| GILDGILEAD SCIENCES, INC. | 5,729,225 | $703.2M |
| ARGXARGENX SE | 422,304 | $355.1M |
| REGNREGENERON PHARMACEUTICALS, INC. | 426,914 | $329.5M |
| GMABGenmab A/S | 9,557,149 | $294.4M |
| BBIOBridgeBio Pharma, Inc. | 1,908,907 | $146.0M |
| INSMINSMED Inc | 688,734 | $119.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 910,413 | $97.5M |
| NUVLNuvalent, Inc. | 784,023 | $78.9M |
| APGEApogee Therapeutics, Inc. | 990,297 | $74.7M |
| FOLDAMICUS THERAPEUTICS, INC. | 4,316,272 | $61.5M |
| OCULOCULAR THERAPEUTIX, INC | 4,129,687 | $50.1M |
| DNLIDenali Therapeutics Inc. | 2,893,618 | $47.8M |
| GPCRStructure Therapeutics Inc. | 638,813 | $44.4M |
| VRDNViridian Therapeutics, Inc.\DE | 1,392,072 | $43.3M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 1,199,325 | $42.1M |
| TERNTerns Pharmaceuticals, Inc. | 1,032,679 | $41.7M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 926,071 | $38.2M |
| RDYDR REDDYS LABORATORIES LTD | 2,541,889 | $35.7M |
| ZBIOZenas BioPharma, Inc. | 897,321 | $32.6M |
| IONSIONIS PHARMACEUTICALS INC | 400,669 | $31.7M |
| CYTKCYTOKINETICS INC | 459,087 | $29.2M |
| PVLAPALVELLA THERAPEUTICS, INC. | 262,835 | $27.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 598,888 | $24.7M |
| JAZZJazz Pharmaceuticals plc | 123,716 | $21.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 280,394 | $18.6M |
| INCYIncyte Corp. | 184,755 | $18.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 44,641 | $17.8M |
| APLSApellis Pharmaceuticals, Inc. | 638,291 | $16.0M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 248,157 | $14.7M |
| ROIVRoivant Sciences Ltd. | 676,344 | $14.7M |
| EXELEXELIXIS, INC. | 324,650 | $14.2M |
| ELVNEnliven Therapeutics, Inc. | 771,885 | $11.9M |
| MRNAModerna, Inc. | 393,975 | $11.6M |
| PTCTPTC THERAPEUTICS, INC. | 152,176 | $11.6M |
| AXSMAxsome Therapeutics, Inc. | 62,822 | $11.5M |
| DAWNDay One Biopharmaceuticals, Inc. | 1,214,783 | $11.3M |
| PTGXProtagonist Therapeutics, Inc | 73,790 | $6.4M |
| PCVXVaxcyte, Inc. | 137,082 | $6.3M |
| TEVATeva Pharmaceutical Industries Limited | 197,067 | $6.2M |
| COGTCogent Biosciences, Inc. | 157,310 | $5.6M |
| TGTXTG THERAPEUTICS, INC. | 186,893 | $5.6M |
| TVTXTravere Therapeutics, Inc. | 143,817 | $5.5M |
| ADMAADMA BIOLOGICS, INC. | 297,883 | $5.4M |
| HRMYHarmony Biosciences Holdings, Inc. | 144,345 | $5.4M |
| OGNOrganon & Co. | 720,512 | $5.2M |
| RVMDREVOLUTION MEDICINES, INC. | 63,643 | $5.1M |
| LGNDLigand Pharmaceuticals Incorporated | 24,295 | $4.6M |
| SRRKScholar Rock Holding Corp | 100,690 | $4.4M |
| ACADACADIA PHARMACEUTICALS INC | 149,327 | $4.0M |
| ARQTArcutis Biotherapeutics, Inc. | 118,223 | $3.4M |
| RCUSArcus Biosciences, Inc. | 124,085 | $3.0M |
| BEAMBeam Therapeutics Inc. | 105,120 | $2.9M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 55,937 | $2.8M |
| MAZEMaze Therapeutics, Inc. | 64,762 | $2.7M |
| LQDALiquidia Corp | 69,653 | $2.4M |
| SYRESpyre Therapeutics, Inc. | 70,900 | $2.3M |
| IMVTImmunovant, Inc. | 90,410 | $2.3M |
| VCELVericel Corp | 59,352 | $2.1M |
| NUVBNuvation Bio Inc. | 237,503 | $2.1M |
| SLNOSOLENO THERAPEUTICS INC | 43,090 | $2.0M |
| ADPTAdaptive Biotechnologies Corp | 121,228 | $2.0M |
| IRONDisc Medicine, Inc. | 24,540 | $1.9M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 457,504 | $1.9M |
| NRIXNurix Therapeutics, Inc. | 98,190 | $1.9M |
| CLDXCelldex Therapeutics, Inc. | 65,540 | $1.8M |
| DFTXDefinium Therapeutics Inc. | 91,703 | $1.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 61,494 | $1.7M |
| INVAInnoviva, Inc. | 80,651 | $1.6M |
| ANIPANI PHARMACEUTICALS INC | 20,332 | $1.6M |
| ARDXARDELYX, INC. | 264,770 | $1.5M |
| ANABANAPTYSBIO, INC | 31,320 | $1.5M |
| ZYMEZymeworks Inc. | 55,896 | $1.5M |
| HROWHARROW, INC. | 29,637 | $1.5M |
| OLMAOlema Pharmaceuticals, Inc. | 57,840 | $1.4M |
