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| ALNYALNYLAM PHARMACEUTICALS, INC. | 14,579,166 | $4.82B |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 67,661,646 | $3.73B |
| ARGXARGENX SE | 4,991,034 | $3.64B |
| MRNAModerna, Inc. | 45,672,024 | $2.32B |
| ROIVRoivant Sciences Ltd. | 77,981,253 | $2.16B |
| INSMINSMED Inc | 13,160,167 | $2.15B |
| IONSIONIS PHARMACEUTICALS INC | 24,556,637 | $1.84B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,518,192 | $1.17B |
| ONCBeOne Medicines Ltd. | 3,693,610 | $1.10B |
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| CYTKCYTOKINETICS INC | 10,723,140 | $706.8M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 7,767,686 | $651.9M |
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| ARWRARROWHEAD PHARMACEUTICALS, INC. | 7,266,652 | $455.6M |
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| NAMSNEWAMSTERDAM PHARMA CO N.V. | 8,765,811 | $280.6M |
| OCULOCULAR THERAPEUTIX, INC | 32,653,764 | $276.6M |
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| ELVNEnliven Therapeutics, Inc. | 6,829,246 | $267.7M |
| AXSMAxsome Therapeutics, Inc. | 1,566,995 | $264.9M |
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| SMMTSummit Therapeutics Inc. | 10,853,199 | $205.8M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 3,567,031 | $201.5M |
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| SLNOSOLENO THERAPEUTICS INC | 5,788,410 | $193.8M |
| SNYSanofi | 4,010,161 | $193.2M |
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| PHVSPharvaris N.V. | 6,284,472 | $177.5M |
| STOKStoke Therapeutics, Inc. | 5,383,666 | $175.3M |
| BBIOBridgeBio Pharma, Inc. | 2,343,754 | $174.0M |
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| CTMXCytomX Therapeutics, Inc. | 31,955,637 | $150.2M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 1,689,671 | $147.0M |
| IMCRImmunocore Holdings plc | 4,829,154 | $145.6M |
| ABVXAbivax SA | 1,286,373 | $143.2M |
| LGNDLigand Pharmaceuticals Incorporated | 596,127 | $119.0M |
| CLDXCelldex Therapeutics, Inc. | 3,749,048 | $118.9M |
| MANEVeradermics Incorporated | 1,792,909 | $113.2M |
| INCYIncyte Corp. | 1,172,890 | $110.4M |
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| PTCTPTC THERAPEUTICS, INC. | 1,528,362 | $104.1M |
| EXELEXELIXIS, INC. | 2,326,390 | $99.8M |
| JBIOJade Biosciences, Inc. | 7,085,423 | $99.6M |
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| DNLIDenali Therapeutics Inc. | 4,575,374 | $87.8M |
| TECXTectonic Therapeutic, Inc. | 2,816,494 | $87.1M |
| NRIXNurix Therapeutics, Inc. | 5,541,271 | $85.9M |
| CBIOCRESCENT BIOPHARMA, INC. | 4,133,514 | $75.9M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 7,551,218 | $73.4M |
| UPBUpstream Bio, Inc. | 8,101,563 | $72.9M |
