| GILDGILEAD SCIENCES, INC. | 15,053,151 | $2.10B |
| REGNREGENERON PHARMACEUTICALS, INC. | 765,411 | $591.4M |
| JAZZJazz Pharmaceuticals plc | 1,679,371 | $317.5M |
| INSMINSMED Inc | 1,262,749 | $206.5M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 491,200 | $162.5M |
| INCYIncyte Corp. | 989,709 | $93.2M |
| MRNAModerna, Inc. | 1,691,205 | $85.9M |
| EXELEXELIXIS, INC. | 1,986,035 | $85.2M |
| ROIVRoivant Sciences Ltd. | 2,735,824 | $75.8M |
| CYTKCYTOKINETICS INC | 1,006,185 | $66.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 1,144,892 | $64.7M |
| RVMDREVOLUTION MEDICINES, INC. | 635,366 | $61.8M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 960,144 | $60.2M |
| TEVATeva Pharmaceutical Industries Limited | 1,794,432 | $54.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 808,139 | $44.6M |
| BBIOBridgeBio Pharma, Inc. | 577,283 | $42.9M |
| IONSIONIS PHARMACEUTICALS INC | 514,617 | $38.6M |
| PTGXProtagonist Therapeutics, Inc | 341,465 | $36.0M |
| PTCTPTC THERAPEUTICS, INC. | 522,763 | $35.6M |
| AXSMAxsome Therapeutics, Inc. | 206,644 | $34.9M |
| TGTXTG THERAPEUTICS, INC. | 887,305 | $29.5M |
| PCVXVaxcyte, Inc. | 474,526 | $27.6M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 293,298 | $25.5M |
| LGNDLigand Pharmaceuticals Incorporated | 119,403 | $23.8M |
| SNYSanofi | 467,759 | $22.5M |
| APLSApellis Pharmaceuticals, Inc. | 524,789 | $21.1M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 362,408 | $18.7M |
| NUVLNuvalent, Inc. | 161,509 | $16.5M |
| ACADACADIA PHARMACEUTICALS INC | 736,558 | $16.4M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 188,412 | $15.8M |
| TERNTerns Pharmaceuticals, Inc. | 281,667 | $14.8M |
| VKTXViking Therapeutics, Inc. | 454,063 | $14.8M |
| DNLIDenali Therapeutics Inc. | 768,039 | $14.7M |
| COGTCogent Biosciences, Inc. | 372,796 | $14.3M |
| DFTXDefinium Therapeutics Inc. | 752,922 | $14.2M |
| OGNOrganon & Co. | 2,231,761 | $13.4M |
| IRONDisc Medicine, Inc. | 204,968 | $13.1M |
| ARGXARGENX SE | 17,183 | $12.5M |
| ADMAADMA BIOLOGICS, INC. | 1,355,443 | $12.2M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 378,800 | $12.1M |
| KALVKalVista Pharmaceuticals, Inc. | 584,347 | $11.8M |
| FOLDAMICUS THERAPEUTICS, INC. | 811,354 | $11.7M |
| SRRKScholar Rock Holding Corp | 232,672 | $11.4M |
| INVAInnoviva, Inc. | 489,497 | $11.4M |
| RCUSArcus Biosciences, Inc. | 511,166 | $11.0M |
| APGEApogee Therapeutics, Inc. | 126,757 | $10.7M |
| SYRESpyre Therapeutics, Inc. | 191,395 | $9.7M |
| SLNOSOLENO THERAPEUTICS INC | 277,851 | $9.3M |
| VCELVericel Corp | 269,757 | $8.7M |
| ANIPANI PHARMACEUTICALS INC | 111,001 | $8.5M |
| BEAMBeam Therapeutics Inc. | 344,486 | $8.2M |
| SMMTSummit Therapeutics Inc. | 404,679 | $7.7M |
| LQDALiquidia Corp | 193,920 | $7.3M |
| ARQTArcutis Biotherapeutics, Inc. | 305,532 | $7.2M |
| TNGXTango Therapeutics, Inc. | 318,458 | $6.7M |
| TVTXTravere Therapeutics, Inc. | 217,226 | $6.5M |
| IBRXImmunityBio, Inc. | 831,430 | $6.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 186,791 | $6.3M |
| CLDXCelldex Therapeutics, Inc. | 190,399 | $6.0M |
| ADPTAdaptive Biotechnologies Corp | 401,901 | $5.6M |
