ALS

Neurology·MeSH: Amyotrophic Lateral Sclerosis

153 drugs in development·89 companies·5 clinical trials

Drug Pipeline by Phase

Approved(81)

Drug	Company
ABRAXANE	ImmunityBio, Inc. (IBRX)
acetazolamide	MANNKIND CORP (MNKD)
acetazolamide	ACADIA PHARMACEUTICALS INC (ACAD)
acetazolamide	Prestige Consumer Healthcare Inc. (PBH)
acetazolamide	ACHIEVE LIFE SCIENCES, INC. (ACHV)
acetazolamide	Greenwich LifeSciences, Inc. (GLSI)
atomoxetine	SUNSET ISLAND GROUP (SUN)
atomoxetine	Teva Pharmaceutical Industries Limited (TEVA)
atomoxetine	DR REDDYS LABORATORIES LTD (RDY)
atomoxetine	Aptinyx Inc. (APTX)
aveed	Endo LP (NDOI)
baclofen	Impax Laboratories, LLC (IPXL)
baclofen	ANI PHARMACEUTICALS INC (ANIP)
breyna	Mylan II B.V. (MYL)
bupropion	Miromatrix Medical Inc. (MIRO)
bupropion	SUNSET ISLAND GROUP (SUN)
bupropion	Prestige Consumer Healthcare Inc. (PBH)
bupropion	Design Therapeutics, Inc. (DSGN)
bupropion	ACADIA PHARMACEUTICALS INC (ACAD)
buspirone	OXFORD IMMUNOTEC GLOBAL PLC (OXFD)
Capvaxive	Merck & Co., Inc. (MRK)
chlordiazepoxide	Amneal Pharmaceuticals, Inc. (AMRX)
diclofenac	Zomedica Corp. (ZOMDF)
dna appliance	Vivos Therapeutics Inc. (VVOS)
Double - Coptis Suppository	China Health Industries Holdings, Inc. (CHHE)
dsuvia	Verrica Pharmaceuticals Inc. (VRCA)
edluar	Viatris Inc (VTRS)
Emylif® (licensed product, formerly Exservan® in U.S.)	Aquestive Therapeutics, Inc. (AQST)
Ervebo	Merck & Co., Inc. (MRK)
exforge	Novartis AG (NVS)
exforge hct	Novartis AG (NVS)
felodipine	Mylan II B.V. (MYL)
fluconazole	ANI PHARMACEUTICALS INC (ANIP)
fosphenytoin	Amneal Pharmaceuticals, Inc. (AMRX)
hydrocortisone	Aptinyx Inc. (APTX)
ibuprofen	SUNSET ISLAND GROUP (SUN)
inFoods® (IBS)	BIOMERICA INC (BMRA)
krazati	BRISTOL MYERS SQUIBB CO (BMY)
leucovorin calcium preservative free	Seagen Inc. (SGEN)
leucovorin calcium preservative free	Mylan II B.V. (MYL)
lidocaine	NVN Liquidation, Inc. (NOVN)
lidocaine	AlphaTON Capital Corp (ATON)
lidocaine	LUMOS PHARMA, INC. (NLNK)
losartan	Teva Pharmaceutical Industries Limited (TEVA)
methylprednisolone	Amneal Pharmaceuticals, Inc. (AMRX)
nebivolol	ANI PHARMACEUTICALS INC (ANIP)
nevirapine	Mylan II B.V. (MYL)
olmesartan medoxomil	Amneal Pharmaceuticals, Inc. (AMRX)
paliperidone	Inventiva S.A. (IVA)
paxlovid	PFIZER INC (PFE)
pet pain-away	NUTRA PHARMA CORP (NPHC)
progesterone	DR REDDYS LABORATORIES LTD (RDY)
QALSODY	BIOGEN INC. (BIIB)
risperidone	Amneal Pharmaceuticals, Inc. (AMRX)
risperidone	Prestige Consumer Healthcare Inc. (PBH)
risperidone	SUNSET ISLAND GROUP (SUN)
risperidone	LANNETT CO INC (LCI)
risperidone	DR REDDYS LABORATORIES LTD (RDY)
risperidone	Aptinyx Inc. (APTX)
risperidone	PRECISION BIOSCIENCES INC (DTIL)
risperidone	AlphaTON Capital Corp (ATON)
risperidone	ANI PHARMACEUTICALS INC (ANIP)
risperidone	REATA PHARMACEUTICALS INC (RETA)
risperidone	Synthorx, Inc. (THOR)
sincalide	MAIA Biotechnology, Inc. (MAIA)
sodium nitroprusside	NEXUS BIOPHARMA INC (NEXS)
sodium oxybate	Nascent Biotech Inc. (NBIO)
supprelin la	Endo LP (NDOI)
TechneLite	Lantheus Holdings, Inc. (LNTH)
telmisartan	Inventiva S.A. (IVA)
testosterone	Amneal Pharmaceuticals, Inc. (AMRX)
thalomid	CELGENE CORP /DE/ (CELG)
ticagrelor	Mylan II B.V. (MYL)
ticagrelor	Amneal Pharmaceuticals, Inc. (AMRX)
ticagrelor	DR REDDYS LABORATORIES LTD (RDY)
triamcinolone acetonide	Teva Pharmaceutical Industries Limited (TEVA)
valsartan	Mylan II B.V. (MYL)
venlafaxine	Teva Pharmaceutical Industries Limited (TEVA)
VOWST	Seres Therapeutics, Inc. (MCRB)
zolpidem	Teva Pharmaceutical Industries Limited (TEVA)
ZULRESSO	Sage Therapeutics, Inc. (SAGE)

