| REGNREGENERON PHARMACEUTICALS, INC. | 408,931 | $316.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 662,365 | $219.2M |
| GILDGILEAD SCIENCES, INC. | 1,242,331 | $173.1M |
| BBIOBridgeBio Pharma, Inc. | 1,977,080 | $146.8M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 2,378,076 | $131.2M |
| JAZZJazz Pharmaceuticals plc | 535,062 | $101.2M |
| ARGXARGENX SE | 49,330 | $36.0M |
| PTCTPTC THERAPEUTICS, INC. | 425,240 | $29.0M |
| AXSMAxsome Therapeutics, Inc. | 117,093 | $19.8M |
| ROIVRoivant Sciences Ltd. | 699,137 | $19.4M |
| MRNAModerna, Inc. | 314,872 | $16.0M |
| RVMDREVOLUTION MEDICINES, INC. | 141,296 | $13.7M |
| PTGXProtagonist Therapeutics, Inc | 127,818 | $13.5M |
| ACADACADIA PHARMACEUTICALS INC | 571,776 | $12.7M |
| INSMINSMED Inc | 72,696 | $11.9M |
| ARQTArcutis Biotherapeutics, Inc. | 503,856 | $11.9M |
| INCYIncyte Corp. | 125,481 | $11.8M |
| SMMTSummit Therapeutics Inc. | 592,810 | $11.2M |
| IONSIONIS PHARMACEUTICALS INC | 149,538 | $11.2M |
| CYTKCYTOKINETICS INC | 167,124 | $11.0M |
| TEVATeva Pharmaceutical Industries Limited | 348,898 | $10.5M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 160,422 | $10.1M |
| SRRKScholar Rock Holding Corp | 173,765 | $8.5M |
| EXELEXELIXIS, INC. | 184,117 | $7.9M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 133,750 | $7.6M |
| NUVLNuvalent, Inc. | 71,295 | $7.3M |
| APGEApogee Therapeutics, Inc. | 68,696 | $5.8M |
| SYRESpyre Therapeutics, Inc. | 112,841 | $5.7M |
| GPCRStructure Therapeutics Inc. | 114,814 | $5.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 65,238 | $5.5M |
| PCVXVaxcyte, Inc. | 86,366 | $5.0M |
| KODKodiak Sciences Inc. | 120,629 | $4.6M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 50,769 | $4.4M |
| ABVXAbivax SA | 38,595 | $4.3M |
| COGTCogent Biosciences, Inc. | 105,517 | $4.1M |
| BEAMBeam Therapeutics Inc. | 151,403 | $3.6M |
| ORKAOruka Therapeutics, Inc. | 72,563 | $3.6M |
| ALMSALUMIS INC. | 154,634 | $3.4M |
| KNSAKiniksa Pharmaceuticals International, plc | 63,346 | $3.1M |
| NRIXNurix Therapeutics, Inc. | 179,177 | $2.8M |
| SIONSionna Therapeutics, Inc. | 64,458 | $2.6M |
| CLDXCelldex Therapeutics, Inc. | 77,772 | $2.5M |
| TERNTerns Pharmaceuticals, Inc. | 46,784 | $2.5M |
| DNLIDenali Therapeutics Inc. | 125,442 | $2.4M |
| TGTXTG THERAPEUTICS, INC. | 71,852 | $2.4M |
| ORICOric Pharmaceuticals, Inc. | 182,139 | $2.3M |
| IMCRImmunocore Holdings plc | 76,519 | $2.3M |
| TNGXTango Therapeutics, Inc. | 108,218 | $2.3M |
| STOKStoke Therapeutics, Inc. | 69,222 | $2.3M |
| PVLAPALVELLA THERAPEUTICS, INC. | 17,907 | $2.2M |
| MLTXMoonLake Immunotherapeutics | 118,961 | $2.2M |
| LQDALiquidia Corp | 58,265 | $2.2M |
| IRONDisc Medicine, Inc. | 32,493 | $2.1M |
| OCULOCULAR THERAPEUTIX, INC | 227,808 | $1.9M |
| BCAXBicara Therapeutics Inc. | 90,285 | $1.8M |
| LGNDLigand Pharmaceuticals Incorporated | 8,909 | $1.8M |
| BHVNBiohaven Ltd. | 202,975 | $1.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 50,046 | $1.7M |
| OLMAOlema Pharmaceuticals, Inc. | 109,582 | $1.6M |
| VRDNViridian Therapeutics, Inc.\DE | 81,425 | $1.6M |
| ONCBeOne Medicines Ltd. | 5,308 | $1.6M |
| IBRXImmunityBio, Inc. | 191,097 | $1.5M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 25,506 | $1.3M |
| FOLDAMICUS THERAPEUTICS, INC. | 89,337 | $1.3M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 365,471 | $1.3M |
| IMVTImmunovant, Inc. | 51,421 | $1.3M |
| PHVSPharvaris N.V. | 44,195 | $1.2M |
| TVTXTravere Therapeutics, Inc. | 39,660 | $1.2M |
| SNYSanofi | 23,516 | $1.1M |
| CLYMClimb Bio, Inc. | 156,317 | $1.1M |
| CGEMCullinan Therapeutics, Inc. | 75,310 | $1.1M |
| ADMAADMA BIOLOGICS, INC. | 114,512 | $1.0M |
| APLSApellis Pharmaceuticals, Inc. | 24,765 | $996K |
| ADPTAdaptive Biotechnologies Corp | 71,672 | $995K |
| ELVNEnliven Therapeutics, Inc. | 23,441 | $919K |
