| REGNREGENERON PHARMACEUTICALS, INC. | 66,400 | $51.3M |
| GILDGILEAD SCIENCES, INC. | 332,096 | $46.3M |
| MRNAModerna, Inc. | 386,906 | $19.7M |
| INCYIncyte Corp. | 202,772 | $19.1M |
| EXELEXELIXIS, INC. | 263,476 | $11.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 159,652 | $9.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 154,094 | $8.5M |
| SNYSanofi | 114,116 | $5.5M |
| ROIVRoivant Sciences Ltd. | 181,899 | $5.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 11,580 | $3.8M |
| JAZZJazz Pharmaceuticals plc | 10,171 | $1.9M |
| AXSMAxsome Therapeutics, Inc. | 7,734 | $1.3M |
| PTCTPTC THERAPEUTICS, INC. | 17,891 | $1.2M |
| BHVNBiohaven Ltd. | 138,410 | $1.2M |
| KNSAKiniksa Pharmaceuticals International, plc | 22,913 | $1.1M |
| KURAKura Oncology, Inc. | 123,686 | $1.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 12,004 | $753K |
| FOLDAMICUS THERAPEUTICS, INC. | 50,819 | $735K |
| ARDXARDELYX, INC. | 117,430 | $703K |
| INSMINSMED Inc | 4,244 | $694K |
| ACADACADIA PHARMACEUTICALS INC | 28,969 | $645K |
| RCKTRocket Pharmaceuticals Inc. | 174,263 | $624K |
| RGNXREGENXBIO Inc. | 72,115 | $604K |
| NTLAIntellia Therapeutics, Inc. | 44,939 | $576K |
| DAWNDay One Biopharmaceuticals, Inc. | 25,043 | $537K |
| BBIOBridgeBio Pharma, Inc. | 6,493 | $482K |
| TEVATeva Pharmaceutical Industries Limited | 15,579 | $469K |
| APLSApellis Pharmaceuticals, Inc. | 11,403 | $459K |
| NUVBNuvation Bio Inc. | 106,444 | $457K |
| SRRKScholar Rock Holding Corp | 9,164 | $451K |
| ARQTArcutis Biotherapeutics, Inc. | 17,702 | $417K |
| ARGXARGENX SE | 529 | $386K |
| TVTXTravere Therapeutics, Inc. | 12,694 | $377K |
| XERSXeris Biopharma Holdings, Inc. | 64,180 | $372K |
| ADPTAdaptive Biotechnologies Corp | 26,084 | $362K |
| IBRXImmunityBio, Inc. | 47,081 | $361K |
| INVAInnoviva, Inc. | 14,060 | $328K |
| VKTXViking Therapeutics, Inc. | 10,001 | $325K |
| OGNOrganon & Co. | 50,836 | $305K |
| LRMRLarimar Therapeutics, Inc. | 64,126 | $289K |
| ABVXAbivax SA | 2,550 | $284K |
| IONSIONIS PHARMACEUTICALS INC | 3,717 | $279K |
| COGTCogent Biosciences, Inc. | 6,990 | $269K |
| SANASana Biotechnology, Inc. | 84,445 | $243K |
| GMABGenmab A/S | 8,668 | $233K |
| ALMSALUMIS INC. | 10,389 | $229K |
| RDYDR REDDYS LABORATORIES LTD | 16,199 | $224K |
| TGTXTG THERAPEUTICS, INC. | 6,742 | $224K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 2,536 | $221K |
| TERNTerns Pharmaceuticals, Inc. | 4,172 | $220K |
| ANNXAnnexon, Inc. | 39,652 | $220K |
| PCVXVaxcyte, Inc. | 3,725 | $216K |
| ARVNARVINAS, INC. | 20,167 | $214K |
| PGENPRECIGEN, INC. | 47,400 | $183K |
| ZYMEZymeworks Inc. | 6,955 | $174K |
| CGEMCullinan Therapeutics, Inc. | 12,196 | $173K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 49,353 | $173K |
| RZLTRezolute, Inc. | 55,800 | $170K |
| FATEFATE THERAPEUTICS INC | 139,796 | $168K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 3,112 | $161K |
| ALDXAldeyra Therapeutics, Inc. | 91,623 | $155K |
| ORICOric Pharmaceuticals, Inc. | 12,095 | $153K |
| NUVLNuvalent, Inc. | 1,308 | $134K |
| KODKodiak Sciences Inc. | 3,449 | $131K |
| CHRSCoherus Oncology, Inc. | 70,341 | $119K |
| ABSIAbsci Corporation | 39,483 | $118K |
| RCUSArcus Biosciences, Inc. | 5,354 | $116K |
| LENZLENZ Therapeutics, Inc. | 12,240 | $112K |
