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| CYTKCYTOKINETICS INC | 898,951 | $59.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 174,268 | $57.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 1,344,953 | $45.5M |
| ABVXAbivax SA | 381,282 | $42.5M |
| LQDALiquidia Corp | 1,001,081 | $37.8M |
| BBIOBridgeBio Pharma, Inc. | 398,943 | $29.6M |
| INSMINSMED Inc | 173,630 | $28.4M |
| TERNTerns Pharmaceuticals, Inc. | 521,571 | $27.5M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 378,833 | $23.8M |
| REGNREGENERON PHARMACEUTICALS, INC. | 30,620 | $23.7M |
| VKTXViking Therapeutics, Inc. | 705,809 | $23.0M |
| SNYSanofi | 464,569 | $22.4M |
| TEVATeva Pharmaceutical Industries Limited | 739,515 | $22.3M |
| ATAIAtai Beckley N.V. | 5,286,326 | $18.7M |
| KNSAKiniksa Pharmaceuticals International, plc | 383,811 | $18.5M |
| SLNOSOLENO THERAPEUTICS INC | 549,877 | $18.4M |
| TGTXTG THERAPEUTICS, INC. | 544,720 | $18.1M |
| NKTRNEKTAR THERAPEUTICS | 249,090 | $17.9M |
| PTGXProtagonist Therapeutics, Inc | 167,576 | $17.7M |
| QUREuniQure N.V. | 1,002,800 | $16.4M |
| HROWHARROW, INC. | 457,782 | $16.1M |
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| PTCTPTC THERAPEUTICS, INC. | 207,938 | $14.2M |
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| RXRXRECURSION PHARMACEUTICALS, INC. | 4,225,277 | $13.0M |
| SMMTSummit Therapeutics Inc. | 603,933 | $11.5M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 2,996,743 | $10.5M |
| ARGXARGENX SE | 14,392 | $10.5M |
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| AXSMAxsome Therapeutics, Inc. | 47,198 | $8.0M |
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| NTLAIntellia Therapeutics, Inc. | 521,465 | $6.7M |
| OGNOrganon & Co. | 1,082,760 | $6.5M |
| MLTXMoonLake Immunotherapeutics | 341,424 | $6.4M |
| LYELLyell Immunopharma, Inc. | 310,198 | $6.2M |
| CMPSCOMPASS Pathways plc | 1,122,588 | $6.2M |
| MESOMesoblast Limited | 386,472 | $5.9M |
| ROIVRoivant Sciences Ltd. | 196,195 | $5.4M |
| RVMDREVOLUTION MEDICINES, INC. | 51,385 | $5.0M |
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| OVIDOvid Therapeutics Inc. | 1,947,594 | $4.3M |
| IMMXImmix Biopharma, Inc. | 471,394 | $4.3M |
| ALMSALUMIS INC. | 194,355 | $4.3M |
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| BEAMBeam Therapeutics Inc. | 178,391 | $4.3M |
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| ANIPANI PHARMACEUTICALS INC | 54,114 | $4.2M |
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| XFORX4 Pharmaceuticals, Inc | 856,222 | $3.5M |
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| LXRXLEXICON PHARMACEUTICALS, INC. | 2,121,164 | $3.3M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 57,448 | $3.2M |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 333,415 | $3.1M |
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| GPCRStructure Therapeutics Inc. | 55,842 | $2.7M |
| ALXOALX ONCOLOGY HOLDINGS INC | 1,328,907 | $2.7M |
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| ABCLAbCellera Biologics Inc. | 750,393 | $2.6M |
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| IVVDInvivyd, Inc. | 1,903,713 | $2.5M |
| SRRKScholar Rock Holding Corp | 48,236 | $2.4M |
| PVLAPALVELLA THERAPEUTICS, INC. | 18,808 | $2.3M |
| ESPREsperion Therapeutics, Inc. | 850,505 | $2.3M |
| ADPTAdaptive Biotechnologies Corp | 157,817 | $2.2M |
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| SUPNSUPERNUS PHARMACEUTICALS, INC. | 40,750 | $2.1M |
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| ABEOABEONA THERAPEUTICS INC. | 432,370 | $1.9M |
| STOKStoke Therapeutics, Inc. | 57,291 | $1.9M |
| GERNGERON CORP | 1,250,017 | $1.9M |
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| ZVRAZEVRA THERAPEUTICS, INC. | 186,582 | $1.7M |
