| GILDGILEAD SCIENCES, INC. | 19,978,936 | $2.78B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,189,584 | $919.1M |
| SNYSanofi | 9,484,350 | $457.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 966,912 | $319.9M |
| ARGXARGENX SE | 400,117 | $292.2M |
| INSMINSMED Inc | 1,502,281 | $245.7M |
| CYTKCYTOKINETICS INC | 3,125,436 | $206.0M |
| JAZZJazz Pharmaceuticals plc | 1,014,800 | $191.8M |
| PTGXProtagonist Therapeutics, Inc | 1,295,434 | $136.5M |
| PTCTPTC THERAPEUTICS, INC. | 1,886,841 | $128.6M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 2,206,152 | $121.8M |
| ONCBeOne Medicines Ltd. | 405,273 | $120.4M |
| TEVATeva Pharmaceutical Industries Limited | 3,958,814 | $119.2M |
| AXSMAxsome Therapeutics, Inc. | 598,091 | $101.1M |
| BBIOBridgeBio Pharma, Inc. | 1,285,748 | $95.5M |
| ROIVRoivant Sciences Ltd. | 3,163,821 | $87.6M |
| LQDALiquidia Corp | 2,287,792 | $86.3M |
| INCYIncyte Corp. | 915,527 | $86.2M |
| ABVXAbivax SA | 735,729 | $81.9M |
| CNTACentessa Pharmaceuticals plc | 1,932,406 | $76.8M |
| APGEApogee Therapeutics, Inc. | 900,871 | $75.8M |
| PCVXVaxcyte, Inc. | 1,216,843 | $70.7M |
| EXELEXELIXIS, INC. | 1,644,737 | $70.5M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,064,455 | $66.7M |
| SRRKScholar Rock Holding Corp | 1,336,632 | $65.7M |
| IONSIONIS PHARMACEUTICALS INC | 840,598 | $63.1M |
| SYRESpyre Therapeutics, Inc. | 1,228,093 | $61.9M |
| RVMDREVOLUTION MEDICINES, INC. | 614,157 | $59.7M |
| FOLDAMICUS THERAPEUTICS, INC. | 3,899,490 | $56.4M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 628,667 | $54.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 936,951 | $52.9M |
| ARQTArcutis Biotherapeutics, Inc. | 2,221,289 | $52.3M |
| MRNAModerna, Inc. | 986,360 | $50.1M |
| TGTXTG THERAPEUTICS, INC. | 1,461,302 | $48.5M |
| CTMXCytomX Therapeutics, Inc. | 10,202,785 | $48.0M |
| APLSApellis Pharmaceuticals, Inc. | 1,190,864 | $47.9M |
| TERNTerns Pharmaceuticals, Inc. | 811,636 | $42.8M |
| DAWNDay One Biopharmaceuticals, Inc. | 1,902,868 | $40.8M |
| COGTCogent Biosciences, Inc. | 1,043,805 | $40.2M |
| TVTXTravere Therapeutics, Inc. | 1,345,111 | $40.0M |
| INVAInnoviva, Inc. | 1,619,994 | $37.7M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 714,226 | $36.9M |
| ADMAADMA BIOLOGICS, INC. | 3,997,675 | $36.0M |
| KNSAKiniksa Pharmaceuticals International, plc | 735,940 | $35.4M |
| VCELVericel Corp | 1,098,771 | $35.3M |
| GRFSGrifols S.A. | 4,327,413 | $34.7M |
| ACADACADIA PHARMACEUTICALS INC | 1,553,770 | $34.6M |
| LGNDLigand Pharmaceuticals Incorporated | 157,865 | $31.5M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 8,490,119 | $29.8M |
| ANABANAPTYSBIO, INC | 501,086 | $27.8M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 847,089 | $27.1M |
| ANNXAnnexon, Inc. | 4,259,995 | $23.6M |
| VRDNViridian Therapeutics, Inc.\DE | 1,163,615 | $22.8M |
| CLDXCelldex Therapeutics, Inc. | 708,647 | $22.5M |
| IMVTImmunovant, Inc. | 893,678 | $22.2M |
| NUVLNuvalent, Inc. | 216,516 | $22.2M |