| KRROKorro Bio, Inc. | 9,772 | $111K |
| RVMDREVOLUTION MEDICINES, INC. | 1,116 | $109K |
| AVXLANAVEX LIFE SCIENCES CORP. | 34,760 | $107K |
| SYRESpyre Therapeutics, Inc. | 2,105 | $106K |
| DFTXDefinium Therapeutics Inc. | 5,600 | $106K |
| TNGXTango Therapeutics, Inc. | 5,039 | $105K |
| OCULOCULAR THERAPEUTIX, INC | 12,377 | $105K |
| VCELVericel Corp | 3,236 | $104K |
| BEAMBeam Therapeutics Inc. | 4,364 | $104K |
| DNAGinkgo Bioworks Holdings Inc. | 16,900 | $104K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 10,276 | $100K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 15,263 | $98K |
| KROSKeros Therapeutics, Inc. | 8,618 | $95K |
| TNXPTonix Pharmaceuticals Holding Corp. | 6,902 | $95K |
| OLMAOlema Pharmaceuticals, Inc. | 6,314 | $94K |
| ADMAADMA BIOLOGICS, INC. | 10,117 | $91K |
| ORGOOrganogenesis Holdings Inc. | 37,912 | $90K |
| DNLIDenali Therapeutics Inc. | 4,651 | $89K |
| CMPSCOMPASS Pathways plc | 15,540 | $86K |
| TRDAEntrada Therapeutics, Inc. | 6,788 | $86K |
| OPKOPKO HEALTH, INC. | 69,834 | $80K |
| PTGXProtagonist Therapeutics, Inc | 737 | $78K |
| LGNDLigand Pharmaceuticals Incorporated | 379 | $76K |
| HURATuHURA Biosciences, Inc./NV | 41,764 | $75K |
| FLGTFulgent Genetics Inc. | 4,310 | $69K |
| IRONDisc Medicine, Inc. | 1,035 | $66K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 21,203 | $65K |
| BIOABioAge Labs, Inc. | 3,678 | $64K |
| MAZEMaze Therapeutics, Inc. | 2,143 | $64K |
| ALECAlector, Inc. | 28,985 | $62K |
| ANIPANI PHARMACEUTICALS INC | 777 | $60K |
| HUMAHumacyte Inc. | 97,873 | $59K |
| TECXTectonic Therapeutic, Inc. | 1,829 | $57K |
| ANABANAPTYSBIO, INC | 1,015 | $56K |
| SLSSELLAS Life Sciences Group, Inc. | 13,275 | $56K |
| ESPREsperion Therapeutics, Inc. | 19,918 | $55K |
| SIGASIGA TECHNOLOGIES INC | 10,173 | $54K |
| FDMT4D Molecular Therapeutics, Inc. | 4,806 | $45K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 1,281 | $43K |
| CYTKCYTOKINETICS INC | 639 | $42K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 1,770 | $38K |
| SLDBSolid Biosciences Inc. | 5,295 | $38K |
| ONCBeOne Medicines Ltd. | 124 | $37K |
| VYGRVoyager Therapeutics, Inc. | 9,234 | $36K |
| IMVTImmunovant, Inc. | 1,427 | $35K |
| UPBUpstream Bio, Inc. | 3,883 | $35K |
| ATAIAtai Beckley N.V. | 9,549 | $34K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 1,018 | $33K |
| ZBIOZenas BioPharma, Inc. | 1,472 | $29K |
| RNACCartesian Therapeutics, Inc. | 4,636 | $29K |
| STROSUTRO BIOPHARMA, INC. | 983 | $24K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 28,890 | $23K |
| CMPXCompass Therapeutics, Inc. | 4,317 | $23K |
| AARDAardvark Therapeutics, Inc. | 6,035 | $23K |
| BCAXBicara Therapeutics Inc. | 1,138 | $23K |
| SMMTSummit Therapeutics Inc. | 1,131 | $21K |
| ORKAOruka Therapeutics, Inc. | 424 | $21K |
| NGNENeurogene Inc. | 1,030 | $21K |
| LQDALiquidia Corp | 536 | $20K |
| STOKStoke Therapeutics, Inc. | 619 | $20K |
| ZVRAZEVRA THERAPEUTICS, INC. | 2,024 | $19K |
| KALVKalVista Pharmaceuticals, Inc. | 901 | $18K |
| CLDXCelldex Therapeutics, Inc. | 544 | $17K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 10,402 | $16K |
| ALTAltimmune, Inc. | 4,519 | $14K |
| TLXTelix Pharmaceuticals Limited | 1,425 | $14K |
| NRIXNurix Therapeutics, Inc. | 841 | $13K |
| NKTRNEKTAR THERAPEUTICS | 176 | $13K |
