| GILDGILEAD SCIENCES, INC. | 2,300,271 | $320.6M |
| REGNREGENERON PHARMACEUTICALS, INC. | 184,691 | $142.7M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 263,375 | $87.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,496,097 | $82.6M |
| MRNAModerna, Inc. | 1,480,034 | $75.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 4,226,882 | $61.1M |
| BBIOBridgeBio Pharma, Inc. | 746,483 | $55.4M |
| INCYIncyte Corp. | 489,649 | $46.1M |
| ROIVRoivant Sciences Ltd. | 1,536,110 | $42.6M |
| INSMINSMED Inc | 233,304 | $38.1M |
| AXSMAxsome Therapeutics, Inc. | 185,658 | $31.4M |
| APLSApellis Pharmaceuticals, Inc. | 657,223 | $26.4M |
| TEVATeva Pharmaceutical Industries Limited | 832,323 | $25.1M |
| JAZZJazz Pharmaceuticals plc | 125,348 | $23.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 393,895 | $22.3M |
| RCKTRocket Pharmaceuticals Inc. | 5,107,708 | $18.3M |
| PTGXProtagonist Therapeutics, Inc | 158,711 | $16.7M |
| CYTKCYTOKINETICS INC | 249,243 | $16.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 251,568 | $15.8M |
| SNYSanofi | 258,597 | $12.5M |
| TGTXTG THERAPEUTICS, INC. | 353,979 | $11.8M |
| ANIPANI PHARMACEUTICALS INC | 144,281 | $11.1M |
| IONSIONIS PHARMACEUTICALS INC | 146,541 | $11.0M |
| RVMDREVOLUTION MEDICINES, INC. | 89,742 | $8.7M |
| QUREuniQure N.V. | 531,885 | $8.7M |
| PCVXVaxcyte, Inc. | 132,178 | $7.7M |
| NRIXNurix Therapeutics, Inc. | 477,410 | $7.4M |
| CLDXCelldex Therapeutics, Inc. | 217,335 | $6.9M |
| ARGXARGENX SE | 9,082 | $6.6M |
| EXELEXELIXIS, INC. | 149,846 | $6.4M |
| KALVKalVista Pharmaceuticals, Inc. | 244,261 | $4.9M |
| LGNDLigand Pharmaceuticals Incorporated | 21,594 | $4.3M |
| ANABANAPTYSBIO, INC | 73,406 | $4.1M |
| ABUSArbutus Biopharma Corp | 898,421 | $4.0M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 75,118 | $3.9M |
| SMMTSummit Therapeutics Inc. | 199,133 | $3.8M |
| NUVLNuvalent, Inc. | 36,688 | $3.8M |
| LQDALiquidia Corp | 94,750 | $3.6M |
| OGNOrganon & Co. | 596,772 | $3.6M |
| VKTXViking Therapeutics, Inc. | 109,295 | $3.6M |
| CMPXCompass Therapeutics, Inc. | 598,238 | $3.2M |
| ONCBeOne Medicines Ltd. | 10,188 | $3.0M |
| CNTACentessa Pharmaceuticals plc | 74,276 | $3.0M |
| RDYDR REDDYS LABORATORIES LTD | 207,932 | $2.9M |
| ZYMEZymeworks Inc. | 114,327 | $2.9M |
| HRMYHarmony Biosciences Holdings, Inc. | 99,662 | $2.8M |
| TERNTerns Pharmaceuticals, Inc. | 51,551 | $2.7M |
| ABEOABEONA THERAPEUTICS INC. | 522,445 | $2.3M |
| ALMSALUMIS INC. | 98,924 | $2.2M |
| CGEMCullinan Therapeutics, Inc. | 144,111 | $2.0M |
| SRRKScholar Rock Holding Corp | 38,728 | $1.9M |
| SLNOSOLENO THERAPEUTICS INC | 56,656 | $1.9M |
