| GILDGILEAD SCIENCES, INC. | 661,397 | $92.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 48,251 | $37.3M |
| JAZZJazz Pharmaceuticals plc | 191,286 | $36.2M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 370,518 | $20.4M |
| INCYIncyte Corp. | 158,226 | $14.9M |
| SNYSanofi | 271,089 | $13.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 33,850 | $11.2M |
| RDYDR REDDYS LABORATORIES LTD | 637,094 | $8.8M |
| MRNAModerna, Inc. | 168,077 | $8.5M |
| ARGXARGENX SE | 11,148 | $8.1M |
| GMABGenmab A/S | 282,498 | $7.6M |
| TEVATeva Pharmaceutical Industries Limited | 216,461 | $6.5M |
| RVMDREVOLUTION MEDICINES, INC. | 63,360 | $6.2M |
| INSMINSMED Inc | 35,552 | $5.8M |
| EXELEXELIXIS, INC. | 115,592 | $5.0M |
| APLSApellis Pharmaceuticals, Inc. | 121,270 | $4.9M |
| IONSIONIS PHARMACEUTICALS INC | 55,502 | $4.2M |
| CYTKCYTOKINETICS INC | 52,598 | $3.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 52,147 | $2.9M |
| GRFSGrifols S.A. | 352,798 | $2.8M |
| ALMSALUMIS INC. | 127,095 | $2.8M |
| ONCBeOne Medicines Ltd. | 8,312 | $2.5M |
| BBIOBridgeBio Pharma, Inc. | 32,240 | $2.4M |
| TGTXTG THERAPEUTICS, INC. | 71,994 | $2.4M |
| FLGTFulgent Genetics Inc. | 137,479 | $2.2M |
| ROIVRoivant Sciences Ltd. | 76,575 | $2.1M |
| CLDXCelldex Therapeutics, Inc. | 65,744 | $2.1M |
| TVTXTravere Therapeutics, Inc. | 68,317 | $2.0M |
| AXSMAxsome Therapeutics, Inc. | 11,497 | $1.9M |
| OGNOrganon & Co. | 265,024 | $1.6M |
| NUVLNuvalent, Inc. | 15,162 | $1.6M |
| OLMAOlema Pharmaceuticals, Inc. | 95,336 | $1.4M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 144,299 | $1.4M |
| SMMTSummit Therapeutics Inc. | 73,835 | $1.4M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 26,209 | $1.4M |
| VKTXViking Therapeutics, Inc. | 41,082 | $1.3M |
| PCVXVaxcyte, Inc. | 21,563 | $1.3M |
| LGNDLigand Pharmaceuticals Incorporated | 6,227 | $1.2M |
| ANIPANI PHARMACEUTICALS INC | 15,167 | $1.2M |
| BHVNBiohaven Ltd. | 121,554 | $1.0M |
| CGEMCullinan Therapeutics, Inc. | 72,282 | $1.0M |
| IMVTImmunovant, Inc. | 40,030 | $994K |
| ZYMEZymeworks Inc. | 39,640 | $993K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 27,591 | $933K |
| TRDAEntrada Therapeutics, Inc. | 71,018 | $896K |
| SPRYARS Pharmaceuticals, Inc. | 101,412 | $814K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 12,790 | $802K |
| ARVNARVINAS, INC. | 74,540 | $790K |
| DFTXDefinium Therapeutics Inc. | 39,958 | $755K |
| KURAKura Oncology, Inc. | 89,303 | $726K |
| INVAInnoviva, Inc. | 31,013 | $723K |
| PTGXProtagonist Therapeutics, Inc | 6,437 | $678K |
| KALVKalVista Pharmaceuticals, Inc. | 32,453 | $653K |
| LQDALiquidia Corp | 17,165 | $648K |
| NUVBNuvation Bio Inc. | 139,257 | $597K |
| DNLIDenali Therapeutics Inc. | 30,170 | $579K |
