inc | 1,988,968 | $325.2M |
| SNYSanofi | 6,621,539 | $319.0M |
| MRNAModerna, Inc. | 4,784,758 | $243.1M |
| PTGXProtagonist Therapeutics, Inc | 2,164,670 | $228.2M |
| AXSMAxsome Therapeutics, Inc. | 1,297,678 | $219.3M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 3,280,647 | $205.7M |
| EXELEXELIXIS, INC. | 4,314,381 | $185.0M |
| ROIVRoivant Sciences Ltd. | 6,439,145 | $178.4M |
| LGNDLigand Pharmaceuticals Incorporated | 823,604 | $164.4M |
| TEVATeva Pharmaceutical Industries Limited | 3,253,233 | $98.0M |
| IONSIONIS PHARMACEUTICALS INC | 1,277,358 | $95.9M |
| COGTCogent Biosciences, Inc. | 2,429,629 | $93.5M |
| ADPTAdaptive Biotechnologies Corp | 4,450,066 | $61.8M |
| PTCTPTC THERAPEUTICS, INC. | 865,451 | $59.0M |
| JAZZJazz Pharmaceuticals plc | 244,763 | $46.3M |
| NUVLNuvalent, Inc. | 408,285 | $41.8M |
| NKTRNEKTAR THERAPEUTICS | 567,458 | $40.8M |
| RVMDREVOLUTION MEDICINES, INC. | 392,844 | $38.2M |
| ADMAADMA BIOLOGICS, INC. | 4,119,577 | $37.1M |
| ALMSALUMIS INC. | 1,511,537 | $33.3M |
| CYTKCYTOKINETICS INC | 484,980 | $32.0M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 364,306 | $31.7M |
| ANIPANI PHARMACEUTICALS INC | 324,349 | $24.9M |
| TGTXTG THERAPEUTICS, INC. | 720,934 | $23.9M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 419,411 | $23.7M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 412,683 | $21.3M |
| INVAInnoviva, Inc. | 904,282 | $21.1M |
| ACADACADIA PHARMACEUTICALS INC | 836,510 | $18.6M |
| LQDALiquidia Corp | 481,446 | $18.2M |
| RCUSArcus Biosciences, Inc. | 820,820 | $17.7M |
| APLSApellis Pharmaceuticals, Inc. | 437,868 | $17.6M |
| TERNTerns Pharmaceuticals, Inc. | 304,487 | $16.1M |
| TVTXTravere Therapeutics, Inc. | 523,711 | $15.6M |
| ABVXAbivax SA | 126,420 | $14.1M |
| OGNOrganon & Co. | 2,226,714 | $13.3M |
| OCULOCULAR THERAPEUTIX, INC | 1,536,779 | $13.0M |
| TNGXTango Therapeutics, Inc. | 580,453 | $12.1M |
| KODKodiak Sciences Inc. | 305,074 | $11.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 130,747 | $11.0M |
| PCVXVaxcyte, Inc. | 184,043 | $10.7M |
| SMMTSummit Therapeutics Inc. | 526,103 | $10.0M |
| VCELVericel Corp | 294,199 | $9.5M |
| FOLDAMICUS THERAPEUTICS, INC. | 512,740 | $7.4M |
| ANABANAPTYSBIO, INC | 121,103 | $6.7M |
| SYRESpyre Therapeutics, Inc. | 132,390 | $6.7M |
| PVLAPALVELLA THERAPEUTICS, INC. | 48,527 | $6.0M |
| RDYDR REDDYS LABORATORIES LTD | 431,724 | $6.0M |
| DNLIDenali Therapeutics Inc. | 310,196 | $6.0M |
| SRRKScholar Rock Holding Corp | 119,597 | $5.9M |
| ONCBeOne Medicines Ltd. | 19,178 | $5.7M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 185,372 | $5.6M |
| NTLAIntellia Therapeutics, Inc. | 434,753 | $5.6M |
| BEAMBeam Therapeutics Inc. | 219,961 | $5.2M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 151,430 | $5.1M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 1,422,317 | $5.0M |
| STOKStoke Therapeutics, Inc. | 150,045 | $4.9M |
| ORKAOruka Therapeutics, Inc. | 97,042 | $4.8M |
