| GILDGILEAD SCIENCES, INC. | 6,222,328 | $867.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 625,388 | $483.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 761,464 | $251.9M |
| INCYIncyte Corp. | 1,264,195 | $119.0M |
| ARGXARGENX SE | 139,381 | $101.8M |
| INSMINSMED Inc | 562,474 | $92.0M |
| TEVATeva Pharmaceutical Industries Limited | 2,829,970 | $85.2M |
| LGNDLigand Pharmaceuticals Incorporated | 306,111 | $61.1M |
| RVMDREVOLUTION MEDICINES, INC. | 465,758 | $45.3M |
| MRNAModerna, Inc. | 810,253 | $41.2M |
| NRIXNurix Therapeutics, Inc. | 2,295,024 | $35.6M |
| TVTXTravere Therapeutics, Inc. | 925,919 | $27.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 523,691 | $25.2M |
| ANIPANI PHARMACEUTICALS INC | 319,675 | $24.6M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 411,302 | $23.2M |
| ZYMEZymeworks Inc. | 921,250 | $23.1M |
| BBIOBridgeBio Pharma, Inc. | 296,683 | $22.0M |
| INVAInnoviva, Inc. | 908,067 | $21.2M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 381,191 | $21.0M |
| VRDNViridian Therapeutics, Inc.\DE | 1,032,316 | $20.2M |
| ACADACADIA PHARMACEUTICALS INC | 840,414 | $18.7M |
| AXSMAxsome Therapeutics, Inc. | 104,266 | $17.6M |
| PCVXVaxcyte, Inc. | 299,693 | $17.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 259,963 | $16.3M |
| PTCTPTC THERAPEUTICS, INC. | 238,754 | $16.3M |
| GPCRStructure Therapeutics Inc. | 331,867 | $16.0M |
| PTGXProtagonist Therapeutics, Inc | 125,451 | $13.2M |
| CYTKCYTOKINETICS INC | 187,138 | $12.3M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 141,601 | $12.3M |
| IONSIONIS PHARMACEUTICALS INC | 159,891 | $12.0M |
| SRRKScholar Rock Holding Corp | 241,794 | $11.9M |
| ADPTAdaptive Biotechnologies Corp | 785,783 | $10.9M |
| ARQTArcutis Biotherapeutics, Inc. | 389,847 | $9.2M |
| NUVLNuvalent, Inc. | 87,746 | $9.0M |
| ADMAADMA BIOLOGICS, INC. | 930,962 | $8.4M |
| ONCBeOne Medicines Ltd. | 27,877 | $8.3M |
| TERNTerns Pharmaceuticals, Inc. | 149,327 | $7.9M |
| DFTXDefinium Therapeutics Inc. | 411,834 | $7.8M |
| GERNGERON CORP | 5,203,516 | $7.8M |
| APGEApogee Therapeutics, Inc. | 91,421 | $7.7M |
| CNTACentessa Pharmaceuticals plc | 189,961 | $7.5M |
| ORKAOruka Therapeutics, Inc. | 140,789 | $6.9M |
| NKTRNEKTAR THERAPEUTICS | 91,671 | $6.6M |
| FDMT4D Molecular Therapeutics, Inc. | 708,044 | $6.6M |
| SYRESpyre Therapeutics, Inc. | 129,242 | $6.5M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 118,550 | $6.1M |
| TGTXTG THERAPEUTICS, INC. | 170,020 | $5.6M |
| OCULOCULAR THERAPEUTIX, INC | 631,741 | $5.4M |
| CGEMCullinan Therapeutics, Inc. | 367,906 | $5.2M |
| LQDALiquidia Corp | 137,652 | $5.2M |
| FLGTFulgent Genetics Inc. | 325,446 | $5.2M |
| SLNOSOLENO THERAPEUTICS INC | 148,374 | $5.0M |
| COGTCogent Biosciences, Inc. | 127,469 | $4.9M |
| JAZZJazz Pharmaceuticals plc | 25,273 | $4.8M |
| SVRASavara Inc | 848,391 | $4.6M |
| CLDXCelldex Therapeutics, Inc. | 143,037 | $4.5M |
