| GILDGILEAD SCIENCES, INC. | 1,914,292 | $266.8M |
| REGNREGENERON PHARMACEUTICALS, INC. | 154,201 | $119.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 196,863 | $65.1M |
| INSMINSMED Inc | 303,182 | $49.6M |
| TEVATeva Pharmaceutical Industries Limited | 1,244,744 | $37.5M |
| INCYIncyte Corp. | 241,287 | $22.7M |
| MRNAModerna, Inc. | 407,190 | $20.7M |
| RVMDREVOLUTION MEDICINES, INC. | 165,277 | $16.1M |
| IONSIONIS PHARMACEUTICALS INC | 176,485 | $13.3M |
| EXELEXELIXIS, INC. | 297,156 | $12.7M |
| BBIOBridgeBio Pharma, Inc. | 165,703 | $12.3M |
| ROIVRoivant Sciences Ltd. | 440,634 | $12.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 214,859 | $12.1M |
| JAZZJazz Pharmaceuticals plc | 63,657 | $12.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 144,313 | $9.0M |
| CYTKCYTOKINETICS INC | 136,599 | $9.0M |
| PCVXVaxcyte, Inc. | 136,100 | $7.9M |
| AXSMAxsome Therapeutics, Inc. | 41,132 | $7.0M |
| PTGXProtagonist Therapeutics, Inc | 58,677 | $6.2M |
| TGTXTG THERAPEUTICS, INC. | 175,750 | $5.8M |
| PTCTPTC THERAPEUTICS, INC. | 84,320 | $5.7M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 65,806 | $5.7M |
| NUVLNuvalent, Inc. | 49,670 | $5.1M |
| FOLDAMICUS THERAPEUTICS, INC. | 341,920 | $4.9M |
| LGNDLigand Pharmaceuticals Incorporated | 23,784 | $4.7M |
| VKTXViking Therapeutics, Inc. | 124,452 | $4.0M |
| COGTCogent Biosciences, Inc. | 100,980 | $3.9M |
| APLSApellis Pharmaceuticals, Inc. | 94,833 | $3.8M |
| TERNTerns Pharmaceuticals, Inc. | 70,219 | $3.7M |
| SRRKScholar Rock Holding Corp | 74,916 | $3.7M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 67,686 | $3.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 40,584 | $3.4M |
| APGEApogee Therapeutics, Inc. | 38,161 | $3.2M |
| TVTXTravere Therapeutics, Inc. | 105,132 | $3.1M |
| DNLIDenali Therapeutics Inc. | 162,576 | $3.1M |
| ACADACADIA PHARMACEUTICALS INC | 138,244 | $3.1M |
| ARQTArcutis Biotherapeutics, Inc. | 128,317 | $3.0M |
| SYRESpyre Therapeutics, Inc. | 59,242 | $3.0M |
| IBRXImmunityBio, Inc. | 386,334 | $3.0M |
| LQDALiquidia Corp | 72,438 | $2.7M |
| BEAMBeam Therapeutics Inc. | 107,741 | $2.6M |
| CLDXCelldex Therapeutics, Inc. | 79,630 | $2.5M |
| ADMAADMA BIOLOGICS, INC. | 279,124 | $2.5M |
| IMVTImmunovant, Inc. | 94,286 | $2.3M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 68,564 | $2.3M |
| RCUSArcus Biosciences, Inc. | 105,776 | $2.3M |
| IRONDisc Medicine, Inc. | 34,382 | $2.2M |
| NKTRNEKTAR THERAPEUTICS | 28,682 | $2.1M |
| KNSAKiniksa Pharmaceuticals International, plc | 41,975 | $2.0M |
| ADPTAdaptive Biotechnologies Corp | 143,658 | $2.0M |
| VCELVericel Corp | 61,233 | $2.0M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 64,716 | $2.0M |
| OGNOrganon & Co. | 327,075 | $2.0M |
| SLNOSOLENO THERAPEUTICS INC | 58,388 | $2.0M |
| ANIPANI PHARMACEUTICALS INC | 24,557 | $1.9M |
| ARDXARDELYX, INC. | 303,137 | $1.8M |
| OCULOCULAR THERAPEUTIX, INC | 213,706 | $1.8M |
| ALMSALUMIS INC. | 80,845 | $1.8M |
| NTLAIntellia Therapeutics, Inc. | 138,259 | $1.8M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 574,637 | $1.8M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 54,329 | $1.7M |
| INVAInnoviva, Inc. | 74,468 | $1.7M |
| STOKStoke Therapeutics, Inc. | 51,606 | $1.7M |
| VRDNViridian Therapeutics, Inc.\DE | 81,021 | $1.6M |
| NRIXNurix Therapeutics, Inc. | 99,042 | $1.5M |
| BHVNBiohaven Ltd. | 172,370 | $1.5M |
| DAWNDay One Biopharmaceuticals, Inc. | 67,463 | $1.4M |
| HROWHARROW, INC. | 39,019 | $1.4M |
| NUVBNuvation Bio Inc. | 303,784 | $1.3M |
| ELVNEnliven Therapeutics, Inc. | 31,914 | $1.3M |
| KODKodiak Sciences Inc. | 29,396 | $1.1M |
| GERNGERON CORP | 737,143 | $1.1M |
| ORKAOruka Therapeutics, Inc. | 21,370 | $1.0M |
| XERSXeris Biopharma Holdings, Inc. | 180,339 | $1.0M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 295,392 | $1.0M |