| STOKStoke Therapeutics, Inc. | 41,830 | $1.3M |
| ORKAOruka Therapeutics, Inc. | 40,400 | $1.2M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 40,430 | $1.2M |
| XERSXeris Biopharma Holdings, Inc. | 145,336 | $1.1M |
| BHVNBiohaven Ltd. | 100,036 | $1.1M |
| KODKodiak Sciences Inc. | 38,480 | $1.1M |
| TNGXTango Therapeutics, Inc. | 117,620 | $1.0M |
| ESPREsperion Therapeutics, Inc. | 261,760 | $969K |
| VKTXViking Therapeutics, Inc. | 26,669 | $938K |
| RGNXREGENXBIO Inc. | 64,730 | $932K |
| NTLAIntellia Therapeutics, Inc. | 103,100 | $927K |
| KURAKura Oncology, Inc. | 84,800 | $881K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 321,650 | $878K |
| ARVNARVINAS, INC. | 73,720 | $874K |
| PGENPRECIGEN, INC. | 206,108 | $862K |
| UPBUpstream Bio, Inc. | 31,010 | $842K |
| SVRASavara Inc | 127,040 | $766K |
| SANASana Biotechnology, Inc. | 186,945 | $761K |
| IBRXImmunityBio, Inc. | 376,120 | $745K |
| GERNGERON CORP | 555,701 | $734K |
| JBIOJade Biosciences, Inc. | 45,334 | $700K |
| SIONSionna Therapeutics, Inc. | 16,410 | $675K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 69,607 | $665K |
| ALMSALUMIS INC. | 68,094 | $665K |
| ORGOOrganogenesis Holdings Inc. | 124,290 | $644K |
| KROSKeros Therapeutics, Inc. | 30,860 | $628K |
| SLSSELLAS Life Sciences Group, Inc. | 163,940 | $618K |
| ABUSArbutus Biopharma Corp | 127,340 | $613K |
| ANNXAnnexon, Inc. | 119,050 | $598K |
| AQSTAquestive Therapeutics, Inc. | 91,990 | $594K |
| ZVRAZEVRA THERAPEUTICS, INC. | 65,190 | $584K |
| ABSIAbsci Corporation | 157,990 | $551K |
| KALVKalVista Pharmaceuticals, Inc. | 33,580 | $542K |
| BCAXBicara Therapeutics Inc. | 31,830 | $536K |
| OPKOPKO HEALTH, INC. | 423,190 | $533K |
| ORICOric Pharmaceuticals, Inc. | 63,810 | $522K |
| CGEMCullinan Therapeutics, Inc. | 47,630 | $493K |
| SPRYARS Pharmaceuticals, Inc. | 41,980 | $489K |
| RCKTRocket Pharmaceuticals Inc. | 135,570 | $476K |
| CMPXCompass Therapeutics, Inc. | 83,940 | $451K |
| DSGNDesign Therapeutics, Inc. | 46,120 | $433K |
| FLGTFulgent Genetics Inc. | 16,021 | $421K |
| FDMT4D Molecular Therapeutics, Inc. | 55,100 | $413K |
| AVXLANAVEX LIFE SCIENCES CORP. | 115,200 | $410K |
| SLDBSolid Biosciences Inc. | 69,260 | $391K |
| CADLCandel Therapeutics, Inc. | 69,110 | $390K |
| SIGASIGA TECHNOLOGIES INC | 63,710 | $389K |
| BIOABioAge Labs, Inc. | 29,000 | $384K |
| ALDXAldeyra Therapeutics, Inc. | 68,140 | $353K |
| SMMTSummit Therapeutics Inc. | 19,853 | $347K |
| CHRSCoherus Oncology, Inc. | 213,590 | $303K |
| LRMRLarimar Therapeutics, Inc. | 74,530 | $284K |
| ALTAltimmune, Inc. | 71,760 | $259K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 198,550 | $258K |
| TRDAEntrada Therapeutics, Inc. | 24,320 | $250K |
| PHVSPharvaris N.V. | 8,980 | $249K |
| VYGRVoyager Therapeutics, Inc. | 58,830 | $231K |
| CATXPerspective Therapeutics, Inc. | 83,470 | $230K |
| NGNENeurogene Inc. | 10,570 | $218K |
| LENZLENZ Therapeutics, Inc. | 13,386 | $214K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 4,243 | $208K |
| TNXPTonix Pharmaceuticals Holding Corp. | 13,070 | $204K |
| DNAGinkgo Bioworks Holdings Inc. | 23,092 | $192K |
| FATEFATE THERAPEUTICS INC | 187,700 | $184K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 12,900 | $177K |
| RNAAtrium Therapeutics Inc. | 12,970 | $173K |
| GYREGYRE THERAPEUTICS, INC. | 21,830 | $154K |
| ALECAlector, Inc. | 92,940 | $145K |
| HUMAHumacyte Inc. | 145,560 | $140K |
| CRDFCardiff Oncology, Inc. | 48,730 | $137K |
| RZLTRezolute, Inc. | 43,870 | $104K |
| ABEOABEONA THERAPEUTICS INC. | 17,920 | $94K |
| RNACCartesian Therapeutics, Inc. | 12,765 | $92K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 13,800 | $82K |
| FENCFENNEC PHARMACEUTICALS INC. | 10,310 | $79K |
| ATAIAtai Beckley N.V. | 21,200 | $75K |
| PLXProtalix BioTherapeutics, Inc. | 11,720 | $21K |