| SMMTSummit Therapeutics Inc. | 237,788 | $4.5M |
| ARDXARDELYX, INC. | 708,589 | $4.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 282,792 | $4.1M |
| ORGOOrganogenesis Holdings Inc. | 1,705,681 | $4.0M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 124,775 | $4.0M |
| APLSApellis Pharmaceuticals, Inc. | 95,365 | $3.8M |
| XERSXeris Biopharma Holdings, Inc. | 623,012 | $3.6M |
| ANNXAnnexon, Inc. | 562,181 | $3.1M |
| ESPREsperion Therapeutics, Inc. | 1,093,291 | $3.0M |
| ANABANAPTYSBIO, INC | 52,038 | $2.9M |
| IBRXImmunityBio, Inc. | 349,522 | $2.7M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 31,460 | $2.6M |
| BCAXBicara Therapeutics Inc. | 131,656 | $2.6M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 734,960 | $2.6M |
| EXELEXELIXIS, INC. | 58,607 | $2.5M |
| OLMAOlema Pharmaceuticals, Inc. | 161,396 | $2.4M |
| ALECAlector, Inc. | 1,092,903 | $2.3M |
| DNLIDenali Therapeutics Inc. | 120,368 | $2.3M |
| HROWHARROW, INC. | 64,635 | $2.3M |
| AVTXAvalo Therapeutics, Inc. | 150,000 | $2.2M |
| RDYDR REDDYS LABORATORIES LTD | 158,903 | $2.2M |
| CTMXCytomX Therapeutics, Inc. | 463,421 | $2.2M |
| NGNENeurogene Inc. | 106,255 | $2.1M |
| NTLAIntellia Therapeutics, Inc. | 164,186 | $2.1M |
| BEAMBeam Therapeutics Inc. | 87,141 | $2.1M |
| IMVTImmunovant, Inc. | 79,000 | $2.0M |
| SNYSanofi | 40,269 | $1.9M |
| TNGXTango Therapeutics, Inc. | 89,975 | $1.9M |
| VCELVericel Corp | 56,899 | $1.8M |
| RCKTRocket Pharmaceuticals Inc. | 482,079 | $1.7M |
| SANASana Biotechnology, Inc. | 591,911 | $1.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 50,384 | $1.7M |
| RGNXREGENXBIO Inc. | 196,971 | $1.7M |
| UPBUpstream Bio, Inc. | 180,889 | $1.6M |
| RCUSArcus Biosciences, Inc. | 73,847 | $1.6M |
| KODKodiak Sciences Inc. | 41,264 | $1.6M |
| RLMDRELMADA THERAPEUTICS, INC. | 224,846 | $1.6M |
| ARVNARVINAS, INC. | 147,522 | $1.6M |
| IRONDisc Medicine, Inc. | 24,401 | $1.6M |
| PHVSPharvaris N.V. | 53,722 | $1.5M |
| DAWNDay One Biopharmaceuticals, Inc. | 66,445 | $1.4M |
| ELVNEnliven Therapeutics, Inc. | 35,319 | $1.4M |
| BHVNBiohaven Ltd. | 162,813 | $1.4M |
| STOKStoke Therapeutics, Inc. | 40,596 | $1.3M |
| RLAYRelay Therapeutics, Inc. | 129,612 | $1.3M |
| ALMSALUMIS INC. | 58,158 | $1.3M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 38,585 | $1.2M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 376,867 | $1.2M |
| PVLAPALVELLA THERAPEUTICS, INC. | 7,784 | $970K |
| NUVBNuvation Bio Inc. | 212,755 | $913K |
| KALVKalVista Pharmaceuticals, Inc. | 38,857 | $782K |
| IVVDInvivyd, Inc. | 585,385 | $761K |
| ABUSArbutus Biopharma Corp | 160,740 | $723K |
| KURAKura Oncology, Inc. | 88,739 | $721K |
| CMPXCompass Therapeutics, Inc. | 133,352 | $705K |
| ORICOric Pharmaceuticals, Inc. | 51,333 | $650K |
| MAZEMaze Therapeutics, Inc. | 20,263 | $605K |
| PGENPRECIGEN, INC. | 152,646 | $591K |
| SLSSELLAS Life Sciences Group, Inc. | 137,646 | $582K |
| KROSKeros Therapeutics, Inc. | 50,765 | $560K |
