| INSMINSMED Inc | 1,395,794 | $228.2M |
| ARGXARGENX SE | 286,966 | $209.6M |
| GILDGILEAD SCIENCES, INC. | 1,158,099 | $161.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 2,286,880 | $126.2M |
| EXELEXELIXIS, INC. | 1,629,670 | $69.9M |
| INCYIncyte Corp. | 714,558 | $67.3M |
| REGNREGENERON PHARMACEUTICALS, INC. | 75,000 | $57.9M |
| TEVATeva Pharmaceutical Industries Limited | 1,182,751 | $35.6M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 100,315 | $33.2M |
| SNYSanofi | 588,729 | $28.4M |
| JAZZJazz Pharmaceuticals plc | 147,270 | $27.8M |
| BBIOBridgeBio Pharma, Inc. | 288,075 | $21.4M |
| LGNDLigand Pharmaceuticals Incorporated | 75,188 | $15.0M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 251,480 | $14.2M |
| KNSAKiniksa Pharmaceuticals International, plc | 284,005 | $13.7M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 203,220 | $12.7M |
| AXSMAxsome Therapeutics, Inc. | 70,064 | $11.8M |
| IONSIONIS PHARMACEUTICALS INC | 157,222 | $11.8M |
| VCELVericel Corp | 360,712 | $11.6M |
| ABVXAbivax SA | 94,220 | $10.5M |
| GRFSGrifols S.A. | 1,251,579 | $10.0M |
| PTCTPTC THERAPEUTICS, INC. | 130,204 | $8.9M |
| PTGXProtagonist Therapeutics, Inc | 83,197 | $8.8M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 162,406 | $8.4M |
| ADPTAdaptive Biotechnologies Corp | 560,554 | $7.8M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 92,229 | $7.7M |
| COGTCogent Biosciences, Inc. | 197,510 | $7.6M |
| SRRKScholar Rock Holding Corp | 143,359 | $7.0M |
| MRNAModerna, Inc. | 129,395 | $6.6M |
| RDYDR REDDYS LABORATORIES LTD | 436,731 | $6.0M |
| TGTXTG THERAPEUTICS, INC. | 176,702 | $5.9M |
| HRMYHarmony Biosciences Holdings, Inc. | 194,188 | $5.4M |
| TVTXTravere Therapeutics, Inc. | 166,477 | $4.9M |
| ARQTArcutis Biotherapeutics, Inc. | 206,141 | $4.9M |
| CYTKCYTOKINETICS INC | 69,812 | $4.6M |
| ANIPANI PHARMACEUTICALS INC | 57,168 | $4.4M |
| APGEApogee Therapeutics, Inc. | 42,203 | $3.6M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 40,685 | $3.5M |
| XERSXeris Biopharma Holdings, Inc. | 579,210 | $3.4M |
| ROIVRoivant Sciences Ltd. | 120,326 | $3.3M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 508,182 | $3.2M |
| INVAInnoviva, Inc. | 131,205 | $3.1M |
| NUVLNuvalent, Inc. | 29,540 | $3.0M |
| RVMDREVOLUTION MEDICINES, INC. | 30,786 | $3.0M |
| TERNTerns Pharmaceuticals, Inc. | 56,061 | $3.0M |
| ADMAADMA BIOLOGICS, INC. | 290,360 | $2.6M |
| KURAKura Oncology, Inc. | 319,266 | $2.6M |
| GMABGenmab A/S | 93,012 | $2.5M |
| ACADACADIA PHARMACEUTICALS INC | 106,390 | $2.4M |
| DAWNDay One Biopharmaceuticals, Inc. | 104,598 | $2.2M |
| OCULOCULAR THERAPEUTIX, INC | 258,164 | $2.2M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 63,550 | $2.1M |
| SLNOSOLENO THERAPEUTICS INC | 62,946 | $2.1M |
| PVLAPALVELLA THERAPEUTICS, INC. | 16,663 | $2.1M |
| PCVXVaxcyte, Inc. | 33,545 | $1.9M |
| IMCRImmunocore Holdings plc | 61,260 | $1.8M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 55,637 | $1.8M |
| DSGNDesign Therapeutics, Inc. | 133,203 | $1.4M |
| LQDALiquidia Corp | 35,655 | $1.3M |
| HROWHARROW, INC. | 38,032 | $1.3M |
| IMMXImmix Biopharma, Inc. | 147,140 | $1.3M |
| VRDNViridian Therapeutics, Inc.\DE | 65,777 | $1.3M |
| ONCBeOne Medicines Ltd. | 4,321 | $1.3M |
| NRIXNurix Therapeutics, Inc. | 82,108 | $1.3M |
| FOLDAMICUS THERAPEUTICS, INC. | 87,585 | $1.3M |
| CLDXCelldex Therapeutics, Inc. | 38,152 | $1.2M |
| FLGTFulgent Genetics Inc. | 74,232 | $1.2M |
| CTMXCytomX Therapeutics, Inc. | 248,248 | $1.2M |
| RLMDRELMADA THERAPEUTICS, INC. | 166,614 | $1.2M |
| TECXTectonic Therapeutic, Inc. | 36,870 | $1.1M |