Phase 3(4)

Drug	Company
AXAL (axalimogene filolisbac / ADXS-HPV)	Ayala Pharmaceuticals, Inc. (ADXS)
Scopoderm® patches arm	Revance Therapeutics, Inc. (RVNC)
Tofersen	BIOGEN INC. (BIIB)
Zipalertinib (CLN-081/TAS6417)	Cullinan Therapeutics, Inc. (CGEM)

Phase 2(27)

Drug	Company
ARV-102	ARVINAS, INC. (ARVN)
ATI-052	Aclaris Therapeutics, Inc. (ACRS)
AUCATZYL/obe-cel	Autolus Therapeutics plc (AUTL)
Autologous Treg cell therapy	Coya Therapeutics, Inc. (COYA)
Cabozantinib	PTC THERAPEUTICS, INC. (PTCT)
cnm-au8	Clene Inc. (CLNN)
Conditioned Medium	Accustem Sciences Inc. (ACUT)
COYA 301	Coya Therapeutics, Inc. (COYA)
COYA 302	Coya Therapeutics, Inc. (COYA)
COYA 303	Coya Therapeutics, Inc. (COYA)
Daratumumab	PTC THERAPEUTICS, INC. (PTCT)
Enzalutamide	PTC THERAPEUTICS, INC. (PTCT)
Express Genes	Twist Bioscience Corp (TWST)
GV1001 0.56mg	Cidara Therapeutics, Inc. (CDTX)
GV1001 1.12mg	Cidara Therapeutics, Inc. (CDTX)
iluzanebart	Vigil Neuroscience, Inc. (VIGL)
ONA-XR	Context Therapeutics Inc. (CNTX)
Regorafinib	PTC THERAPEUTICS, INC. (PTCT)
Relatlimab	PTC THERAPEUTICS, INC. (PTCT)
Rucaparib	PTC THERAPEUTICS, INC. (PTCT)
Sapanisertib (CB-228, formerly TAK-228)	Calithera Biosciences, Inc. (CALA)
tegoprubart	Eledon Pharmaceuticals, Inc. (ELDN)
Trametinib	PTC THERAPEUTICS, INC. (PTCT)
Utreloxastat	PTC THERAPEUTICS, INC. (PTCT)
vgl101	Vigil Neuroscience, Inc. (VIGL)
vhb937	Novartis AG (NVS)
vhb937	Novartis AG (NVS)