| JBIOJade Biosciences, Inc. | 39,199 | $551K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 24,626 | $532K |
| SIONSionna Therapeutics, Inc. | 13,249 | $531K |
| ZVRAZEVRA THERAPEUTICS, INC. | 51,373 | $479K |
| SPRYARS Pharmaceuticals, Inc. | 54,491 | $438K |
| OPKOPKO HEALTH, INC. | 370,948 | $423K |
| LRMRLarimar Therapeutics, Inc. | 93,132 | $419K |
| BIOABioAge Labs, Inc. | 23,096 | $404K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 40,018 | $389K |
| ALTAltimmune, Inc. | 124,516 | $384K |
| LBRXLB PHARMACEUTICALS INC | 15,359 | $379K |
| ZBIOZenas BioPharma, Inc. | 19,266 | $377K |
| AQSTAquestive Therapeutics, Inc. | 87,448 | $363K |
| SLDBSolid Biosciences Inc. | 46,275 | $333K |
| ABSIAbsci Corporation | 105,158 | $315K |
| OGNOrganon & Co. | 52,616 | $315K |
| TRDAEntrada Therapeutics, Inc. | 24,679 | $311K |
| TECXTectonic Therapeutic, Inc. | 9,345 | $289K |
| VKTXViking Therapeutics, Inc. | 8,701 | $283K |
| MPLTMapLight Therapeutics, Inc. | 13,679 | $278K |
| XOMAXOMA Royalty Corporation | 8,447 | $265K |
| DNAGinkgo Bioworks Holdings Inc. | 39,793 | $244K |
| AVXLANAVEX LIFE SCIENCES CORP. | 74,895 | $230K |
| CATXPerspective Therapeutics, Inc. | 53,163 | $222K |
| DSGNDesign Therapeutics, Inc. | 20,644 | $220K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 33,145 | $212K |
| ABEOABEONA THERAPEUTICS INC. | 44,927 | $201K |
| SIGASIGA TECHNOLOGIES INC | 37,164 | $199K |
| RZLTRezolute, Inc. | 64,211 | $196K |
| DMACDiaMedica Therapeutics Inc. | 28,354 | $192K |
| PRQRProQR Therapeutics N.V. | 108,762 | $176K |
| TNXPTonix Pharmaceuticals Holding Corp. | 12,161 | $167K |
| CADLCandel Therapeutics, Inc. | 33,300 | $163K |
| PLXProtalix BioTherapeutics, Inc. | 74,985 | $163K |
| MDWDMediWound Ltd. | 9,905 | $160K |
| VYGRVoyager Therapeutics, Inc. | 40,030 | $155K |
| LENZLENZ Therapeutics, Inc. | 15,280 | $140K |
| RNAAtrium Therapeutics Inc. | 10,019 | $134K |
| FENCFENNEC PHARMACEUTICALS INC. | 21,202 | $130K |
| HURATuHURA Biosciences, Inc./NV | 71,960 | $129K |
| CHRSCoherus Oncology, Inc. | 71,762 | $121K |
| KRROKorro Bio, Inc. | 10,544 | $119K |
| FATEFATE THERAPEUTICS INC | 91,679 | $110K |
| HUMAHumacyte Inc. | 168,628 | $103K |
| NVCTNuvectis Pharma, Inc. | 12,672 | $98K |
| ALDXAldeyra Therapeutics, Inc. | 50,271 | $85K |
| BCABBioAtla, Inc. | 525,352 | $84K |
| QUREuniQure N.V. | 5,053 | $83K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 93,081 | $74K |
| GYREGYRE THERAPEUTICS, INC. | 10,613 | $74K |
| CRDFCardiff Oncology, Inc. | 43,784 | $71K |
| AARDAardvark Therapeutics, Inc. | 17,901 | $67K |
| IMCRImmunocore Holdings plc | 2,022 | $61K |
| RNACCartesian Therapeutics, Inc. | 8,116 | $50K |
| MLTXMoonLake Immunotherapeutics | 2,052 | $38K |
| MESOMesoblast Limited | 1,716 | $26K |
| ATAIAtai Beckley N.V. | 6,911 | $24K |
| TVRDTvardi Therapeutics, Inc. | 3,030 | $10K |
| SCLXSCILEX HOLDING CO | 800 | $5K |
| CLYMClimb Bio, Inc. | 1 | $7 |