| IMVTImmunovant, Inc. | 216,225 | $5.4M |
| ORKAOruka Therapeutics, Inc. | 106,883 | $5.2M |
| DAWNDay One Biopharmaceuticals, Inc. | 231,043 | $5.0M |
| ELVNEnliven Therapeutics, Inc. | 120,057 | $4.7M |
| STOKStoke Therapeutics, Inc. | 143,407 | $4.7M |
| NRIXNurix Therapeutics, Inc. | 295,345 | $4.6M |
| ALMSALUMIS INC. | 206,729 | $4.6M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 1,462,631 | $4.5M |
| KODKodiak Sciences Inc. | 111,341 | $4.2M |
| VRDNViridian Therapeutics, Inc.\DE | 216,525 | $4.2M |
| NTLAIntellia Therapeutics, Inc. | 328,000 | $4.2M |
| ARDXARDELYX, INC. | 700,783 | $4.2M |
| OCULOCULAR THERAPEUTIX, INC | 475,987 | $4.0M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 130,730 | $4.0M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 956,780 | $3.4M |
| ZYMEZymeworks Inc. | 124,105 | $3.1M |
| NUVBNuvation Bio Inc. | 683,497 | $2.9M |
| OLMAOlema Pharmaceuticals, Inc. | 193,483 | $2.9M |
| ANABANAPTYSBIO, INC | 51,115 | $2.8M |
| HROWHARROW, INC. | 78,682 | $2.8M |
| BHVNBiohaven Ltd. | 307,244 | $2.6M |
| ARVNARVINAS, INC. | 236,714 | $2.5M |
| XERSXeris Biopharma Holdings, Inc. | 426,285 | $2.5M |
| ORICOric Pharmaceuticals, Inc. | 190,470 | $2.4M |
| XOMAXOMA Royalty Corporation | 74,984 | $2.4M |
| GERNGERON CORP | 1,540,236 | $2.3M |
| PVLAPALVELLA THERAPEUTICS, INC. | 18,041 | $2.2M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 347,881 | $2.2M |
| MAZEMaze Therapeutics, Inc. | 74,268 | $2.2M |
| ANNXAnnexon, Inc. | 395,019 | $2.2M |
| KURAKura Oncology, Inc. | 254,325 | $2.1M |
| CGEMCullinan Therapeutics, Inc. | 143,708 | $2.0M |
| SLSSELLAS Life Sciences Group, Inc. | 478,366 | $2.0M |
| ABUSArbutus Biopharma Corp | 379,373 | $1.7M |
| SVRASavara Inc | 309,695 | $1.7M |
| PGENPRECIGEN, INC. | 433,307 | $1.7M |
| BCAXBicara Therapeutics Inc. | 83,264 | $1.7M |
| ZVRAZEVRA THERAPEUTICS, INC. | 172,427 | $1.6M |
| GMABGenmab A/S | 58,921 | $1.6M |
| CMPXCompass Therapeutics, Inc. | 297,301 | $1.6M |
| ESPREsperion Therapeutics, Inc. | 555,177 | $1.5M |
| OPKOPKO HEALTH, INC. | 1,280,042 | $1.5M |
| ONCBeOne Medicines Ltd. | 4,632 | $1.4M |
| SIGASIGA TECHNOLOGIES INC | 256,803 | $1.4M |
| CTMXCytomX Therapeutics, Inc. | 289,868 | $1.4M |
| SIONSionna Therapeutics, Inc. | 33,778 | $1.4M |
| KROSKeros Therapeutics, Inc. | 120,944 | $1.3M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 136,322 | $1.3M |
| BIOABioAge Labs, Inc. | 75,568 | $1.3M |
| SPRYARS Pharmaceuticals, Inc. | 164,064 | $1.3M |
| SANASana Biotechnology, Inc. | 442,604 | $1.3M |
| ALTAltimmune, Inc. | 413,503 | $1.3M |
| JBIOJade Biosciences, Inc. | 89,964 | $1.3M |
| FDMT4D Molecular Therapeutics, Inc. | 133,607 | $1.2M |
| FLGTFulgent Genetics Inc. | 76,294 | $1.2M |
| ZBIOZenas BioPharma, Inc. | 60,864 | $1.2M |
| RGNXREGENXBIO Inc. | 140,219 | $1.2M |
| LBRXLB PHARMACEUTICALS INC | 45,457 | $1.1M |
| AQSTAquestive Therapeutics, Inc. | 255,184 | $1.1M |
| ABSIAbsci Corporation | 337,844 | $1.0M |
| SLDBSolid Biosciences Inc. | 137,944 | $993K |
| TRDAEntrada Therapeutics, Inc. | 76,427 | $965K |
| ABEOABEONA THERAPEUTICS INC. | 193,632 | $867K |