| NKTRNEKTAR THERAPEUTICS | 25,048 | $1.8M |
| KNSAKiniksa Pharmaceuticals International, plc | 33,714 | $1.6M |
| BEAMBeam Therapeutics Inc. | 66,858 | $1.6M |
| PTCTPTC THERAPEUTICS, INC. | 22,146 | $1.5M |
| ACADACADIA PHARMACEUTICALS INC | 67,487 | $1.5M |
| PGENPRECIGEN, INC. | 381,365 | $1.5M |
| NUVBNuvation Bio Inc. | 315,776 | $1.4M |
| IBRXImmunityBio, Inc. | 168,356 | $1.3M |
| COGTCogent Biosciences, Inc. | 32,925 | $1.3M |
| APGEApogee Therapeutics, Inc. | 13,988 | $1.2M |
| ARQTArcutis Biotherapeutics, Inc. | 48,337 | $1.1M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 12,336 | $1.1M |
| GPCRStructure Therapeutics Inc. | 20,494 | $988K |
| GERNGERON CORP | 633,501 | $944K |
| CATXPerspective Therapeutics, Inc. | 212,131 | $885K |
| MNOVMEDICINOVA INC | 635,715 | $871K |
| GMABGenmab A/S | 30,943 | $830K |
| TVTXTravere Therapeutics, Inc. | 27,131 | $806K |
| DNLIDenali Therapeutics Inc. | 39,278 | $754K |
| INVAInnoviva, Inc. | 31,732 | $739K |
| SIONSionna Therapeutics, Inc. | 18,058 | $724K |
| MANEVeradermics Incorporated | 10,691 | $675K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 7,685 | $645K |
| IMVTImmunovant, Inc. | 25,350 | $630K |
| ADMAADMA BIOLOGICS, INC. | 69,209 | $624K |
| SYRESpyre Therapeutics, Inc. | 12,006 | $606K |
| IMTXImmatics N.V. | 60,914 | $599K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 17,096 | $578K |
| ELVNEnliven Therapeutics, Inc. | 14,701 | $576K |
| HROWHARROW, INC. | 16,243 | $573K |
| RCUSArcus Biosciences, Inc. | 26,396 | $570K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 182,610 | $561K |
| ORKAOruka Therapeutics, Inc. | 10,387 | $509K |
| XERSXeris Biopharma Holdings, Inc. | 87,325 | $506K |
| DFTXDefinium Therapeutics Inc. | 26,486 | $501K |
| SLDBSolid Biosciences Inc. | 69,376 | $500K |
| IRONDisc Medicine, Inc. | 7,742 | $495K |
| CTMXCytomX Therapeutics, Inc. | 101,801 | $478K |
| VCELVericel Corp | 14,726 | $474K |
| OCULOCULAR THERAPEUTIX, INC | 55,777 | $472K |
| NTLAIntellia Therapeutics, Inc. | 36,757 | $471K |
| STROSUTRO BIOPHARMA, INC. | 18,845 | $469K |
| VRDNViridian Therapeutics, Inc.\DE | 23,458 | $459K |
| KURAKura Oncology, Inc. | 53,995 | $439K |
| STOKStoke Therapeutics, Inc. | 12,726 | $414K |
| OLMAOlema Pharmaceuticals, Inc. | 27,578 | $411K |
| TNGXTango Therapeutics, Inc. | 19,633 | $411K |
| KODKodiak Sciences Inc. | 10,686 | $407K |
| MESOMesoblast Limited | 26,463 | $407K |
| ARDXARDELYX, INC. | 66,136 | $396K |
| CBIOCRESCENT BIOPHARMA, INC. | 20,169 | $371K |
| ESPREsperion Therapeutics, Inc. | 133,596 | $366K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 11,036 | $335K |