| OGNOrganon & Co. | 190,057 | $1.1M |
| ANNXAnnexon, Inc. | 203,236 | $1.1M |
| ORKAOruka Therapeutics, Inc. | 22,840 | $1.1M |
| BIOABioAge Labs, Inc. | 62,385 | $1.1M |
| ASRTAssertio Holdings, Inc. | 54,940 | $1.0M |
| DNLIDenali Therapeutics Inc. | 52,235 | $1.0M |
| IRONDisc Medicine, Inc. | 15,510 | $992K |
| AVTXAvalo Therapeutics, Inc. | 56,854 | $849K |
| ARVNARVINAS, INC. | 78,587 | $833K |
| ARDXARDELYX, INC. | 134,413 | $805K |
| ABEOABEONA THERAPEUTICS INC. | 172,460 | $773K |
| CHRSCoherus Oncology, Inc. | 453,763 | $767K |
| ARMPArmata Pharmaceuticals, Inc. | 74,192 | $760K |
| DMACDiaMedica Therapeutics Inc. | 111,320 | $754K |
| OVIDOvid Therapeutics Inc. | 328,924 | $730K |
| GPCRStructure Therapeutics Inc. | 13,990 | $674K |
| TNGXTango Therapeutics, Inc. | 31,962 | $669K |
| LCTXLineage Cell Therapeutics, Inc. | 422,274 | $667K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 17,805 | $541K |
| DFTXDefinium Therapeutics Inc. | 28,117 | $531K |
| VKTXViking Therapeutics, Inc. | 14,749 | $480K |
| APLSApellis Pharmaceuticals, Inc. | 11,747 | $473K |
| SYRESpyre Therapeutics, Inc. | 8,975 | $453K |
| ZNTLZentalis Pharmaceuticals, Inc. | 191,551 | $448K |
| RZLTRezolute, Inc. | 146,576 | $447K |
| IMVTImmunovant, Inc. | 17,746 | $441K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 122,180 | $429K |
| ANABANAPTYSBIO, INC | 7,654 | $424K |
| KODKodiak Sciences Inc. | 10,287 | $392K |
| PLRXPLIANT THERAPEUTICS, INC. | 297,291 | $375K |
| SMMTSummit Therapeutics Inc. | 19,681 | $373K |
| RLAYRelay Therapeutics, Inc. | 36,130 | $359K |
| STOKStoke Therapeutics, Inc. | 9,994 | $325K |
| NKTRNEKTAR THERAPEUTICS | 4,471 | $322K |
| ESPREsperion Therapeutics, Inc. | 116,229 | $318K |
| IBRXImmunityBio, Inc. | 39,330 | $302K |
| BHVNBiohaven Ltd. | 33,435 | $283K |
| BEAMBeam Therapeutics Inc. | 11,451 | $273K |
| SIGASIGA TECHNOLOGIES INC | 48,420 | $259K |
| NTLAIntellia Therapeutics, Inc. | 20,093 | $258K |
| BCYCBICYCLE THERAPEUTICS PLC | 52,784 | $245K |
| KALVKalVista Pharmaceuticals, Inc. | 12,143 | $244K |
| SVRASavara Inc | 44,569 | $243K |
| ZBIOZenas BioPharma, Inc. | 12,386 | $242K |
| RCUSArcus Biosciences, Inc. | 10,295 | $222K |
| ALMSALUMIS INC. | 9,318 | $205K |
| QUREuniQure N.V. | 11,434 | $187K |
| NUVBNuvation Bio Inc. | 43,203 | $185K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 17,248 | $168K |
| FATEFATE THERAPEUTICS INC | 138,580 | $166K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 50,448 | $155K |
| TNXPTonix Pharmaceuticals Holding Corp. | 10,971 | $151K |
| RGNXREGENXBIO Inc. | 14,920 | $125K |
| FDMT4D Molecular Therapeutics, Inc. | 12,862 | $120K |
| ALECAlector, Inc. | 53,846 | $116K |
| SLSSELLAS Life Sciences Group, Inc. | 26,581 | $112K |
| VYGRVoyager Therapeutics, Inc. | 28,937 | $112K |
| SPRYARS Pharmaceuticals, Inc. | 12,983 | $104K |
| AQSTAquestive Therapeutics, Inc. | 24,845 | $103K |
| RCKTRocket Pharmaceuticals Inc. | 28,093 | $101K |
| ORGOOrganogenesis Holdings Inc. | 40,244 | $95K |
| SLDBSolid Biosciences Inc. | 13,078 | $94K |
| CRDFCardiff Oncology, Inc. | 54,685 | $89K |
| BDTXBlack Diamond Therapeutics, Inc. | 39,683 | $85K |
| RNACCartesian Therapeutics, Inc. | 12,764 | $78K |
| LRMRLarimar Therapeutics, Inc. | 16,336 | $74K |
| CCCCC4 Therapeutics, Inc. | 25,134 | $66K |
| GERNGERON CORP | 41,891 | $62K |
| HUMAHumacyte Inc. | 93,054 | $56K |
| SANASana Biotechnology, Inc. | 17,668 | $51K |
| PGENPRECIGEN, INC. | 11,799 | $46K |
| AVXLANAVEX LIFE SCIENCES CORP. | 11,611 | $36K |
| OPKOPKO HEALTH, INC. | 10,163 | $12K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 12,685 | $10K |