| RCKTRocket Pharmaceuticals Inc. | 239,842 | $859K |
| DSGNDesign Therapeutics, Inc. | 79,645 | $847K |
| KNSAKiniksa Pharmaceuticals International, plc | 17,388 | $837K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 38,477 | $831K |
| MPLTMapLight Therapeutics, Inc. | 39,465 | $802K |
| CATXPerspective Therapeutics, Inc. | 185,335 | $773K |
| TECXTectonic Therapeutic, Inc. | 24,760 | $765K |
| IMMXImmix Biopharma, Inc. | 83,611 | $762K |
| AVXLANAVEX LIFE SCIENCES CORP. | 247,849 | $761K |
| DNAGinkgo Bioworks Holdings Inc. | 123,959 | $760K |
| DMACDiaMedica Therapeutics Inc. | 111,079 | $752K |
| UPBUpstream Bio, Inc. | 81,383 | $732K |
| QUREuniQure N.V. | 42,914 | $702K |
| ORGOOrganogenesis Holdings Inc. | 293,651 | $696K |
| CADLCandel Therapeutics, Inc. | 136,266 | $668K |
| RNAAtrium Therapeutics Inc. | 43,697 | $584K |
| RZLTRezolute, Inc. | 189,779 | $579K |
| ALECAlector, Inc. | 252,297 | $542K |
| VYGRVoyager Therapeutics, Inc. | 139,770 | $540K |
| NGNENeurogene Inc. | 26,043 | $525K |
| RDYDR REDDYS LABORATORIES LTD | 37,333 | $517K |
| CRDFCardiff Oncology, Inc. | 303,428 | $492K |
| LRMRLarimar Therapeutics, Inc. | 107,331 | $483K |
| CHRSCoherus Oncology, Inc. | 285,033 | $482K |
| PLXProtalix BioTherapeutics, Inc. | 219,307 | $476K |
| NKTRNEKTAR THERAPEUTICS | 6,597 | $475K |
| LENZLENZ Therapeutics, Inc. | 49,797 | $456K |
| TNXPTonix Pharmaceuticals Holding Corp. | 30,426 | $418K |
| BDTXBlack Diamond Therapeutics, Inc. | 189,148 | $403K |
| HURATuHURA Biosciences, Inc./NV | 211,568 | $379K |
| FATEFATE THERAPEUTICS INC | 306,987 | $368K |
| CNTACentessa Pharmaceuticals plc | 8,298 | $330K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 406,806 | $325K |
| FENCFENNEC PHARMACEUTICALS INC. | 52,462 | $323K |
| GYREGYRE THERAPEUTICS, INC. | 43,144 | $301K |
| MDWDMediWound Ltd. | 17,151 | $276K |
| KRROKorro Bio, Inc. | 21,730 | $246K |
| NVCTNuvectis Pharma, Inc. | 30,315 | $234K |
| MANEVeradermics Incorporated | 3,668 | $232K |
| ALDXAldeyra Therapeutics, Inc. | 136,746 | $231K |
| HUMAHumacyte Inc. | 353,410 | $214K |
| ATAIAtai Beckley N.V. | 45,609 | $161K |
| RNACCartesian Therapeutics, Inc. | 26,099 | $161K |
| OCGNOcugen, Inc. | 86,118 | $156K |
| GRFSGrifols S.A. | 16,419 | $132K |
| CSBRCHAMPIONS ONCOLOGY, INC. | 21,614 | $124K |
| ANIXAnixa Biosciences Inc | 47,442 | $122K |
| OVIDOvid Therapeutics Inc. | 55,038 | $122K |
| AARDAardvark Therapeutics, Inc. | 29,320 | $111K |
| MNOVMEDICINOVA INC | 78,277 | $107K |
| CAMPCamp4 Therapeutics Corp | 18,718 | $83K |
| TVRDTvardi Therapeutics, Inc. | 17,405 | $55K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 27,459 | $43K |
| PDSBPDS Biotechnology Corp | 69,311 | $42K |
| LCTXLineage Cell Therapeutics, Inc. | 23,213 | $37K |
| IVVDInvivyd, Inc. | 27,184 | $35K |
| FLNAFilana Therapeutics Inc. | 20,481 | $35K |
| ANVSAnnovis Bio, Inc. | 15,476 | $35K |
| IMUXIMMUNIC, INC. | 28,358 | $31K |
| LTRNLantern Pharma Inc. | 21,301 | $29K |
| PROKPROKIDNEY CORP. | 11,192 | $20K |
| PLRXPLIANT THERAPEUTICS, INC. | 15,824 | $20K |
| SGMOQSANGAMO THERAPEUTICS, INC | 49,772 | $12K |
| CGTXCOGNITION THERAPEUTICS INC | 13,462 | $10K |