| GILDGILEAD SCIENCES, INC. | 7,287,230 | $1.02B |
| INSMINSMED Inc | 3,057,718 | $500.0M |
| JAZZJazz Pharmaceuticals plc | 1,608,476 | $304.1M |
| REGNREGENERON PHARMACEUTICALS, INC. | 319,677 | $247.1M |
| ARGXARGENX SE | 215,910 | $157.7M |
| RVMDREVOLUTION MEDICINES, INC. | 1,579,793 | $153.6M |
| BBIOBridgeBio Pharma, Inc. | 1,248,521 | $92.7M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 239,941 | $79.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 1,173,516 | $66.3M |
| NUVLNuvalent, Inc. | 563,768 | $57.8M |
| INCYIncyte Corp. | 605,474 | $57.0M |
| VKTXViking Therapeutics, Inc. | 1,678,745 | $54.6M |
| IONSIONIS PHARMACEUTICALS INC | 660,144 | $49.6M |
| SNYSanofi | 1,028,639 | $49.6M |
| EXELEXELIXIS, INC. | 999,132 | $42.9M |
| ADPTAdaptive Biotechnologies Corp | 3,017,341 | $41.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 383,957 | $33.4M |
| MANEVeradermics Incorporated | 514,035 | $32.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 358,470 | $30.1M |
| AXSMAxsome Therapeutics, Inc. | 176,314 | $29.8M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 753,054 | $24.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 381,099 | $21.1M |
| ANIPANI PHARMACEUTICALS INC | 270,262 | $20.8M |
| CYTKCYTOKINETICS INC | 302,802 | $20.0M |
| ANNXAnnexon, Inc. | 3,449,121 | $19.1M |
| DFTXDefinium Therapeutics Inc. | 966,608 | $18.3M |
| SLDBSolid Biosciences Inc. | 2,438,849 | $17.6M |
| LGNDLigand Pharmaceuticals Incorporated | 77,273 | $15.4M |
| PTGXProtagonist Therapeutics, Inc | 145,690 | $15.4M |
| ACADACADIA PHARMACEUTICALS INC | 624,260 | $13.9M |
| ROIVRoivant Sciences Ltd. | 438,565 | $12.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 191,054 | $12.0M |
| TGTXTG THERAPEUTICS, INC. | 355,588 | $11.8M |
| PTCTPTC THERAPEUTICS, INC. | 166,659 | $11.4M |
| TNGXTango Therapeutics, Inc. | 506,158 | $10.6M |
| GPCRStructure Therapeutics Inc. | 219,516 | $10.6M |
| NKTRNEKTAR THERAPEUTICS | 136,730 | $9.8M |
| COGTCogent Biosciences, Inc. | 252,114 | $9.7M |
| ABSIAbsci Corporation | 3,180,141 | $9.5M |
| ABVXAbivax SA | 83,031 | $9.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 173,905 | $9.0M |
| FLGTFulgent Genetics Inc. | 563,375 | $9.0M |
| CMPXCompass Therapeutics, Inc. | 1,596,815 | $8.4M |
| SYRESpyre Therapeutics, Inc. | 159,217 | $8.0M |
| APLSApellis Pharmaceuticals, Inc. | 183,578 | $7.4M |
| MRNAModerna, Inc. | 143,449 | $7.3M |
| VCELVericel Corp | 207,335 | $6.7M |
| PCVXVaxcyte, Inc. | 110,986 | $6.4M |
| ELVNEnliven Therapeutics, Inc. | 160,577 | $6.3M |
| TERNTerns Pharmaceuticals, Inc. | 118,246 | $6.2M |
| APGEApogee Therapeutics, Inc. | 69,888 | $5.9M |
| SABSSAB BIOTHERAPEUTICS, INC. | 1,476,106 | $5.7M |
| IVAInventiva S.A. | 844,215 | $4.7M |
| SRZNSurrozen Inc. | 159,711 | $4.7M |
| KALVKalVista Pharmaceuticals, Inc. | 229,984 | $4.6M |
| OGNOrganon & Co. | 754,240 | $4.5M |
| INVAInnoviva, Inc. | 192,799 | $4.5M |
| TENXTENAX THERAPEUTICS, INC. | 279,537 | $4.5M |
| TECXTectonic Therapeutic, Inc. | 143,432 | $4.4M |
| ADMAADMA BIOLOGICS, INC. | 465,602 | $4.2M |
| RLMDRELMADA THERAPEUTICS, INC. | 533,258 | $3.7M |
| RLAYRelay Therapeutics, Inc. | 356,924 | $3.6M |