| PVLAPALVELLA THERAPEUTICS, INC. | 2,504 | $312K |
| BHVNBiohaven Ltd. | 35,237 | $298K |
| DAWNDay One Biopharmaceuticals, Inc. | 13,848 | $297K |
| DMRADamora Therapeutics, Inc. | 11,095 | $287K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 81,725 | $287K |
| FLGTFulgent Genetics Inc. | 17,405 | $277K |
| LCTXLineage Cell Therapeutics, Inc. | 175,078 | $277K |
| ARVNARVINAS, INC. | 25,122 | $266K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 166,398 | $260K |
| OCGNOcugen, Inc. | 143,159 | $259K |
| MAZEMaze Therapeutics, Inc. | 8,563 | $256K |
| MLTXMoonLake Immunotherapeutics | 13,691 | $255K |
| ADPTAdaptive Biotechnologies Corp | 18,311 | $254K |
| OVIDOvid Therapeutics Inc. | 114,242 | $254K |
| FDMT4D Molecular Therapeutics, Inc. | 26,180 | $244K |
| ALTAltimmune, Inc. | 76,327 | $235K |
| BIOABioAge Labs, Inc. | 13,384 | $234K |
| ORICOric Pharmaceuticals, Inc. | 16,994 | $215K |
| RGNXREGENXBIO Inc. | 25,650 | $215K |
| ZVRAZEVRA THERAPEUTICS, INC. | 21,930 | $204K |
| ZBIOZenas BioPharma, Inc. | 9,888 | $193K |
| ABVXAbivax SA | 1,729 | $193K |
| BCAXBicara Therapeutics Inc. | 9,585 | $191K |
| ZNTLZentalis Pharmaceuticals, Inc. | 77,255 | $181K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 6,483 | $180K |
| SVRASavara Inc | 32,292 | $176K |
| AARDAardvark Therapeutics, Inc. | 46,265 | $174K |
| SANASana Biotechnology, Inc. | 60,391 | $174K |
| AQSTAquestive Therapeutics, Inc. | 41,907 | $174K |
| ATAIAtai Beckley N.V. | 49,052 | $174K |
| ANNXAnnexon, Inc. | 30,817 | $171K |
| CMPSCOMPASS Pathways plc | 29,652 | $164K |
| LRMRLarimar Therapeutics, Inc. | 36,107 | $162K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 16,708 | $157K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 4,766 | $153K |
| SPRYARS Pharmaceuticals, Inc. | 18,625 | $150K |
| XFORX4 Pharmaceuticals, Inc | 35,765 | $148K |
| IVVDInvivyd, Inc. | 109,874 | $143K |
| SABSSAB BIOTHERAPEUTICS, INC. | 36,805 | $141K |
| LBRXLB PHARMACEUTICALS INC | 5,569 | $137K |
| IMCRImmunocore Holdings plc | 4,517 | $136K |
| LYELLyell Immunopharma, Inc. | 5,912 | $119K |
| CCCCC4 Therapeutics, Inc. | 42,428 | $112K |
| SLSSELLAS Life Sciences Group, Inc. | 25,646 | $108K |
| RLMDRELMADA THERAPEUTICS, INC. | 15,414 | $107K |
| JBIOJade Biosciences, Inc. | 7,616 | $107K |
| CADLCandel Therapeutics, Inc. | 21,382 | $105K |
| SIGASIGA TECHNOLOGIES INC | 17,271 | $92K |
| ABSIAbsci Corporation | 30,789 | $92K |
| AVXLANAVEX LIFE SCIENCES CORP. | 28,981 | $89K |
| CHRSCoherus Oncology, Inc. | 52,333 | $88K |
| PROKPROKIDNEY CORP. | 49,384 | $88K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 8,150 | $79K |
