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| LLYELI LILLY & Co | 2,984,392 | $2.74B |
| ABBVAbbVie Inc. | 11,068,310 | $2.41B |
| MRKMerck & Co., Inc. | 16,262,708 | $1.96B |
| BMYBRISTOL MYERS SQUIBB CO | 26,470,718 | $1.61B |
| ABTABBOTT LABORATORIES | 14,119,549 | $1.45B |
| PMPhilip Morris International Inc | 7,973,116 | $1.32B |
| VRTXVERTEX PHARMACEUTICALS INC / MA | 2,633,481 | $1.18B |
| AZNASTRAZENECA PLC | 5,747,087 | $1.13B |
| GILDGILEAD SCIENCES, INC. | 7,287,230 | $1.02B |
| UNHUnitedHealth Group Incorporated Common Stock (DE) | 3,499,098 | $946.9M |
| AMGNAMGEN INC | 2,023,367 | $713.7M |
| PFEPFIZER INC | 19,519,056 | $548.1M |
| INSMINSMED Inc | 3,057,718 | $500.0M |
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| IQVIQVIA Holdings Inc. | 1,624,321 | $277.0M |
| VTRSViatris Inc | 20,014,966 | $270.4M |
| REGNREGENERON PHARMACEUTICALS, INC. | 319,677 | $247.1M |
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| ZTSZoetis Inc. | 1,610,634 | $190.5M |
| CORCencora Inc. | 560,410 | $176.1M |
| DGXQuest Diagnostics Incorporated | 807,477 | $158.3M |
| ARGXARGENX SE | 215,910 | $157.7M |
| RVMDREVOLUTION MEDICINES, INC. | 1,579,793 | $153.6M |
| GHGuardant Health Inc. | 1,461,386 | $135.0M |
| RGENREPLIGEN CORP | 925,214 | $109.0M |
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| TECHBIO-TECHNE Corp | 1,711,179 | $89.4M |
| ZBHZimmer Biomet Holdings Inc. | 927,085 | $83.8M |
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| NVSNovartis AG | 532,554 | $81.4M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 239,941 | $79.4M |
| ICUIICU Medical Inc. | 605,728 | $78.2M |
| IDXXIDEXX LABORATORIES INC /DE | 134,296 | $75.4M |
| NBIXNEUROCRINE BIOSCIENCES INC | 512,033 | $67.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 1,173,516 | $66.3M |
| NVONovo Nordisk A/S | 1,747,225 | $63.9M |
| NUVLNuvalent, Inc. | 563,768 | $57.8M |
| INCYIncyte Corp. | 605,474 | $57.0M |
| VKTXViking Therapeutics, Inc. | 1,678,745 | $54.6M |
| UTHRUNITED THERAPEUTICS Corp | 91,225 | $54.1M |
| MDGLMADRIGAL PHARMACEUTICALS, INC. | 98,181 | $51.4M |
| IONSIONIS PHARMACEUTICALS INC | 660,144 | $49.6M |
| SNYSanofi | 1,028,639 | $49.6M |
| MEDPMedpace Holdings Inc. | 102,418 | $49.2M |
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| GEHCGE HealthCare Technologies Inc. | 638,356 | $45.4M |
| GLPGGalapagos NV | 1,424,674 | $42.7M |
| ADPTAdaptive Biotechnologies Corp | 3,017,341 | $41.9M |
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| RYTMRHYTHM PHARMACEUTICALS, INC. | 383,957 | $33.4M |
| MANEVeradermics Incorporated | 514,035 | $32.5M |
| CYTKCYTOKINETICS INC | 484,502 | $31.9M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 358,470 | $30.1M |
| AXSMAxsome Therapeutics, Inc. | 176,314 | $29.8M |
| CRNXCrinetics Pharmaceuticals, Inc. | 798,334 | $29.0M |
| RPRXRoyalty Pharma plc | 577,125 | $27.7M |
| ALKSAlkermes plc. | 741,141 | $26.2M |
| BIIBBIOGEN INC. | 132,603 | $24.3M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 753,054 | $24.1M |
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| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 381,099 | $21.1M |