| ANNXAnnexon, Inc. | 763,005 | $4.2M |
| VKTXViking Therapeutics, Inc. | 112,339 | $3.7M |
| CGEMCullinan Therapeutics, Inc. | 244,150 | $3.5M |
| DAWNDay One Biopharmaceuticals, Inc. | 159,898 | $3.4M |
| ARVNARVINAS, INC. | 316,654 | $3.4M |
| ARQTArcutis Biotherapeutics, Inc. | 139,843 | $3.3M |
| APGEApogee Therapeutics, Inc. | 38,763 | $3.3M |
| NRIXNurix Therapeutics, Inc. | 203,609 | $3.2M |
| ZYMEZymeworks Inc. | 125,630 | $3.1M |
| BIOABioAge Labs, Inc. | 176,110 | $3.1M |
| VRDNViridian Therapeutics, Inc.\DE | 152,596 | $3.0M |
| CLDXCelldex Therapeutics, Inc. | 93,684 | $3.0M |
| SLSSELLAS Life Sciences Group, Inc. | 698,080 | $3.0M |
| FDMT4D Molecular Therapeutics, Inc. | 310,684 | $2.9M |
| MLTXMoonLake Immunotherapeutics | 139,574 | $2.6M |
| MAZEMaze Therapeutics, Inc. | 86,419 | $2.6M |
| SLDBSolid Biosciences Inc. | 340,940 | $2.5M |
| ELVNEnliven Therapeutics, Inc. | 61,752 | $2.4M |
| IMVTImmunovant, Inc. | 93,894 | $2.3M |
| ZBIOZenas BioPharma, Inc. | 113,479 | $2.2M |
| BHVNBiohaven Ltd. | 252,931 | $2.1M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 691,153 | $2.1M |
| IBRXImmunityBio, Inc. | 267,490 | $2.1M |
| ESPREsperion Therapeutics, Inc. | 742,640 | $2.0M |
| IRONDisc Medicine, Inc. | 30,638 | $2.0M |
| OLMAOlema Pharmaceuticals, Inc. | 130,933 | $2.0M |
| GERNGERON CORP | 1,304,458 | $1.9M |
| NUVBNuvation Bio Inc. | 437,806 | $1.9M |
| ARDXARDELYX, INC. | 312,712 | $1.9M |
| KURAKura Oncology, Inc. | 206,771 | $1.7M |
| DFTXDefinium Therapeutics Inc. | 88,121 | $1.7M |
| SANASana Biotechnology, Inc. | 569,186 | $1.6M |
| KALVKalVista Pharmaceuticals, Inc. | 75,282 | $1.5M |
| DSGNDesign Therapeutics, Inc. | 141,920 | $1.5M |
| SLNOSOLENO THERAPEUTICS INC | 44,814 | $1.5M |
| DNAGinkgo Bioworks Holdings Inc. | 234,808 | $1.4M |
| ORICOric Pharmaceuticals, Inc. | 108,954 | $1.4M |
| KNSAKiniksa Pharmaceuticals International, plc | 27,656 | $1.3M |
| RGNXREGENXBIO Inc. | 158,829 | $1.3M |
| RCKTRocket Pharmaceuticals Inc. | 347,543 | $1.2M |
| SVRASavara Inc | 223,010 | $1.2M |
| ABUSArbutus Biopharma Corp | 247,925 | $1.1M |
| KROSKeros Therapeutics, Inc. | 87,772 | $969K |
| CATXPerspective Therapeutics, Inc. | 231,355 | $965K |
| FLGTFulgent Genetics Inc. | 56,980 | $906K |
| OPKOPKO HEALTH, INC. | 793,169 | $904K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 512,426 | $799K |
| HROWHARROW, INC. | 21,954 | $774K |
| ALTAltimmune, Inc. | 227,857 | $702K |
| CCCCC4 Therapeutics, Inc. | 244,507 | $643K |
| BCAXBicara Therapeutics Inc. | 31,650 | $630K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 95,044 | $607K |
| XERSXeris Biopharma Holdings, Inc. | 103,294 | $599K |
| SIGASIGA TECHNOLOGIES INC | 111,518 | $597K |
| ALECAlector, Inc. | 265,067 | $570K |
| CHRSCoherus Oncology, Inc. | 335,309 | $567K |
| CMPXCompass Therapeutics, Inc. | 101,207 | $535K |
| TRDAEntrada Therapeutics, Inc. | 41,926 | $529K |