| DNLIDenali Therapeutics Inc. | 1,134,183 | $21.8M |
| IBRXImmunityBio, Inc. | 2,447,843 | $18.8M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 866,061 | $18.7M |
| NTLAIntellia Therapeutics, Inc. | 1,381,703 | $17.7M |
| STOKStoke Therapeutics, Inc. | 543,095 | $17.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 507,900 | $17.2M |
| ADPTAdaptive Biotechnologies Corp | 1,227,917 | $17.0M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 188,779 | $15.8M |
| SLNOSOLENO THERAPEUTICS INC | 439,902 | $14.7M |
| ARDXARDELYX, INC. | 2,336,994 | $14.0M |
| RCUSArcus Biosciences, Inc. | 646,068 | $14.0M |
| NUVBNuvation Bio Inc. | 3,219,826 | $13.8M |
| MLTXMoonLake Immunotherapeutics | 724,794 | $13.5M |
| ORICOric Pharmaceuticals, Inc. | 1,043,159 | $13.2M |
| BEAMBeam Therapeutics Inc. | 538,290 | $12.8M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 415,483 | $12.6M |
| NRIXNurix Therapeutics, Inc. | 802,153 | $12.4M |
| ANIPANI PHARMACEUTICALS INC | 150,532 | $11.6M |
| KODKodiak Sciences Inc. | 300,356 | $11.4M |
| SMMTSummit Therapeutics Inc. | 598,692 | $11.4M |
| KALVKalVista Pharmaceuticals, Inc. | 555,628 | $11.2M |
| GPCRStructure Therapeutics Inc. | 227,132 | $10.9M |
| VKTXViking Therapeutics, Inc. | 330,720 | $10.8M |
| IRONDisc Medicine, Inc. | 166,775 | $10.7M |
| ABCLAbCellera Biologics Inc. | 2,999,936 | $10.5M |
| KURAKura Oncology, Inc. | 1,230,131 | $10.0M |
| AQSTAquestive Therapeutics, Inc. | 2,405,050 | $10.0M |
| AVTXAvalo Therapeutics, Inc. | 643,000 | $9.6M |
| FDMT4D Molecular Therapeutics, Inc. | 974,173 | $9.1M |
| RZLTRezolute, Inc. | 2,970,549 | $9.1M |
| SANASana Biotechnology, Inc. | 2,946,861 | $8.5M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 2,496,831 | $7.7M |
| ZBIOZenas BioPharma, Inc. | 388,347 | $7.6M |
| OLMAOlema Pharmaceuticals, Inc. | 508,706 | $7.6M |
| ABUSArbutus Biopharma Corp | 1,683,628 | $7.6M |
| CGEMCullinan Therapeutics, Inc. | 516,724 | $7.3M |
| TNGXTango Therapeutics, Inc. | 327,144 | $6.8M |
| GERNGERON CORP | 4,556,278 | $6.8M |
| BCAXBicara Therapeutics Inc. | 327,989 | $6.5M |
| GMABGenmab A/S | 241,520 | $6.5M |
| BHVNBiohaven Ltd. | 759,425 | $6.4M |
| IMCRImmunocore Holdings plc | 206,866 | $6.2M |
| CCCCC4 Therapeutics, Inc. | 2,359,241 | $6.2M |
| ZYMEZymeworks Inc. | 236,754 | $5.9M |
| MAZEMaze Therapeutics, Inc. | 195,084 | $5.8M |
| PGENPRECIGEN, INC. | 1,471,279 | $5.7M |
| RDYDR REDDYS LABORATORIES LTD | 375,232 | $5.2M |
| XERSXeris Biopharma Holdings, Inc. | 874,397 | $5.1M |
| LENZLENZ Therapeutics, Inc. | 547,534 | $5.0M |
| ORKAOruka Therapeutics, Inc. | 100,091 | $4.9M |
| PVLAPALVELLA THERAPEUTICS, INC. | 37,972 | $4.7M |
| CMPXCompass Therapeutics, Inc. | 865,613 | $4.6M |
| OGNOrganon & Co. | 738,502 | $4.4M |
| NKTRNEKTAR THERAPEUTICS | 58,958 | $4.2M |
| MANEVeradermics Incorporated | 65,675 | $4.1M |
| QUREuniQure N.V. | 246,851 | $4.0M |
| HRMYHarmony Biosciences Holdings, Inc. | 140,717 | $3.9M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 393,632 | $3.8M |