| ANIPANI PHARMACEUTICALS INC | 270,262 | $20.8M |
| NEOGNEOGEN CORP | 2,222,776 | $20.6M |
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| MOHMolina Healthcare Inc | 152,462 | $20.3M |
| MIRMMirum Pharmaceuticals, Inc. | 219,255 | $20.3M |
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| DFTXDefinium Therapeutics Inc. | 966,608 | $18.3M |
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| ACHCAcadia Healthcare Company Inc. | 746,439 | $17.5M |
| MMSIMerit Medical Systems Inc. | 250,938 | $17.3M |
| GMEDGlobus Medical Inc. | 193,429 | $16.7M |
| ELANElanco Animal Health Inc | 663,096 | $15.9M |
| LGNDLigand Pharmaceuticals Incorporated | 77,273 | $15.4M |
| PTGXProtagonist Therapeutics, Inc | 145,690 | $15.4M |
| PALIPALISADE BIO, INC. | 8,711,385 | $15.2M |
| ACADACADIA PHARMACEUTICALS INC | 624,260 | $13.9M |
| CRSPCRISPR Therapeutics AG | 286,839 | $13.6M |
| KRYSKrystal Biotech, Inc. | 49,837 | $12.9M |
| HALOHALOZYME THERAPEUTICS, INC. | 191,279 | $12.4M |
| ROIVRoivant Sciences Ltd. | 438,565 | $12.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 191,054 | $12.0M |
| TGTXTG THERAPEUTICS, INC. | 355,588 | $11.8M |
| PTCTPTC THERAPEUTICS, INC. | 166,659 | $11.4M |
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| GPCRStructure Therapeutics Inc. | 219,516 | $10.6M |
| PRAXPraxis Precision Medicines, Inc. | 31,220 | $10.1M |
| NKTRNEKTAR THERAPEUTICS | 136,730 | $9.8M |
| WSTWest Pharmaceutical Services Inc. | 39,255 | $9.8M |
| COGTCogent Biosciences, Inc. | 252,114 | $9.7M |
| ABSIAbsci Corporation | 3,180,141 | $9.5M |
| ABVXAbivax SA | 83,031 | $9.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 173,905 | $9.0M |
| FLGTFulgent Genetics Inc. | 563,375 | $9.0M |
| CORTCORCEPT THERAPEUTICS INC | 212,074 | $8.5M |
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| VMDViemed Healthcare Inc. | 898,319 | $8.3M |
| AVNSAvanos Medical Inc. | 584,277 | $8.2M |
| SYRESpyre Therapeutics, Inc. | 159,217 | $8.0M |
| INSPInspire Medical Systems Inc. | 143,451 | $7.4M |
| APLSApellis Pharmaceuticals, Inc. | 183,578 | $7.4M |
| CAICaris Life Sciences Inc. | 408,079 | $7.3M |
| MRNAModerna, Inc. | 143,449 | $7.3M |
| VCELVericel Corp | 207,335 | $6.7M |
| SNDXSyndax Pharmaceuticals Inc | 284,245 | $6.6M |
| PCVXVaxcyte, Inc. | 110,986 | $6.4M |
| PBHPrestige Consumer Healthcare Inc. | 107,505 | $6.4M |
| EWTXEdgewise Therapeutics, Inc. | 200,661 | $6.3M |
| INDVIndivior Pharmaceuticals, Inc. | 206,879 | $6.3M |
| ELVNEnliven Therapeutics, Inc. | 160,577 | $6.3M |
| TERNTerns Pharmaceuticals, Inc. | 118,246 | $6.2M |
| CPRXCATALYST PHARMACEUTICALS, INC. | 249,305 | $6.2M |
| TRVITrevi Therapeutics, Inc. | 504,836 | $6.0M |
| MLYSMineralys Therapeutics, Inc. | 221,305 | $6.0M |
| APGEApogee Therapeutics, Inc. | 69,888 | $5.9M |
| SRPTSarepta Therapeutics, Inc. | 261,310 | $5.7M |
| SABSSAB BIOTHERAPEUTICS, INC. | 1,476,106 | $5.7M |
| TYRATyra Biosciences, Inc. | 144,900 | $5.5M |
| DBVTDBV Technologies S.A. | 231,417 | $4.8M |
| IVAInventiva S.A. | 844,215 | $4.7M |
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| KALVKalVista Pharmaceuticals, Inc. | 229,984 | $4.6M |