| RCUSArcus Biosciences, Inc. | 160,082 | $3.5M |
| TEVATeva Pharmaceutical Industries Limited | 111,491 | $3.4M |
| SIONSionna Therapeutics, Inc. | 81,974 | $3.3M |
| MAZEMaze Therapeutics, Inc. | 107,486 | $3.2M |
| CMPSCOMPASS Pathways plc | 570,496 | $3.2M |
| DMRADamora Therapeutics, Inc. | 117,675 | $3.0M |
| IRONDisc Medicine, Inc. | 45,837 | $2.9M |
| FBRXForte Biosciences, Inc. | 111,788 | $2.9M |
| LBRXLB PHARMACEUTICALS INC | 108,307 | $2.7M |
| AVTXAvalo Therapeutics, Inc. | 172,149 | $2.6M |
| KODKodiak Sciences Inc. | 65,492 | $2.5M |
| ARQTArcutis Biotherapeutics, Inc. | 101,674 | $2.4M |
| ADAGAdagene Inc. | 607,903 | $2.4M |
| ANTXAN2 Therapeutics, Inc. | 696,181 | $2.4M |
| ARVNARVINAS, INC. | 185,495 | $2.0M |
| SRRKScholar Rock Holding Corp | 37,887 | $1.9M |
| ZYMEZymeworks Inc. | 74,222 | $1.9M |
| KURAKura Oncology, Inc. | 226,160 | $1.8M |
| IRDOpus Genetics, Inc. | 388,491 | $1.8M |
| DNLIDenali Therapeutics Inc. | 89,534 | $1.7M |
| RGNXREGENXBIO Inc. | 200,352 | $1.7M |
| GMABGenmab A/S | 61,924 | $1.7M |
| NTLAIntellia Therapeutics, Inc. | 128,209 | $1.6M |
| IVVDInvivyd, Inc. | 1,218,214 | $1.6M |
| KNSAKiniksa Pharmaceuticals International, plc | 31,755 | $1.5M |
| ATOSATOSSA THERAPEUTICS, INC. | 255,134 | $1.3M |
| KROSKeros Therapeutics, Inc. | 102,479 | $1.1M |
| BIOABioAge Labs, Inc. | 59,133 | $1.0M |
| KTTAPasithea Therapeutics Corp. | 1,350,896 | $1.0M |
| SIGASIGA TECHNOLOGIES INC | 183,537 | $982K |
| GERNGERON CORP | 651,185 | $970K |
| NRIXNurix Therapeutics, Inc. | 61,825 | $958K |
| QUREuniQure N.V. | 57,133 | $934K |
| SMMTSummit Therapeutics Inc. | 47,667 | $904K |
| TRDAEntrada Therapeutics, Inc. | 70,280 | $887K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 89,212 | $867K |
| OLMAOlema Pharmaceuticals, Inc. | 57,362 | $855K |
| XERSXeris Biopharma Holdings, Inc. | 142,148 | $824K |
| ONCBeOne Medicines Ltd. | 2,395 | $711K |
| CNTACentessa Pharmaceuticals plc | 16,893 | $671K |
| STOKStoke Therapeutics, Inc. | 18,113 | $590K |
| ALECAlector, Inc. | 271,272 | $583K |
| IBRXImmunityBio, Inc. | 64,523 | $495K |
| RDYDR REDDYS LABORATORIES LTD | 34,692 | $480K |
| BHVNBiohaven Ltd. | 55,340 | $468K |
| VRDNViridian Therapeutics, Inc.\DE | 22,781 | $446K |
| HROWHARROW, INC. | 11,450 | $404K |
| DSGNDesign Therapeutics, Inc. | 34,990 | $372K |
| OCULOCULAR THERAPEUTIX, INC | 42,533 | $360K |
| BCAXBicara Therapeutics Inc. | 15,818 | $315K |
| CTMXCytomX Therapeutics, Inc. | 65,015 | $306K |
| SLNOSOLENO THERAPEUTICS INC | 8,471 | $284K |
| DNAGinkgo Bioworks Holdings Inc. | 41,199 | $253K |
| AVXLANAVEX LIFE SCIENCES CORP. | 74,373 | $228K |
| HCMHUTCHMED (China) Limited | 14,962 | $224K |
| ALTAltimmune, Inc. | 71,968 | $222K |
| ATAIAtai Beckley N.V. | 45,307 | $160K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 37,139 | $114K |
| OPKOPKO HEALTH, INC. | 96,722 | $110K |
| LPCNLipocine Inc. | 11,448 | $91K |
| ORGOOrganogenesis Holdings Inc. | 35,911 | $85K |
| RNACCartesian Therapeutics, Inc. | 13,416 | $83K |
| PLRXPLIANT THERAPEUTICS, INC. | 55,129 | $69K |
| ARDXARDELYX, INC. | 11,080 | $66K |
| RCKTRocket Pharmaceuticals Inc. | 12,998 | $47K |
| OCGNOcugen, Inc. | 15,850 | $29K |