| GILDGILEAD SCIENCES, INC. | 8,181,780 | $1.14B |
| REGNREGENERON PHARMACEUTICALS, INC. | 804,508 | $621.6M |
| MRNAModerna, Inc. | 4,734,356 | $240.5M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 673,356 | $222.8M |
| INSMINSMED Inc | 1,069,390 | $174.9M |
| RVMDREVOLUTION MEDICINES, INC. | 1,735,476 | $168.8M |
| INCYIncyte Corp. | 1,729,102 | $162.7M |
| BBIOBridgeBio Pharma, Inc. | 1,976,094 | $146.7M |
| IONSIONIS PHARMACEUTICALS INC | 1,583,266 | $118.9M |
| EXELEXELIXIS, INC. | 2,318,236 | $99.4M |
| ROIVRoivant Sciences Ltd. | 3,457,448 | $95.8M |
| CYTKCYTOKINETICS INC | 1,397,045 | $92.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 1,587,683 | $89.7M |
| JAZZJazz Pharmaceuticals plc | 440,510 | $83.3M |
| PCVXVaxcyte, Inc. | 1,403,948 | $81.6M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,192,085 | $74.7M |
| AXSMAxsome Therapeutics, Inc. | 395,118 | $66.8M |
| TEVATeva Pharmaceutical Industries Limited | 2,087,679 | $62.9M |
| PTGXProtagonist Therapeutics, Inc | 552,956 | $58.3M |
| PTCTPTC THERAPEUTICS, INC. | 731,642 | $49.8M |
| COGTCogent Biosciences, Inc. | 1,242,322 | $47.8M |
| NUVLNuvalent, Inc. | 450,801 | $46.2M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 526,459 | $45.8M |
| TGTXTG THERAPEUTICS, INC. | 1,295,055 | $43.0M |
| TERNTerns Pharmaceuticals, Inc. | 747,377 | $39.4M |
| LGNDLigand Pharmaceuticals Incorporated | 182,887 | $36.5M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 705,976 | $36.5M |
| FOLDAMICUS THERAPEUTICS, INC. | 2,514,240 | $36.4M |
| APGEApogee Therapeutics, Inc. | 420,684 | $35.4M |
| SRRKScholar Rock Holding Corp | 701,011 | $34.5M |
| SYRESpyre Therapeutics, Inc. | 562,653 | $28.4M |
| APLSApellis Pharmaceuticals, Inc. | 675,864 | $27.2M |
| INVAInnoviva, Inc. | 1,163,713 | $27.1M |
| ACADACADIA PHARMACEUTICALS INC | 1,173,560 | $26.1M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 305,440 | $25.6M |
| VKTXViking Therapeutics, Inc. | 736,465 | $24.0M |
| ARQTArcutis Biotherapeutics, Inc. | 1,012,555 | $23.9M |
| TVTXTravere Therapeutics, Inc. | 790,812 | $23.5M |
| DNLIDenali Therapeutics Inc. | 1,207,399 | $23.2M |
| LQDALiquidia Corp | 557,200 | $21.0M |
| OGNOrganon & Co. | 3,362,349 | $20.1M |
| RCUSArcus Biosciences, Inc. | 903,638 | $19.5M |
| BEAMBeam Therapeutics Inc. | 808,436 | $19.3M |
| IBRXImmunityBio, Inc. | 2,477,941 | $19.0M |
| ADMAADMA BIOLOGICS, INC. | 2,095,772 | $18.9M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 336,506 | $18.6M |
| SMMTSummit Therapeutics Inc. | 960,867 | $18.2M |
| ANIPANI PHARMACEUTICALS INC | 234,288 | $18.0M |
| TNGXTango Therapeutics, Inc. | 838,675 | $17.5M |
| CLDXCelldex Therapeutics, Inc. | 545,486 | $17.3M |
| IMVTImmunovant, Inc. | 660,438 | $16.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 477,032 | $16.1M |
| IRONDisc Medicine, Inc. | 251,195 | $16.1M |
| ADPTAdaptive Biotechnologies Corp | 1,145,682 | $15.9M |
| ORKAOruka Therapeutics, Inc. | 321,949 | $15.8M |
| VCELVericel Corp | 475,924 | $15.3M |
| DFTXDefinium Therapeutics Inc. | 808,715 | $15.3M |
| NRIXNurix Therapeutics, Inc. | 924,039 | $14.3M |
| VRDNViridian Therapeutics, Inc.\DE | 727,937 | $14.2M |
| STOKStoke Therapeutics, Inc. | 437,175 | $14.2M |
| ELVNEnliven Therapeutics, Inc. | 360,577 | $14.1M |
| ALMSALUMIS INC. | 635,389 | $14.0M |