| RCUSArcus Biosciences, Inc. | 42,170 | $911K |
| TRDAEntrada Therapeutics, Inc. | 70,656 | $892K |
| VKTXViking Therapeutics, Inc. | 27,196 | $885K |
| RNAAtrium Therapeutics Inc. | 62,379 | $834K |
| ZYMEZymeworks Inc. | 31,592 | $791K |
| DAWNDay One Biopharmaceuticals, Inc. | 36,186 | $776K |
| SLNOSOLENO THERAPEUTICS INC | 22,878 | $766K |
| VCELVericel Corp | 23,487 | $756K |
| ANNXAnnexon, Inc. | 134,786 | $747K |
| INVAInnoviva, Inc. | 31,971 | $745K |
| ANIPANI PHARMACEUTICALS INC | 9,577 | $736K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 219,998 | $675K |
| ARDXARDELYX, INC. | 107,139 | $642K |
| BCYCBICYCLE THERAPEUTICS PLC | 127,863 | $593K |
| NTLAIntellia Therapeutics, Inc. | 46,257 | $593K |
| ANABANAPTYSBIO, INC | 10,166 | $564K |
| CNTACentessa Pharmaceuticals plc | 13,965 | $555K |
| IMTXImmatics N.V. | 55,300 | $544K |
| RCKTRocket Pharmaceuticals Inc. | 149,204 | $534K |
| HROWHARROW, INC. | 14,778 | $521K |
| TENXTENAX THERAPEUTICS, INC. | 31,336 | $501K |
| DFTXDefinium Therapeutics Inc. | 26,404 | $499K |
| CBIOCRESCENT BIOPHARMA, INC. | 24,903 | $457K |
| NUVBNuvation Bio Inc. | 104,682 | $449K |
| MAZEMaze Therapeutics, Inc. | 14,570 | $435K |
| TECXTectonic Therapeutic, Inc. | 13,929 | $431K |
| XERSXeris Biopharma Holdings, Inc. | 72,804 | $422K |
| SVRASavara Inc | 68,175 | $372K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 11,302 | $362K |
| CMPXCompass Therapeutics, Inc. | 67,466 | $357K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 11,684 | $355K |
| PGENPRECIGEN, INC. | 90,143 | $349K |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 35,692 | $319K |
| OGNOrganon & Co. | 52,816 | $316K |
| IMMXImmix Biopharma, Inc. | 28,964 | $264K |
| SANASana Biotechnology, Inc. | 79,537 | $229K |
| ATAIAtai Beckley N.V. | 64,100 | $227K |
| GERNGERON CORP | 148,669 | $222K |
| MDWDMediWound Ltd. | 13,572 | $219K |
| KALVKalVista Pharmaceuticals, Inc. | 10,551 | $212K |
| SLSSELLAS Life Sciences Group, Inc. | 45,691 | $193K |
| QUREuniQure N.V. | 11,770 | $192K |
| ABUSArbutus Biopharma Corp | 42,429 | $191K |
| KURAKura Oncology, Inc. | 21,993 | $179K |
| ESPREsperion Therapeutics, Inc. | 64,523 | $177K |
| ARVNARVINAS, INC. | 15,160 | $161K |
| ZVRAZEVRA THERAPEUTICS, INC. | 15,137 | $141K |
| OPKOPKO HEALTH, INC. | 122,128 | $139K |
| UPBUpstream Bio, Inc. | 15,338 | $138K |
| SPRYARS Pharmaceuticals, Inc. | 16,637 | $134K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 12,184 | $118K |
| SLDBSolid Biosciences Inc. | 16,273 | $117K |
| AQSTAquestive Therapeutics, Inc. | 27,922 | $116K |
| FDMT4D Molecular Therapeutics, Inc. | 12,256 | $114K |
| ABSIAbsci Corporation | 36,989 | $111K |
| RGNXREGENXBIO Inc. | 12,937 | $108K |
| ALTAltimmune, Inc. | 34,763 | $107K |
| DNAGinkgo Bioworks Holdings Inc. | 17,210 | $105K |
| CMPSCOMPASS Pathways plc | 14,073 | $78K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 11,765 | $75K |
| AVXLANAVEX LIFE SCIENCES CORP. | 24,351 | $75K |
| CATXPerspective Therapeutics, Inc. | 16,681 | $70K |
| CADLCandel Therapeutics, Inc. | 12,993 | $64K |
| AUTLAutolus Therapeutics plc | 45,749 | $63K |
| RZLTRezolute, Inc. | 20,512 | $63K |
| SIGASIGA TECHNOLOGIES INC | 11,642 | $62K |
| LRMRLarimar Therapeutics, Inc. | 13,445 | $61K |
| ABEOABEONA THERAPEUTICS INC. | 12,901 | $58K |
| ALECAlector, Inc. | 26,148 | $56K |
| VYGRVoyager Therapeutics, Inc. | 13,358 | $52K |
| ORGOOrganogenesis Holdings Inc. | 20,673 | $49K |
| CHRSCoherus Oncology, Inc. | 28,066 | $47K |
| PLXProtalix BioTherapeutics, Inc. | 19,528 | $42K |
| FATEFATE THERAPEUTICS INC | 32,117 | $39K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 45,988 | $37K |
| CRDFCardiff Oncology, Inc. | 18,624 | $30K |
| HUMAHumacyte Inc. | 46,547 | $28K |
| ALDXAldeyra Therapeutics, Inc. | 16,155 | $27K |