| GHRSGH Research PLC | 5,136,045 | $72.2M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 45,056,338 | $70.3M |
| PTGXProtagonist Therapeutics, Inc | 661,997 | $69.8M |
| ABSIAbsci Corporation | 22,550,997 | $67.7M |
| ANNXAnnexon, Inc. | 10,635,648 | $58.9M |
| CADLCandel Therapeutics, Inc. | 10,987,017 | $53.8M |
| AVTXAvalo Therapeutics, Inc. | 2,879,481 | $43.0M |
| BCAXBicara Therapeutics Inc. | 2,100,929 | $41.8M |
| XOMAXOMA Royalty Corporation | 1,302,974 | $40.9M |
| DFTXDefinium Therapeutics Inc. | 1,809,610 | $34.2M |
| XFORX4 Pharmaceuticals, Inc | 8,103,400 | $33.5M |
| LENZLENZ Therapeutics, Inc. | 3,597,784 | $32.9M |
| ORICOric Pharmaceuticals, Inc. | 2,434,080 | $30.8M |
| ZVRAZEVRA THERAPEUTICS, INC. | 3,211,877 | $29.9M |
| QUREuniQure N.V. | 1,743,808 | $28.5M |
| GMABGenmab A/S | 1,011,726 | $27.1M |
| PVLAPALVELLA THERAPEUTICS, INC. | 215,808 | $26.9M |
| NTLAIntellia Therapeutics, Inc. | 2,067,222 | $26.5M |
| ANABANAPTYSBIO, INC | 472,704 | $26.2M |
| SLDBSolid Biosciences Inc. | 3,606,404 | $26.0M |
| MAZEMaze Therapeutics, Inc. | 864,214 | $25.8M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,753,843 | $25.4M |
| RCUSArcus Biosciences, Inc. | 1,165,252 | $25.2M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 772,649 | $23.5M |
| LQDALiquidia Corp | 582,200 | $22.0M |
| CAMPCamp4 Therapeutics Corp | 4,933,432 | $21.8M |
| ALMSALUMIS INC. | 973,782 | $21.5M |
| BHVNBiohaven Ltd. | 2,359,047 | $20.0M |
| ZYMEZymeworks Inc. | 667,153 | $16.7M |
| INOINOVIO PHARMACEUTICALS, INC. | 9,339,614 | $16.3M |
| TERNTerns Pharmaceuticals, Inc. | 295,622 | $15.6M |
| OGNOrganon & Co. | 2,558,692 | $15.3M |
| AGMBAgomAb Therapeutics NV | 1,458,677 | $15.3M |
| BMEABiomea Fusion, Inc. | 8,813,359 | $13.5M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 209,370 | $10.8M |
| GERNGERON CORP | 6,597,156 | $9.8M |
| CMPXCompass Therapeutics, Inc. | 1,801,721 | $9.5M |
| TGTXTG THERAPEUTICS, INC. | 280,446 | $9.3M |
| FBRXForte Biosciences, Inc. | 340,695 | $8.8M |
| DSGNDesign Therapeutics, Inc. | 798,411 | $8.5M |
| ADPTAdaptive Biotechnologies Corp | 567,032 | $7.9M |
| ACADACADIA PHARMACEUTICALS INC | 350,340 | $7.8M |
| PGENPRECIGEN, INC. | 1,998,596 | $7.7M |
| NGNENeurogene Inc. | 382,647 | $7.7M |
| RLYBRallybio Corp | 793,451 | $7.1M |
| KODKodiak Sciences Inc. | 183,919 | $7.0M |
| ARQTArcutis Biotherapeutics, Inc. | 278,736 | $6.6M |
| LBRXLB PHARMACEUTICALS INC | 222,508 | $5.5M |
| TLXTelix Pharmaceuticals Limited | 564,757 | $5.4M |
| TENXTENAX THERAPEUTICS, INC. | 322,600 | $5.2M |
| RNACCartesian Therapeutics, Inc. | 799,743 | $4.9M |
| MPLTMapLight Therapeutics, Inc. | 204,501 | $4.2M |
| ALECAlector, Inc. | 1,796,104 | $3.9M |
| KALVKalVista Pharmaceuticals, Inc. | 187,848 | $3.8M |
| BIOABioAge Labs, Inc. | 190,298 | $3.3M |