| IVVDInvivyd, Inc. | 380,412 | $495K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 49,808 | $484K |
| VYGRVoyager Therapeutics, Inc. | 119,171 | $460K |
| FATEFATE THERAPEUTICS INC | 375,886 | $451K |
| PGENPRECIGEN, INC. | 112,474 | $435K |
| SIONSionna Therapeutics, Inc. | 10,787 | $432K |
| STROSUTRO BIOPHARMA, INC. | 17,165 | $428K |
| JBIOJade Biosciences, Inc. | 29,560 | $415K |
| ORGOOrganogenesis Holdings Inc. | 162,737 | $386K |
| UPBUpstream Bio, Inc. | 40,510 | $365K |
| AQSTAquestive Therapeutics, Inc. | 82,759 | $343K |
| ABSIAbsci Corporation | 110,120 | $330K |
| SPRYARS Pharmaceuticals, Inc. | 38,186 | $307K |
| ZVRAZEVRA THERAPEUTICS, INC. | 32,874 | $306K |
| ZNTLZentalis Pharmaceuticals, Inc. | 125,767 | $294K |
| CTMXCytomX Therapeutics, Inc. | 61,555 | $289K |
| ALDXAldeyra Therapeutics, Inc. | 169,698 | $287K |
| CNTACentessa Pharmaceuticals plc | 7,034 | $279K |
| ALVOAlvotech | 78,447 | $269K |
| LBRXLB PHARMACEUTICALS INC | 10,729 | $265K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 326,512 | $261K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 4,690 | $259K |
| SGMOQSANGAMO THERAPEUTICS, INC | 1,045,232 | $258K |
| MPLTMapLight Therapeutics, Inc. | 12,252 | $249K |
| TECXTectonic Therapeutic, Inc. | 7,675 | $237K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 7,291 | $233K |
| BDTXBlack Diamond Therapeutics, Inc. | 107,400 | $229K |
| OVIDOvid Therapeutics Inc. | 101,581 | $226K |
| AVXLANAVEX LIFE SCIENCES CORP. | 72,430 | $222K |
| GPCRStructure Therapeutics Inc. | 4,581 | $221K |
| XOMAXOMA Royalty Corporation | 6,782 | $213K |
| ABCLAbCellera Biologics Inc. | 60,395 | $211K |
| TNXPTonix Pharmaceuticals Holding Corp. | 15,265 | $210K |
| ATAIAtai Beckley N.V. | 53,199 | $188K |
| ADAGAdagene Inc. | 47,124 | $185K |
| DMACDiaMedica Therapeutics Inc. | 24,799 | $168K |
| RLMDRELMADA THERAPEUTICS, INC. | 22,442 | $156K |
| PLRXPLIANT THERAPEUTICS, INC. | 115,218 | $145K |
| LENZLENZ Therapeutics, Inc. | 14,927 | $137K |
| RNAAtrium Therapeutics Inc. | 10,193 | $136K |
| RZLTRezolute, Inc. | 40,324 | $123K |
| SPROSpero Therapeutics, Inc. | 45,374 | $106K |
| HUMAHumacyte Inc. | 172,435 | $105K |
| ABEOABEONA THERAPEUTICS INC. | 22,979 | $103K |
| PLXProtalix BioTherapeutics, Inc. | 47,402 | $103K |
| CADLCandel Therapeutics, Inc. | 20,907 | $102K |
| LRMRLarimar Therapeutics, Inc. | 19,647 | $88K |
| XFORX4 Pharmaceuticals, Inc | 19,968 | $82K |
| AUTLAutolus Therapeutics plc | 53,153 | $73K |
| PRQRProQR Therapeutics N.V. | 44,592 | $72K |
| FENCFENNEC PHARMACEUTICALS INC. | 11,677 | $72K |
| BCYCBICYCLE THERAPEUTICS PLC | 15,067 | $70K |
| NBPNovaBridge Biosciences | 28,161 | $69K |
| GALTGALECTIN THERAPEUTICS INC | 23,793 | $66K |
| FLNAFilana Therapeutics Inc. | 31,130 | $53K |
| MISTMilestone Pharmaceuticals Inc. | 41,356 | $49K |
| CRDFCardiff Oncology, Inc. | 20,904 | $34K |
| HURATuHURA Biosciences, Inc./NV | 15,159 | $27K |
| ALXOALX ONCOLOGY HOLDINGS INC | 10,980 | $22K |