Phase 1(9)

Drug	Company
[11C]CPPC PET ligand	UNITED THERAPEUTICS Corp (UTHR)
AMX0114	Amylyx Pharmaceuticals, Inc. (AMLX)
AUTO6NG	Autolus Therapeutics plc (AUTL)
LY4256984	ELI LILLY & Co (LLY)
Moxifloxacin	CYTOKINETICS INC (CYTK)
pas-003	Pasithea Therapeutics Corp. (KTTA)
prulacabtagene leucel (prula-cel	Adicet Bio, Inc. (ACET)
rinvatercept	Keros Therapeutics, Inc. (KROS)
Umbilical Cord Mesenchymal Stem Cells	Accustem Sciences Inc. (ACUT)

Preclinical(14)

Drug	Company
aav-upf1	MeiraGTx Holdings plc (MGTX)
aav.105	Decibel Therapeutics, Inc. (DBTX)
ALPHA-0602	Alpha Cognition Inc. (ACOG)
ALPHA-0702	Alpha Cognition Inc. (ACOG)
ALPHA-0802	Alpha Cognition Inc. (ACOG)
als program	Korro Bio, Inc. (KRRO)
BP1003	BIO-PATH HOLDINGS, INC. (BPTH)
green meadow pr formula	Optec International, Inc. (GM)
onp-002	Odyssey Health, Inc. (ODYY)
rpi-78m	NUTRA PHARMA CORP (NPHC)
sls-009	SEELOS THERAPEUTICS, INC. (SEEL)
sod1 silencing gene therapy	Voyager Therapeutics, Inc. (VYGR)
terpene synthesis	EXOZYMES INC. (EXOZ)
undisclosed als program	Korro Bio, Inc. (KRRO)

Unknown(9)

Drug	Company
250 nutritional supplements (R&D agreement)	Cosmos Health Inc. (COSM)
Alpha Research Institute	Cannabis Bioscience International Holdings, Inc. (CBIH)
clonoSEQ assay (MRD Pharma)	Adaptive Biotechnologies Corp (ADPT)
Culpeo QCL-IR Liquid Analyzer	REPLIGEN CORP (RGEN)
emylif	Aquestive Therapeutics, Inc. (AQST)
Full Spectrum topical products (Don Polly)	Charlie's Holdings, Inc. (CHUC)
NaturaComplete™	BIOADAPTIVES, INC. (BDPT)
Sky Premium Life (SPL)	Cosmos Health Inc. (COSM)
Vaxneuvance	Merck & Co., Inc. (MRK)

BLA Filed(3)

Drug	Company
dccr	SOLENO THERAPEUTICS INC (SLNO)
prv-031	PROVENTION BIO, INC. (PBI)
teplizumab	PROVENTION BIO, INC. (PBI)

Phase 2/Phase 3(2)

Drug	Company
ath-1105	LeonaBio, Inc. (LONA)
sls-005	SEELOS THERAPEUTICS, INC. (SEEL)

Phase 4(4)

Drug	Company
Botox® injection	Revance Therapeutics, Inc. (RVNC)
Control	Revance Therapeutics, Inc. (RVNC)
onabotulinumtoxin A	Revance Therapeutics, Inc. (RVNC)
OnabotulinumtoxinA	Revance Therapeutics, Inc. (RVNC)

Compare drugs

ABRAXANE vs acetazolamide ABRAXANE vs atomoxetine ABRAXANE vs aveed

Frequently asked questions

How many drugs are in development for ALS?

BioSniper tracks 153 drugs in development for ALS across 89 companies.

How many clinical trials target ALS?

There are 5 clinical trials targeting ALS tracked by BioSniper.

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