| SIONSionna Therapeutics, Inc. | 81,395 | $3.3M |
| ZURAZura Bio Ltd | 529,346 | $3.1M |
| ADMAADMA BIOLOGICS, INC. | 338,939 | $3.1M |
| XERSXeris Biopharma Holdings, Inc. | 513,076 | $3.0M |
| VCELVericel Corp | 86,073 | $2.8M |
| SPRYARS Pharmaceuticals, Inc. | 342,042 | $2.7M |
| MLTXMoonLake Immunotherapeutics | 143,559 | $2.7M |
| RGNXREGENXBIO Inc. | 311,268 | $2.6M |
| KURAKura Oncology, Inc. | 317,652 | $2.6M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 736,654 | $2.3M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 240,300 | $2.2M |
| ALTAltimmune, Inc. | 673,964 | $2.1M |
| RCKTRocket Pharmaceuticals Inc. | 462,630 | $1.7M |
| INVAInnoviva, Inc. | 68,730 | $1.6M |
| ANIPANI PHARMACEUTICALS INC | 18,777 | $1.4M |
| BDTXBlack Diamond Therapeutics, Inc. | 623,827 | $1.3M |
| CATXPerspective Therapeutics, Inc. | 313,658 | $1.3M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 191,833 | $1.2M |
| RDYDR REDDYS LABORATORIES LTD | 83,683 | $1.2M |
| ESPREsperion Therapeutics, Inc. | 374,481 | $1.0M |
| ARVNARVINAS, INC. | 88,232 | $935K |
| ORGOOrganogenesis Holdings Inc. | 375,815 | $891K |
| ABEOABEONA THERAPEUTICS INC. | 194,813 | $873K |
| ARDXARDELYX, INC. | 126,306 | $757K |
| CCCCC4 Therapeutics, Inc. | 272,368 | $716K |
| ZNTLZentalis Pharmaceuticals, Inc. | 283,917 | $664K |
| ABUSArbutus Biopharma Corp | 145,126 | $653K |
| FDMT4D Molecular Therapeutics, Inc. | 70,097 | $653K |
| VYGRVoyager Therapeutics, Inc. | 163,682 | $632K |
| GRFSGrifols S.A. | 68,556 | $550K |
| DAWNDay One Biopharmaceuticals, Inc. | 23,640 | $507K |
| KRROKorro Bio, Inc. | 38,900 | $440K |
| RNAAtrium Therapeutics Inc. | 29,292 | $392K |
| SVRASavara Inc | 69,031 | $377K |
| KROSKeros Therapeutics, Inc. | 32,674 | $361K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 9,121 | $309K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 14,150 | $305K |
| LCTXLineage Cell Therapeutics, Inc. | 193,308 | $305K |
| LRMRLarimar Therapeutics, Inc. | 63,570 | $286K |
| OCGNOcugen, Inc. | 148,674 | $269K |
| IBRXImmunityBio, Inc. | 30,704 | $236K |
| APLSApellis Pharmaceuticals, Inc. | 5,563 | $224K |
| TRDAEntrada Therapeutics, Inc. | 16,943 | $214K |
| IVVDInvivyd, Inc. | 141,270 | $184K |
| RZLTRezolute, Inc. | 57,366 | $175K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 49,301 | $173K |
| GYREGYRE THERAPEUTICS, INC. | 18,717 | $130K |
| HROWHARROW, INC. | 3,699 | $130K |
| SIGASIGA TECHNOLOGIES INC | 23,402 | $125K |
| BTAIBioXcel Therapeutics, Inc. | 90,300 | $121K |
| CGEMCullinan Therapeutics, Inc. | 7,232 | $103K |
| OVIDOvid Therapeutics Inc. | 42,138 | $94K |
| KZRKezar Life Sciences, Inc. | 10,208 | $76K |
| MDWDMediWound Ltd. | 4,700 | $76K |
| DMACDiaMedica Therapeutics Inc. | 10,463 | $71K |