| ZNTLZentalis Pharmaceuticals, Inc. | 5,377 | $13K |
| MISTMilestone Pharmaceuticals Inc. | 10,000 | $12K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 132 | $11K |
| ABUSArbutus Biopharma Corp | 2,423 | $11K |
| VRDNViridian Therapeutics, Inc.\DE | 538 | $11K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 318 | $10K |
| IMUXIMMUNIC, INC. | 8,642 | $10K |
| IMMXImmix Biopharma, Inc. | 1,000 | $9K |
| OCGNOcugen, Inc. | 4,699 | $9K |
| AQSTAquestive Therapeutics, Inc. | 1,726 | $7K |
| SPRYARS Pharmaceuticals, Inc. | 834 | $7K |
| FENCFENNEC PHARMACEUTICALS INC. | 1,063 | $7K |
| QUREuniQure N.V. | 375 | $6K |
| GPCRStructure Therapeutics Inc. | 125 | $6K |
| CATXPerspective Therapeutics, Inc. | 1,419 | $6K |
| MLTXMoonLake Immunotherapeutics | 304 | $6K |
| ELVNEnliven Therapeutics, Inc. | 142 | $6K |
| TVRDTvardi Therapeutics, Inc. | 1,706 | $5K |
| GERNGERON CORP | 3,527 | $5K |
| APGEApogee Therapeutics, Inc. | 62 | $5K |
| MDWDMediWound Ltd. | 313 | $5K |
| CRDFCardiff Oncology, Inc. | 3,040 | $5K |
| DSGNDesign Therapeutics, Inc. | 423 | $5K |
| PVLAPALVELLA THERAPEUTICS, INC. | 35 | $4K |
| LCTXLineage Cell Therapeutics, Inc. | 2,329 | $4K |
| GRFSGrifols S.A. | 455 | $4K |
| XOMAXOMA Royalty Corporation | 113 | $4K |
| PLXProtalix BioTherapeutics, Inc. | 1,534 | $3K |
| SVRASavara Inc | 554 | $3K |
| AGENAGENUS INC | 820 | $3K |
| SIONSionna Therapeutics, Inc. | 67 | $3K |
| HROWHARROW, INC. | 66 | $2K |
| PRLDPrelude Therapeutics Inc | 573 | $2K |
| CADLCandel Therapeutics, Inc. | 387 | $2K |
| SLNOSOLENO THERAPEUTICS INC | 52 | $2K |
| DMACDiaMedica Therapeutics Inc. | 199 | $1K |
| NVCTNuvectis Pharma, Inc. | 170 | $1K |
| MPLTMapLight Therapeutics, Inc. | 57 | $1K |
| HYFTMindWalk Holdings Corp. | 1,000 | $1K |
| ONCYONCOLYTICS BIOTECH INC | 1,325 | $1K |
| JBIOJade Biosciences, Inc. | 75 | $1K |
| PROKPROKIDNEY CORP. | 455 | $814 |
| FLNAFilana Therapeutics Inc. | 455 | $769 |
| GYREGYRE THERAPEUTICS, INC. | 104 | $725 |
| LBRXLB PHARMACEUTICALS INC | 29 | $715 |
| ZURAZura Bio Ltd | 116 | $690 |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 69 | $648 |
| IVVDInvivyd, Inc. | 422 | $549 |
| IMCRImmunocore Holdings plc | 16 | $482 |
| GALTGALECTIN THERAPEUTICS INC | 139 | $388 |
| ATNMActinium Pharmaceuticals, Inc. | 351 | $349 |
| ABEOABEONA THERAPEUTICS INC. | 75 | $336 |
| VTGNVistagen Therapeutics, Inc. | 582 | $333 |
| RNAAtrium Therapeutics Inc. | 21 | $281 |
| PLRXPLIANT THERAPEUTICS, INC. | 212 | $267 |
| IGCIGC Pharma, Inc. | 1,000 | $263 |
| INOINOVIO PHARMACEUTICALS, INC. | 146 | $254 |
| KYNBKYNTRA BIO INC. | 26 | $176 |
| BDTXBlack Diamond Therapeutics, Inc. | 74 | $158 |
| CRVOCervoMed Inc. | 39 | $154 |
| ALXOALX ONCOLOGY HOLDINGS INC | 65 | $130 |
| CLYMClimb Bio, Inc. | 18 | $123 |
| WHWKWhitehawk Therapeutics, Inc. | 25 | $86 |
| OTLKOutlook Therapeutics, Inc. | 283 | $58 |
| LYELLyell Immunopharma, Inc. | 2 | $40 |
| MGXMetagenomi Therapeutics, Inc. | 25 | $34 |
| SCLXSCILEX HOLDING CO | 5 | $33 |
| HCMHUTCHMED (China) Limited | 2 | $30 |
| ARTLARTELO BIOSCIENCES, INC. | 1 | $8 |
| PHGEBiomX Inc. | 1 | $4 |
| INDPIndaptus Therapeutics, Inc. | 2 | $4 |
| LGVNLongeveron Inc. | 3 | $3 |
| LITSLite Strategy, Inc. | 1 | $1 |
| MBIOMUSTANG BIO, INC. | 2 | $1 |
| PMCBPharmaCyte Biotech, Inc. | 1 | $1 |