| GILDGILEAD SCIENCES, INC. | 2,561,652 | $354.9M |
| SNYSanofi | 3,812,745 | $183.7M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 406,956 | $130.0M |
| REGNREGENERON PHARMACEUTICALS, INC. | 165,542 | $127.9M |
| INSMINSMED Inc | 775,148 | $121.4M |
| VKTXViking Therapeutics, Inc. | 2,075,403 | $113.5M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,371,577 | $75.7M |
| TEVATeva Pharmaceutical Industries Limited | 1,816,715 | $54.7M |
| EXELEXELIXIS, INC. | 1,045,595 | $44.8M |
| JAZZJazz Pharmaceuticals plc | 184,464 | $34.6M |
| ARGXARGENX SE | 36,802 | $26.9M |
| AXSMAxsome Therapeutics, Inc. | 147,766 | $24.3M |
| BBIOBridgeBio Pharma, Inc. | 311,959 | $22.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 331,373 | $18.7M |
| PTGXProtagonist Therapeutics, Inc | 177,361 | $17.8M |
| IONSIONIS PHARMACEUTICALS INC | 235,121 | $17.7M |
| PCVXVaxcyte, Inc. | 260,395 | $14.6M |
| COGTCogent Biosciences, Inc. | 369,715 | $14.2M |
| TGTXTG THERAPEUTICS, INC. | 426,379 | $14.2M |
| NUVLNuvalent, Inc. | 145,288 | $14.1M |
| RVMDREVOLUTION MEDICINES, INC. | 137,160 | $13.3M |
| VCELVericel Corp | 422,333 | $13.1M |
| SRRKScholar Rock Holding Corp | 253,599 | $12.5M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 182,555 | $11.4M |
| MRNAModerna, Inc. | 197,219 | $10.0M |
| INCYIncyte Corp. | 105,242 | $9.9M |
| NTLAIntellia Therapeutics, Inc. | 576,930 | $7.4M |
| OCULOCULAR THERAPEUTIX, INC | 859,485 | $7.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 125,293 | $6.5M |
| ANIPANI PHARMACEUTICALS INC | 80,620 | $6.2M |
| LQDALiquidia Corp | 162,456 | $6.1M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 196,300 | $6.0M |
| ADMAADMA BIOLOGICS, INC. | 650,989 | $5.9M |
| ONCBeOne Medicines Ltd. | 19,047 | $5.7M |
| VRDNViridian Therapeutics, Inc.\DE | 293,308 | $5.4M |
| ADPTAdaptive Biotechnologies Corp | 382,295 | $5.3M |
| NRIXNurix Therapeutics, Inc. | 353,733 | $5.2M |
| CYTKCYTOKINETICS INC | 68,503 | $4.5M |
| ZYMEZymeworks Inc. | 176,411 | $4.4M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 49,920 | $4.3M |
| SPRYARS Pharmaceuticals, Inc. | 525,224 | $4.2M |
| BHVNBiohaven Ltd. | 446,611 | $3.8M |
| LGNDLigand Pharmaceuticals Incorporated | 18,258 | $3.6M |
| PTCTPTC THERAPEUTICS, INC. | 52,455 | $3.6M |
| ARQTArcutis Biotherapeutics, Inc. | 149,867 | $3.5M |
| PVLAPALVELLA THERAPEUTICS, INC. | 25,446 | $3.2M |
| ARDXARDELYX, INC. | 486,712 | $2.9M |
| IBRXImmunityBio, Inc. | 375,701 | $2.9M |
| KALVKalVista Pharmaceuticals, Inc. | 140,651 | $2.8M |
| IRONDisc Medicine, Inc. | 44,700 | $2.7M |
| APLSApellis Pharmaceuticals, Inc. | 62,631 | $2.5M |
| FDMT4D Molecular Therapeutics, Inc. | 266,147 | $2.5M |
| GPCRStructure Therapeutics Inc. | 45,139 | $2.2M |
| MAZEMaze Therapeutics, Inc. | 69,375 | $2.1M |
| TECXTectonic Therapeutic, Inc. | 64,196 | $2.0M |
| OGNOrganon & Co. | 327,935 | $2.0M |
| CTMXCytomX Therapeutics, Inc. | 380,160 | $1.8M |
| GMABGenmab A/S | 66,902 | $1.8M |
| SGMTSagimet Biosciences Inc. | 317,550 | $1.7M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 425,492 | $1.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 31,089 | $1.4M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 15,088 | $1.3M |
| XERSXeris Biopharma Holdings, Inc. | 208,273 | $1.2M |
| DSGNDesign Therapeutics, Inc. | 108,449 | $1.2M |
| ABCLAbCellera Biologics Inc. | 289,836 | $1.0M |
| SYRESpyre Therapeutics, Inc. | 19,755 | $996K |
| PRQRProQR Therapeutics N.V. | 546,079 | $885K |