| SLNOSOLENO THERAPEUTICS INC | 405,910 | $13.6M |
| KODKodiak Sciences Inc. | 349,803 | $13.3M |
| DAWNDay One Biopharmaceuticals, Inc. | 617,561 | $13.2M |
| SNYSanofi | 273,346 | $13.2M |
| ARDXARDELYX, INC. | 2,114,098 | $12.7M |
| OCULOCULAR THERAPEUTIX, INC | 1,461,177 | $12.4M |
| NKTRNEKTAR THERAPEUTICS | 168,007 | $12.1M |
| NTLAIntellia Therapeutics, Inc. | 941,285 | $12.1M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 3,808,798 | $11.7M |
| ANABANAPTYSBIO, INC | 192,687 | $10.7M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 2,783,730 | $9.8M |
| HROWHARROW, INC. | 270,536 | $9.5M |
| NUVBNuvation Bio Inc. | 1,992,451 | $8.5M |
| BHVNBiohaven Ltd. | 941,077 | $8.0M |
| XERSXeris Biopharma Holdings, Inc. | 1,359,657 | $7.9M |
| ORICOric Pharmaceuticals, Inc. | 605,037 | $7.7M |
| OLMAOlema Pharmaceuticals, Inc. | 466,546 | $7.0M |
| ARGXARGENX SE | 9,404 | $6.9M |
| GERNGERON CORP | 4,483,376 | $6.7M |
| KALVKalVista Pharmaceuticals, Inc. | 323,451 | $6.5M |
| ABUSArbutus Biopharma Corp | 1,401,157 | $6.3M |
| SVRASavara Inc | 1,140,244 | $6.2M |
| MANEVeradermics Incorporated | 98,009 | $6.2M |
| CGEMCullinan Therapeutics, Inc. | 432,893 | $6.2M |
| QUREuniQure N.V. | 375,852 | $6.1M |
| ANNXAnnexon, Inc. | 1,102,445 | $6.1M |
| PGENPRECIGEN, INC. | 1,460,620 | $5.7M |
| FLGTFulgent Genetics Inc. | 354,184 | $5.6M |
| KURAKura Oncology, Inc. | 690,817 | $5.6M |
| ARVNARVINAS, INC. | 525,174 | $5.6M |
| MAZEMaze Therapeutics, Inc. | 186,433 | $5.6M |
| BCAXBicara Therapeutics Inc. | 263,985 | $5.3M |
| SIONSionna Therapeutics, Inc. | 120,253 | $4.8M |
| ZYMEZymeworks Inc. | 185,124 | $4.6M |
| LBRXLB PHARMACEUTICALS INC | 186,095 | $4.6M |
| ZBIOZenas BioPharma, Inc. | 224,402 | $4.4M |
| BIOABioAge Labs, Inc. | 247,276 | $4.3M |
| SPRYARS Pharmaceuticals, Inc. | 533,394 | $4.3M |
| ATAIAtai Beckley N.V. | 1,181,583 | $4.2M |
| OPKOPKO HEALTH, INC. | 3,574,039 | $4.1M |
| SANASana Biotechnology, Inc. | 1,366,148 | $3.9M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 126,023 | $3.8M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 356,665 | $3.5M |
| GMABGenmab A/S | 127,571 | $3.4M |
| MPLTMapLight Therapeutics, Inc. | 161,146 | $3.3M |
| RGNXREGENXBIO Inc. | 390,601 | $3.3M |
| ABSIAbsci Corporation | 1,084,264 | $3.3M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 147,768 | $3.2M |
| FDMT4D Molecular Therapeutics, Inc. | 328,379 | $3.1M |
| PVLAPALVELLA THERAPEUTICS, INC. | 22,970 | $2.9M |
| CATXPerspective Therapeutics, Inc. | 661,318 | $2.8M |
| TRDAEntrada Therapeutics, Inc. | 214,751 | $2.7M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 290,806 | $2.6M |
| RCKTRocket Pharmaceuticals Inc. | 724,392 | $2.6M |
| DSGNDesign Therapeutics, Inc. | 241,485 | $2.6M |
| KNSAKiniksa Pharmaceuticals International, plc | 50,299 | $2.4M |
| AVXLANAVEX LIFE SCIENCES CORP. | 756,558 | $2.3M |
| UPBUpstream Bio, Inc. | 257,729 | $2.3M |
| ORGOOrganogenesis Holdings Inc. | 879,832 | $2.1M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,311,298 | $2.0M |
| DNAGinkgo Bioworks Holdings Inc. | 332,394 | $2.0M |
| SLSSELLAS Life Sciences Group, Inc. | 480,604 | $2.0M |
| KROSKeros Therapeutics, Inc. | 179,952 | $2.0M |
| CMPXCompass Therapeutics, Inc. | 371,058 | $2.0M |