| ADPTAdaptive Biotechnologies Corp | 41,538 | $577K |
| FOLDAMICUS THERAPEUTICS, INC. | 39,781 | $575K |
| VCELVericel Corp | 17,634 | $567K |
| SRRKScholar Rock Holding Corp | 11,272 | $554K |
| NTLAIntellia Therapeutics, Inc. | 39,709 | $509K |
| ARQTArcutis Biotherapeutics, Inc. | 19,113 | $450K |
| PTCTPTC THERAPEUTICS, INC. | 6,606 | $450K |
| UPBUpstream Bio, Inc. | 49,389 | $445K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 14,472 | $440K |
| LENZLENZ Therapeutics, Inc. | 47,648 | $436K |
| KODKodiak Sciences Inc. | 11,396 | $434K |
| JBIOJade Biosciences, Inc. | 30,551 | $429K |
| ZBIOZenas BioPharma, Inc. | 21,126 | $413K |
| KRROKorro Bio, Inc. | 35,978 | $407K |
| FDMT4D Molecular Therapeutics, Inc. | 43,525 | $405K |
| BIOABioAge Labs, Inc. | 23,087 | $404K |
| TNGXTango Therapeutics, Inc. | 18,444 | $386K |
| ADMAADMA BIOLOGICS, INC. | 42,541 | $383K |
| BEAMBeam Therapeutics Inc. | 16,076 | $383K |
| DAWNDay One Biopharmaceuticals, Inc. | 17,556 | $376K |
| RCUSArcus Biosciences, Inc. | 17,295 | $374K |
| RGNXREGENXBIO Inc. | 43,951 | $368K |
| BCAXBicara Therapeutics Inc. | 17,612 | $350K |
| NRIXNurix Therapeutics, Inc. | 22,133 | $343K |
| ACADACADIA PHARMACEUTICALS INC | 15,332 | $341K |
| ANABANAPTYSBIO, INC | 6,084 | $337K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 3,851 | $335K |
| ORICOric Pharmaceuticals, Inc. | 25,526 | $323K |
| TERNTerns Pharmaceuticals, Inc. | 6,123 | $323K |
| STOKStoke Therapeutics, Inc. | 9,773 | $318K |
| SLSSELLAS Life Sciences Group, Inc. | 74,378 | $315K |
| ZVRAZEVRA THERAPEUTICS, INC. | 32,022 | $298K |
| COGTCogent Biosciences, Inc. | 7,542 | $290K |
| CATXPerspective Therapeutics, Inc. | 65,494 | $273K |
| RCKTRocket Pharmaceuticals Inc. | 76,248 | $273K |
| KROSKeros Therapeutics, Inc. | 23,759 | $262K |
| APGEApogee Therapeutics, Inc. | 3,052 | $257K |
| ELVNEnliven Therapeutics, Inc. | 6,538 | $256K |
| ORKAOruka Therapeutics, Inc. | 5,176 | $254K |
| HROWHARROW, INC. | 7,199 | $254K |
| IBRXImmunityBio, Inc. | 32,209 | $247K |
| SYRESpyre Therapeutics, Inc. | 4,561 | $230K |
| ABUSArbutus Biopharma Corp | 48,715 | $219K |
| ATAIAtai Beckley N.V. | 58,246 | $206K |
| XERSXeris Biopharma Holdings, Inc. | 30,971 | $180K |
| SIGASIGA TECHNOLOGIES INC | 31,589 | $169K |
| AVXLANAVEX LIFE SCIENCES CORP. | 54,547 | $167K |
| RNAAtrium Therapeutics Inc. | 12,454 | $167K |
| DSGNDesign Therapeutics, Inc. | 14,128 | $150K |
| VYGRVoyager Therapeutics, Inc. | 35,703 | $138K |
| ARDXARDELYX, INC. | 18,774 | $112K |
| OCULOCULAR THERAPEUTIX, INC | 11,612 | $98K |
| AQSTAquestive Therapeutics, Inc. | 18,014 | $75K |
| SANASana Biotechnology, Inc. | 19,033 | $55K |
| VERUVERU INC. | 20,000 | $44K |
| ALTAltimmune, Inc. | 10,636 | $33K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 10,328 | $32K |