| SLSSELLAS Life Sciences Group, Inc. | 397,056 | $1.7M |
| PGENPRECIGEN, INC. | 432,711 | $1.7M |
| ZBIOZenas BioPharma, Inc. | 85,005 | $1.7M |
| XERSXeris Biopharma Holdings, Inc. | 286,071 | $1.7M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 53,375 | $1.6M |
| GALTGALECTIN THERAPEUTICS INC | 555,702 | $1.6M |
| DFTXDefinium Therapeutics Inc. | 81,456 | $1.5M |
| CAMPCamp4 Therapeutics Corp | 336,047 | $1.5M |
| ANABANAPTYSBIO, INC | 26,577 | $1.5M |
| RLAYRelay Therapeutics, Inc. | 147,158 | $1.5M |
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| OCGNOcugen, Inc. | 769,549 | $1.4M |
| RCKTRocket Pharmaceuticals Inc. | 385,639 | $1.4M |
| APGEApogee Therapeutics, Inc. | 16,099 | $1.4M |
| LGNDLigand Pharmaceuticals Incorporated | 6,703 | $1.3M |
| ZNTLZentalis Pharmaceuticals, Inc. | 571,257 | $1.3M |
| KODKodiak Sciences Inc. | 34,227 | $1.3M |
| OCULOCULAR THERAPEUTIX, INC | 150,744 | $1.3M |
| PHVSPharvaris N.V. | 44,974 | $1.3M |
| NRIXNurix Therapeutics, Inc. | 81,455 | $1.3M |
| SANASana Biotechnology, Inc. | 421,555 | $1.2M |
| TVTXTravere Therapeutics, Inc. | 40,058 | $1.2M |
| FDMT4D Molecular Therapeutics, Inc. | 124,228 | $1.2M |
| IMUXIMMUNIC, INC. | 1,028,256 | $1.1M |
| CLDXCelldex Therapeutics, Inc. | 35,948 | $1.1M |
| JAZZJazz Pharmaceuticals plc | 5,914 | $1.1M |
| ABUSArbutus Biopharma Corp | 241,970 | $1.1M |
| VRDNViridian Therapeutics, Inc.\DE | 54,277 | $1.1M |
| BIOABioAge Labs, Inc. | 60,089 | $1.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 18,513 | $1.0M |
| ORKAOruka Therapeutics, Inc. | 20,984 | $1.0M |
| LENZLENZ Therapeutics, Inc. | 110,304 | $1.0M |
| INVAInnoviva, Inc. | 43,214 | $1.0M |
| ACADACADIA PHARMACEUTICALS INC | 44,792 | $997K |
| ELVNEnliven Therapeutics, Inc. | 25,172 | $987K |
| IRONDisc Medicine, Inc. | 15,406 | $985K |
| DNLIDenali Therapeutics Inc. | 50,475 | $969K |
| BMEABiomea Fusion, Inc. | 629,865 | $964K |
| KALVKalVista Pharmaceuticals, Inc. | 46,760 | $941K |
| IONSIONIS PHARMACEUTICALS INC | 12,359 | $928K |
| PRLDPrelude Therapeutics Inc | 267,788 | $916K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 32,949 | $914K |
| ANNXAnnexon, Inc. | 158,640 | $879K |
| CMPXCompass Therapeutics, Inc. | 157,025 | $831K |
| NVCTNuvectis Pharma, Inc. | 105,286 | $814K |
| VCELVericel Corp | 25,100 | $807K |
| KURAKura Oncology, Inc. | 98,592 | $802K |
| SPROSpero Therapeutics, Inc. | 333,115 | $779K |
| CATXPerspective Therapeutics, Inc. | 186,630 | $778K |
| RGNXREGENXBIO Inc. | 91,084 | $763K |
| ELTXElicio Therapeutics, Inc. | 70,804 | $757K |
| FLNAFilana Therapeutics Inc. | 447,278 | $756K |
| MAZEMaze Therapeutics, Inc. | 25,301 | $755K |
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| MDWDMediWound Ltd. | 44,300 | $714K |
| HRMYHarmony Biosciences Holdings, Inc. | 25,401 | $711K |
| CNTACentessa Pharmaceuticals plc | 17,737 | $705K |
| WHWKWhitehawk Therapeutics, Inc. | 203,465 | $702K |
| CGEMCullinan Therapeutics, Inc. | 47,377 | $673K |
| ARMPArmata Pharmaceuticals, Inc. | 64,759 | $663K |
| SGMTSagimet Biosciences Inc. | 124,604 | $651K |
| HUMAHumacyte Inc. | 1,058,048 | $642K |
| LRMRLarimar Therapeutics, Inc. | 140,060 | $630K |
| MISTMilestone Pharmaceuticals Inc. | 519,046 | $618K |
| NUVBNuvation Bio Inc. | 143,613 | $616K |
| ZYMEZymeworks Inc. | 24,421 | $612K |
| SLNSilence Therapeutics Plc | 115,281 | $608K |
| FLGTFulgent Genetics Inc. | 38,078 | $605K |
| HYFTMindWalk Holdings Corp. | 534,016 | $603K |
| RDYDR REDDYS LABORATORIES LTD | 42,300 | $586K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 17,825 | $571K |
| CADLCandel Therapeutics, Inc. | 112,973 | $554K |
| AUTLAutolus Therapeutics plc | 399,143 | $551K |
| XOMAXOMA Royalty Corporation | 17,390 | $546K |
| TECXTectonic Therapeutic, Inc. | 16,175 | $500K |