| OCULOCULAR THERAPEUTIX, INC | 397,092 | $3.4M |
| HROWHARROW, INC. | 94,578 | $3.3M |
| SVRASavara Inc | 588,199 | $3.2M |
| DFTXDefinium Therapeutics Inc. | 158,345 | $3.0M |
| DNAGinkgo Bioworks Holdings Inc. | 476,913 | $2.9M |
| ATAIAtai Beckley N.V. | 819,664 | $2.9M |
| ALMSALUMIS INC. | 127,812 | $2.8M |
| SLDBSolid Biosciences Inc. | 386,793 | $2.8M |
| RGNXREGENXBIO Inc. | 324,860 | $2.7M |
| SLSSELLAS Life Sciences Group, Inc. | 641,683 | $2.7M |
| AVXLANAVEX LIFE SCIENCES CORP. | 863,150 | $2.6M |
| ZNTLZentalis Pharmaceuticals, Inc. | 1,132,294 | $2.6M |
| SIGASIGA TECHNOLOGIES INC | 484,672 | $2.6M |
| AUTLAutolus Therapeutics plc | 1,844,671 | $2.5M |
| CTORCITIUS ONCOLOGY, INC. | 3,835,160 | $2.4M |
| SPRYARS Pharmaceuticals, Inc. | 285,728 | $2.3M |
| GRCEGrace Therapeutics, Inc. | 494,723 | $2.3M |
| RCKTRocket Pharmaceuticals Inc. | 630,125 | $2.3M |
| OCGNOcugen, Inc. | 1,174,180 | $2.1M |
| SIONSionna Therapeutics, Inc. | 50,870 | $2.0M |
| FLGTFulgent Genetics Inc. | 120,583 | $1.9M |
| RNAAtrium Therapeutics Inc. | 136,248 | $1.8M |
| ELVNEnliven Therapeutics, Inc. | 45,162 | $1.8M |
| ABEOABEONA THERAPEUTICS INC. | 394,274 | $1.8M |
| IFRXInflaRx N.V. | 1,975,000 | $1.8M |
| ALTAltimmune, Inc. | 570,203 | $1.8M |
| ALGSAligos Therapeutics, Inc. | 229,754 | $1.7M |
| MESOMesoblast Limited | 100,004 | $1.5M |
| ABSIAbsci Corporation | 487,193 | $1.5M |
| PROKPROKIDNEY CORP. | 753,412 | $1.3M |
| ANTXAN2 Therapeutics, Inc. | 393,702 | $1.3M |
| OPKOPKO HEALTH, INC. | 1,141,849 | $1.3M |
| ORGOOrganogenesis Holdings Inc. | 548,262 | $1.3M |
| IVVDInvivyd, Inc. | 962,386 | $1.3M |
| ARVNARVINAS, INC. | 116,800 | $1.2M |
| ALXOALX ONCOLOGY HOLDINGS INC | 577,783 | $1.2M |
| BIOABioAge Labs, Inc. | 61,508 | $1.1M |
| CATXPerspective Therapeutics, Inc. | 241,924 | $1.0M |
| RLMDRELMADA THERAPEUTICS, INC. | 125,941 | $877K |
| TNXPTonix Pharmaceuticals Holding Corp. | 60,958 | $838K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 526,103 | $821K |
| ALECAlector, Inc. | 380,908 | $819K |
| ZURAZura Bio Ltd | 136,523 | $812K |
| ESPREsperion Therapeutics, Inc. | 249,395 | $683K |
| LYELLyell Immunopharma, Inc. | 33,321 | $668K |
| LCTXLineage Cell Therapeutics, Inc. | 419,355 | $663K |
| OVIDOvid Therapeutics Inc. | 290,432 | $645K |
| XFORX4 Pharmaceuticals, Inc | 150,676 | $622K |
| ZVRAZEVRA THERAPEUTICS, INC. | 64,837 | $604K |
| KROSKeros Therapeutics, Inc. | 53,654 | $592K |
| FBRXForte Biosciences, Inc. | 21,606 | $560K |
| CHRSCoherus Oncology, Inc. | 324,133 | $548K |
| JBIOJade Biosciences, Inc. | 38,598 | $542K |
| CBIOCRESCENT BIOPHARMA, INC. | 29,277 | $538K |
| ORMPORAMED PHARMACEUTICALS INC. | 146,152 | $497K |
| TRDAEntrada Therapeutics, Inc. | 39,212 | $495K |
| ASRTAssertio Holdings, Inc. | 25,033 | $477K |
| STROSUTRO BIOPHARMA, INC. | 18,873 | $470K |
| SGMOQSANGAMO THERAPEUTICS, INC | 1,838,390 | $452K |
| PLRXPLIANT THERAPEUTICS, INC. | 352,708 | $444K |
| PHVSPharvaris N.V. | 15,645 | $442K |
| RGCRegencell Bioscience Holdings Ltd | 17,172 | $437K |