| SGMTSagimet Biosciences Inc. | 13,586 | $71K |
| PHVSPharvaris N.V. | 2,442 | $69K |
| ANTXAN2 Therapeutics, Inc. | 19,088 | $65K |
| CRDFCardiff Oncology, Inc. | 40,266 | $65K |
| GALTGALECTIN THERAPEUTICS INC | 22,295 | $62K |
| TRDAEntrada Therapeutics, Inc. | 4,853 | $61K |
| SCLXSCILEX HOLDING CO | 8,954 | $60K |
| ZURAZura Bio Ltd | 9,409 | $56K |
| ARMPArmata Pharmaceuticals, Inc. | 5,160 | $53K |
| KLRSKalaris Therapeutics, Inc. | 8,703 | $50K |
| UPBUpstream Bio, Inc. | 5,055 | $45K |
| DSGNDesign Therapeutics, Inc. | 4,263 | $45K |
| SPROSpero Therapeutics, Inc. | 19,135 | $45K |
| LENZLENZ Therapeutics, Inc. | 4,801 | $44K |
| CAMPCamp4 Therapeutics Corp | 9,887 | $44K |
| TNXPTonix Pharmaceuticals Holding Corp. | 2,898 | $40K |
| CLYMClimb Bio, Inc. | 5,794 | $40K |
| OPKOPKO HEALTH, INC. | 33,676 | $38K |
| TECXTectonic Therapeutic, Inc. | 1,147 | $35K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 1,631 | $35K |
| CNTXContext Therapeutics Inc. | 12,182 | $32K |
| ALVOAlvotech | 9,230 | $32K |
| ORMPORAMED PHARMACEUTICALS INC. | 8,989 | $31K |
| ABCLAbCellera Biologics Inc. | 8,472 | $30K |
| GRFSGrifols S.A. | 3,667 | $29K |
| KROSKeros Therapeutics, Inc. | 2,208 | $24K |
| GHRSGH Research PLC | 1,733 | $24K |
| XOMAXOMA Royalty Corporation | 753 | $24K |
| ARTLARTELO BIOSCIENCES, INC. | 3,076 | $23K |
| IMMXImmix Biopharma, Inc. | 2,464 | $22K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 3,422 | $22K |
| WHWKWhitehawk Therapeutics, Inc. | 6,159 | $21K |
| MPLTMapLight Therapeutics, Inc. | 960 | $20K |
| DNAGinkgo Bioworks Holdings Inc. | 3,164 | $19K |
| NGNENeurogene Inc. | 930 | $19K |
| ORGOOrganogenesis Holdings Inc. | 7,175 | $17K |
| CANFCan-Fite BioPharma Ltd. | 5,482 | $17K |
| VYGRVoyager Therapeutics, Inc. | 3,869 | $15K |
| TAOXTAO Synergies Inc. | 2,582 | $15K |
| DMACDiaMedica Therapeutics Inc. | 1,896 | $13K |
| RZLTRezolute, Inc. | 3,811 | $12K |
| ALECAlector, Inc. | 4,639 | $10K |
| SLNSilence Therapeutics Plc | 1,835 | $10K |
| VIVSVivoSim Labs, INC. | 6,504 | $9K |
| RNAAtrium Therapeutics Inc. | 638 | $9K |
| FENCFENNEC PHARMACEUTICALS INC. | 1,393 | $8K |
| MDWDMediWound Ltd. | 514 | $8K |
| GLSIGreenwich LifeSciences, Inc. | 340 | $8K |
| NBPNovaBridge Biosciences | 3,187 | $8K |
| AUTLAutolus Therapeutics plc | 5,606 | $8K |
| ACIUAC Immune SA | 2,811 | $8K |
| APLMApollomics Inc. | 438 | $7K |
| HUMAHumacyte Inc. | 11,049 | $7K |
| PLXProtalix BioTherapeutics, Inc. | 2,958 | $6K |
| NVCTNuvectis Pharma, Inc. | 824 | $6K |
| ASRTAssertio Holdings, Inc. | 325 | $6K |
| BMEABiomea Fusion, Inc. | 4,000 | $6K |
| FATEFATE THERAPEUTICS INC | 5,054 | $6K |
| BCYCBICYCLE THERAPEUTICS PLC | 1,295 | $6K |