| XENEXenon Pharmaceuticals Inc. | 78,905 | $4.6M |
| ZLABZai Lab Ltd | 243,557 | $4.6M |
| OGNOrganon & Co. | 754,240 | $4.5M |
| INVAInnoviva, Inc. | 192,799 | $4.5M |
| TECXTectonic Therapeutic, Inc. | 143,432 | $4.4M |
| ADMAADMA BIOLOGICS, INC. | 465,602 | $4.2M |
| QDELQuidelOrtho Corp | 254,497 | $4.2M |
| AVBPArriVent BioPharma, Inc. | 180,028 | $4.2M |
| EPRXEUPRAXIA PHARMACEUTICALS INC. | 524,257 | $3.8M |
| PCRXPacira BioSciences, Inc. | 167,006 | $3.8M |
| RLMDRELMADA THERAPEUTICS, INC. | 533,258 | $3.7M |
| DRUGBRIGHT MINDS BIOSCIENCES INC. | 50,027 | $3.7M |
| TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) | 194,037 | $3.6M |
| PBIPROVENTION BIO, INC. | 323,302 | $3.6M |
| RLAYRelay Therapeutics, Inc. | 356,924 | $3.6M |
| VIRVir Biotechnology, Inc. | 395,038 | $3.5M |
| PRGOPERRIGO Co plc | 326,398 | $3.5M |
| RCUSArcus Biosciences, Inc. | 160,082 | $3.5M |
| BNTCBenitec Biopharma Inc. | 318,346 | $3.4M |
| TEVATeva Pharmaceutical Industries Limited | 111,491 | $3.4M |
| SIONSionna Therapeutics, Inc. | 81,974 | $3.3M |
| PAHCPHIBRO ANIMAL HEALTH CORP | 58,155 | $3.2M |
| MAZEMaze Therapeutics, Inc. | 107,486 | $3.2M |
| CMPSCOMPASS Pathways plc | 570,496 | $3.2M |
| DMRADamora Therapeutics, Inc. | 117,675 | $3.0M |
| DYNDyne Therapeutics, Inc. | 162,972 | $3.0M |
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| FBRXForte Biosciences, Inc. | 111,788 | $2.9M |
| IMNMImmunome Inc. | 129,515 | $2.8M |
| PHATPhathom Pharmaceuticals, Inc. | 254,219 | $2.8M |
| HRMYHarmony Biosciences Holdings, Inc. | 98,676 | $2.8M |
| SHCSotera Health Company | 192,107 | $2.8M |
| NATRNATURES SUNSHINE PRODUCTS INC | 112,956 | $2.7M |
| LBRXLB PHARMACEUTICALS INC | 108,307 | $2.7M |
| AVTXAvalo Therapeutics, Inc. | 172,149 | $2.6M |
| DVADaVita Inc. | 16,292 | $2.5M |
| NEONeoGenomics Inc. | 337,378 | $2.5M |
| KODKodiak Sciences Inc. | 65,492 | $2.5M |
| ARQTArcutis Biotherapeutics, Inc. | 101,674 | $2.4M |
| ADAGAdagene Inc. | 607,903 | $2.4M |
| ANTXAN2 Therapeutics, Inc. | 696,181 | $2.4M |
| COLLCOLLEGIUM PHARMACEUTICAL, INC | 69,763 | $2.3M |
| BAXBaxter International Inc. | 135,963 | $2.3M |
| SUNSUNSET ISLAND GROUP | 34,610 | $2.2M |
| BNTXBioNTech SE | 24,531 | $2.2M |
| FHTXFoghorn Therapeutics Inc. | 448,976 | $2.1M |
| EVMNEvommune, Inc. | 91,429 | $2.1M |
| ARVNARVINAS, INC. | 185,495 | $2.0M |
| CRMDCorMedix Inc. | 277,784 | $1.9M |
| SRRKScholar Rock Holding Corp | 37,887 | $1.9M |
| ZYMEZymeworks Inc. | 74,222 | $1.9M |
| AKTSAktis Oncology Inc. | 102,925 | $1.8M |
| KURAKura Oncology, Inc. | 226,160 | $1.8M |
| IRDOpus Genetics, Inc. | 388,491 | $1.8M |
| DNLIDenali Therapeutics Inc. | 89,534 | $1.7M |
| RGNXREGENXBIO Inc. | 200,352 | $1.7M |
| GMABGenmab A/S | 61,924 | $1.7M |
| NTLAIntellia Therapeutics, Inc. | 128,209 | $1.6M |
| IVVDInvivyd, Inc. | 1,218,214 | $1.6M |
| TWSTTwist Bioscience Corp | 33,300 | $1.6M |
| HLFHerbalife Ltd. | 106,797 | $1.6M |
| XNCRXencor Inc | 128,558 | $1.6M |
| AMPHAmphastar Pharmaceuticals, Inc. | 78,775 | $1.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 31,755 | $1.5M |
