| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 980,479 | $54.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 74,661 | $24.7M |
| TERNTerns Pharmaceuticals, Inc. | 400,000 | $21.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 324,939 | $18.4M |
| ARGXARGENX SE | 23,488 | $17.2M |
| APLSApellis Pharmaceuticals, Inc. | 403,622 | $16.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,049,700 | $15.2M |
| RVMDREVOLUTION MEDICINES, INC. | 130,000 | $12.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 116,444 | $9.8M |
| ABVXAbivax SA | 76,552 | $8.5M |
| DAWNDay One Biopharmaceuticals, Inc. | 362,641 | $7.8M |
| CNTACentessa Pharmaceuticals plc | 125,000 | $5.0M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 213,137 | $4.6M |
| NKTRNEKTAR THERAPEUTICS | 48,294 | $3.5M |
| PTGXProtagonist Therapeutics, Inc | 30,850 | $3.3M |
| AGMBAgomAb Therapeutics NV | 300,000 | $3.1M |
| COGTCogent Biosciences, Inc. | 55,389 | $2.1M |
| IONSIONIS PHARMACEUTICALS INC | 15,000 | $1.1M |
| CTMXCytomX Therapeutics, Inc. | 234,931 | $1.1M |
| SRZNSurrozen Inc. | 23,557 | $686K |
| IMVTImmunovant, Inc. | 26,045 | $647K |
| SMMTSummit Therapeutics Inc. | 34,122 | $647K |
| INSMINSMED Inc | 3,300 | $540K |
| ROIVRoivant Sciences Ltd. | 16,750 | $464K |
| ORICOric Pharmaceuticals, Inc. | 35,267 | $447K |
| RLMDRELMADA THERAPEUTICS, INC. | 63,584 | $443K |
| RNAAtrium Therapeutics Inc. | 32,500 | $435K |
| CYTKCYTOKINETICS INC | 4,300 | $283K |
| BMEABiomea Fusion, Inc. | 200,000 | $267K |
| MPLTMapLight Therapeutics, Inc. | 10,000 | $203K |
| APGEApogee Therapeutics, Inc. | 2,029 | $171K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 41,211 | $145K |
| REGNREGENERON PHARMACEUTICALS, INC. | 143 | $110K |
| ESPREsperion Therapeutics, Inc. | 35,859 | $98K |
| OGNOrganon & Co. | 13,213 | $79K |
| OCGNOcugen, Inc. | 36,874 | $67K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 23,305 | $36K |
| TVTXTravere Therapeutics, Inc. | 1,220 | $36K |
| MRNAModerna, Inc. | 699 | $36K |
| LCTXLineage Cell Therapeutics, Inc. | 21,160 | $33K |
| IVVDInvivyd, Inc. | 24,874 | $32K |
| OCULOCULAR THERAPEUTIX, INC | 2,728 | $23K |
| VRDNViridian Therapeutics, Inc.\DE | 1,159 | $23K |
| PROKPROKIDNEY CORP. | 12,484 | $22K |