| MENSJyong Biotech Ltd. | 2,787 | $6K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 7,240 | $6K |
| ALZNAlzamend Neuro, Inc. | 5,231 | $6K |
| ALDXAldeyra Therapeutics, Inc. | 3,111 | $5K |
| CTXRCitius Pharmaceuticals, Inc. | 5,228 | $5K |
| PLURPluri Inc. | 1,360 | $5K |
| MIRAMIRA PHARMACEUTICALS, INC. | 4,226 | $5K |
| BIVIBIOVIE INC. | 3,164 | $4K |
| GYREGYRE THERAPEUTICS, INC. | 629 | $4K |
| IOBTQIO Biotech, Inc. | 72,495 | $4K |
| DRTSAlpha Tau Medical Ltd. | 500 | $4K |
| KRROKorro Bio, Inc. | 308 | $3K |
| HURATuHURA Biosciences, Inc./NV | 1,937 | $3K |
| BDTXBlack Diamond Therapeutics, Inc. | 1,592 | $3K |
| RNACCartesian Therapeutics, Inc. | 495 | $3K |
| HCMHUTCHMED (China) Limited | 191 | $3K |
| HOWLWerewolf Therapeutics, Inc. | 3,384 | $3K |
| EDSAEdesa Biotech, Inc. | 487 | $3K |
| ASBPAspire Biopharma Holdings Inc. | 1,846 | $2K |
| SCNXScienture Holdings, Inc. | 5,547 | $2K |
| PHIOPhio Pharmaceuticals Corp. | 1,025 | $1K |
| IFRXInflaRx N.V. | 1,302 | $1K |
| LIMNLIMINATUS PHARMA, INC. | 6,769 | $1K |
| IMAImageneBio, Inc. | 224 | $1K |
| INKTMiNK Therapeutics, Inc. | 91 | $958 |
| TVRDTvardi Therapeutics, Inc. | 276 | $878 |
| AEONAEON Biopharma, Inc. | 742 | $731 |
| ATNMActinium Pharmaceuticals, Inc. | 678 | $675 |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 808 | $642 |
| CPHICHINA PHARMA HOLDINGS, INC. | 996 | $608 |
| AZTRAzitra, Inc. | 1,705 | $399 |
| TOVXTheriva Biologics, Inc. | 1,391 | $272 |
| ANVSAnnovis Bio, Inc. | 55 | $123 |
| LTRNLantern Pharma Inc. | 45 | $62 |
| PCSAProcessa Pharmaceuticals, Inc. | 14 | $35 |
| ALXOALX ONCOLOGY HOLDINGS INC | 17 | $34 |
| HINDVyome Holdings, Inc | 16 | $34 |
| FLNAFilana Therapeutics Inc. | 20 | $34 |
| NBTXNanobiotix S.A. | 1 | $31 |
| RGCRegencell Bioscience Holdings Ltd | 1 | $25 |
| PTHSPelthos Therapeutics Inc. | 1 | $21 |
| PRLDPrelude Therapeutics Inc | 5 | $17 |
| TENXTENAX THERAPEUTICS, INC. | 1 | $16 |
| TPSTTempest Therapeutics, Inc. | 8 | $13 |
| LONALeonaBio, Inc. | 1 | $10 |
| HYFTMindWalk Holdings Corp. | 7 | $8 |
| KYNBKYNTRA BIO INC. | 1 | $7 |
| PTNPALATIN TECHNOLOGIES INC | 0 | $7 |
| LSTALISATA THERAPEUTICS, INC. | 1 | $5 |
| OKUROnKure Therapeutics, Inc. | 1 | $4 |
| ACXPAcurx Pharmaceuticals, Inc. | 1 | $4 |
| CNTNCanton Strategic Holdings, Inc. | 1 | $3 |
| AGENAGENUS INC | 1 | $3 |
| CLLSCellectis S.A. | 1 | $3 |
| CODXCo-Diagnostics Inc. | 1 | $2 |
| LITSLite Strategy, Inc. | 1 | $1 |
| SKYESkye Bioscience, Inc. | 2 | $1 |
| VTGNVistagen Therapeutics, Inc. | 1 | $1 |
| COCPCocrystal Pharma, Inc. | 1 | $1 |
| MBIOMUSTANG BIO, INC. | 1 | $1 |
| SILOSilo Pharma, Inc. | 1 | $0 |