| TNGXTango Therapeutics, Inc. | 47,691 | $998K |
| ZYMEZymeworks Inc. | 37,389 | $936K |
| PVLAPALVELLA THERAPEUTICS, INC. | 6,895 | $859K |
| ANABANAPTYSBIO, INC | 14,000 | $776K |
| KURAKura Oncology, Inc. | 95,317 | $775K |
| PHVSPharvaris N.V. | 24,153 | $682K |
| PGENPRECIGEN, INC. | 171,189 | $663K |
| ABUSArbutus Biopharma Corp | 142,985 | $643K |
| ORICOric Pharmaceuticals, Inc. | 48,369 | $613K |
| CMPXCompass Therapeutics, Inc. | 112,316 | $594K |
| QUREuniQure N.V. | 35,947 | $588K |
| OLMAOlema Pharmaceuticals, Inc. | 39,079 | $583K |
| MLTXMoonLake Immunotherapeutics | 29,296 | $546K |
| OPKOPKO HEALTH, INC. | 414,037 | $472K |
| SANASana Biotechnology, Inc. | 163,559 | $471K |
| ARVNARVINAS, INC. | 43,341 | $459K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 21,033 | $454K |
| CGEMCullinan Therapeutics, Inc. | 30,397 | $432K |
| SPRYARS Pharmaceuticals, Inc. | 53,658 | $431K |
| CTMXCytomX Therapeutics, Inc. | 88,379 | $415K |
| UPBUpstream Bio, Inc. | 39,661 | $357K |
| BCAXBicara Therapeutics Inc. | 16,923 | $337K |
| KALVKalVista Pharmaceuticals, Inc. | 15,442 | $311K |
| ZBIOZenas BioPharma, Inc. | 15,819 | $309K |
| FLGTFulgent Genetics Inc. | 18,094 | $288K |
| DNAGinkgo Bioworks Holdings Inc. | 30,852 | $189K |
| SMMTSummit Therapeutics Inc. | 6,391 | $121K |
| LENZLENZ Therapeutics, Inc. | 10,818 | $99K |
| SVRASavara Inc | 7,917 | $43K |
| MAZEMaze Therapeutics, Inc. | 1,435 | $43K |
| ANNXAnnexon, Inc. | 7,173 | $40K |
| SLSSELLAS Life Sciences Group, Inc. | 9,337 | $39K |
| ESPREsperion Therapeutics, Inc. | 13,076 | $36K |
| SIONSionna Therapeutics, Inc. | 868 | $35K |
| BIOABioAge Labs, Inc. | 1,641 | $29K |
| ZVRAZEVRA THERAPEUTICS, INC. | 3,015 | $28K |
| LBRXLB PHARMACEUTICALS INC | 1,041 | $26K |
| JBIOJade Biosciences, Inc. | 1,734 | $24K |
| AQSTAquestive Therapeutics, Inc. | 5,654 | $23K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 2,383 | $23K |
| SLDBSolid Biosciences Inc. | 3,190 | $23K |
| FDMT4D Molecular Therapeutics, Inc. | 2,429 | $23K |
| ABSIAbsci Corporation | 7,381 | $22K |
| ALTAltimmune, Inc. | 7,124 | $22K |
| MPLTMapLight Therapeutics, Inc. | 1,062 | $22K |
| RGNXREGENXBIO Inc. | 2,532 | $21K |
| TRDAEntrada Therapeutics, Inc. | 1,540 | $19K |
| TECXTectonic Therapeutic, Inc. | 595 | $18K |
| KROSKeros Therapeutics, Inc. | 1,581 | $17K |
| RCKTRocket Pharmaceuticals Inc. | 4,586 | $16K |
| XOMAXOMA Royalty Corporation | 514 | $16K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 2,330 | $15K |
| AVXLANAVEX LIFE SCIENCES CORP. | 4,764 | $15K |
| CATXPerspective Therapeutics, Inc. | 3,432 | $14K |
| DSGNDesign Therapeutics, Inc. | 1,292 | $14K |
| DMACDiaMedica Therapeutics Inc. | 1,837 | $12K |
| NGNENeurogene Inc. | 604 | $12K |
| RZLTRezolute, Inc. | 3,950 | $12K |
| SIGASIGA TECHNOLOGIES INC | 2,223 | $12K |
| LRMRLarimar Therapeutics, Inc. | 2,631 | $12K |
| CADLCandel Therapeutics, Inc. | 2,372 | $12K |
| ABEOABEONA THERAPEUTICS INC. | 2,364 | $11K |
| ALECAlector, Inc. | 4,894 | $11K |
| TNXPTonix Pharmaceuticals Holding Corp. | 757 | $10K |
| FENCFENNEC PHARMACEUTICALS INC. | 1,603 | $10K |
| VYGRVoyager Therapeutics, Inc. | 2,520 | $10K |
| CHRSCoherus Oncology, Inc. | 5,740 | $10K |
| ORGOOrganogenesis Holdings Inc. | 3,696 | $9K |
| MDWDMediWound Ltd. | 528 | $9K |
| PLXProtalix BioTherapeutics, Inc. | 3,909 | $8K |
| FATEFATE THERAPEUTICS INC | 5,885 | $7K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 8,316 | $7K |
| NVCTNuvectis Pharma, Inc. | 837 | $6K |
| CRDFCardiff Oncology, Inc. | 3,355 | $5K |
| ALDXAldeyra Therapeutics, Inc. | 2,937 | $5K |
| GYREGYRE THERAPEUTICS, INC. | 639 | $4K |
| RNACCartesian Therapeutics, Inc. | 567 | $3K |
| AARDAardvark Therapeutics, Inc. | 689 | $3K |
| HURATuHURA Biosciences, Inc./NV | 550 | $985 |