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| SPRYARS Pharmaceuticals, Inc. | 60,537 | $486K |
| CHRSCoherus Oncology, Inc. | 287,500 | $486K |
| ALDXAldeyra Therapeutics, Inc. | 278,442 | $471K |
| TENXTENAX THERAPEUTICS, INC. | 28,977 | $463K |
| ORMPORAMED PHARMACEUTICALS INC. | 136,218 | $463K |
| OPKOPKO HEALTH, INC. | 391,516 | $446K |
| RZLTRezolute, Inc. | 141,889 | $433K |
| SGMOQSANGAMO THERAPEUTICS, INC | 1,687,463 | $417K |
| TNXPTonix Pharmaceuticals Holding Corp. | 29,579 | $407K |
| SVRASavara Inc | 71,599 | $391K |
| PROKPROKIDNEY CORP. | 204,488 | $366K |
| FATEFATE THERAPEUTICS INC | 298,496 | $358K |
| DNAGinkgo Bioworks Holdings Inc. | 56,236 | $345K |
| VYGRVoyager Therapeutics, Inc. | 78,891 | $305K |
| KLRSKalaris Therapeutics, Inc. | 52,684 | $304K |
| SIONSionna Therapeutics, Inc. | 7,310 | $293K |
| ORICOric Pharmaceuticals, Inc. | 23,055 | $292K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 13,411 | $290K |
| ZURAZura Bio Ltd | 47,886 | $285K |
| IMCRImmunocore Holdings plc | 8,622 | $260K |
| JBIOJade Biosciences, Inc. | 18,308 | $257K |
| ANIXAnixa Biosciences Inc | 99,468 | $257K |
| TRDAEntrada Therapeutics, Inc. | 20,315 | $256K |
| DMRADamora Therapeutics, Inc. | 9,770 | $253K |
| ACIUAC Immune SA | 89,262 | $245K |
| DRTSAlpha Tau Medical Ltd. | 32,738 | $231K |
| ALECAlector, Inc. | 107,597 | $231K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 288,253 | $231K |
| BCAXBicara Therapeutics Inc. | 10,944 | $218K |
| PPBTPURPLE BIOTECH LTD. | 53,403 | $216K |
| CLLSCellectis S.A. | 65,942 | $209K |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 262,953 | $209K |
| LPCNLipocine Inc. | 24,908 | $199K |
| AGENAGENUS INC | 57,659 | $193K |
| BCYCBICYCLE THERAPEUTICS PLC | 37,888 | $176K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 17,792 | $173K |
| BDTXBlack Diamond Therapeutics, Inc. | 78,858 | $168K |
| RNAAtrium Therapeutics Inc. | 11,343 | $152K |
| CRDFCardiff Oncology, Inc. | 92,359 | $150K |
| DMACDiaMedica Therapeutics Inc. | 21,650 | $147K |
| UPBUpstream Bio, Inc. | 15,961 | $144K |
| SIGASIGA TECHNOLOGIES INC | 24,767 | $133K |
| KROSKeros Therapeutics, Inc. | 11,242 | $124K |
| ATNMActinium Pharmaceuticals, Inc. | 123,998 | $123K |
| PLXProtalix BioTherapeutics, Inc. | 49,085 | $107K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 16,089 | $103K |
| INOINOVIO PHARMACEUTICALS, INC. | 56,862 | $99K |
| NNVCNANOVIRICIDES, INC. | 99,031 | $90K |
| VTGNVistagen Therapeutics, Inc. | 142,607 | $82K |
| IFRXInflaRx N.V. | 77,114 | $69K |
| ORGOOrganogenesis Holdings Inc. | 28,307 | $67K |
| PLRXPLIANT THERAPEUTICS, INC. | 52,956 | $67K |
| MRKRMarker Therapeutics, Inc. | 48,780 | $63K |
| CGTXCOGNITION THERAPEUTICS INC | 80,663 | $61K |
| MNOVMEDICINOVA INC | 43,926 | $60K |
| LSTALISATA THERAPEUTICS, INC. | 11,604 | $58K |
| HURATuHURA Biosciences, Inc./NV | 30,847 | $55K |
| BOLTBolt Biotherapeutics, Inc. | 11,657 | $47K |
| BCDABioCardia, Inc. | 38,827 | $47K |
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| ONCYONCOLYTICS BIOTECH INC | 41,323 | $35K |
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| DAREDare Bioscience, Inc. | 17,130 | $31K |
| VERUVERU INC. | 12,771 | $28K |
| OTLKOutlook Therapeutics, Inc. | 134,084 | $28K |
| MIRAMIRA PHARMACEUTICALS, INC. | 25,146 | $27K |
| SILOSilo Pharma, Inc. | 62,795 | $23K |
| CELZCREATIVE MEDICAL TECHNOLOGY HOLDINGS, INC. | 10,469 | $22K |
| CMMBChemomab Therapeutics Ltd. | 13,491 | $21K |
| TLSATiziana Life Sciences Ltd | 17,267 | $20K |
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| QNCXQuince Therapeutics, Inc. | 172,640 | $18K |
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| PDSBPDS Biotechnology Corp | 22,052 | $13K |
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| CUECue Biopharma, Inc. | 24,614 | $6K |