| IDYAIDEAYA Biosciences, Inc. | 45,263 | $1.5M |
| SDGRSchrodinger, Inc. | 120,853 | $1.4M |
| LEGNLegend Biotech Corp | 75,439 | $1.4M |
| ATOSATOSSA THERAPEUTICS, INC. | 255,134 | $1.3M |
| USNAUSANA HEALTH SCIENCES INC | 73,380 | $1.3M |
| OMEROMEROS CORP | 117,948 | $1.2M |
| MYGNMYRIAD GENETICS INC | 267,328 | $1.2M |
| SGPSpyGlass Pharma Inc. | 44,477 | $1.2M |
| KROSKeros Therapeutics, Inc. | 102,479 | $1.1M |
| GENBGenerate Biomedicines Inc. | 87,335 | $1.1M |
| BIOABioAge Labs, Inc. | 59,133 | $1.0M |
| KTTAPasithea Therapeutics Corp. | 1,350,896 | $1.0M |
| SIGASIGA TECHNOLOGIES INC | 183,537 | $982K |
| GERNGERON CORP | 651,185 | $970K |
| NRIXNurix Therapeutics, Inc. | 61,825 | $958K |
| QUREuniQure N.V. | 57,133 | $934K |
| SMMTSummit Therapeutics Inc. | 47,667 | $904K |
| PRCTPROCEPT BioRobotics Corporation | 35,599 | $890K |
| TRDAEntrada Therapeutics, Inc. | 70,280 | $887K |
| RAREUltragenyx Pharmaceutical Inc. | 42,295 | $886K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 89,212 | $867K |
| OLMAOlema Pharmaceuticals, Inc. | 57,362 | $855K |
| OFIXOrthofix Medical Inc. Common Stock (DE) | 73,213 | $840K |
| ANLAdlai Nortye Ltd. | 120,156 | $831K |
| XERSXeris Biopharma Holdings, Inc. | 142,148 | $824K |
| ANIKAnika Therapeutics Inc. | 52,237 | $757K |
| ONCBeOne Medicines Ltd. | 2,395 | $711K |
| NRCNational Research Corporation Common Stock (Delaware) | 41,856 | $711K |
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| CNTACentessa Pharmaceuticals plc | 16,893 | $671K |
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| ALLOAllogene Therapeutics, Inc. | 244,592 | $597K |
| GLUEMonte Rosa Therapeutics, Inc. | 35,997 | $592K |
| STOKStoke Therapeutics, Inc. | 18,113 | $590K |
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| URGNUroGen Pharma Ltd. | 30,166 | $542K |
| FMSFresenius Medical Care AG American Depositary Shares (Each representing 1/2 of an Ordinary Share) | 22,729 | $513K |
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| RDYDR REDDYS LABORATORIES LTD | 34,692 | $480K |
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| INNVINNOVUS PHARMACEUTICALS, INC. | 50,608 | $406K |
| EDITEditas Medicine, Inc. | 155,792 | $385K |
| MNPRMonopar Therapeutics | 6,819 | $374K |
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| OCULOCULAR THERAPEUTIX, INC | 42,533 | $360K |
| IRWDIRONWOOD PHARMACEUTICALS INC | 99,341 | $349K |
| QGENQIAGEN N.V. | 8,517 | $341K |
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| SLNOSOLENO THERAPEUTICS INC | 8,471 | $284K |
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| KYMRKymera Therapeutics, Inc. | 3,358 | $280K |
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| MRVIMARAVAI LIFESCIENCES HOLDINGS, INC. | 85,541 | $242K |
| AVXLANAVEX LIFE SCIENCES CORP. | 74,373 | $228K |
| HCMHUTCHMED (China) Limited | 14,962 | $224K |
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| OPKOPKO HEALTH, INC. | 96,722 | $110K |
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| ORGOOrganogenesis Holdings Inc. | 35,911 | $85K |
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