| CRDFCardiff Oncology, Inc. | 40,896 | $66K |
| SLSSELLAS Life Sciences Group, Inc. | 15,561 | $66K |
| SGMOQSANGAMO THERAPEUTICS, INC | 244,139 | $60K |
| NVCTNuvectis Pharma, Inc. | 7,568 | $59K |
| FATEFATE THERAPEUTICS INC | 47,590 | $57K |
| TPSTTempest Therapeutics, Inc. | 33,225 | $54K |
| HCMHUTCHMED (China) Limited | 3,531 | $53K |
| OPKOPKO HEALTH, INC. | 41,343 | $47K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 58,195 | $47K |
| KLRSKalaris Therapeutics, Inc. | 7,806 | $45K |
| CLYMClimb Bio, Inc. | 6,397 | $44K |
| CRVOCervoMed Inc. | 11,040 | $43K |
| HURATuHURA Biosciences, Inc./NV | 24,093 | $43K |
| LYELLyell Immunopharma, Inc. | 1,823 | $37K |
| GALTGALECTIN THERAPEUTICS INC | 12,987 | $36K |
| AARDAardvark Therapeutics, Inc. | 8,958 | $34K |
| ALDXAldeyra Therapeutics, Inc. | 16,503 | $28K |
| FENCFENNEC PHARMACEUTICALS INC. | 4,254 | $26K |
| STROSUTRO BIOPHARMA, INC. | 1,050 | $26K |
| AVXLANAVEX LIFE SCIENCES CORP. | 8,495 | $26K |
| ALXOALX ONCOLOGY HOLDINGS INC | 12,986 | $26K |
| TNXPTonix Pharmaceuticals Holding Corp. | 1,738 | $24K |
| AQSTAquestive Therapeutics, Inc. | 5,496 | $23K |
| IMTXImmatics N.V. | 2,232 | $22K |
| PRLDPrelude Therapeutics Inc | 6,009 | $21K |
| PROKPROKIDNEY CORP. | 10,254 | $18K |
| AGENAGENUS INC | 5,405 | $18K |
| HUMAHumacyte Inc. | 28,562 | $17K |
| TVRDTvardi Therapeutics, Inc. | 5,278 | $17K |
| CHRSCoherus Oncology, Inc. | 8,895 | $15K |
| FLGTFulgent Genetics Inc. | 790 | $13K |
| DNAGinkgo Bioworks Holdings Inc. | 2,012 | $12K |
| FLNAFilana Therapeutics Inc. | 6,062 | $10K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 688 | $6K |
| MGXMetagenomi Therapeutics, Inc. | 4,718 | $6K |
| PLXProtalix BioTherapeutics, Inc. | 2,905 | $6K |
| LPCNLipocine Inc. | 626 | $5K |
| TAOXTAO Synergies Inc. | 325 | $2K |
| LGVNLongeveron Inc. | 752 | $782 |
| SGMTSagimet Biosciences Inc. | 148 | $774 |
| LTRNLantern Pharma Inc. | 500 | $685 |
| ORMPORAMED PHARMACEUTICALS INC. | 200 | $680 |
| PLRXPLIANT THERAPEUTICS, INC. | 524 | $660 |
| CELZCREATIVE MEDICAL TECHNOLOGY HOLDINGS, INC. | 250 | $515 |
| IMUXIMMUNIC, INC. | 455 | $505 |
| ASRTAssertio Holdings, Inc. | 23 | $438 |
| COCPCocrystal Pharma, Inc. | 334 | $337 |
| ARMPArmata Pharmaceuticals, Inc. | 22 | $225 |
| NNVCNANOVIRICIDES, INC. | 112 | $102 |
| SCLXSCILEX HOLDING CO | 12 | $80 |
| ATNMActinium Pharmaceuticals, Inc. | 79 | $79 |
| TLPHTALPHERA, INC. | 50 | $37 |
| IRDOpus Genetics, Inc. | 8 | $36 |
| AZTRAzitra, Inc. | 150 | $35 |
| HOWLWerewolf Therapeutics, Inc. | 39 | $32 |
| CLRBCellectar Biosciences, Inc. | 10 | $25 |
| LITSLite Strategy, Inc. | 3 | $3 |
| IMNNImunon, Inc. | 1 | $3 |
| CGTXCOGNITION THERAPEUTICS INC | 1 | $1 |
| GOVXGeoVax Labs, Inc. | 1 | $1 |
| LSTALISATA THERAPEUTICS, INC. | 0 | $0 |
| BIVIBIOVIE INC. | 0 | $0 |