| ABUSArbutus Biopharma Corp | 191,355 | $861K |
| RGNXREGENXBIO Inc. | 101,245 | $848K |
| RCUSArcus Biosciences, Inc. | 37,766 | $816K |
| AGENAGENUS INC | 239,554 | $800K |
| BEAMBeam Therapeutics Inc. | 32,563 | $776K |
| ROIVRoivant Sciences Ltd. | 26,136 | $724K |
| ACADACADIA PHARMACEUTICALS INC | 31,923 | $711K |
| KLRSKalaris Therapeutics, Inc. | 118,887 | $686K |
| DNLIDenali Therapeutics Inc. | 34,383 | $660K |
| CMPXCompass Therapeutics, Inc. | 121,889 | $645K |
| QUREuniQure N.V. | 36,756 | $601K |
| RCKTRocket Pharmaceuticals Inc. | 149,207 | $534K |
| KRROKorro Bio, Inc. | 42,838 | $485K |
| DFTXDefinium Therapeutics Inc. | 23,713 | $448K |
| GERNGERON CORP | 290,780 | $433K |
| ELVNEnliven Therapeutics, Inc. | 10,612 | $416K |
| SMMTSummit Therapeutics Inc. | 20,904 | $396K |
| ABSIAbsci Corporation | 127,932 | $384K |
| ARVNARVINAS, INC. | 35,232 | $373K |
| IFRXInflaRx N.V. | 395,803 | $354K |
| ORGOOrganogenesis Holdings Inc. | 139,642 | $331K |
| OLMAOlema Pharmaceuticals, Inc. | 20,600 | $307K |
| FOLDAMICUS THERAPEUTICS, INC. | 19,565 | $283K |
| NUVBNuvation Bio Inc. | 62,940 | $270K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 86,214 | $265K |
| AQSTAquestive Therapeutics, Inc. | 55,222 | $229K |
| ZVRAZEVRA THERAPEUTICS, INC. | 23,231 | $217K |
| ESPREsperion Therapeutics, Inc. | 77,607 | $213K |
| NKTRNEKTAR THERAPEUTICS | 2,953 | $212K |
| IMVTImmunovant, Inc. | 8,257 | $205K |
| CADLCandel Therapeutics, Inc. | 40,000 | $196K |
| ALTAltimmune, Inc. | 53,796 | $166K |
| ZURAZura Bio Ltd | 26,892 | $160K |
| VERUVERU INC. | 67,561 | $149K |
| PGENPRECIGEN, INC. | 37,382 | $145K |
| LENZLENZ Therapeutics, Inc. | 15,008 | $137K |
| LCTXLineage Cell Therapeutics, Inc. | 83,984 | $133K |
| SLNSilence Therapeutics Plc | 25,000 | $132K |
| CLYMClimb Bio, Inc. | 17,727 | $121K |
| ELTXElicio Therapeutics, Inc. | 11,100 | $119K |
| KZIAKAZIA THERAPEUTICS LTD | 15,749 | $117K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 11,884 | $116K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 138,203 | $111K |
| ANNXAnnexon, Inc. | 19,369 | $107K |
| DMACDiaMedica Therapeutics Inc. | 15,791 | $107K |
| ATAIAtai Beckley N.V. | 29,990 | $106K |
| GRFSGrifols S.A. | 13,104 | $105K |
| SANASana Biotechnology, Inc. | 36,407 | $105K |
| VYGRVoyager Therapeutics, Inc. | 27,019 | $104K |
| CMPSCOMPASS Pathways plc | 17,429 | $96K |
| IRDOpus Genetics, Inc. | 19,508 | $89K |
| AVXLANAVEX LIFE SCIENCES CORP. | 22,433 | $69K |
| ACOGAlpha Cognition Inc. | 10,000 | $55K |
| ZNTLZentalis Pharmaceuticals, Inc. | 22,895 | $54K |
| GALTGALECTIN THERAPEUTICS INC | 14,967 | $42K |
| AARDAardvark Therapeutics, Inc. | 10,890 | $41K |
| OPKOPKO HEALTH, INC. | 32,624 | $37K |
| CRDFCardiff Oncology, Inc. | 22,672 | $37K |
| CGTXCOGNITION THERAPEUTICS INC | 47,500 | $36K |
| RZLTRezolute, Inc. | 10,532 | $32K |
| MISTMilestone Pharmaceuticals Inc. | 26,600 | $32K |
| BDTXBlack Diamond Therapeutics, Inc. | 14,115 | $30K |
| HUMAHumacyte Inc. | 48,329 | $29K |
| FLNAFilana Therapeutics Inc. | 17,104 | $29K |
| INOINOVIO PHARMACEUTICALS, INC. | 16,543 | $29K |
| ONCYONCOLYTICS BIOTECH INC | 33,751 | $29K |
| DAREDare Bioscience, Inc. | 15,334 | $28K |
| HOWLWerewolf Therapeutics, Inc. | 19,778 | $16K |
| VTGNVistagen Therapeutics, Inc. | 14,884 | $9K |
| PDSBPDS Biotechnology Corp | 10,236 | $6K |
| MEDSDataMeds AI, Inc. | 58,421 | $6K |
| OTLKOutlook Therapeutics, Inc. | 27,051 | $6K |