| CHRSCoherus Oncology, Inc. | 1,155,901 | $2.0M |
| RZLTRezolute, Inc. | 638,384 | $1.9M |
| ESPREsperion Therapeutics, Inc. | 670,285 | $1.8M |
| SIGASIGA TECHNOLOGIES INC | 340,321 | $1.8M |
| LYELLyell Immunopharma, Inc. | 85,971 | $1.7M |
| ALECAlector, Inc. | 787,408 | $1.7M |
| RNAAtrium Therapeutics Inc. | 116,598 | $1.6M |
| ZVRAZEVRA THERAPEUTICS, INC. | 161,981 | $1.5M |
| LENZLENZ Therapeutics, Inc. | 149,544 | $1.4M |
| JBIOJade Biosciences, Inc. | 91,647 | $1.3M |
| CCCCC4 Therapeutics, Inc. | 452,228 | $1.2M |
| SLDBSolid Biosciences Inc. | 160,730 | $1.2M |
| GYREGYRE THERAPEUTICS, INC. | 165,238 | $1.2M |
| PROKPROKIDNEY CORP. | 627,771 | $1.1M |
| AQSTAquestive Therapeutics, Inc. | 267,419 | $1.1M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 1,376,367 | $1.1M |
| ALTAltimmune, Inc. | 351,681 | $1.1M |
| GRFSGrifols S.A. | 119,303 | $957K |
| FATEFATE THERAPEUTICS INC | 756,273 | $908K |
| TECXTectonic Therapeutic, Inc. | 29,110 | $900K |
| XOMAXOMA Royalty Corporation | 27,151 | $852K |
| HUMAHumacyte Inc. | 1,291,345 | $783K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 115,915 | $741K |
| LRMRLarimar Therapeutics, Inc. | 145,342 | $654K |
| NGNENeurogene Inc. | 30,058 | $606K |
| CTMXCytomX Therapeutics, Inc. | 128,796 | $605K |
| DMACDiaMedica Therapeutics Inc. | 88,421 | $599K |
| SGMOQSANGAMO THERAPEUTICS, INC | 2,352,360 | $581K |
| ABEOABEONA THERAPEUTICS INC. | 127,109 | $569K |
| CADLCandel Therapeutics, Inc. | 111,716 | $547K |
| VYGRVoyager Therapeutics, Inc. | 125,113 | $483K |
| TNXPTonix Pharmaceuticals Holding Corp. | 29,790 | $410K |
| FENCFENNEC PHARMACEUTICALS INC. | 63,537 | $391K |
| OCGNOcugen, Inc. | 212,094 | $384K |
| NVCTNuvectis Pharma, Inc. | 49,645 | $384K |
| RLMDRELMADA THERAPEUTICS, INC. | 53,081 | $369K |
| PLXProtalix BioTherapeutics, Inc. | 159,311 | $346K |
| MDWDMediWound Ltd. | 21,407 | $345K |
| DMRADamora Therapeutics, Inc. | 12,500 | $324K |
| XFORX4 Pharmaceuticals, Inc | 66,749 | $276K |
| CRDFCardiff Oncology, Inc. | 164,708 | $267K |
| STROSUTRO BIOPHARMA, INC. | 10,577 | $263K |
| IMMXImmix Biopharma, Inc. | 27,462 | $250K |
| ALDXAldeyra Therapeutics, Inc. | 139,029 | $235K |
| LCTXLineage Cell Therapeutics, Inc. | 129,924 | $205K |
| ZURAZura Bio Ltd | 31,096 | $185K |
| HURATuHURA Biosciences, Inc./NV | 98,937 | $177K |
| OVIDOvid Therapeutics Inc. | 72,000 | $160K |
| IRDOpus Genetics, Inc. | 35,000 | $159K |
| IVVDInvivyd, Inc. | 118,012 | $153K |
| RNACCartesian Therapeutics, Inc. | 24,929 | $153K |
| KRROKorro Bio, Inc. | 13,394 | $152K |
| CLYMClimb Bio, Inc. | 22,051 | $151K |
| AVTXAvalo Therapeutics, Inc. | 10,000 | $149K |
| ZNTLZentalis Pharmaceuticals, Inc. | 51,087 | $120K |
| AARDAardvark Therapeutics, Inc. | 28,000 | $106K |
| MNOVMEDICINOVA INC | 71,506 | $98K |
| IMUXIMMUNIC, INC. | 85,000 | $94K |
| CAMPCamp4 Therapeutics Corp | 20,000 | $88K |
| GALTGALECTIN THERAPEUTICS INC | 30,010 | $84K |
| SGMTSagimet Biosciences Inc. | 15,000 | $78K |
| SPROSpero Therapeutics, Inc. | 28,565 | $67K |
| CGTXCOGNITION THERAPEUTICS INC | 84,940 | $65K |
| AGENAGENUS INC | 15,000 | $50K |
| FLNAFilana Therapeutics Inc. | 25,561 | $43K |
| TVRDTvardi Therapeutics, Inc. | 11,784 | $37K |
| ANIXAnixa Biosciences Inc | 12,785 | $33K |
| BDTXBlack Diamond Therapeutics, Inc. | 14,484 | $31K |