| UPBUpstream Bio, Inc. | 48,460 | $436K |
| VYGRVoyager Therapeutics, Inc. | 107,431 | $415K |
| LBRXLB PHARMACEUTICALS INC | 16,618 | $410K |
| DMRADamora Therapeutics, Inc. | 15,647 | $405K |
| AGENAGENUS INC | 118,782 | $397K |
| MPLTMapLight Therapeutics, Inc. | 18,869 | $384K |
| IMMXImmix Biopharma, Inc. | 41,131 | $375K |
| ALDXAldeyra Therapeutics, Inc. | 215,332 | $364K |
| CLYMClimb Bio, Inc. | 52,921 | $363K |
| TECXTectonic Therapeutic, Inc. | 11,466 | $354K |
| XOMAXOMA Royalty Corporation | 11,018 | $346K |
| LONALeonaBio, Inc. | 32,566 | $335K |
| IRDOpus Genetics, Inc. | 67,015 | $305K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 10,902 | $303K |
| CNTXContext Therapeutics Inc. | 114,888 | $301K |
| PRQRProQR Therapeutics N.V. | 185,110 | $300K |
| TENXTENAX THERAPEUTICS, INC. | 18,569 | $297K |
| DRTSAlpha Tau Medical Ltd. | 41,392 | $293K |
| DMACDiaMedica Therapeutics Inc. | 42,768 | $290K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 40,364 | $258K |
| JSPRJasper Therapeutics Inc. | 293,259 | $257K |
| IMTXImmatics N.V. | 25,394 | $250K |
| DSGNDesign Therapeutics, Inc. | 23,264 | $248K |
| BDTXBlack Diamond Therapeutics, Inc. | 114,143 | $243K |
| HUMAHumacyte Inc. | 396,113 | $240K |
| CADLCandel Therapeutics, Inc. | 47,402 | $232K |
| SGMTSagimet Biosciences Inc. | 43,858 | $229K |
| FATEFATE THERAPEUTICS INC | 188,564 | $226K |
| HOWLWerewolf Therapeutics, Inc. | 264,583 | $220K |
| NGNENeurogene Inc. | 10,864 | $219K |
| SABSSAB BIOTHERAPEUTICS, INC. | 55,697 | $213K |
| LRMRLarimar Therapeutics, Inc. | 47,359 | $213K |
| PLYXPolaryx Therapeutics Inc. | 25,881 | $196K |
| PRLDPrelude Therapeutics Inc | 56,525 | $193K |
| HCMHUTCHMED (China) Limited | 12,489 | $187K |
| WHWKWhitehawk Therapeutics, Inc. | 52,861 | $182K |
| CMPSCOMPASS Pathways plc | 32,332 | $179K |
| PLXProtalix BioTherapeutics, Inc. | 79,079 | $172K |
| ELTXElicio Therapeutics, Inc. | 15,333 | $164K |
| FENCFENNEC PHARMACEUTICALS INC. | 26,405 | $162K |
| IMUXIMMUNIC, INC. | 143,867 | $160K |
| SLNSilence Therapeutics Plc | 29,773 | $157K |
| GALTGALECTIN THERAPEUTICS INC | 53,862 | $150K |
| HURATuHURA Biosciences, Inc./NV | 78,142 | $140K |
| CAMPCamp4 Therapeutics Corp | 31,196 | $138K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 13,960 | $131K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 160,979 | $129K |
| CSBRCHAMPIONS ONCOLOGY, INC. | 21,833 | $126K |
| ARMPArmata Pharmaceuticals, Inc. | 11,714 | $120K |
| NVCTNuvectis Pharma, Inc. | 14,847 | $115K |
| TLXTelix Pharmaceuticals Limited | 10,031 | $96K |
| CRDFCardiff Oncology, Inc. | 51,119 | $83K |
| GYREGYRE THERAPEUTICS, INC. | 10,538 | $73K |
| INOINOVIO PHARMACEUTICALS, INC. | 32,677 | $57K |
| LSTALISATA THERAPEUTICS, INC. | 10,353 | $52K |
| ACIUAC Immune SA | 17,437 | $48K |
| CUECue Biopharma, Inc. | 207,708 | $48K |
| MNOVMEDICINOVA INC | 34,359 | $47K |
| TTRXTurn Therapeutics Inc. | 14,124 | $45K |
| AARDAardvark Therapeutics, Inc. | 11,486 | $43K |
| IMMPImmutep Limited | 10,000 | $4K |